CN106659404B

CN106659404B - Continuous blood pressure measuring method, device and equipment

Info

Publication number: CN106659404B
Application number: CN201580042649.2A
Authority: CN
Inventors: 汝剑飞
Original assignee: Huawei Technologies Co Ltd
Current assignee: Huawei Technologies Co Ltd
Priority date: 2015-05-27
Filing date: 2015-05-27
Publication date: 2020-02-14
Anticipated expiration: 2035-05-27
Also published as: WO2016187835A1; CN106659404A

Abstract

A method, apparatus and device for continuous blood pressure measurement, the method comprising: the acquisition equipment acquires an electrocardiosignal and a photoplethysmography pulse signal, determines an actual measurement blood pressure according to the electrocardiosignal and the photoplethysmography pulse signal, corrects a coefficient of a prediction equation according to the actual measurement blood pressure and the prediction equation for determining the predicted blood pressure, and calculates a blood pressure value according to the corrected prediction equation. The continuous blood pressure measuring method, the device and the equipment can improve the accuracy of continuous blood pressure measurement.

Description

Continuous blood pressure measuring method, device and equipment

Technical Field

The embodiment of the invention relates to the technology of medical equipment, in particular to a continuous blood pressure measuring method, a device and equipment.

Background

Human blood pressure is an important reference index in human health, particularly in cardiovascular and cerebrovascular aspects, and is also an important basis for medical workers to diagnose diseases, so that users often measure and master their own blood pressure, which is an important means for health care and disease prevention.

In the related art, there are many ways of measuring blood pressure, and in recent years, blood pressure measurement using a sphygmomanometer based on a pulse wave transmission rate is a method in which an electrocardiographic signal and a photoplethysmographic pulse signal are collected from an electrocardiographic sensor (ECG) and a photoelectric sensor (PPG) provided at a fingertip or other peripheral tissue position, and the blood pressure is determined according to a relationship between arterial blood pressure and a pulse wave transmission rate, and when the blood pressure rises, a blood vessel expands, the pulse wave transmission rate increases, and conversely, the pulse wave transmission rate decreases.

However, when the blood pressure is measured by the pulse wave velocity, it is necessary to simultaneously measure the blood pressure by the electrocardiograph and the photoelectric sensor, and it is not preferable to continuously detect the blood pressure. Although a technique for estimating blood pressure by using PPG alone has been studied, it is difficult to measure blood pressure continuously because of measurement errors caused by interference of photodetection of PPG due to noise such as body motion noise, external interference light, or sweat.

Disclosure of Invention

The embodiment of the invention provides a continuous blood pressure measuring method, a device and equipment, which are used for improving the accuracy of continuous blood pressure measurement.

The embodiment of the invention provides a continuous blood pressure measuring method, which comprises the following steps:

the acquisition equipment acquires an electrocardiosignal and a photoplethysmography pulse signal;

the acquisition device determines a measured blood pressure from the electrocardiographic signal and the photoplethysmographic pulse signal;

and the obtaining equipment determines a prediction equation for predicting the blood pressure according to the actually measured blood pressure, corrects the coefficient of the prediction equation and calculates the blood pressure value according to the corrected prediction equation.

With reference to the first aspect, in a first possible implementation manner of the first aspect, the acquiring device acquires an electrocardiographic signal, and includes:

the acquisition equipment acquires an electrocardiowave through an electrocardio sensor;

the acquisition equipment carries out Fast Fourier Transform (FFT) processing on the electrocardiowaves to obtain processed signals;

and the acquisition equipment carries out noise removal processing on the processed signal to obtain the electrocardiosignal.

With reference to the first aspect or the first possible implementation manner of the first aspect, in a second possible implementation manner of the first aspect, the acquiring device acquires a photoplethysmographic pulse signal, and includes:

the acquisition equipment acquires pulse waves through a pulse sensor;

the acquisition equipment carries out Fast Fourier Transform (FFT) processing on the pulse wave to obtain a processed signal;

the acquisition equipment carries out noise removal processing on the processed signal to obtain the photoplethysmography pulse signal.

With reference to the first aspect, the first to any second possible implementation manner of the first aspect, in a third possible implementation manner of the first aspect, the determining, by the obtaining device, a measured blood pressure value according to the electrocardiographic signal and the photoplethysmographic pulse signal includes:

the acquisition device synchronizes the electrocardiosignals and the photoplethysmography pulse signals to obtain synchronous signals;

the acquisition equipment calculates pulse transmission time PTT according to the synchronous signal;

and the acquisition equipment determines the actually measured blood pressure according to the PTT.

With reference to the first aspect and any one of the first to the third possible implementation manners of the first aspect, in a fourth possible implementation manner of the first aspect, the correcting, by the obtaining device, coefficients of a predictor equation according to the measured blood pressure and the predictor equation for determining the predicted blood pressure includes:

the acquisition equipment performs secondary differentiation on the photoplethysmography pulse signal to obtain a characteristic quantity;

the obtaining device obtains predicted blood pressure according to the characteristic quantity and a preset prediction equation;

and the obtaining equipment corrects the coefficient of the preset pre-estimation equation according to the measured blood pressure and the predicted blood pressure.

In a second aspect, an embodiment of the present invention provides a method for continuous blood pressure measurement, including:

the method comprises the steps that a receiving side device obtains an electrocardiosignal and a photoplethysmography pulse signal;

the receiving side equipment determines the measured blood pressure according to the electrocardio signals and the photoplethysmography pulse signals;

and the receiving side equipment sends the measured blood pressure to the sending side equipment so that the sending side equipment can correct the coefficient of the prediction equation according to the measured blood pressure and the prediction equation for determining the predicted blood pressure, and calculate the blood pressure value according to the corrected prediction equation.

In a third aspect, an embodiment of the present invention provides a method for continuous blood pressure measurement, including:

the method comprises the steps that a sending side device acquires a photoplethysmography pulse signal and sends the photoplethysmography pulse signal to a receiving side device, so that the receiving side device can determine actually-measured blood pressure according to the acquired electrocardiosignal and the photoplethysmography pulse signal;

the transmitting side equipment receives the measured blood pressure transmitted by the receiving side equipment;

and the transmitting side equipment corrects the coefficient of the pre-estimation equation according to the actually measured blood pressure and the pre-estimation equation for determining the predicted blood pressure, and calculates the blood pressure value according to the corrected pre-estimation equation.

In a fourth aspect, an embodiment of the present invention provides a continuous blood pressure measuring apparatus, including:

the acquisition module is used for acquiring the electrocardiosignals and the photoplethysmography pulse signals;

a determination module for determining a measured blood pressure from the electrocardiographic signal and the photoplethysmographic pulse signal;

and the processing module is used for correcting the coefficient of the prediction equation according to the actually measured blood pressure and the prediction equation for determining the predicted blood pressure, and calculating the blood pressure value according to the corrected prediction equation.

