WO2016161698A1 - 用于治疗儿童哮喘的中药组合物及其制备方法 - Google Patents

用于治疗儿童哮喘的中药组合物及其制备方法 Download PDF

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WO2016161698A1
WO2016161698A1 PCT/CN2015/080423 CN2015080423W WO2016161698A1 WO 2016161698 A1 WO2016161698 A1 WO 2016161698A1 CN 2015080423 W CN2015080423 W CN 2015080423W WO 2016161698 A1 WO2016161698 A1 WO 2016161698A1
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parts
servings
medicine composition
chinese medicine
traditional chinese
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PCT/CN2015/080423
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English (en)
French (fr)
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张贯京
陈兴明
葛新科
张少鹏
方静芳
克里斯基捏普拉纽克
古列莎艾琳娜
波达别特伊万
高伟明
梁昊原
梁艳妮
周荣
徐之艳
周亮
肖应芬
郑慧华
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深圳市贝沃德克生物技术研究院有限公司
深圳市易特科信息技术有限公司
深圳市前海安测信息技术有限公司
深圳市共创百业科技开发有限公司
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Publication of WO2016161698A1 publication Critical patent/WO2016161698A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/487—Psoralea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/758—Zanthoxylum, e.g. pricklyash
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966—Fritillaria, e.g. checker lily or mission bells

