WO2016181302A1 - Système d'apport de substances à une plaie - Google Patents

Système d'apport de substances à une plaie Download PDF

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Publication number
WO2016181302A1
WO2016181302A1 PCT/IB2016/052661 IB2016052661W WO2016181302A1 WO 2016181302 A1 WO2016181302 A1 WO 2016181302A1 IB 2016052661 W IB2016052661 W IB 2016052661W WO 2016181302 A1 WO2016181302 A1 WO 2016181302A1
Authority
WO
WIPO (PCT)
Prior art keywords
wound
care system
kapillarmembransystem
wound care
shaped
Prior art date
Application number
PCT/IB2016/052661
Other languages
German (de)
English (en)
Inventor
Florian BONN
Original Assignee
3M Innovative Properties Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Company filed Critical 3M Innovative Properties Company
Priority to EP16724720.4A priority Critical patent/EP3294362B1/fr
Priority to US15/571,373 priority patent/US20190151155A1/en
Priority to JP2017558676A priority patent/JP2018519013A/ja
Priority to CN201680027173.XA priority patent/CN108064177A/zh
Publication of WO2016181302A1 publication Critical patent/WO2016181302A1/fr

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Classifications

    • A61F13/05—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/71—Suction drainage systems
    • A61M1/77—Suction-irrigation systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/84—Drainage tubes; Aspiration tips
    • A61M1/85—Drainage tubes; Aspiration tips with gas or fluid supply means, e.g. for supplying rinsing fluids or anticoagulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/90—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/90—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing
    • A61M1/92—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing with liquid supply means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/90—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing
    • A61M1/94—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing with gas supply means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/02—Enemata; Irrigators
    • A61M3/0233—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs
    • A61M3/025—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs supplied directly from the pressurised water source, e.g. with medicament supply
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/02—Enemata; Irrigators
    • A61M3/0279—Cannula; Nozzles; Tips; their connection means
    • A61M3/0283—Cannula; Nozzles; Tips; their connection means with at least two inner passageways, a first one for irrigating and a second for evacuating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A61M35/30—Gas therapy for therapeutic treatment of the skin

Definitions

  • the invention relates to a wound care system for introduction into a wound or for application to a skin wound and under a wound dressing, comprising at least a first and a second planar-shaped Kapillarmembransystem, wherein the first and the second planar
  • Supply line are connected so that through the supply line and the respective Kapillarmembransystem liquids, media, gases and / or other substances are impressleitbar.
  • a method and apparatus for removing exudate from wounds is commercially known as the VAC® Therapy System (KCl, USA). at This system is provided for an alternating introduction of liquid into the wound and a subsequent so also alternating and thus non-continuous running of liquid from the wound.
  • a Kapillarmembransystem for wound treatment in which the wound is perfused and supplied via a hollow fiber membrane arrangement of up to 1000 hollow fibers with at least one common supply and at least one common discharge in the sense of flow through a capillary and antibiotics - such as
  • a wound care system for treating a wound which comprises at least a first and a second planar-shaped capillary arm system,
  • Kapillarmembransystem are each connected to at least one supply line, so that through the supply line and the respective Kapillarmembransystem liquids, media, gases and / or other substances are istleitbar,
  • wound care system further comprises
  • a first removal container having an outlet which is detachably connected to the first capillary armature system via a first discharge line, which comprises at least one of the supply lines of the first capillary armament system, and via which a rinsing liquid can be supplied to the first capillary armature system,
  • a second removal container having an outlet which is releasably connected to the second Kapillarmembransystem via a second discharge line comprising at least one of the supply lines of the second Kapillarmembransystems and via the second Kapillarmembransystem a treatment solution can be supplied, and
  • a drainage system which can be coupled to a vacuum unit and via which fluids can be discharged from the wound to be treated.
  • wound care system at the same time allows safe and easy handling.
  • the wound care system can be inserted into the wound and, for example, covered by means of a semi-occlusive transparent film in order to protect the wound from drying out or from infection.
