EP3068456B1 - Système de traitement des plaies doté d'un matelas constitué de membranes capillaires - Google Patents

Système de traitement des plaies doté d'un matelas constitué de membranes capillaires Download PDF

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Publication number
EP3068456B1
EP3068456B1 EP14798796.0A EP14798796A EP3068456B1 EP 3068456 B1 EP3068456 B1 EP 3068456B1 EP 14798796 A EP14798796 A EP 14798796A EP 3068456 B1 EP3068456 B1 EP 3068456B1
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Prior art keywords
capillary membranes
wound
treatment system
capillary
mat
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EP14798796.0A
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German (de)
English (en)
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EP3068456A1 (fr
Inventor
Carsten MEIXNER
Haythem KORBI
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3M Innovative Properties Co
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3M Innovative Properties Co
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/05—Bandages or dressings; Absorbent pads specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/01—Non-adhesive bandages or dressings
    • A61F13/01008—Non-adhesive bandages or dressings characterised by the material
    • A61F13/01012—Non-adhesive bandages or dressings characterised by the material being made of natural material, e.g. cellulose-, protein-, collagen-based
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/01—Non-adhesive bandages or dressings
    • A61F13/01008—Non-adhesive bandages or dressings characterised by the material
    • A61F13/01017—Non-adhesive bandages or dressings characterised by the material synthetic, e.g. polymer based
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/01—Non-adhesive bandages or dressings
    • A61F13/01021—Non-adhesive bandages or dressings characterised by the structure of the dressing
    • A61F13/01025—Non-adhesive bandages or dressings characterised by the structure of the dressing made of a single layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/01—Non-adhesive bandages or dressings
    • A61F13/01034—Non-adhesive bandages or dressings characterised by a property
    • A61F13/01042—Absorbency
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/84—Drainage tubes; Aspiration tips
    • A61M1/85—Drainage tubes; Aspiration tips with gas or fluid supply means, e.g. for supplying rinsing fluids or anticoagulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/90—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing
    • A61M1/92—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing with liquid supply means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/02—Enemata; Irrigators
    • A61M3/0279—Cannula; Nozzles; Tips; their connection means
    • A61M3/0283—Cannula; Nozzles; Tips; their connection means with at least two inner passageways, a first one for irrigating and a second for evacuating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/021—Manufacturing thereof
    • B01D63/0231—Manufacturing thereof using supporting structures, e.g. filaments for weaving mats
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/021—Manufacturing thereof
    • B01D63/0232—Manufacturing thereof using hollow fibers mats as precursor, e.g. wound or pleated mats
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/026—Wafer type modules or flat-surface type modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
    • B01D65/02—Membrane cleaning or sterilisation ; Membrane regeneration
    • B01D65/022—Membrane sterilisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/08—Hollow fibre membranes
    • B01D69/081—Hollow fibre membranes characterised by the fibre diameter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00544—Plasters form or structure
    • A61F2013/00548—Plasters form or structure net
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/71—Suction drainage systems
    • A61M1/74—Suction control
    • A61M1/75—Intermittent or pulsating suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/71—Suction drainage systems
    • A61M1/77—Suction-irrigation systems
    • A61M1/772—Suction-irrigation systems operating alternately
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/68—Biocompatibility of parts of the module

Definitions

  • the invention relates to a wound care system for introduction into a wound or for application to a skin wound and under a wound dressing, comprising a single-layer arrangement of parallel arranged capillary membranes with a porous, semipermeable wall and a lumen and at least one open end, wherein the capillary membranes a Outside diameter in the range of 50 to 5000 microns and a wall thickness in the range of 5 to 1000 microns and wherein the capillary membranes are at least one open end with at least one common supply line in fluid communication with a wall and a lumen, so that through the supply line and the capillary membranes liquids, media, gases and / or other substances are impressleitbar.
  • wound care The aim of modern wound care is to create a moist wound remedy for wound care that promotes healing processes. Depending on the healing phase, modern, active dressings must therefore be able to remove large amounts of exudate or keep the wound moist.
  • wound treatment it is important to provide improved fluid / mass transfer, factor / drug delivery, and / or improved fluid / secretion and / or tissue removal in the wound or wound.
  • Applications exclude usage such wound dressing systems in a soft tissue wound, in an abdominal wound and on a skin wound.
  • a method and apparatus for removing exudate from wounds is commercially known as V.A.C.® Therapy System (KCI, USA).
  • KCI V.A.C.® Therapy System
  • an alternating introduction of liquid into the wound and a subsequent, so also alternating and thus non-continuous running of liquid out of the wound is provided.
  • a foam material introduced into the wound, which exerts forces on the wound under negative pressure, should promote wound healing in this system.