With reference to the fourth aspect, in a first possible implementation manner of the fourth aspect, the obtaining module includes:

the first acquisition unit is used for acquiring an electrocardiowave through the electrocardio sensor;

a first processing unit, configured to perform Fast Fourier Transform (FFT) processing on the cardiac electric wave to obtain a processed signal;

the first processing unit is further configured to perform noise removal processing on the processed signal to obtain the electrocardiographic signal.

With reference to the fourth aspect or the first possible implementation manner of the fourth aspect, in a second possible implementation manner of the fourth aspect, the obtaining module includes:

the second acquisition unit is used for acquiring pulse waves through the pulse sensor;

the second processing unit is used for carrying out Fast Fourier Transform (FFT) processing on the pulse wave to obtain a processing signal;

the second processing unit is used for removing noise from the processed signal to obtain the photoplethysmography pulse signal.

With reference to the fourth aspect and the second possible implementation manner of the first to fourth aspects of the fourth aspect, in a third possible implementation manner of the fourth aspect, the determining module includes:

a synchronization unit for synchronizing the electrocardiographic signal and the photoplethysmographic pulse signal to obtain a synchronization signal;

the calculation unit is used for calculating the pulse transmission time PTT according to the synchronous signal;

and the determining unit is used for determining the actually measured blood pressure according to the PTT.

With reference to the fourth aspect and the third possible implementation manner of the first to fourth aspects of the fourth aspect, in a fourth possible implementation manner of the fourth aspect, the processing module includes:

an acquisition unit for performing secondary differentiation on the photoplethysmography pulse signal to obtain a characteristic quantity;

the obtaining unit is used for obtaining predicted blood pressure according to the characteristic quantity and a preset pre-estimation equation;

and the correcting unit is used for correcting the coefficient of the preset pre-estimation equation according to the measured blood pressure and the predicted blood pressure.

In a fifth aspect, an embodiment of the present invention provides an apparatus for continuous blood pressure measurement, including:

and the sending module is used for sending the measured blood pressure to sending side equipment so that the sending side equipment can correct the coefficient of the prediction equation according to the measured blood pressure and the prediction equation for determining the predicted blood pressure, and can calculate the blood pressure value according to the corrected prediction equation.

In a sixth aspect, an embodiment of the present invention provides an apparatus for continuous blood pressure measurement, including:

the acquisition module is used for acquiring a photoplethysmography pulse signal;

the sending module is used for sending the photoplethysmography pulse signal to receiving side equipment so that the receiving side equipment can determine an actually measured blood pressure according to the acquired electrocardiosignal and the photoplethysmography pulse signal;

the receiving module is used for receiving the actually measured blood pressure sent by the receiving side equipment;

In a seventh aspect, an embodiment of the present invention provides an acquisition apparatus, including:

the receiver is used for acquiring the electrocardiosignal and the photoplethysmography pulse signal;

a processor for determining a measured blood pressure from the electrocardiographic signal and the photoplethysmographic pulse signal;

the processor is further configured to correct a coefficient of the prediction equation according to the measured blood pressure and the prediction equation for determining the predicted blood pressure, and calculate a blood pressure value according to the corrected prediction equation.

With reference to the seventh aspect, in a first possible implementation manner of the seventh aspect, the receiver is further configured to acquire an electrocardiographic wave through an electrocardiograph sensor;

the processor is further configured to perform Fast Fourier Transform (FFT) processing on the cardiac electric wave to obtain a processed signal;

the processor is further configured to perform noise removal processing on the processed signal to obtain the electrocardiosignal.

With reference to the seventh aspect or the first possible implementation manner of the seventh aspect, in a second possible implementation manner of the seventh aspect, the receiver is further configured to acquire a pulse wave through a pulse sensor;

the processor is further used for performing Fast Fourier Transform (FFT) processing on the pulse wave to obtain a processed signal;

the processor is further used for removing noise from the processed signal to obtain the photoplethysmography pulse signal.

With reference to the seventh aspect and the second possible implementation manner of the first to seventh aspects of the seventh aspect, in a third possible implementation manner of the seventh aspect, the processor is further configured to synchronize the electrocardiographic signal and the photoplethysmographic pulse signal to obtain a synchronization signal;

the processor is further used for calculating pulse transmission time PTT according to the synchronous signal;

the processor is further configured to determine a measured blood pressure from the PTT.

With reference to the seventh aspect and the third possible implementation manner of the first to seventh aspects of the seventh aspect, in a fourth possible implementation manner of the seventh aspect, the processor is further configured to perform secondary differentiation on the photoplethysmographic pulse signal to obtain a feature quantity;

the processor is further used for obtaining predicted blood pressure according to the characteristic quantity and a preset pre-estimation equation;

the processor is further configured to correct the coefficient of the preset pre-estimation equation according to the measured blood pressure and the predicted blood pressure.

In an eighth aspect, an embodiment of the present invention provides a receiving-side device, including:

and the transmitter is used for transmitting the measured blood pressure to the transmitting side equipment, so that the transmitting side equipment corrects the coefficient of the prediction equation according to the measured blood pressure and the prediction equation for determining the predicted blood pressure, and calculates the blood pressure value according to the corrected prediction equation.

In a ninth aspect, an embodiment of the present invention provides a transmitting-side device, including:

a receiver for acquiring a photoplethysmographic pulse signal;

the transmitter is used for transmitting the photoplethysmography pulse signal to a receiving side device so that the receiving side device can determine the measured blood pressure according to the electrocardio signal and the photoplethysmography pulse signal;

the receiver is used for receiving the measured blood pressure sent by the receiving side equipment;

and the processor is used for correcting the coefficient of the prediction equation according to the actually measured blood pressure and the prediction equation for determining the predicted blood pressure, and calculating the blood pressure value according to the corrected prediction equation.

According to the continuous blood pressure measuring method, the device and the equipment provided by the embodiment of the invention, the acquisition equipment acquires the electrocardiosignal and the photoplethysmography pulse signal, the actually measured blood pressure is determined according to the electrocardiosignal and the photoplethysmography pulse signal, the estimation equation of the predicted blood pressure is determined according to the actually measured blood pressure, the error correction is carried out on the coefficient of the estimation equation, and the blood pressure value is calculated according to the corrected estimation equation. After the measured blood pressure is obtained, the blood pressure is predicted according to the related parameters related to the blood pressure and the photoplethysmography pulse signal, the measured blood pressure is used for correcting the coefficient of the prediction equation for determining the predicted blood pressure, and the blood pressure value is calculated according to the corrected prediction equation, so that the accuracy in continuously measuring the blood pressure is improved.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.