  • the supply lines of the Kapillarmembransysteme are then led out of the wound area under the film and are connected outside the wound area with the first and the second removal container.
  • Drainage system may be connected to a vacuum unit e.g. via a suitable, stable against negative pressure hose, which is also led out of the wound area.
  • Kapillarmembransystem consist of a single capillary membrane, which is arranged meandering.
  • at least one of the ends of the meandering capillary membrane is open and with a
  • the at least one Kapillarmembransystem may also comprise a plurality of meandering arranged Kapillarmembranen, which together with their ends in a common
  • the first and the second Kapillarmembransystem comprises a plurality of mutually parallel arranged Kapillarmembranen.
  • the mutually parallel arranged capillary membranes of a respective Kapillarmembransystems are at least at one of its ends so fluid-tight in its outer periphery embedded in the wall of a supply line that between the lumen of the supply line and the lumen of the
  • Capillary membranes is a fluid connection and through the
  • Liquids, media, gases and / or other substances are impressedleitbar.
  • the embedding can be done for example with a curable silicone material, with a polyurethane or an epoxy resin.
  • curable silicone materials are preferably used.
  • the capillary membranes are embedded with only one of their ends in one supply line, the other, opposite end of the capillary membranes closed, for example by welding or gluing.
  • Capillary membranes can also be embedded at their two ends open and with these two ends on one side of the arrangement in a single supply line, the capillary membranes are then formed at its free end U-shaped and thereby are closed there. In these cases, the capillary membranes are operated in dead-end mode.
  • the embodiment of the capillary armature systems are arranged parallel to one another
  • Capillary membranes advantageous in which the capillary membranes are open at both ends and embedded in each case a supply line, wherein the supply lines are then preferably located on opposite sides of the respective sheet-shaped Kapillarmembransystems. Also in this case, the embedding is carried out so that the capillary membranes are embedded in a fluid-tight manner on their outer circumference and there is a fluid connection between the lumen of the respective supply line and the lumen of the capillary membranes.
  • Supply lines allow supply and / or disposal via the at least one Kapillarmembransystem in cross-flow mode. Also with regard to a good homogeneity of the supply or disposal over the area of the
  • Wound can especially with broader mats or wound care systems, the execution of at least one Kapillarmembransystems with two
  • supply lines also allow simultaneous or alternate supply of a wound with different media via the same capillary armature system.
  • the diameter of the supply lines depends primarily on the outer diameter of the capillary membranes embedded in them. Therefore, the at least one supply line preferably has an inner diameter in the range of 0.1 to 10 mm. It is also preferred if the wall thickness in Range is from 0, 1 to 5 mm. In case of using a
  • Inner diameter of the equivalent diameter d 4A / U of the inner cross section set with A as the area of the inner cross section and U as its circumference.
  • the supply line can also be an oval, or
  • the supply lines for example, silicone hoses have proven to be suitable, pass through the wall of the Kapillarmembranenden and in which they are glued.
  • the supply lines are formed of a flexible silicone tube.
  • the embedding or sticking in the wall of the supply line can by means of conventional glue such. using curable silicone materials, polyurethane resins or an epoxy resins.
  • Kapillarmembransystem be formed in the form of a Kapillarmembranmatte from mutually parallel Kapillarmembranen, wherein the
  • Connecting elements can extend transversely to the mutually parallel arranged capillary membranes or at a different angle.
  • the connecting elements touch the capillary membranes on their outer circumference or wrap around them.
  • the connecting elements do not have any closed flow channels along their longitudinal extension, and consequently are not traversed by fluids along their longitudinal extent.
  • the connecting elements may be adhesive strips or
  • the capillary membranes are by means of
  • the connecting elements are textile Multifilament yarns.
  • Multifilament polyester yarns, polypropylene yarns or polytetrafluoroethylene yarns have proved particularly suitable as textile multifilament yarns.
  • Most suitable are hydrophilic yarns, preferably of polyester.