  • the DE 10 2006 042 732 describes a Kapillarmembransystem for wound treatment in which the wound is perfused and supplied via a hollow fiber membrane assembly of up to 1000 hollow fibers with at least one common supply and at least one common derivative in the sense of flow through a capillary and antibiotic and growth factors perfusion is to be made possible. In this case, a uniform material distribution under continuous perfusion should be made possible while producing a moderate negative pressure.
  • the DE 10 2006 042 732 points out that further capillary manifold systems are an advantage for optimal supply and disposal.
  • the wound care system can be inserted into the wound and e.g. covered by a semi-occlusive transparent film to protect the wound from drying out or infection.
  • the at least one umbilical is then led out of the wound area under the film and, e.g. via a pump with a supply unit for e.g. a nutrient solution, e.g. connected to a storage container for the nutrient solution.
  • the arrangement of the capillary membranes can also be used for the suction of exudate from the wound.
  • the at least one supply line is connected to a unit for disposal, in particular a vacuum unit.
  • the supply of the wound with a liquid and the extraction of exudate from the wound can also be carried out intermittently on the arrangement of Kapillarmembranen by the at least one supply line via, for example, a T-piece via a first line with a liquid feed and a second part line with a vacuum unit is connected.
  • the at least one supply line via, for example, a T-piece via a first line with a liquid feed and a second part line with a vacuum unit is connected.
  • the wound care system may further comprise a bag-shaped dressing, the bag-shaped dressing being closed at its outer edge and having a top, a bottom, and a pocket interior, wherein the underside and the top are each formed of a sheet material and the bottom is permeable to fluids, wherein the array of mutually parallel arranged capillary membranes inside the bag is arranged and wherein the at least one supply line outside the pocket-shaped wound dressing with a unit for supply or disposal is connectable.
  • a bag-shaped dressing being closed at its outer edge and having a top, a bottom, and a pocket interior, wherein the underside and the top are each formed of a sheet material and the bottom is permeable to fluids, wherein the array of mutually parallel arranged capillary membranes inside the bag is arranged and wherein the at least one supply line outside the pocket-shaped wound dressing with a unit for supply or disposal is connectable.
  • the pocket-shaped wound dressing with the wound care system can be inserted into a wound to be treated in such a way that the underside is in contact with the wound.
  • the wound care system can provide the wound with fluid, e.g. be supplied in the form of a nutrient solution, which is distributed after exiting the capillary membranes in the bag and discharged through the semipermeable pocket bottom to the wound.
  • the wound care system Via the at least one supply line, the wound care system, e.g. via a pump with a supply unit for the liquid, e.g. be connected to a storage container for the nutrient solution.
  • the pocket-shaped wound dressing can preferably be designed such that the connection of the arrangement of capillary membranes arranged parallel to one another or of the capillary membranes with the at least one supply line is inside the pocket and the at least one supply line via a passage opening adapted in a fluid-tight manner to the outer cross section of the pocket-shaped wound dressing out leads.
  • the connection of the arrangement of capillary membranes arranged parallel to one another or of the capillary membranes with the at least one supply line outside the pocket-shaped wound dressing can be arranged on the upper side and the arrangement of mutually parallel arranged capillary membranes for connection to the at least one supply line via a fluid-tight adapted passage opening take out the pocket-shaped wound dressing.
  • the capillary membranes through the mat-shaped structure are at a uniform distance to each other in which they are held by the connecting elements, and that the capillary membranes within the mat in such a density that the distance of the capillary membranes to each other in the mat is 1 to 10 times the outer diameter of the Kapillarmembranen, wherein the distance from the longitudinal axes of the Kapillarmembranen is measured.
  • Mats are preferred in which the distance between the capillary membranes to each other in the mat 1.05 to 6 times the outer diameter of the Capillary membranes is.
  • Distances of the capillary membranes relative to one another in the mat are particularly preferred in the range of 1.05 to 3 times the outside diameter of the capillary membranes.
  • spacings of the capillary membranes relative to one another in the mat are more than 1.5 times the outside diameter of the capillary membranes. It has been found that this allows a secure separation of the capillary membranes from each other.
  • the capillary membranes in the arrangement of the capillary membranes are connected to one another by means of a plurality of mutually spaced and mutually parallel connecting elements to a mat and kept at a distance from each other by the connecting elements.
  • the connecting elements are located at a defined distance from each other, which is preferably in the range of 1 to 50 mm, with a distance in the range of 3 to 20 mm being particularly preferred, and such being in the range of 4 to 6 mm being best suited.
  • the capillary membranes preferably have an outer diameter in the range of 200 to 1500 .mu.m.
  • the arrangement of the capillary membranes is designed for the supply or discharge of liquid media.
  • the capillary membranes on a high permeability to liquids.