FIG. 1 is a schematic flow chart of a continuous blood pressure measurement method according to a first embodiment of the present invention;

FIG. 2 is a schematic flow chart of a second embodiment of the continuous blood pressure measuring method of the present invention;

FIG. 3 is a schematic flow chart of a third embodiment of a continuous blood pressure measurement method according to the present invention;

FIG. 4 is a schematic flow chart of a fourth embodiment of the continuous blood pressure measuring method of the present invention;

FIG. 5 is a schematic flow chart of a fifth embodiment of the continuous blood pressure measuring method of the present invention;

FIG. 6 is a schematic flow chart of a sixth embodiment of the continuous blood pressure measuring method of the present invention;

FIG. 7 is a schematic flow chart of a seventh embodiment of a continuous blood pressure measurement method according to the present invention;

FIG. 8 is a schematic structural diagram of a continuous blood pressure measuring device according to a first embodiment of the present invention;

FIG. 9 is a schematic structural diagram of a second continuous blood pressure measuring device according to an embodiment of the present invention;

FIG. 10 is a schematic structural diagram of a third continuous blood pressure measuring device according to the present invention;

FIG. 11 is a schematic structural diagram of a fourth continuous blood pressure measuring device according to the present invention;

FIG. 12 is a schematic structural diagram of a fifth embodiment of the continuous blood pressure measuring device according to the present invention;

FIG. 13 is a schematic structural diagram of a sixth embodiment of the continuous blood pressure measuring device of the present invention;

FIG. 14 is a schematic structural diagram of a first embodiment of an acquisition apparatus according to the present invention;

fig. 15 is a schematic structural diagram of a first apparatus at a receiving side according to the present invention;

fig. 16 is a schematic structural diagram of a first transmitting-side device according to an embodiment of the present invention.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Fig. 1 is a schematic flow chart of a continuous blood pressure measurement method according to a first embodiment of the present invention. Embodiments of the present invention provide a continuous blood pressure measurement method, which may be performed by any device that performs the continuous blood pressure measurement method, and the device may be implemented by software and/or hardware. In this embodiment, the apparatus may be integrated in an acquisition device, where the acquisition device may be, for example, a mobile terminal or a wearable device. As shown in fig. 1, the method of this embodiment may include:

step 101, obtaining an electrocardiosignal and a photoplethysmography pulse signal by an obtaining device.

In the embodiment, the acquisition device acquires an electrocardiographic signal through an electrocardiographic sensor, and acquires a photoplethysmographic pulse signal through a pulse sensor, wherein the electrocardiographic sensor can be an ECG electrode, for example. In practice, the electrocardiographic signals are acquired by placing at least two ECG electrodes at different positions of the acquisition device, for example: at least two ECG electrodes can be placed at positions that can be touched by the left and right hands of the user, respectively, to acquire electrocardiographic signals of the user through the ECG electrodes. The present invention is not limited in this regard as to the number of ECG electrodes and the specific placement location.

And 102, determining the actually measured blood pressure by the acquisition equipment according to the electrocardiosignal and the photoplethysmography pulse signal.

In this embodiment, after the obtaining device obtains the electrocardiographic signal and the photoplethysmography pulse signal, the actually measured blood pressure of the user is determined jointly according to the electrocardiographic signal and the photoplethysmography pulse signal.

And 103, the obtaining equipment corrects the coefficient of the prediction equation according to the actually measured blood pressure value and the prediction equation for determining the predicted blood pressure, and calculates the blood pressure value according to the corrected prediction equation.

In this embodiment, the establishment of the pre-estimation equation requires machine learning with the input data in advance. Wherein the input data is a parameter related to blood pressure, which comprises at least one of: sex, weight, height, daily pulse, living habit, work and rest system, electrocardiogram characteristics, administration condition, velocity pulse of photoplethysmography pulse signal, acceleration pulse, etc. In a specific implementation process, the photoplethysmography pulse signals can be classified according to each parameter, and then the classified photoplethysmography pulse signals are subjected to multiple regression analysis to obtain a relationship between each parameter and blood pressure, so as to determine a most appropriate prediction equation, for example: when machine learning is carried out, the photoplethysmography pulse signals are classified according to the medicine taking condition of a user, if the user does not take medicine, the photoplethysmography pulse signals are continuously classified … … according to the age of the user, finally, the photoplethysmography pulse signals are divided into N types, after classification, multivariate regression analysis is carried out on the photoplethysmography pulse signals according to the classification result, the relation between each parameter and the blood pressure is obtained, and therefore an estimation equation is obtained, namely the obtained estimation equation for calculating and predicting the blood pressure is as follows: the method includes the steps of (i) setting the predicted blood pressure as sBPe, (i, Ci), wherein sBPe is the predicted blood pressure, t is a feature quantity, and Ci is a random factor and is used for adjusting the regression effect.

Wherein, as for the feature quantity, the acquisition device may acquire the photoplethysmography pulse signal by performing a differential operation on the photoplethysmography pulse signal after acquiring the photoplethysmography pulse signal. In a specific implementation process, the characteristic quantity can be obtained by differentiating the photoplethysmography pulse signal twice, wherein after differentiating the photoplethysmography pulse signal once, a velocity pulse can be obtained, and then after differentiating twice, an acceleration pulse can be obtained, and then the characteristic quantity can be obtained.

In addition, after the acquisition device obtains the characteristic quantity, the predicted blood pressure can be calculated according to a prediction equation which is determined by performing machine learning in advance and used for calculating the predicted blood pressure.

In a specific implementation process, as described above, after classifying the photoplethysmographic pulse signals according to the input data and performing multiple regression analysis on the classified photoplethysmographic pulse signals, there are a plurality of sets (n) of corresponding estimation equations, which set of estimation equations is used for predicting the blood pressure of the time, which is determined according to the actually measured blood pressure determined by the obtaining device. Specifically, the measured blood pressure may be taken as the average value X, and the calculated predicted blood pressure may be assumed to be X_iWherein i is the number of predicted blood pressures (number of samples), and the measured blood pressure X and the predicted blood pressure X are calculated_iStandard deviation between (samples) S_n. Iteratively using all n groups of estimation equations to obtain the standard deviation S of the predicted blood pressure sample and X_nIf the calculated standard deviation S corresponding to the jth predicted blood pressure_jFor all n groups S_nThe minimum value in (A) is then selected as the set of pre-estimated equations (standard deviation is S)_jOf (a) for measurement, where j is less than or equal to i. For multiple regression analysis, other models may be used, and the invention is not limited in this regard.

According to the continuous blood pressure measuring method provided by the embodiment of the invention, the acquisition equipment acquires the electrocardiosignal and the photoplethysmography pulse signal, the actually measured blood pressure is determined according to the electrocardiosignal and the photoplethysmography pulse signal, the estimation equation of the actually measured blood pressure and the predicted blood pressure is determined, the error correction is carried out on the coefficient of the estimation equation, and the blood pressure value is calculated according to the corrected estimation equation. After the measured blood pressure is obtained, the blood pressure is predicted according to the related parameters related to the blood pressure and the photoplethysmography pulse signal, the measured blood pressure is used for correcting the coefficient of a prediction equation for determining the predicted blood pressure, and the blood pressure value is calculated according to the corrected prediction equation, so that the accuracy of continuous blood pressure measurement is improved.