  • the capillary membrane mat may in a preferred embodiment be an active mat. In such active mats, the capillary membranes and the connecting threads are forfeited together and the capillary membranes extend transversely to the direction of extension of the capillary membrane mat. The length of the capillary membranes is determined by the width of the mat. In a further preferred embodiment, the capillary membrane mat may be a woven mat.
  • the capillary membranes and the connective threads are interwoven.
  • the capillary membranes run in the direction of extension or running direction of the capillary membrane mat and the textile threads transversely thereto.
  • Kapillarmembranwirkmatten and -webmatten and ways of their preparation are described for example in DE 38 39 567, DE 43 08 850 and in EP 0 442 147.
  • mats can be produced in a simple manner in which the capillary membranes are U-shaped at their free end and closed there.
  • Such mats can be prepared by meandering storage of a capillary membrane in parallel strands which are interconnected by the knitting threads. In this case, after completion of the active mat, the U-shaped ends are separated on at least one side of the active mat and the resulting open ends of the
  • the capillary membranes are present within the mat in such a density that the distance between the capillary membranes to each other in the mat 1 to 10 times the outer diameter of the Capillary membranes is, wherein the distance from the longitudinal axes of
  • Mats are preferred in which the distance of the capillary membranes to each other in the mat is 1.05 to 6 times the outer diameter of the capillary membranes. Distances of the capillary membranes relative to one another in the mat in the range of 1.05 to 3 times the outside diameter of the capillary membranes are particularly preferred. In a further particularly preferred embodiment, distances are the
  • Kapillarmembransystemen by means of a plurality of mutually spaced and mutually parallel connecting elements connected to a mat and held by the connecting elements to each other at a distance, and that the connecting elements are at a defined distance from each other, which is preferably in the range of 1 to 50 mm, wherein a Distance in the range of 3 to 20 mm particularly preferred and such in the
  • Range of 4 to 6 mm is ideal. It has been found that the contact points between the capillary membranes and the connecting elements, e.g. at a supply of the wound to be treated e.g. with a
  • the capillary membranes of Kapillarmembransysteme preferably have an outer diameter in the range of 200 to 1500 pm.
  • the present wound care system includes first and second
  • Capillary arm system designed for the supply or discharge of liquid media.
  • the wound to be treated in a preferred embodiment, the
  • Capillary membranes have a high permeability to liquids.
  • the capillary membranes of the first and / or second Kapillarmembransystems are preferably bacteria-tight. This can ensure that no bacteria get into the wound by supplying rinsing liquid and / or treatment solution.
  • bacterial leakage is understood to mean that the capillary membranes have a nominal pore of 0.2 ⁇ m. Preferably, therefore, have the
  • Capillary membranes of the first and / or the second Kapillarmembransystems a nominal pore of 0.2 pm.
  • the nominal pore is defined by the retention capacity of the membrane towards specific microorganisms.
  • a membrane with a nominal pore of 0.2 ⁇ m will retain bacteria of the genus Brevundimonas diminuta, but also bacteria of the genus Serratia marcescens, for which a membrane with a nominal pore of 0.45 m would be sufficient.
  • the tests or the determination of the nominal pore sizes are described, for example, in HIMA regulation no. 3, Vol. 4, 1982 (Health Industry Manufacturers Association).
  • Suitable materials for the capillary membranes are in principle all known in the art organic polymers in question, which are suitable for the formation of Kapillarmembranen, said polymers have a good Must have biocompatibility. In addition, it is also required that the membrane polymer sterilize the wound care system
  • the organic polymers may be natural polymers or polymers prepared by synthetic routes. Natural polymers are especially those based on
  • cellulosic polymers which includes polymers that have been subjected to so-called polymer-analogous reactions.
  • cellulose based polymers are regenerated cellulose, cellulose acetate or
  • modified cellulose e.g. Cellulose esters, cellulose ethers, benzyl-modified cellulose (benzylcellulose) or diethylaminoethyl-modified cellulose or mixtures of these cellulosic polymers.
