WO2016161991A3 - 一种硫酸氢氯吡格雷固体制剂及其制备方法 - Google Patents

一种硫酸氢氯吡格雷固体制剂及其制备方法 Download PDF

Info

Publication number
WO2016161991A3
WO2016161991A3 PCT/CN2016/090137 CN2016090137W WO2016161991A3 WO 2016161991 A3 WO2016161991 A3 WO 2016161991A3 CN 2016090137 W CN2016090137 W CN 2016090137W WO 2016161991 A3 WO2016161991 A3 WO 2016161991A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
method therefor
clopidogrel bisulphate
solid preparation
solid
Prior art date
Application number
PCT/CN2016/090137
Other languages
English (en)
French (fr)
Other versions
WO2016161991A2 (zh
Inventor
蔡燕霞
谭岳尧
叶冠豪
Original Assignee
深圳信立泰药业股份有限公司
山东信立泰药业有限公司
惠州信立泰药业有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 深圳信立泰药业股份有限公司, 山东信立泰药业有限公司, 惠州信立泰药业有限公司 filed Critical 深圳信立泰药业股份有限公司
Publication of WO2016161991A2 publication Critical patent/WO2016161991A2/zh
Publication of WO2016161991A3 publication Critical patent/WO2016161991A3/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明提供了硫酸氢氯吡格雷固体制剂，采用熔融制粒工艺制备，所得颗粒中药物含量高，均匀性好。
PCT/CN2016/090137 2015-12-04 2016-07-15 一种硫酸氢氯吡格雷固体制剂及其制备方法 WO2016161991A2 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201510888830.7A CN105616407B (zh) 2015-12-04 2015-12-04 一种硫酸氢氯吡格雷固体制剂及其制备方法
CN201510888830.7 2015-12-04

Publications (2)

Publication Number Publication Date
WO2016161991A2 WO2016161991A2 (zh) 2016-10-13
WO2016161991A3 true WO2016161991A3 (zh) 2016-12-01

Family

ID=56032032

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2016/090137 WO2016161991A2 (zh) 2015-12-04 2016-07-15 一种硫酸氢氯吡格雷固体制剂及其制备方法

Country Status (3)

Country Link
US (1) US20170157098A1 (zh)
CN (1) CN105616407B (zh)
WO (1) WO2016161991A2 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105616407B (zh) * 2015-12-04 2016-12-28 深圳信立泰药业股份有限公司 一种硫酸氢氯吡格雷固体制剂及其制备方法
CN108186604A (zh) * 2018-03-28 2018-06-22 北京睿悦生物医药科技有限公司 一种硫酸氢氯吡格雷颗粒及其制备方法
CN110339178B (zh) * 2019-06-28 2021-07-02 广州白云山天心制药股份有限公司 一种硫酸氢氯吡格雷固体制剂的制备方法
CN113057944B (zh) * 2019-12-13 2022-09-16 华益泰康药业股份有限公司 一种改善性能的片剂的制备方法
CN114767642A (zh) * 2022-03-25 2022-07-22 扬子江药业集团广州海瑞药业有限公司 硫酸氢氯吡格雷片剂及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101690719A (zh) * 2007-07-01 2010-04-07 深圳信立泰药业股份有限公司 一种硫酸氢氯吡格雷的固体制剂、其颗粒及其制备方法
CN105616407A (zh) * 2015-12-04 2016-06-01 深圳信立泰药业股份有限公司 一种硫酸氢氯吡格雷固体制剂及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3397385B2 (ja) * 1993-09-20 2003-04-14 第一製薬株式会社 崩壊遅延防止錠剤
CN103006599A (zh) * 2012-12-31 2013-04-03 广州白云山天心制药股份有限公司 含氯化钠药物载体的抗凝血片剂及其制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101690719A (zh) * 2007-07-01 2010-04-07 深圳信立泰药业股份有限公司 一种硫酸氢氯吡格雷的固体制剂、其颗粒及其制备方法
CN105616407A (zh) * 2015-12-04 2016-06-01 深圳信立泰药业股份有限公司 一种硫酸氢氯吡格雷固体制剂及其制备方法