Fig. 2 is a schematic flow chart of a second continuous blood pressure measurement method according to an embodiment of the present invention, and this embodiment describes in detail an embodiment in which the obtaining device obtains the electrocardiographic signal based on the first continuous blood pressure measurement method. As shown in fig. 2, the method of this embodiment may include:

step 201, acquiring an electrocardiowave by an acquisition device through an electrocardio sensor.

In this embodiment, the acquisition device acquires an electrocardiographic wave as an unprocessed and processed time-series signal.

Step 202, the acquisition device performs Fast Fourier Transform (FFT) processing on the cardiac electric wave to obtain a processed signal.

In the embodiment, the acquisition device adopts the signal processing circuit to perform a/D conversion and Fast Fourier Transform (FFT) processing on the cardiac waves, so as to Transform the time domain signal into the frequency domain signal, thereby facilitating the analysis and processing of the signal.

And step 203, the acquisition equipment performs noise removal processing on the processed signal to obtain an electrocardiosignal.

In this embodiment, after the acquisition device detects the peak waveform of the electrocardiograph in the obtained processed signal, it performs noise removal processing, where noise removal mainly adopts a method of filtering the signal, for example, a motion mode may be detected by an acceleration sensor, and then noise introduced due to motion or the like may be removed by comparing with the frequency domain signal fluctuation of the electrocardiograph sensor.

According to the continuous blood pressure measuring method provided by the embodiment of the invention, the acquisition equipment acquires the electrocardio waves through the electrocardio sensor, processes the electrocardio waves to obtain the processed signals, and then carries out noise removal processing on the processed signals to obtain the electrocardio signals, so that the accuracy of electrocardio signal measurement is improved.

Fig. 3 is a schematic flow chart of a third embodiment of the continuous blood pressure measuring method according to the present invention, and this embodiment explains an embodiment of acquiring a photoplethysmographic pulse signal by an acquiring device in detail based on the embodiment shown in fig. 1 or fig. 2. As shown in fig. 3, the method of this embodiment may include:

step 301, the obtaining device collects pulse waves through a pulse sensor.

In this embodiment, the pulse wave acquired by the acquisition device is an unprocessed and processed time-series signal.

Step 302, the obtaining device performs Fast Fourier Transform (FFT) processing on the pulse wave to obtain a processed signal.

In this embodiment, the obtaining device performs a/D conversion on the pulse wave by using the signal processing circuit, and performs FFT processing on the converted signal, so as to transform the time domain signal into a frequency domain signal, thereby facilitating analysis and processing of the signal.

And step 303, the acquisition equipment removes noise from the processed signal to obtain a photoplethysmography pulse signal.

In this embodiment, after the obtaining device detects the peak waveform of the pulse in the obtained processed signal, it performs a noise removal process, where the noise removal process mainly adopts a method of filtering the signal, for example, a motion pattern may be detected by an acceleration sensor, etc., and then noise introduced due to motion may be removed by comparing the fluctuation of the frequency domain signal of the pulse sensor.

According to the continuous blood pressure measuring method provided by the embodiment of the invention, the acquisition equipment acquires the pulse wave through the pulse sensor, processes the pulse wave to obtain the processed signal, and removes noise from the processed signal to obtain the photoplethysmography pulse signal, so that the accuracy of the photoplethysmography pulse signal measurement is improved. In addition, the pulse sensor measures the photoplethysmography pulse signals, and the purpose of continuous measurement is achieved.

Fig. 4 is a schematic flow chart of a fourth embodiment of the continuous blood pressure measurement method according to the present invention, and this embodiment describes in detail an embodiment in which the obtaining device determines the measured blood pressure according to the electrocardiographic signal and the photoplethysmographic pulse signal based on the above embodiments. As shown in fig. 4, the method of this embodiment may include:

step 401, the obtaining device synchronizes the electrocardiographic signal and the photoplethysmography pulse signal to obtain a synchronization signal.

In this embodiment, since the electrocardiographic signal is measured by the electrocardiographic sensor and the photoplethysmographic pulse signal is measured by the pulse sensor, it is necessary to synchronize the two signals to find the rising points of the R-wave and the pulse of the same electrocardiogram and to calculate the time difference between the rising points of the R-wave and the pulse. In a specific implementation process, the acquisition time of the electrocardiosignal and the photoplethysmography pulse signal can be synchronized by synchronously aligning the acquisition time of the electrocardiosignal and the pulse sensor.

Step 402, the obtaining device calculates the pulse transmission time PTT according to the synchronous signal.

In this embodiment, assuming that the contraction of the heart and the pumping of blood are simultaneous, the Pulse Transit Time (PTT) can be calculated by the time difference between the R-wave of the electrocardiogram and the rising point of the pulse, specifically, assuming that the time a represents the position of the peak of the R-wave on the electrocardiogram on the time axis, and the time b and the time c represent the positions of a bottom point and a peak on the photoplethysmography pulse signal on the time axis, respectively, the PTT can be obtained by calculating the time difference between the time a and the time b, or the PTT can be obtained by calculating the time difference between the time a and the time c, and the method for calculating PTT is not limited herein.

And step 403, the obtaining device determines the actually measured blood pressure according to the PTT.

In this embodiment, after the obtaining device calculates the PTT, it calculates the PTT according to a formula

The actually measured blood pressure value P can be calculated_sWherein b is₁、b₂And b₃Respectively, coefficients, which are related to the elasticity and movement of the blood vessels, T_PTTThe pulse propagation velocity.

According to the continuous blood pressure measuring method provided by the embodiment of the invention, the acquisition equipment acquires the electrocardiosignal and the photoplethysmography pulse signal, determines the actually measured blood pressure according to the electrocardiosignal and the photoplethysmography pulse signal, performs error correction on the coefficient of the prediction equation according to the actually measured blood pressure and the prediction equation for determining and predicting the blood pressure, and calculates the blood pressure value according to the corrected prediction equation. Since the acquisition device predicts the blood pressure based on the related parameters related to the blood pressure and the photoplethysmography pulse signal after obtaining the measured blood pressure, and corrects the coefficients of the prediction equation for calculating the predicted blood pressure by using the measured blood pressure, the accuracy of continuous blood pressure measurement is improved. In addition, the acquisition equipment can determine the actually measured blood pressure by combining the measured photoplethysmography pulse signal without adding extra hardware, thereby simplifying the complexity of the blood pressure measuring device, reducing the cost and ensuring the precision of continuous blood pressure detection.