  • polymers based on chitin or chitosan As synthetically produced polymers, i. as synthetic
  • Polymers may be used those which consist of polyolefins, polyamides, polyacrylonitriles, polycarbonates, polyesters or sulfone polymers, as well as modifications, blends, mixtures or copolymers of these polymers obtained therefrom.
  • those are used which are based on sulfone polymers, in particular polysulfone or polyethersulfone.
  • Polymers may contain other polymers such as e.g. Polyethylene oxide, polyhydroxyether, polyethylene glycol, polyvinyl alcohol or polycaprolactone be added as additives.
  • the capillary membranes may additionally have a coating with an additive. Preferably contain such
  • Capillary membranes a hydrophilizing agent, e.g. Polyvinylpyrrolidone or hydrophilic modifications of these polymers.
  • the capillary membranes may be modified in view of certain applications, for example by coupling functional groups or be coated, for example with heparin or an antibiotic or more antibiotics.
  • the shape of the surface-shaped Kapillarmembransysteme in their areal extent may be arbitrary. In the case of Kapillarmembransystemen from parallel capillary membranes have the
  • Kapillarmembransysteme in the simplest version a square or rectangular shape. However, it is e.g. in systems where the
  • Capillary membranes are embedded only at one end in a supply line, possible that, for example, by appropriately adapted Ab performen the free, closed ends of the mutually parallel
  • Capillary membranes an arcuate contour is formed. It is also possible that the arrangement of mutually parallel capillary membranes e.g. also has a trapezoidal contour.
  • the present wound care system may also include other components, such as e.g. at least one further arrangement of capillary membranes.
  • the capillary membranes of the further arrangement may, for example, be membranes for oxygenation, i. Membranes, over the one
  • Kapillarmembransysteme and any other planar-shaped systems of semipermeable capillary membranes or fluid-impermeable capillaries are placed on each other.
  • the capillary membranes of different Kapillarmembransysteme are connected together to form a mat, the different capillary membranes are embedded with their ends in different supply lines, which are preferably arranged on opposite sides of the mat.
  • Such mats can be obtained, for example, by forcibly disposed mutually staggered, meandering capillary membranes, in which the U-shaped deflections of the capillary membranes to
  • Capillary membranes are opened on only one side of the mat and can be embedded there in a supply line.
  • the wound care system comprises, in addition to the first and the second Kapillarmembransystem a drainage system, by means of which a discharge, for. the rinsing fluid or exudate from the wound is possible.
  • the wound care system may comprise a suction sponge having a drain line for the irrigation fluid and / or for exudate.
  • the drainage system can also be another
  • the drainage system is at least one drainage catheter, e.g. in the form of a piece of tubing, such as a silicone material, or a tube.
  • a drainage catheter may have perforations in its wall, via which after connection of the drainage catheter to a
  • the at least one drainage catheter preferably has an inner diameter in the range of 0.1 to 15 mm and a wall thickness in the range of 0.1 to 3 mm.
  • the drainage catheter may also have a non-circular cross-section.
  • the equivalent diameter d D 4A D / UD of the inner cross section is set with A D as the area of the
  • Inner cross section of the drainage catheter and UD as its circumference.
  • the wound care system may further comprise a pocket-shaped dressing, the pocket-shaped dressing being closed at its outer edge and having a top, a bottom, and a pocket interior, the bottom and top each formed of a sheet material and the bottom permeable to fluids, and wherein first and second capillary arm systems are in the pocket interior are arranged.
  • the connection of the supply lines with the respective receptacles outside the pocket-shaped wound dressing may further comprise a pocket-shaped dressing, the pocket-shaped dressing being closed at its outer edge and having a top, a bottom, and a pocket interior, the bottom and top each formed of a sheet material and the bottom permeable to fluids, and wherein first and second capillary arm systems are in the pocket interior are arranged.
  • Capillary arm systems can be placed in a wound to be treated so that the underside is in contact with the wound.
  • the wound can be supplied to the desired liquids, which are distributed after exiting the capillary membranes in the bag and discharged through the semipermeable bottom pocket of the bag to the wound.