  • the transmembrane flux for water of the capillary membranes is in the range of 0.01 to 50 ml / (min ⁇ cm 2 ⁇ bar).
  • the number of capillary membranes in the assembly of the capillary membranes of the wound care system depends primarily on the size of the wound care system, and thus on the size of the capillary membrane assembly, which, in turn, is tuned to the size of the wound to be treated therewith.
  • the arrangement of capillary membranes can therefore be composed of from about 10 to several hundred or a thousand mutually parallel arranged capillary membranes.
  • the mutually parallel arranged capillary membranes are at least at one of their ends fluid-tightly embedded in the wall of the at least one supply line so that there is a fluid connection between the lumen of the supply line and the lumen of Kapillarmembranen and through the supply line and the capillary membranes liquids, media , Gases and / or other substances are passable.
  • the at least one supply line is at its one end open and connectable to a supply unit or unit for disposal, while the other end of the at least one supply line is closed.
  • the embedding can be done by means of conventional adhesives such as curable silicone materials, polyurethane resins or an epoxy resins. For their better flexibility, curable silicone materials are preferably used.
  • the capillary membranes are embedded in one supply line with only one of their ends, the other, opposite end of the capillary membranes is closed, for example by welding or gluing.
  • the capillary membranes can also be open at both ends and embedded with these two ends on one side of the arrangement in a supply line, the capillary membranes are then formed at its free end U-shaped and thereby closed there. In these cases, the capillary membranes are operated in dead-end mode.
  • an embodiment of the single-layer capillary membrane arrangement is advantageous, in which the capillary membranes arranged parallel to one another are open at both ends and the opposite ends are embedded in a respective supply line, wherein the supply lines are then preferably located on opposite sides of the capillary membrane arrangement. Also in this case, the embedding is carried out so that the capillary membranes are embedded in a fluid-tight manner on their outer circumference and there is a fluid connection between the lumen of the respective supply line and the lumen of the capillary membranes.
  • Such an embodiment with two supply lines allows a supply and / or disposal via the capillary membrane arrangement in cross-flow mode.
  • the capillary membrane assembly may also be advantageous for the capillary membrane assembly to be applied in dead-end mode, particularly in wider capillary membrane arrangements, for good homogeneity of disposal over the area of the wound when the capillary membrane assembly has a supply line at both ends of the capillary membranes.
  • the supply line can also have an oval, or approximately square or rectangular inner cross section.
  • a silicone tube has proved suitable for the at least one supply line, through the wall of which the capillary membrane ends pass and in which they are glued.
  • the at least one common supply line is a flexible silicone tube.
  • the embedding or sticking in the wall of the supply line can by means of conventional glue such. using curable silicone materials, polyurethane resins or an epoxy resins.
  • the capillary membranes arranged parallel to one another are connected to one another by means of a plurality of mutually spaced and mutually parallel connecting elements and kept at a distance from one another by the connecting elements, wherein the connecting elements touch the capillary membranes on their outer circumference or wrap around the capillary membranes.
  • the connecting elements do not have any closed flow channels along their longitudinal extension, and consequently can not be flowed through by fluids along their longitudinal extent.
  • the connecting elements can extend transversely to the mutually parallel capillary membranes or at a different angle.
  • the connecting elements may be adhesive strips or, for example, also strand-like elements of a silicone material.
  • the capillary membranes are connected to a mat by means of yarn-shaped connecting elements.
  • the connecting elements are particularly preferably textile multifilament yarns.
  • Multifilament polyester yarns, polypropylene yarns or polytetrafluoroethylene yarns have proved particularly suitable as textile multifilament yarns.
  • the capillary membrane mat may be an active mat in which the capillary membranes and the connecting threads are forfeited and in which the capillary membranes extend transversely to the direction of extension of the capillary membrane mat and the length of the capillary membranes is determined by the width of the mat.
  • the capillary membrane mat may be a woven mat in which the capillary membranes and the connecting threads are interwoven and in which the capillary membranes extend in the direction of extension or running direction of the capillary membrane mat and the textile threads transversely thereto.
  • the shape of the single-layer arrangement of capillary membranes arranged parallel to one another in their planar extension can be arbitrary, as far as this is possible for arrangements of mutually parallel capillary membranes.
  • the arrangement of mutually parallel Kapillarmembranen a square or rectangular shape.
  • an arcuate contour to be formed, for example, by suitably adapted welding of the free, closed ends of the mutually parallel capillary membranes.
  • the arrangement of mutually parallel capillary membranes e.g. also has a trapezoidal contour.
  • Suitable materials for the capillary membranes are in principle all known in the prior art organic polymers in question, which are suitable for the formation of capillary membranes, these polymers must have a good biocompatibility.
  • the membrane polymer allow sterilization of the wound care system, for example, by steam sterilization, ⁇ -ray sterilization or ethylene oxide sterilization.