Fig. 5 is a schematic flow chart of a fifth embodiment of the continuous blood pressure measurement method according to the present invention, and this embodiment describes in detail an embodiment in which the obtaining device corrects coefficients of a prediction equation according to an actual blood pressure and the prediction equation for determining a predicted blood pressure based on the above embodiments. As shown in fig. 5, the method of this embodiment may include:

step 501, the obtaining device performs second differentiation on the photoplethysmography pulse signal to obtain a characteristic quantity.

In the present embodiment, the acquisition device may acquire the characteristic amount by performing a differential operation on the photoplethysmography pulse signal after acquiring the photoplethysmography pulse signal. In a specific implementation process, the characteristic quantity may be obtained by differentiating the photoplethysmography pulse signal twice, wherein after differentiating the photoplethysmography pulse signal once, a velocity pulse may be obtained, and then after differentiating twice, an acceleration pulse may be obtained, and then the characteristic quantity may be obtained.

And 502, obtaining the predicted blood pressure by the obtaining equipment according to the characteristic quantity and a preset prediction equation.

In this embodiment, after the device obtains the feature quantity, the predicted blood pressure can be calculated according to a pre-estimation equation for calculating the predicted blood pressure determined by performing machine learning in advance.

Step 503, the obtaining device corrects the coefficient of the preset pre-estimation equation according to the measured blood pressure and the predicted blood pressure.

In this embodiment, after calculating the predicted blood pressure, the obtaining device may perform a multiple regression analysis to correct the coefficients of the pre-estimate equation for calculating the predicted blood pressure by combining the determined measured blood pressure (e.g., systolic pressure), wherein the multiple regression analysis may use a linear regression model, i.e., the coefficients of the pre-estimate equation are determined by least squares estimation of the parameters related to the blood pressure. In the specific implementation process, the photoplethysmography pulse signals are classified according to input data, after multivariate regression analysis is carried out on the classified photoplethysmography pulse signals, a plurality of groups (n) of estimation equations are obtained, and which group of estimation equations is adopted to predict the blood pressure is determined according to the actually measured blood pressure sent by the receiving side equipment. Specifically, the measured blood pressure may be taken as the average value X, and the calculated predicted blood pressure may be assumed to be X_iWherein i is the number of predicted blood pressures (number of samples), and the measured blood pressure X and the predicted blood pressure X are calculated_iStandard deviation between (samples) S_n. Iteratively using all n groups of estimation equations to obtain the standard deviation S of the predicted blood pressure sample and X_nIf the calculated standard deviation S corresponding to the jth predicted blood pressure_jFor all n groups S_nThe minimum value in (A) is then selected as the set of pre-estimated equations (standard deviation is S)_jOf (a) for measurement, where j is less than or equal to i. For multiple regression analysis, other models may be used, and the invention is not limited in this regard.

According to the continuous blood pressure measuring method provided by the embodiment of the invention, the acquisition equipment acquires the electrocardiosignal and the photoplethysmography pulse signal, determines the actually measured blood pressure according to the electrocardiosignal and the photoplethysmography pulse signal, performs error correction on the coefficient of the prediction equation according to the actually measured blood pressure and the prediction equation for determining and predicting the blood pressure, and calculates the blood pressure value according to the corrected prediction equation. Since the acquisition device predicts the blood pressure based on the related parameters related to the blood pressure and the photoplethysmography pulse signal after obtaining the measured blood pressure, and corrects the coefficients of the prediction equation for calculating the predicted blood pressure by using the measured blood pressure, the accuracy of continuous blood pressure measurement is improved.

Fig. 6 is a schematic flow chart of a sixth embodiment of the continuous blood pressure measuring method of the present invention. Embodiments of the present invention provide a continuous blood pressure measurement method, which may be performed by any device that performs the continuous blood pressure measurement method, and the device may be implemented by software and/or hardware. In this embodiment, the apparatus may be integrated in a receiving-side device. As shown in fig. 6, the method of this embodiment may include:

step 601, the receiving side equipment acquires the electrocardiosignal and the photoplethysmography pulse signal.

In this embodiment, the electrocardiographic signal and the photoplethysmographic pulse signal may also be acquired by a receiving-side device, wherein the receiving-side device may be various mobile terminals, such as: the receiving side equipment of the mobile phone, the PAD and the like can acquire electrocardiosignals through an electrocardio sensor and acquire photoplethysmography pulse signals through a pulse sensor.

Step 602, the receiving side device determines the actually measured blood pressure according to the electrocardio signal and the photoplethysmography pulse signal.

In this embodiment, after acquiring the electrocardiographic signal and the photoplethysmography pulse signal, the receiving-side device determines the actually measured blood pressure of the user together according to the electrocardiographic signal and the photoplethysmography pulse signal.

Step 603, the receiving side device sends the measured blood pressure to the sending side device, so that the sending side device can correct the coefficient of the pre-estimation equation according to the measured blood pressure and the pre-estimation equation for determining the predicted blood pressure, and calculate the blood pressure value according to the corrected pre-estimation equation.

In this embodiment, the transmitting device may be any device having the function of acquiring a photoplethysmographic pulse signal, such as: smart band, smart watch, etc. After the receiving side device determines the measured blood pressure, the measured blood pressure is sent to the sending side device through Bluetooth Low Energy (BLE for short), the sending side device can correct the coefficient of the pre-estimation equation according to the measured blood pressure and the preset pre-estimation equation, and after the correction is completed, the blood pressure value is calculated according to the corrected pre-estimation equation.

According to the continuous blood pressure measuring method provided by the embodiment of the invention, the receiving side equipment obtains the electrocardiosignal and the photoplethysmography pulse signal, determines the actually measured blood pressure according to the electrocardiosignal and the photoplethysmography pulse signal, and sends the actually measured blood pressure to the sending side equipment, so that the sending side equipment corrects the coefficient of the estimated equation according to the actually measured blood pressure and the estimated equation for determining the predicted blood pressure, and calculates the blood pressure value according to the corrected estimated equation. After the measured blood pressure is obtained, the sending side equipment predicts the blood pressure according to the related parameters related to the blood pressure and the photoplethysmography pulse signal, corrects the coefficient of a prediction equation for determining the predicted blood pressure by using the measured blood pressure, and calculates the blood pressure value according to the corrected prediction equation, thereby improving the accuracy of continuous blood pressure measurement.

Fig. 7 is a flow chart of a seventh embodiment of the continuous blood pressure measuring method of the present invention. Embodiments of the present invention provide a continuous blood pressure measurement method, which may be performed by any device that performs the continuous blood pressure measurement method, and the device may be implemented by software and/or hardware. In this embodiment, the apparatus may be integrated in the transmitting-side device. As shown in fig. 7, the method of this embodiment may include:

step 701, the sending side device obtains a photoplethysmography pulse signal, and sends the photoplethysmography pulse signal to the receiving side device, so that the receiving side device determines the actually measured blood pressure according to the obtained electrocardiosignal and the photoplethysmography pulse signal.