  • the pocket-shaped wound dressing can preferably be designed such that the connection of the capillary membranes of the capillary armature systems to the respective supply line is inside the pocket and the respective supply lines lead out of the pocket-shaped wound dressing via passage openings which are adapted in a fluid-tight manner to their outer cross section. Likewise, the connection of the capillary membranes with the respective
  • the wound care system comprises a pocket-shaped wound dressing
  • the first and second Kapillarmembransystem extend the Kapillarmembransysteme area inside the bag.
  • the dimensions of the Kapillarmembransysteme each result from their outer dimensions in the planar extension.
  • the first or second Kapillarmembransystem fill in terms of their areal extent the pockets interior of the pocket-shaped wound dressing in its planar extent at least 20% and more preferably at least 50%. From It is particularly advantageous if the first or second Kapillarmembransystem in terms of their areal extent of the pocket interior of the pocket-shaped wound dressing in its planar extent at least 70% fills, with filling levels in the range of 90% can be realized. It is advantageous if the first and second Kapillarmembransystem are centrally located in the pocket-shaped wound dressing.
  • the pocket-shaped wound dressing can have any contours.
  • the contour is round, oval, square or rectangular.
  • the underside and upper side of the pocket-shaped wound dressing are connected to one another at the outer edge or at the outer edges of the wound dressing, for example by welding or gluing.
  • gluing u.a. Suitable silicone strips that are cured.
  • the sheet-like capillary membrane systems arranged therein preferably also have a rectangular or square contour. For round or oval
  • Kapillarmembransysteme expediently also square or rectangular formed, with respect to the dimensions also apply the aforementioned dimensions. However, they can also be adapted to the contour of the pocket-shaped wound dressing, for example by
  • the underside of the pocket-shaped wound dressing is permeable to fluids, ie permeable.
  • the underside may for example consist of a non-woven, sheet-like material, a latticed or net-like material, a perforated film or a semipermeable microporous flat membrane.
  • the underside consists of a non-woven, sheet material or a semi-permeable microporous
  • the underside preferably has a permeability to water of at least 0.01 ml / (min cm 2 bar) and more preferably of at least 10 ml / (min cm 2 bar). Best proven to have a bottom with a
  • the openings are present in the bottom, the openings preferably a
  • the underside consists of a semipermeable microporous flat membrane, in an advantageous embodiment this has additional openings, e.g. in the form of perforations.
  • this has additional openings, e.g. in the form of perforations.
  • the openings may be regularly or irregularly distributed over the surface of the bottom, with a regular, homogeneous distribution is preferred. In this case, the distance between the openings can be in the range of 1 to 20 mm, measured from the outer edge of the openings.
  • the bottom and the top of the bag-shaped wound pad can be made of the same or different materials.
  • the upper side is preferably formed of a fluid-impermeable, preferably foil-shaped material which is fluid-tightly connected at its or its side edges to the underside. It can also be a semipermeable, microporous at the top
  • the top has a smaller one Permeability to fluids on than the underside, in order to distribute a supply of liquid supplied to the bottom of the bag-shaped
  • the underside has perforations.
  • Wound dressing are basically the same organic polymers in question, which were previously mentioned as polymers for the capillary membranes and can be processed into flat films or flat membranes.
  • lower and / or upper side of the pocket-shaped wound dressing are made of polyolefins,
  • the lower and upper sides comprise as material sulfone polymers, with polysulfone or polyethersulfone being most suitable.
  • the drainage system preferably in the form of at least one
  • Drainage catheter leads in the preferred case that the wound care system comprises a pocket-shaped wound dressing, via a corresponding fluid-tight passage opening out of the pocket-shaped wound dressing and outside the pocket-shaped wound dressing with a vacuum unit connected, so as to generate a negative pressure inside the bag in the application.
  • the at least one drainage catheter can be a piece of tubing, for example of a silicone material, or a tube, which is arranged in the pocket interior of the wound dressing and leads out of the wound dressing via the passage opening.