  • the organic polymers may be natural polymers or polymers prepared by synthetic routes. Natural polymers are especially those based on cellulosic polymers, which also includes polymers which have been subjected to so-called polymer-analogous reactions.
  • cellulose-based polymers examples include those of regenerated cellulose, cellulose acetate or modified cellulose such as cellulose esters, cellulose ethers, benzyl group-modified cellulose (benzyl cellulose) or diethylaminoethyl-modified cellulose or mixtures of these cellulosic polymers. Furthermore, it is also possible to use polymers based on chitin or chitosan.
  • synthetically produced polymers i. as synthetic polymers it is possible to use those which consist of polyolefins, polyamides, polyacrylonitriles, polycarbonates, polyesters or sulfone polymers and also of modifications, blends, mixtures or copolymers of these polymers obtained therefrom.
  • those are used which are based on sulfone polymers, in particular polysulfone or polyethersulfone.
  • the synthetic polymers may contain other polymers such as e.g. Polyethylene oxide, polyhydroxyether, polyethylene glycol, polyvinyl alcohol or polycaprolactone be added as additives.
  • the capillary membranes may additionally have a coating with an additive.
  • such capillary membranes contain a hydrophilizing agent, e.g. Polyvinylpyrrolidone or hydrophilic modifications of these polymers.
  • the capillary membranes may be designed for specific applications e.g. be modified via coupling functional groups or be coated for example with heparin or an antibiotic or more antibiotics.
  • the wound care system can have further components, such as at least one further arrangement of capillary membranes, in which the capillary membranes of the further arrangement are membranes for oxygenation, ie membranes via which an oxygen supply to the wound is possible.
  • the capillary membranes of the further arrangement are membranes for oxygenation, ie membranes via which an oxygen supply to the wound is possible.
  • membranes are described for example in the in EP-A-1 144 096 , the EP-A-0 299 381 or the DE-A-28 33 493 disclosed.
  • the combination with a further mat-shaped arrangement of semipermeable capillary membranes is also possible, so that, for example, via the first arrangement of capillary membranes, a supply of the wound with growth factors or with antibiotics and, via the further arrangement, a temperature control or a pH regulation can take place.
  • the respective mat-shaped arrangements can be placed on top of each other.
  • two different capillary membranes are connected together to a mat, wherein the different capillary membranes are embedded with their ends in different supply lines, which are preferably arranged on opposite sides of the mat.
  • Such mats can be obtained, for example, by forcibly disposed mutually staggered capillary membranes deposited meandering, in which the U-shaped deflections of the capillary membranes are located at different positions above the mat width. By cutting the respective outer U-shaped deflections, the capillary membranes are opened on only one side of the mat and can be embedded there in a supply line.
  • the wound-care system can have, for example, a drainage system by means of which a separate discharge of exudate is possible.
  • the wound care system may include a suction sponge having an exudate suction line.
  • the drainage system may also be formed as another capillary membrane mat, but it may also be in the form of a drainage catheter, which may be a piece of tubing, such as a silicone material, or a tube.
  • a drainage catheter may have perforations in its wall, via which, after connection of the drainage catheter to a vacuum unit, e.g. Exudate from the wound or from the inside of the pocket-shaped wound dressing and can be sucked out of the wound.
  • the wound care system further comprises a pocket-shaped wound dressing, in which the arrangement of capillary membranes arranged parallel to one another is arranged, the at least one arrangement of capillary membranes arranged parallel to one another extends flatly in the pocket interior.
  • the dimensions of the arrangement are parallel to each other arranged capillary membranes arise from their outer dimensions in the planar extension.
  • the arrangement of the capillary membranes preferably fills the pocket interior of the pocket-shaped wound dressing in its planar extent at least to 20% and particularly preferably at least 50%.
  • the arrangement of the capillary membranes in terms of their areal extent at least 70% fills the pocket interior of the pocket-shaped wound dressing in its planar extent, wherein fill levels in the range of 90% can be realized. It is advantageous if the arrangement of the capillary membranes is arranged centrally in the pocket-shaped wound dressing.
  • the pocket-shaped wound dressing can have any contours. Preferably, however, the contour is round, oval, square or rectangular.
  • the underside and upper side of the pocket-shaped wound dressing are connected to one another at the outer edge or at the outer edges of the wound dressing, for example by welding or gluing.
  • silicone strips are suitable, which are cured.
  • the planar-shaped capillary membrane system arranged therein preferably likewise has a rectangular or square contour.
  • the at least one sheet-like capillary arm system located therein is expediently also square or rectangular, the dimensions mentioned above likewise being valid with regard to the dimensions.