In this embodiment, the transmitting device may be any device having the function of acquiring a photoplethysmographic pulse signal, such as: smart band, smart watch, etc. After the sending-side equipment acquires the pulse signals through the pulse sensor, the sending-side equipment does not perform any processing on the photoplethysmography pulse signals, but directly sends the photoplethysmography pulse signals to the receiving-side equipment through BLE, and the receiving-side equipment can determine the actually measured blood pressure of the user according to the received photoplethysmography pulse signals and the electrocardiosignals acquired by the receiving-side equipment. The receiving side equipment can be various mobile terminals, and ECG electrodes are placed at different positions of the receiving side equipment to obtain electrocardiosignals of a user.

Step 702, the transmitting side equipment receives the measured blood pressure transmitted by the receiving side equipment.

Step 703, the sending side device corrects the coefficient of the pre-estimation equation according to the measured blood pressure and the pre-estimation equation for determining the predicted blood pressure, and calculates the blood pressure value according to the corrected pre-estimation equation.

In this embodiment, the establishment of the pre-estimation equation of the transmitting device requires machine learning in advance by combining the input data. Wherein the input data is a parameter related to blood pressure, which comprises at least one of: sex, weight, height, daily pulse, living habit, work and rest system, electrocardiogram characteristics, administration condition, velocity pulse of photoplethysmography pulse signal, acceleration pulse, etc. In a specific implementation process, the photoplethysmography pulse signals can be classified according to each parameter, and then the classified photoplethysmography pulse signals are subjected to multiple regression analysis to obtain a relationship between each parameter and blood pressure, so as to determine a most appropriate prediction equation, for example: when machine learning is carried out, classifying the photoplethysmography pulse signals according to the medicine taking condition of a user, if the user does not take medicine, continuously classifying … … according to the age of the user, finally, classifying the photoplethysmography pulse signals into N types, after classification, carrying out multivariate regression analysis on the photoplethysmography pulse signals according to the classification result, obtaining the relation between each parameter and the blood pressure, and obtaining a prediction equation, namely the obtained prediction equation for calculating and predicting the blood pressure: and f (t, Ci), wherein sBPe is the predicted blood pressure, t is the characteristic quantity, Ci is a random factor, and Ci is used for adjusting the regression effect.

Wherein, for the characteristic amount, the velocity pulse, and the acceleration pulse, the transmission-side device may acquire the photoplethysmography pulse signal by performing a differential operation on the photoplethysmography pulse signal after acquiring the photoplethysmography pulse signal. In a specific implementation process, the characteristic quantity may be obtained by performing two-time differentiation on the photoplethysmography pulse signal, wherein after performing one-time differentiation on the photoplethysmography pulse signal, a velocity pulse may be obtained, and then after performing two-time differentiation, an acceleration pulse may be obtained.

And after the transmitting side equipment calculates the predicted blood pressure according to the determined prediction equation, the coefficient of the prediction equation is corrected according to the received actually-measured blood pressure and the calculated predicted blood pressure, and after the correction is finished, the blood pressure value is calculated according to the corrected prediction equation.

According to the continuous blood pressure measuring method provided by the embodiment of the invention, the sending side equipment acquires the photoplethysmography pulse signal and sends the photoplethysmography pulse signal to the receiving side equipment, so that the receiving side equipment determines the actual measurement blood pressure according to the acquired electrocardiosignal and the photoplethysmography pulse signal, receives the actual measurement blood pressure sent by the receiving side equipment, corrects the coefficient of the preset estimation equation according to the actual measurement blood pressure and the estimation equation for determining the predicted blood pressure, and calculates the blood pressure value according to the corrected estimation equation. After the actual blood pressure is obtained, the transmitting side equipment carries out error correction on the coefficient of the estimation equation according to the actual blood pressure so as to calculate the blood pressure value, thereby improving the accuracy of continuous blood pressure measurement.

Fig. 8 is a schematic structural diagram of a first continuous blood pressure measuring device according to an embodiment of the present invention, and as shown in fig. 8, the continuous blood pressure measuring device according to the embodiment of the present invention includes an obtaining module 11, a determining module 12, and a processing module 13.

The acquisition module 11 is used for acquiring an electrocardiosignal and a photoplethysmography pulse signal; the determination module 12 is configured to determine a measured blood pressure from the electrocardiographic signal and the photoplethysmographic pulse signal; the processing module 13 is configured to correct a coefficient of the pre-estimation equation according to the measured blood pressure and a pre-estimation equation for determining a predicted blood pressure, and calculate a blood pressure value according to the corrected pre-estimation equation.

According to the continuous blood pressure measuring device provided by the embodiment of the invention, the acquisition equipment acquires the electrocardiosignal and the photoplethysmography pulse signal, the actually measured blood pressure is determined according to the electrocardiosignal and the photoplethysmography pulse signal, the estimation equation of the actually measured blood pressure and the predicted blood pressure is determined, the error correction is carried out on the coefficient of the estimation equation, and the blood pressure value is calculated according to the corrected estimation equation. After the measured blood pressure is obtained, the blood pressure is predicted according to the related parameters related to the blood pressure and the photoplethysmography pulse signal, the measured blood pressure is used for correcting the coefficient of the prediction equation for determining the predicted blood pressure, and the blood pressure value is calculated according to the corrected prediction equation, so that the accuracy in continuously measuring the blood pressure is improved.

Fig. 9 is a schematic structural diagram of a second continuous blood pressure measuring device according to an embodiment of the present invention, as shown in fig. 9, in this embodiment, on the basis of the embodiment shown in fig. 8, the obtaining module 11 includes:

the first acquisition unit 111 is used for acquiring an electrocardiographic wave through the electrocardiograph sensor;

the first processing unit 112 is configured to perform Fast Fourier Transform (FFT) processing on the cardiac electric wave to obtain a processed signal;

the first processing unit 112 is further configured to perform noise removal processing on the processed signal to obtain the electrocardiographic signal.

The device for continuous blood pressure measurement of this embodiment may be used to implement the technical solution of the method for continuous blood pressure measurement provided in any embodiment of the present invention, and the implementation principle and technical effect are similar, which are not described herein again.

Fig. 10 is a schematic structural diagram of a third embodiment of the continuous blood pressure measuring device of the present invention, and as shown in fig. 10, in this embodiment, on the basis of the above embodiments, the obtaining module 11 includes:

the second collecting unit 113 is used for collecting pulse waves through the pulse sensor;

the second processing unit 114 is configured to perform Fast Fourier Transform (FFT) processing on the pulse wave to obtain a processed signal;

the second processing unit 114 is configured to perform noise removal processing on the processed signal to obtain the photoplethysmography pulse signal.