  • this preferably has perforations in its wall, via which after connection of the at least one drainage catheter to a
  • Vacuum unit Liquids such as exudate from the wound or from the inside of the pocket-shaped wound dressing and can be sucked out of the wound.
  • first and second are
  • Kapillarmembransystem the wound care system identical and form a single supply Kapillarmembransystem, which is connected to at least one supply line, and the first removal container and the second removal container via the at least one supply line of the
  • Supply capillary arm system connected to the supply capillary arm system.
  • Kapillarmembransystem have two supply lines, which are located at the opposite ends of its capillary membranes.
  • the first removal container for rinsing liquid e.g. the first removal container for rinsing liquid and the second
  • Removal container to be connected with treatment solution with different and separate supply lines.
  • Collection container with treatment solution via e.g. By means of a T-piece or Y-connector interconnected line sections with only one
  • Supply line of the supply Kapillarmembransystems are connected.
  • embodiments of the supply Kapillarmembransystems are possible to serve in the supply Kapillarmembransystem with only one supply line is connected.
  • Removal container separated from each other and can be supplied alternately.
  • Tapping piece or Y-connector or be mounted in the respective supply line.
  • the regulatory organs can in one
  • Embodiment be a shut-off device by means of which the respective drain line can be opened or closed. It can also be about
  • Act control organs by means of which the flow through the drain line can be adjusted to defined values.
  • the first and second extraction containers are detachably connected to the respective supply line via male / female connectors.
  • Particularly preferred male / female connectors are Luer-Lock connectors.
  • a hose section can also be connected to the respective removal container, which in turn can be connected to the respective one
  • Supply line is connected.
  • the connection between the respective sampling container and the supply line i. e.g. between
  • Removal container and supply line, between hose section and supply line or between sections of the hose section can also be designed as a sterile welded joint, as they by means of a
  • Sterile connector e.g., TSCD® II Sterile Tubing Weider, Terumo.
  • the first and / or the second removal container consists of a plurality of first part removal containers, which are arranged in parallel to each other. The outlets of the
  • Part removal containers are each connected to a partial drain line, which via a connecting element and a connecting line connected thereto to the supply line of the first and the second Kapillarmembransystems are connected.
  • the partial drain lines preferably each have a control element, by means of which the respective partial removal container to or
  • Such an embodiment is e.g. particularly advantageous when the wound is e.g. Self-serum should be supplied, which is divided as aliquots on several parts containers.
  • the present wound treatment system comprises a first
  • Removal container for a rinsing liquid and a second removal container for a treatment solution are supplied to the wound area only in small amounts, while larger volumes of rinsing solution are needed to sufficiently clean the wound and to remove degradation products. Therefore, in a preferred
  • the ratio of the volume of the first removal container to the volume of the second withdrawal container at least 5. Particularly preferably, the ratio is at least 10 and most preferably at least 20.
  • Removal containers hang u.a. on the size of the wound to be treated.
  • the first removal container preferably contains a saline solution.
  • the treatment solution comes with solutions
  • the second withdrawal container contains a serum.
  • First and / or second removal containers may be in a preferred
  • first and / or second removal container via a suitable holding device at a defined vertical distance above the wound, so that the outflow from the first and / or second removal container and the introduction of the rinsing liquid and / or the
  • Treatment solution is done under the influence of gravity.
  • a test cell with a defined capillary membrane number and length is manufactured.
  • the capillary membranes are embedded on both sides at their ends in a polyurethane resin.
  • the embedding are cut to a length of about 30 mm, the lumens of the capillary membranes are opened by the cut.
  • the capillaries in the embedding must be checked for patency.
  • Embedding is usually 120 +/- 10 mm.
  • Capillary membranes should be dimensioned such that, taking into account the free length and the inner diameter of the capillary membranes, a filtration area of approximately 30 cm 2 is provided in the test cell.
  • the test cell is included in a test apparatus and flowed through at 25 ° C tempered ultrafiltered and demineralized water at a defined test pressure (about 0.4 bar).