  • the pocket-shaped wound dressing can also be adapted to the contour of the pocket-shaped wound dressing, for example, by appropriately adapted welding off of the non-embedded ends of the capillary membranes in an arrangement of Kapillarmembranen with only one supply line, so that there is an arcuate contour at this edge of the arrangement of Kapillarmembranen.
  • the underside of the pocket-shaped wound dressing is permeable to fluids, ie permeable.
  • the underside may for example consist of a non-woven, sheet-like material, a latticed or net-like material, a perforated film or a semipermeable microporous flat membrane.
  • the underside consists of a non-woven, sheet material or a semipermeable microporous flat membrane.
  • the underside preferably has a water permeability of at least 0.01 ml / (min.cm 2 .bar) and more preferably at least 10 ml / (min.cm 2 .bar). An underside with a permeability to water of at least 500 ml / (min.cm 2 .bar) has proven to be most effective.
  • openings are present in the bottom, wherein the openings preferably have a diameter of at least 100 microns. In this case, the diameter of the openings of at most 10 mm is preferred and of at most 5 mm is particularly preferred. In the case where the underside consists of a semipermeable microporous flat membrane, in an advantageous embodiment this has additional openings, e.g. in the form of perforations.
  • the openings may be regularly or irregularly distributed over the surface of the bottom, with a regular, homogeneous distribution is preferred. In this case, the distance between the openings can be in the range of 1 to 20 mm, measured from the outer edge of the openings.
  • the bottom and the top of the bag-shaped wound pad can be made of the same or different materials. While the bottom is always is permeable to liquids, the upper side is preferably formed of a fluid-impermeable, preferably film-shaped material, which is fluid-tightly connected at its or its side edges with the underside.
  • the upper side may also be a semipermeable, microporous flat membrane. In this case, however, the upper side has a lower permeability to fluids than the lower side, in order to ensure in the application a distribution of supplied liquid on the underside of the pocket-shaped wound dressing and thus towards the wound.
  • the underside has perforations.
  • lower and / or upper side of the pocket-shaped wound dressing are built up from polyolefins, polyamides, polyacrylonitrile, polycarbonates, polyesters or sulfone polymers and modifications, blends, mixtures or copolymers of these polymers obtained therefrom.
  • the lower and upper sides comprise as material sulfone polymers, with polysulfone or polyethersulfone being most suitable.
  • a drainage system may be arranged in the pocket interior, which is suitable for the removal of exudate from wounds to be treated.
  • the drainage system may preferably be at least one drainage catheter which leads out of the pocket-shaped wound dressing via a passage opening which is adapted in a fluid-tight manner to its cross-section and can be connected to a vacuum unit so as to generate a negative pressure in the pocket interior in the application.
  • the at least one drainage catheter may be a Hose piece, for example, from a silicone material, or act around a tube, which is arranged in the pocket interior of the wound dressing and leads out through the passage opening from the wound dressing.
  • the segment of the at least one drainage catheter which is located inside the pocket-shaped wound dressing, preferably has perforations in its wall, via which, after connection of the at least one drainage catheter to a vacuum unit, exudate from the wound or from the inside of the pocket-shaped wound dressing and out of the Wound can be sucked.
  • the at least one drainage catheter preferably has an inner diameter in the range of 0.1 to 15 mm and a wall thickness in the range of 0.1 to 3 mm and preferably extends over at least the entire length or width of the pocket interior.
  • a test cell with a defined capillary membrane number and length is manufactured.
  • the capillary membranes are embedded on both sides at their ends in a polyurethane resin. After curing of the resin, the embedding is cut to a length of about 30 mm, with the lumens of the capillary membranes are opened by the cut.
  • the capillaries in the embedding must be checked for patency.
  • the free length of the capillary membranes between the embedding is usually 120 +/- 10 mm.
  • the number of Capillary membranes should be dimensioned such that, taking into account the free length and the inner diameter of the capillary membranes, a filtration area of approximately 30 cm 2 is provided in the test cell.
  • the test cell is included in a test apparatus and flowed through at 25 ° C tempered ultrafiltered and demineralized water at a defined test pressure (about 0.4 bar).
  • the amount of filtered water obtained during a measuring time of 2 minutes, i. the permeate produced during the measurement is recorded gravimetrically or volumetrically.
  • the system Before starting the measurement, the system must be purged without air.
  • the inlet and outlet pressure at the test cell are measured in the test apparatus. The measurement is carried out at 25 ° C.
  • FIG. 1 shows in plan view schematically and not to scale a wound care system 1 according to the invention with a single-layer arrangement 2 of capillary membranes 3.
  • the capillary membranes 3 are connected by mutually parallel connecting elements 4 to a mat so that they are arranged parallel to each other and spaced from each other.