Fig. 11 is a schematic structural diagram of a fourth embodiment of the continuous blood pressure measuring device of the present invention, and as shown in fig. 11, in this embodiment, on the basis of the foregoing embodiments, the determining module 12 includes:

the synchronization unit 121 is configured to synchronize the electrocardiographic signal and the photoplethysmography pulse signal to obtain a synchronization signal;

the calculating unit 122 is configured to calculate a pulse transmission time PTT according to the synchronization signal;

the determining unit 123 is configured to determine an actually measured blood pressure according to the PTT.

Optionally, the processing module 13 includes:

the obtaining unit 131 is configured to perform secondary differentiation on the photoplethysmography pulse signal to obtain a feature quantity;

the obtaining unit 131 is configured to obtain a predicted blood pressure according to the feature quantity and a preset pre-estimation equation;

the correction unit 132 is configured to correct the coefficient of the preset pre-estimation equation according to the measured blood pressure and the predicted blood pressure.

Fig. 12 is a schematic structural diagram of a fifth continuous blood pressure measuring device according to an embodiment of the present invention, and as shown in fig. 12, the continuous blood pressure measuring device according to the embodiment of the present invention includes an obtaining module 21, a determining module 22, and a sending module 23.

The acquisition module 21 is used for acquiring an electrocardiosignal and a photoplethysmography pulse signal; the determination module 22 is configured to determine a measured blood pressure from the electrocardiographic signal and the photoplethysmographic pulse signal; the sending module 23 is configured to send the measured blood pressure to a sending-side device, so that the sending-side device corrects a coefficient of a prediction equation according to the measured blood pressure and the prediction equation for determining a predicted blood pressure, and calculates a blood pressure value according to the corrected prediction equation.

According to the continuous blood pressure measuring device provided by the embodiment of the invention, the receiving side equipment acquires the electrocardiosignal and the photoplethysmography pulse signal, determines the actually measured blood pressure according to the electrocardiosignal and the photoplethysmography pulse signal, and sends the actually measured blood pressure to the sending side equipment, so that the sending side equipment corrects the coefficient of the estimated equation according to the actually measured blood pressure and the estimated equation for determining the predicted blood pressure, and calculates the blood pressure value according to the corrected estimated equation. After the measured blood pressure is obtained, the sending side equipment predicts the blood pressure according to the related parameters related to the blood pressure and the photoplethysmography pulse signal, corrects the coefficient of a prediction equation for determining the predicted blood pressure by using the measured blood pressure, and calculates the blood pressure value according to the corrected prediction equation, thereby improving the accuracy of continuous blood pressure measurement.

Fig. 13 is a schematic structural diagram of a sixth continuous blood pressure measuring device according to an embodiment of the present invention, and as shown in fig. 13, the continuous blood pressure measuring device according to the embodiment of the present invention includes an obtaining module 31, a sending module 32, a receiving module 33, and a processing module 34.

The acquisition module 31 is used for acquiring a photoplethysmography pulse signal; the sending module 32 is configured to send the photoplethysmography pulse signal to a receiving side device, so that the receiving side device determines an actually measured blood pressure according to the acquired electrocardiographic signal and the photoplethysmography pulse signal; the receiving module 33 is configured to receive the measured blood pressure sent by the receiving-side device; the processing module 34 is configured to correct a coefficient of the prediction equation according to the measured blood pressure and the prediction equation for determining the predicted blood pressure, and calculate a blood pressure value according to the corrected prediction equation.

According to the continuous blood pressure measuring device provided by the embodiment of the invention, the sending side equipment acquires the photoplethysmography pulse signal and sends the photoplethysmography pulse signal to the receiving side equipment, so that the receiving side equipment determines the actual measurement blood pressure according to the acquired electrocardiosignal and the photoplethysmography pulse signal, receives the actual measurement blood pressure sent by the receiving side equipment, corrects the coefficient of the preset estimation equation according to the actual measurement blood pressure and the estimation equation for determining the predicted blood pressure, and calculates the blood pressure value according to the corrected estimation equation. After the actual blood pressure is obtained, the transmitting side equipment carries out error correction on the coefficient of the estimation equation according to the actual blood pressure so as to calculate the blood pressure value, thereby improving the accuracy of continuous blood pressure measurement.

Fig. 14 is a schematic structural diagram of a first embodiment of the acquisition apparatus according to the present invention, and as shown in fig. 14, the acquisition apparatus provided in the embodiment of the present invention includes a receiver 41 and a processor 42.

Wherein, the receiver 41 is used for acquiring an electrocardiosignal and a photoplethysmography pulse signal; a processor 42 for determining a measured blood pressure from the electrocardiographic signal and the photoplethysmographic pulse signal; the processor 42 is further configured to correct a coefficient of the pre-estimation equation according to the measured blood pressure and the pre-estimation equation for determining the predicted blood pressure, and calculate a blood pressure value according to the corrected pre-estimation equation.

The obtaining device provided in this embodiment may be used to implement the technical solution of the method for continuous blood pressure measurement provided in any embodiment of the present invention, and the implementation principle and technical effect are similar, which are not described herein again.

Optionally, the receiver 41 is further configured to collect an electrocardiographic wave through the electrocardiograph sensor;

the processor 42 is further configured to perform fast fourier transform, FFT, processing on the cardiac electric wave to obtain a processed signal;

the processor 42 is further configured to perform noise removal processing on the processed signal to obtain the electrocardiographic signal.

Optionally, the receiver 41 is further configured to acquire a pulse wave through a pulse sensor;

the processor 42 is further configured to perform fast fourier transform, FFT, processing on the pulse wave to obtain a processed signal;

the processor 42 is further configured to perform denoising processing on the processed signal to obtain the photoplethysmography pulse signal.

Optionally, the processor 42 is further configured to synchronize the electrocardiographic signal and the photoplethysmographic pulse signal to obtain a synchronization signal;

the processor 42 is further configured to calculate a pulse transmission time PTT according to the synchronization signal;

the processor 42 is also configured to determine a measured blood pressure from the PTT.

The processor 42 is further configured to perform a second differentiation on the photoplethysmography pulse signal to obtain a characteristic quantity;

the processor 42 is further configured to obtain a predicted blood pressure according to the feature quantity and a preset pre-estimation equation;

the processor 42 is further configured to correct the coefficient of the preset pre-estimation equation according to the measured blood pressure and the predicted blood pressure.

Fig. 15 is a schematic structural diagram of a first receiving-side device according to the present invention, and as shown in fig. 15, the transmitting-side device according to the present invention includes a receiver 51, a processor 52, and a transmitter 53.

The receiver 51 is used for acquiring an electrocardiosignal and a photoplethysmography pulse signal; a processor 52 for determining a measured blood pressure from the electrocardiographic signal and the photoplethysmographic pulse signal; the transmitter 53 is configured to transmit the measured blood pressure to a transmitting-side device, so that the transmitting-side device corrects a coefficient of an estimation equation according to the measured blood pressure and the estimation equation for determining the predicted blood pressure, and calculates a blood pressure value according to the corrected estimation equation.