  • the amount of filtered water obtained during a measuring time of 2 minutes, ie that produced during the measurement Permeate is detected gravimetrically or volumetrically.
  • the system Before starting the measurement, the system must be purged without air.
  • the inlet and outlet pressure at the test cell are measured in the test apparatus. The measurement is carried out at 25 ° C.
  • the transmembrane flow TMF is calculated according to the formula (I) w ml
  • V w has flowed through the membrane sample during the measurement time
  • a M area of membrane sample (usually 30 cm 2 )
  • Disc-shaped samples are punched out of the flat material of the underside of the pocket-shaped wound dressing to be tested and fluid-tightly clamped in a suitable sample holder on the circumference in such a way that a free measurement area of 17.35 cm 2 results.
  • the sample holder is located in a housing, which can be flowed through by pressurized water.
  • the clamped sample is then passed through at 25 ° C tempered, demineralized water under a defined pressure between 0, 1 and 0.2 bar. This is passed through the sample during a measuring time of 60 s
  • V w through the sample during the measurement time
  • a M flow area of the sample (17.35 cm 2 )
  • Fig. 1 In the wound care system deployable Kapillarmembransystem with a mat of Kapillarmembranen and supply lines at both ends of the mat.
  • Fig. 2 In the wound care system deployable Kapillarmembransystem with a supply line to one of the mat ends and U-shaped Kapillarmembranenden on the opposite
  • Fig. 3 cross-section (schematically) by an insertable in the wound care system pocket-shaped Wundholz system.
  • FIG. 4 shows section A - A of the pocket-shaped wound dressing system shown in cross-section in FIG.
  • FIG. 1 shows a plan view schematically and not to scale in FIG
  • Inventive wound care system 1 can be used
  • the Kapillarmembranen 3 are connected by means of mutually parallel connecting elements 4 to form a mat so that they are arranged parallel to each other and held each other at a distance.
  • the capillary membranes 3 are embedded with their opposite ends in supply lines 5, 6 such that there is a fluid connection between the lumens of the supply lines 5, 6 and the lumen of the capillary membranes 3.
  • the supply lines 5, 6 are combined via a Y-piece 7 to a common line 8. From this structure it follows that the rinsing liquid or the
  • Supply lines 5, 6 is divided and the capillary 3 is supplied in the dead-end mode.
  • the rinsing liquid or the treatment solution then flows out of these via the porous, semipermeable walls of the capillary membranes 3 and is uniformly supplied to the wound over the surface of the capillary armature system 2,
  • FIG. 2 likewise shows schematically and in a non-scale representation a wound care system 1, in which the capillary membranes 3 are connected only to a supply line 5.
  • the capillary membranes are open at both ends and embedded with their two ends in a supply line 5.
  • the free ends 10 of the capillary membranes 3 are at the
  • FIG. 3 shows schematically a cross section through a pocket-shaped
  • Wound dressing 10 which has a top 1 1 and a bottom 12, which at its edge 13 a, 13 b, e.g. welded together, creating a closed pocket interior 14 is formed.
  • a first Kapillarmembransystem 2 is arranged to simplify the illustration, which comprises Kapillarmembranen 3, which preferably via mutually parallel connecting elements 4 in the form of
  • Multifilament yarns are connected together and held each other at a distance. A required according to the present invention second
  • Kapillarmembransystem can be arranged in one embodiment above or below the illustrated Kapillarmembransystems 2, wherein the
  • the capillary membranes 3 open in the present case with their
  • Supply lines 5, 6 are led out through the upper side 11 of the pocket-shaped wound dressing 10 (not shown here).
  • FIG. 4 shows the wound support system shown in FIG. 3 in a cross section along the line A - A. In principle, it is a plan view, from a position above the underside 12 of the pocket-shaped wound support layer 10 in the direction of the top side 1 1 of the pocket-shaped wound support layer 10. Below the top 1 1, that is, as shown in Figure 3, between the bottom 12 and
  • the Kapillarmembransystem 2 is arranged, which is composed of mutually parallel Kapillarmembranen 3, which are interconnected via the connecting elements 4 and held to each other at a distance.