  • the capillary membranes 3 are embedded with their opposite ends in supply lines 5, 6 such that there is a fluid connection between the lumens of the supply lines 5, 6 and the lumen of the capillary membranes 3.
  • the supply lines 5, 6 are combined via a Y-piece 7 to a common line 8.
  • a nutrient solution which is supplied via the line 8 is split between the supply lines 5, 6 and is supplied to the capillary membranes 3 in the dead-end mode.
  • the nutrient solution flows out of the porous, semi-permeable walls of the capillary membranes 3 from these and is uniformly supplied to the wound over the surface of the assembly 2 of capillary 3, wherein the uniform distribution of compliance of the Conditions according to the invention with respect to one another, on the one hand, the distance of the capillary membranes 3 from one another and, on the other hand, the spacing of the connecting elements from one another must be maintained.
  • FIG. 2 is also shown schematically and in non-scale representation of a wound care system 1 with a single-layer arrangement 2 of capillary membranes 3, in which the capillary membranes 3 are embedded with only one of their ends in a supply line 5.
  • the second, opposite ends of the capillary membranes 3 are enclosed by means of, for example, a silicone material 9 and sealed in this way.
  • the capillary membranes 3 are also connected by means of mutually parallel connecting elements 4 to form a mat so that they are arranged parallel to each other and held at a distance from each other.
  • a wound care system 1 as in FIG. 2 shown is usually appropriate for smaller widths, so that despite an only one-sided supply to the mat of Kapillarmembranen 3 with eg a nutrient solution, an at least substantially homogeneous distribution of the nutrient solution to the wound to be treated over the mat width.
  • FIG. 3 also shows schematically and in non-scale representation of a wound care system 1, in which the capillary membranes 3 are connected only to a supply line 5.
  • the capillary membranes are open at both ends and embedded with its two ends in a supply line 5.
  • the free ends 10 of the capillary membranes 3 are formed at the opposite end of the supply line 5 of the mat U-shaped and thus closed there. In this way, also takes place in the capillary 3 of the in FIG. 3 wound care system 1 shown the flow in dead-end mode.
  • FIG. 4 shows a photograph of a segment of a wound care system according to the invention with a single-layer arrangement of mutually parallel capillary membranes in a trial with a simulation solution.
  • the segment shown is a part of a mat with the dimensions 200 mm in the longitudinal direction (in the direction of the capillary membranes) and 200 mm in the transverse direction (in the direction transverse to the capillary membranes) of capillary membranes of the type MicroPES® TF10 (Membrana GmbH), which in the segment shown in the vertical direction zT arcuately guided.
  • the capillary membranes are connected by means of connecting elements in the form of multifilament polyester threads to a knit mat, wherein the polyester threads run in the horizontal direction.
  • the polyester threads have a distance of 5 mm from each other, the distance between the capillary membranes to each other is about 2.7 times the outer diameter of the capillary membranes (500 microns).
  • the capillary membranes are embedded with their one end in a supply line, which can be seen at the bottom of the picture.
  • the photograph of the FIG. 4 shows a snapshot at the beginning of an attempt to test the homogeneity of the distribution of a liquid supplied through the capillary membrane mat.
  • the model liquid used was a dyed safranine solution.
  • the distribution of the liquid across the capillary membranes at the early stage of the experiment begins at the supply line at the bottom of the mat.
  • a distribution of the liquid also starts from the crossing points of the capillary membranes with the polyester threads, which results in FIG. 4 can be seen at the dark points or lines above the surface of the mat.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Surgery (AREA)
  • Pulmonology (AREA)
  • Manufacturing & Machinery (AREA)
  • External Artificial Organs (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Claims (15)

  1. Système de traitement des plaies, comprenant un agencement monocouche de membranes capillaires parallèles les unes aux autres (3) avec une paroi poreuse, semi-perméable et une lumière et au moins une extrémité ouverte,
    - dans lequel les membranes capillaires présentent un diamètre extérieur dans la plage de 50 à 500 µm et une épaisseur de paroi dans la plage de 5 à 1 000 µm,
    - dans lequel les membranes capillaires sont reliées par leur au moins une extrémité ouverte avec au moins une tubulure d'alimentation commune avec une paroi et une lumière,
    caractérisé en ce que,
    - les membranes capillaires sont intégrées avec leur au moins une extrémité ouverte à leur pourtour externe de manière étanche aux fluides dans la paroi de l'au moins une tubulure d'alimentation commune (5, 6), de sorte qu'une liaison fluidique existe entre la lumière de la tubulure d'alimentation et la lumière des membranes capillaires,
    - en ce que l'agencement de membranes capillaires disposées parallèlement les unes aux autres présente en outre plusieurs éléments de liaison (4) espacés les uns des autres et s'étendant parallèlement les uns aux autres, au moyen desquels les membranes capillaires sont liées les unes aux autres en un tissu et sont maintenues à distance les unes des autres par les éléments de liaison,
    - en ce que la distance des membranes capillaires les unes par rapport aux autres dans le tissu représente 1 à 10 fois le diamètre extérieur des membranes capillaires, la distance des axes longitudinaux des membranes capillaires étant mesurée et
    - en ce que la distance des éléments de liaison les uns par rapport aux autres est dans une plage de 1 à 50 mm.