Fig. 16 is a schematic structural diagram of a first transmitting-side device according to the present invention, and as shown in fig. 16, the transmitting-side device according to the present invention includes a receiver 61, a transmitter 62, and a processor 63.

Wherein, the receiver 61 is used for acquiring a photoplethysmography pulse signal; the transmitter 62 is configured to transmit the photoplethysmography pulse signal to a receiving-side device, so that the receiving-side device determines a measured blood pressure according to the electrocardiographic signal and the photoplethysmography pulse signal; the receiver 61 is configured to receive the measured blood pressure sent by the receiving-side device; the processor 63 is configured to correct a coefficient of the pre-estimation equation according to the measured blood pressure and a pre-estimation equation for determining a predicted blood pressure, and calculate a blood pressure value according to the corrected pre-estimation equation.

The transmitting-side device provided in this embodiment may be used to implement the technical solution of the method for continuous blood pressure measurement provided in any embodiment of the present invention, and the implementation principle and technical effect are similar, which are not described herein again.

It will be clear to those skilled in the art that, for convenience and simplicity of description, the foregoing division of the functional modules is merely used as an example, and in practical applications, the above function distribution may be performed by different functional modules according to needs, that is, the internal structure of the device is divided into different functional modules to perform all or part of the above described functions. For the specific working processes of the system, the apparatus and the unit described above, reference may be made to the corresponding processes in the foregoing method embodiments, and details are not described here again.

In the several embodiments provided in the present application, it should be understood that the disclosed system, apparatus and method may be implemented in other manners. For example, the above-described apparatus embodiments are merely illustrative, and for example, the division of the modules or units is only one logical division, and there may be other divisions when actually implemented, for example, a plurality of units or components may be combined or may be integrated into another system, or some features may be omitted, or not executed. In addition, the shown or discussed mutual coupling or direct coupling or communication connection may be an indirect coupling or communication connection through some interfaces, devices or units, and may be in an electrical, mechanical or other form.

The units described as separate parts may or may not be physically separate, and parts displayed as units may or may not be physical units, may be located in one place, or may be distributed on a plurality of network units. Some or all of the units can be selected according to actual needs to achieve the purpose of the solution of the embodiment.

In addition, functional units in the embodiments of the present application may be integrated into one processing unit, or each unit may exist alone physically, or two or more units are integrated into one unit. The integrated unit can be realized in a form of hardware, and can also be realized in a form of a software functional unit.

The integrated unit, if implemented in the form of a software functional unit and sold or used as a stand-alone product, may be stored in a computer readable storage medium. Based on such understanding, the technical solution of the present application may be substantially implemented or contributed by the prior art, or all or part of the technical solution may be embodied in a software product, which is stored in a storage medium and includes instructions for causing a computer device (which may be a personal computer, a server, a network device, or the like) or a processor (processor) to execute all or part of the steps of the method according to the embodiments of the present application. And the aforementioned storage medium includes: a U-disk, a removable hard disk, a Read-Only Memory (ROM), a Random Access Memory (RAM), a magnetic disk or an optical disk, and other various media capable of storing program codes.

The above embodiments are only used for illustrating the technical solutions of the present application, and not for limiting the same; although the present application has been described in detail with reference to the foregoing embodiments, it should be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions in the embodiments of the present application.

Claims

1. A continuous blood pressure measuring device, comprising:

the processing module is used for carrying out secondary differentiation on the photoplethysmographic pulse signal to obtain a characteristic quantity, obtaining a plurality of predicted blood pressures according to the characteristic quantity and a plurality of preset prediction equations, determining a prediction equation corresponding to the predicted blood pressure with the minimum standard deviation of the measured blood pressure according to the measured blood pressure and the plurality of predicted blood pressures, correcting the coefficient of the determined prediction equation, and calculating a blood pressure value according to the corrected prediction equation.

2. The apparatus of claim 1, wherein the obtaining module comprises:

3. The apparatus of claim 1 or 2, wherein the obtaining module comprises:

4. The apparatus of claim 1 or 2, wherein the determining module comprises:

5. The apparatus of claim 3, wherein the determining module comprises:

6. A device for continuous blood pressure measurement, comprising:

the sending module is used for sending the measured blood pressure to a sending side device, so that the sending side device determines an estimation equation corresponding to the predicted blood pressure with the minimum standard deviation of the measured blood pressure according to the measured blood pressure and a plurality of predicted blood pressures, corrects the coefficient of the determined estimation equation, and calculates a blood pressure value according to the corrected estimation equation, wherein the plurality of predicted blood pressures are obtained by the sending side device through a characteristic quantity and a plurality of preset estimation equations, and the characteristic quantity is obtained by performing secondary differentiation on the photoplethysmography pulse signal by the sending side device.

7. A device for continuous blood pressure measurement, comprising:

8. An acquisition device, comprising:

the processor is further configured to perform secondary differentiation on the photoplethysmographic pulse signal to obtain a characteristic quantity, obtain a plurality of predicted blood pressures according to the characteristic quantity and a plurality of preset prediction equations, determine a prediction equation corresponding to a predicted blood pressure with a minimum standard deviation of the measured blood pressure according to the measured blood pressure and the plurality of predicted blood pressures, correct coefficients of the determined prediction equation, and calculate a blood pressure value according to the corrected prediction equation.

9. The acquisition device according to claim 8,

the receiver is also used for collecting electrocardiowaves through the electrocardio sensor;

10. The acquisition device according to claim 8 or 9,

the receiver is also used for acquiring pulse waves through the pulse sensor;

11. The acquisition device according to claim 8 or 9,

the processor is further used for synchronizing the electrocardiosignal and the photoplethysmography pulse signal to obtain a synchronization signal;

12. The acquisition device according to claim 10,

13. A reception-side apparatus, characterized by comprising:

and the transmitter is used for transmitting the measured blood pressure to the transmitting side equipment, so that the transmitting side equipment determines a pre-estimation equation corresponding to the predicted blood pressure with the minimum standard deviation of the measured blood pressure according to the measured blood pressure and the plurality of predicted blood pressures, corrects the coefficient of the determined pre-estimation equation and calculates the blood pressure value according to the corrected pre-estimation equation.

14. A transmission-side apparatus, characterized by comprising:

a receiver for acquiring a photoplethysmographic pulse signal;

the processor is used for carrying out secondary differentiation on the photoplethysmographic pulse signal to obtain a characteristic quantity, obtaining a plurality of predicted blood pressures according to the characteristic quantity and a plurality of preset prediction equations, determining a prediction equation corresponding to the predicted blood pressure with the minimum standard deviation of the measured blood pressure according to the measured blood pressure and the plurality of predicted blood pressures, correcting the coefficient of the determined prediction equation, and calculating the blood pressure value according to the corrected prediction equation.