  • Kapillarmembranen 3 are with their opposite ends in the
  • the supply lines 5, 6 are led out of the pocket-shaped wound dressing 10 through the upper side 11 of the pocket-shaped wound dressing 10 through correspondingly adapted openings in the upper side 11 and, in the present example, brought together outside the pocket-shaped wound dressing 10 via a Y-connector 16. in the
  • the Kapillarmembransystem 2 is operated in the dead-end mode, i. a medium supplied via the supply lines 5, 6 is introduced into the capillary armature system 2 and enters completely into the pocket interior via the walls of the capillary membranes 3.
  • FIG. 2 also shows the drainage tube 15, which is arranged below the capillary membrane system 2.
  • the drainage tube has perforations in its wall, so that e.g. sucked in the wound accumulating exudate via the drainage tube and so can be removed from the wound.
  • the drainage tube 15 is also a corresponding

Abstract

Système d'apport de substances à une plaie pour la traiter, comprenant au moins un premier et un deuxième système de membrane capillaire réalisé de manière plane, le premier et le deuxième système de membrane capillaire réalisé de manière plane étant reliés respectivement à au moins une conduite d'alimentation de sorte que la conduite d'alimentation et le système de membrane capillaire respectif permettent à des liquides, des milieux, des gaz et/ou d'autres substances d'être véhiculés, le système d'apport de substances à une plaie comprenant en outre : un premier contenant de prélèvement qui est relié de manière amovible au premier système de membrane capillaire par une voie de conduite qui comprend au moins l'une des conduites d'alimentation du premier système de membrane capillaire et qui peut être alimenté en un liquide de rinçage par le premier système de membrane capillaire ; un deuxième contenant de prélèvement qui est relié de manière amovible au deuxième système de membrane capillaire par une voie de conduite qui comprend au moins l'une des conduites d'alimentation du deuxième système de membrane capillaire et qui peut être alimenté en une solution de traitement par le deuxième système de membrane capillaire ; et un système de drainage qui peut être couplé à une unité basse pression et permet l'évacuation de liquides hors de la plaie à traiter.
PCT/IB2016/052661 2015-05-11 2016-05-10 Système d'apport de substances à une plaie WO2016181302A1 (fr)

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EP16724720.4A EP3294362B1 (fr) 2015-05-11 2016-05-10 Système de traitement des plaies
US15/571,373 US20190151155A1 (en) 2015-05-11 2016-05-10 Wound dressing system
JP2017558676A JP2018519013A (ja) 2015-05-11 2016-05-10 創傷管理システム
CN201680027173.XA CN108064177A (zh) 2015-05-11 2016-05-10 伤口护理系统

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EP15167090.8A EP3093031A1 (fr) 2015-05-11 2015-05-11 Système de traitement des plaies
EP15167090.8 2015-05-11

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WO2012078781A1 (fr) 2010-12-08 2012-06-14 Convatec Technologies Inc. Système intégré pour évaluer des exsudats de plaie
GB201115182D0 (en) 2011-09-02 2011-10-19 Trio Healthcare Ltd Skin contact material
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EP3093032B1 (fr) * 2015-05-11 2018-09-19 3M Innovative Properties Company Dispositif et procédé destinés à la production de sérum
CN109310528B (zh) 2016-03-30 2021-07-20 康沃特克科技公司 检测伤口中的微生物感染
KR20190008199A (ko) 2016-03-30 2019-01-23 시노보 게엠베하 상처에서 미생물 감염의 검출 방법
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EP3481360B1 (fr) 2016-07-08 2022-03-09 ConvaTec Technologies Inc. Détecteur de l'écoulement d'un liquide.
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CN108064177A (zh) 2018-05-22
EP3093031A1 (fr) 2016-11-16
US20190151155A1 (en) 2019-05-23
EP3294362A1 (fr) 2018-03-21
EP3294362B1 (fr) 2019-10-02

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