  2. Système de traitement des plaies selon la revendication 1, caractérisé en ce que l'agencement de membranes capillaires est relié avec deux tubulures d'alimentation, les membranes capillaires étant intégrées avec leurs extrémités opposées respectivement dans une tubulure d'alimentation.
  3. Système de traitement des plaies selon la revendication 1 ou 2,
    caractérisé en ce que les membranes capillaires présentent un flux transmembranaire pour l'eau dans la plage de 0,01 à 50 ml/(min•cm2•bar).
  4. Système de traitement des plaies selon une ou plusieurs des revendications 1 à 3, caractérisé en ce que les membranes capillaires sont liées en un tissu par des éléments de liaison en forme de fils.
  5. Système de traitement des plaies selon la revendication 4, caractérisé en ce que les éléments de liaison en forme de fil sont des fils textiles à plusieurs filaments.
  6. Système de traitement des plaies selon la revendication 5, caractérisé en ce que les fils textiles à plusieurs filaments sont des fils de polyester, des fils de polypropylène ou des fils de polytétrafluoréthylène multifils.
  7. Système de traitement des plaies selon une ou plusieurs des revendications 4 à 6, caractérisé en ce que le tissu est un tissu tissé, dans lequel les membranes capillaires et les fils de liaison sont tissés les uns avec les autres.
  8. Système de traitement des plaies selon une ou plusieurs des revendications 4 à 6, caractérisé en ce que le tissu est un tissu actif, dans lequel les membranes capillaires et les fils de liaison sont tricotés les uns avec les autres.
  9. Système de traitement des plaies selon une ou plusieurs des revendications 1 à 8, caractérisé en ce que ladite au moins une tubulure d'alimentation commune est un tube flexible en silicone.
  10. Système de traitement des plaies selon une ou plusieurs des revendications 1 à 9, caractérisé en ce qu'il contient au moins un agencement supplémentaire de membranes capillaires.
  11. Système de traitement des plaies selon une ou plusieurs des revendications 1 à 10, caractérisé en ce qu'il contient un système de drainage.
  12. Système de traitement des plaies selon une ou plusieurs des revendications 1 à 11, caractérisé en ce qu'il comporte en outre un pansement en forme de poche, le pansement en forme de poche étant fermé à son bord extérieur et présentant une face supérieure, une face inférieure et un intérieur de poche, dans lequel la face inférieure et la face supérieure sont constituées chacune d'un matériau plat et la face inférieure est perméable aux fluides et dans lequel l'agencement de membranes capillaires parallèles les unes aux autres est disposé à l'intérieur de la poche et dans lequel l'au moins une tubulure d'alimentation à l'extérieur du pansement en forme de poche peut être reliée à une unité d'alimentation ou d'évacuation.
  13. Système de traitement des plaies selon la revendication 12, caractérisé en ce qu'il comporte un système de drainage, qui est disposé à l'intérieur de la poche et qui convient pour l'élimination de l'exsudant des plaies à traiter.
  14. Système de traitement des plaies selon la revendication 13, caractérisé en ce que le système de drainage est un cathéter de drainage, qui fait saillie par le biais d'un orifice de passage adapté à sa section transversale de manière étanche aux fluides hors du pansement en forme de poche et qui peut être relié à une unité de dépression.
  15. Système de traitement des plaies selon une ou plusieurs des revendications 12 à 14, caractérisé en ce que la face inférieure du pansement en forme de poche est constituée d'un matériau plat en feuillet non tissé ou d'une membrane plane microporeuse semi-perméable.