Also Published As

Publication number Publication date
CN105616407A (zh) 2016-06-01
CN105616407B (zh) 2016-12-28
WO2016161991A2 (zh) 2016-10-13
US20170157098A1 (en) 2017-06-08

Similar Documents

Publication Publication Date Title
WO2016161991A3 (zh) 一种硫酸氢氯吡格雷固体制剂及其制备方法
EP3326778A4 (en) DIE-TYPE DEVICE, MOLDING APPARATUS, INJECTION MOLDING SYSTEM, AND MOLDING MANUFACTURING METHOD
EP3354649A4 (en) Oxa spiro derivative, preparation method therefor, and applications thereof in medicines
EP3260476A4 (en) Modified conjugated diene-based polymer, manufacturing method thereof, and modified conjugated diene-based polymer composition
EP3579957A4 (en) POLYHALITE GRANULATION PROCESS
EP3436417A4 (en) SPHERICAL FERTILIZERS AND ASSOCIATED PRODUCTION METHOD
EP3305429A4 (en) PRESS MOLDED PRODUCT, PRESS MOLDING METHOD, AND PRESS MOLDING DEVICE
EP3269757A4 (en) METHOD FOR PRODUCING AQUEOUS LIQUID ABSORBING RESIN PARTICLES, AQUEOUS LIQUID ABSORBING RESIN PARTICLE, ABSORBENT, AND ABSORBENT ARTICLE
EP3409713A4 (en) MOLDED ARTICLE AND METHOD FOR PRODUCING THE SAME
EP3466646A4 (en) SHAPING DEVICE, SHAPING METHOD, AND SHAPED ARTICLE
EP3489282A4 (en) POLYAMIDE PARTICLES AND PROCESS FOR PRODUCING THE SAME, RESIN COMPOSITION, AND MOLDED ARTICLE
EP3546603A4 (en) DEVICE FOR PRODUCING GRANULATED PRODUCT, DEVICE THEREFOR FOR PRODUCING Sintered Ore, and Method for Producing Sintered Ore
SG10201502461VA (en) MEMBRANE COMPRISING SELF-ASSEMBLED BLOCK COPOLYMER AND PROCESS FOR PRODUCING THE SAME BY SPIN COATING (Ia)
EP3546525A4 (en) RESIN COMPOSITION AND METHOD FOR MANUFACTURING THE SAME, AND MOLDED BODY OF RESIN COMPOSITION AND METHOD FOR MANUFACTURING THE SAME
EP3626693A4 (en) COMPOSITION FOR THE MANUFACTURING OF INORGANIC SHAPED BODIES AND METHOD FOR MANUFACTURING INORGANIC SHAPED BODIES
EP3510058A4 (en) POLYMERIZING COMPOSITION, METHOD FOR PRODUCING IT AND ITEM THEREOF
EP3260217A4 (en) Granular material, method for manufacturing granular material, device for manufacturing mold by additive manufacturing, and method for manufacturing mold by additive manufacturing
EP3323840A4 (en) Methacrylic resin, methacrylic resin production method, molded article, and automobile
EP3348378A4 (en) Composite material production method, composite material production device, preform for composite material, and composite material
EP3327070A4 (en) POROUS PARTICLE, PROCESS FOR PRODUCING POROUS PARTICLE, AND BLOCK COPOLYMER
EP3369551A4 (en) METAL SHAPE, BLOWING DEVICE AND BLOWING METHOD
EP3467043A4 (en) HEAT-CONDUCTING ELEMENT, HEAT-CONDUCTING COMPOSITION AND PRODUCTION METHOD FOR HEAT-CONDUCTING COMPOSITION
EP3210942A4 (en) Method for producing glass raw material granulated body, method for producing molten glass, and method for producing glass article
EP3231531A4 (en) Granular material, mold formed by three-dimensional additive manufacturing, process for producing mold by three-dimensional additive manufacturing, and device for producing mold by three-dimensional additive manufacturing
EP3103561A4 (en) Granular material, device for producing three-dimensional-laminate moulding mould, and method for producing three-dimensional-laminate moulding mould

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 16776166

Country of ref document: EP

Kind code of ref document: A2