EP14798796.0A 2013-11-13 2014-11-12 Système de traitement des plaies doté d'un matelas constitué de membranes capillaires Active EP3068456B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP14798796.0A EP3068456B1 (fr) 2013-11-13 2014-11-12 Système de traitement des plaies doté d'un matelas constitué de membranes capillaires

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13192648 2013-11-13
PCT/EP2014/074312 WO2015071280A1 (fr) 2013-11-13 2014-11-12 Système d'alimentation de plaie comprenant un tapis de membranes capillaires
EP14798796.0A EP3068456B1 (fr) 2013-11-13 2014-11-12 Système de traitement des plaies doté d'un matelas constitué de membranes capillaires

Publications (2)

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EP3068456A1 EP3068456A1 (fr) 2016-09-21
EP3068456B1 true EP3068456B1 (fr) 2019-08-28

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US (1) US10292871B2 (fr)
EP (1) EP3068456B1 (fr)
JP (1) JP6453879B2 (fr)
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WO (1) WO2015071280A1 (fr)

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EP3093032B1 (fr) * 2015-05-11 2018-09-19 3M Innovative Properties Company Dispositif et procédé destinés à la production de sérum
EP3092987A1 (fr) 2015-05-11 2016-11-16 3M Innovative Properties Company Système de traitement de plaies à l'aide de sérum
JP7231227B2 (ja) 2017-02-22 2023-03-01 コーネル ユニヴァーシティー 小さい切開創を機械式に管理、保護及び吸引するための機械式真空ドレッシング
CN111432855B (zh) 2017-12-06 2024-02-23 康奈尔大学 具有提高的泵效率、自动压力指示器和自动压力限制器的手动操作的负压伤口治疗（npwt）绷带

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2833493C2 (de) 1978-07-31 1989-10-12 Akzo Gmbh, 5600 Wuppertal Hohlfäden
WO1980001139A1 (fr) * 1978-12-06 1980-06-12 Svedman Paul Dispositif de traitement des tissus, par exemple de la peau
EP0299381B2 (fr) 1987-07-11 1999-06-30 Dainippon Ink And Chemicals, Inc. Poumon artificiel du type à membrane et son procédé d'utilisation
DE3839567A1 (de) 1988-11-24 1990-06-07 Akzo Gmbh Hohlfadenmodul zum abtrennen von gas
US5224522A (en) * 1990-02-16 1993-07-06 Akzo N.V. Manufacture of woven hollow fiber tape
DE4004797A1 (de) * 1990-02-16 1991-08-22 Akzo Gmbh Gewebtes hohlfadenband
DE4308850A1 (de) * 1993-03-19 1994-09-22 Akzo Nv Hohlfadenmatte
US5549584A (en) 1994-02-14 1996-08-27 The Kendall Company Apparatus for removing fluid from a wound
BR0007614B1 (pt) 1999-01-21 2010-10-19 processo de preparação de membrana hidrofóbica integralmente assimétrica, e, membrana hidrofóbica.
WO2000053796A1 (fr) 1999-03-09 2000-09-14 Acordis Industrial Fibers Gmbh Module a membranes destine a tester des principes actifs sur des cellules
DE10221565A1 (de) 2002-05-15 2003-12-04 Evotec Ag Vorrichtung zum Kultivieren von Partikeln
EP2007507B1 (fr) 2006-04-10 2011-06-15 Vlaamse Instelling voor Technologisch Onderzoek (VITO) Support tricote pour une membrane tubulaire
DE102006031871B4 (de) 2006-07-10 2008-10-23 Gerlach, Jörg, Dr.med. 3-D Petri-Schale zur Züchtung und Untersuchung von Zellen
DE102006042732B3 (de) * 2006-09-12 2008-04-10 Gerlach, Jörg, Dr.med. Künstliches arterio-venöses permeables Hohlfaserkapillarsystem
DE102006047041A1 (de) 2006-10-02 2008-04-10 Birgit Riesinger Flächenhafter Absorptionskörper
US8501462B2 (en) 2007-02-27 2013-08-06 The Board Of Trustees Of The University Of Illinois Insert device for multiwell plate
WO2010037092A1 (fr) * 2008-09-29 2010-04-01 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Dispositif auto-régulateur pour moduler l'inflammation
DE102009039868B4 (de) 2009-09-03 2020-12-31 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Anordnung zur Durchführung eines Verfahrens zur Untersuchung der Wirkung eines gasförmigen Mediums auf ein biologisches Prüfsystem unter Verwendung eines extrazellulären Metabolisierungssystems
SG184164A1 (en) 2010-03-23 2012-10-30 Wuhan Vsd Medical Science & Technology Co Ltd Medical vacuum sealing drainage device
CA2826575C (fr) 2011-02-22 2016-10-11 Oleg Siniaguine Pansement adaptatif et a adaptabilite variable selon les besoins
CN103702646B (zh) * 2011-06-24 2016-03-30 凯希特许有限公司 采用组织固定元件的减压敷件
EP3508182A1 (fr) 2011-07-14 2019-07-10 Smith & Nephew PLC Pansement pour plaies et procédé de traitement

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
None *

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Publication number Publication date
EP3068456A1 (fr) 2016-09-21
JP6453879B2 (ja) 2019-01-16
JP2016539689A (ja) 2016-12-22
US20160287446A1 (en) 2016-10-06
CN106102786B (zh) 2018-05-18
CN106102786A (zh) 2016-11-09
US10292871B2 (en) 2019-05-21
WO2015071280A1 (fr) 2015-05-21

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