Definitions

  • the invention relates to the technical field of medicine, in particular to a traditional Chinese medicine composition for promoting health promotion of children's asthma and a preparation method thereof.
  • Bronchial asthma is one of the most common chronic respiratory diseases. Common symptoms of asthma patients are paroxysmal wheezing, shortness of breath, chest tightness, cough and other symptoms. A few patients also have symptoms of chest pain. With the rapid development of the economy, people's living environment has undergone tremendous changes, and the incidence of asthma has increased. Western medicine for the treatment of asthma, often the use of antibiotics, resulting in increased drug resistance, the treatment effect is getting worse, and there is also the phenomenon of abuse of antitussives. Because of its mild effect and long-lasting effect, traditional Chinese medicine can significantly improve the symptoms of asthma, reduce the pain of asthma patients, protect against the suffering of asthma, and improve the quality of life of patients. For children with mild disease and less severe asthma attacks Can achieve the effect of curing asthma.
  • the object of the present invention is to provide a traditional Chinese medicine composition for promoting the health promotion of asthma in children, and a preparation method thereof, which has mild effect and long-lasting effect, can obviously improve asthma symptoms, and can cure for children with mild disease and less severe asthma attack. The effect of asthma.
  • the present invention provides a traditional Chinese medicine composition for promoting the health of asthma in children, which composition is composed of the following parts by weight:
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Radix Pseudostellariae 10 ⁇ 12 parts, red dates: 10 ⁇ 12 parts, Astragalus: 8 ⁇ 9 parts, Ejiao: 8 ⁇ 9 parts, rock sugar: 7 ⁇ 9 parts, Asparagus: 7 ⁇ 9 parts, Rehmannia: 2 ⁇ 3 parts , Coltsfoot flower: 5 ⁇ 7 servings, psoralen: 5 ⁇ 7 servings, Salvia: 5 ⁇ 6 servings, pepper: 3 ⁇ 5 servings, Zhigancao: 3 ⁇ 4 servings, Chuanbei powder: 2 ⁇ 3 servings, dried tangerine peel : 2 ⁇ 4, yellow wine: 8 ⁇ 10 copies.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Radix Pseudostellariae 12 servings, red dates: 12 servings, astragalus: 8 servings, donkey-hide gelatin: 8 servings, rock sugar: 8 servings, asparagus: 8 servings, rehmannia: 2 servings, coltsfoot flower: 6 servings, psoralen: 6 servings, Salvia: 6 parts, pepper: 3 parts, licorice: 3.2 parts, Chuanbei powder: 2 parts, dried tangerine peel: 2.4 parts, yellow wine: 8 parts.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Radix Pseudostellariae 10 parts, red dates: 10 parts, astragalus: 9 parts, donkey-hide gelatin: 9 parts, rock sugar: 9 parts, asparagus: 8 parts, rehmannia: 3 parts, coltsfoot flower: 5 parts, psoralen: 6 parts, Salvia: 6 parts, pepper: 3 parts, licorice: 3.2 parts, Chuanbei powder: 2 parts, dried tangerine peel: 2.4 parts, yellow wine: 10 parts.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Radix Pseudostellariae 10 parts, red dates: 12 parts, astragalus: 8 parts, donkey-hide gelatin: 8 parts, rock sugar: 8 parts, asparagus: 8 parts, rehmannia: 2 parts, coltsfoot flower: 5 parts, psoralen: 7 parts, Salvia: 5 parts, pepper: 5 parts, licorice: 3.2 parts, Chuanbei powder: 2 parts, dried tangerine peel: 4 parts, yellow wine: 10 parts.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Radix Pseudostellariae 12 parts, 10 red dates, 9 yellow peony, 8 gelatin, 9 sugar, 9 winter, 3 rehmannia, 7 coltsfoot, 5 psoralen, 6 salvia, 5 pepper, 3 parts of licorice, 3 parts of Chuanbei powder, dried tangerine peel 4, 9 pieces of yellow wine.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Radix Pseudostellariae 12 parts, red dates: 10 parts, astragalus: 8 parts, donkey-hide gelatin: 8 parts, rock sugar: 9 parts, asparagus: 9 parts, rehmannia: 2 parts, coltsfoot flower: 7 parts, psoralen: 5 parts, Salvia: 6 parts, pepper: 3 parts, licorice: 3 parts, Chuanbei powder: 2 parts, dried tangerine peel: 3, yellow wine: 10 parts.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Radix Pseudostellariae 10 parts, red dates: 10 parts, astragalus: 8 parts, donkey-hide gelatin: 8 parts, rock sugar: 8 parts, asparagus: 8 parts, rehmannia: 2 parts, coltsfoot flower: 6 parts, psoralen: 6 parts, Salvia: 6 parts, pepper: 3 parts, licorice: 3.2 parts, Chuanbei powder: 2 parts, dried tangerine peel: 2.4 parts, yellow wine: 10 parts.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Radix Pseudostellariae 10 parts, red dates: 10 parts, astragalus: 8 parts, donkey-hide gelatin: 8 parts, rock sugar: 8 parts, asparagus: 8 parts, rehmannia: 2 parts, coltsfoot flower: 6 parts, psoralen: 6 parts, Salvia: 6 parts, pepper: 3 parts, licorice: 3.2 parts, Chuanbei powder: 2 parts, dried tangerine peel: 2.4 parts, yellow wine: 10 parts.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Radix Pseudostellariae 11 servings, red dates: 12 servings, astragalus: 8 servings, donkey-hide gelatin: 8 servings, rock sugar: 7 servings, asparagus: 8 servings, rehmannia: 2 servings, coltsfoot flower: 6 servings, psoralen: 6 servings, Salvia: 5 parts, pepper: 4 parts, licorice: 3 parts, Chuanbei powder: 2 parts, dried tangerine peel: 2.4 parts, yellow wine: 8 parts.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Radix Pseudostellariae 11 servings, red dates: 12 servings, astragalus: 8 servings, donkey-hide gelatin: 8 servings, rock sugar: 7 servings, asparagus: 9 servings, rehmannia: 3 servings, coltsfoot flower: 5 servings, psoralen: 6 servings, Salvia: 5 parts, pepper: 4 parts, licorice: 3 parts, Chuanbei powder: 2 parts, dried tangerine peel: 2.4 parts, yellow wine: 8 parts.
  • the traditional Chinese medicine composition consists of the following parts by weight:
  • Radix Pseudostellariae 11 servings, red dates: 12 servings, astragalus: 8 servings, donkey-hide gelatin: 8 servings, rock sugar: 9 servings, asparagus: 9 servings, rehmannia: 3 servings, coltsfoot flower: 5 servings, psoralen: 6 servings Salvia: 6 parts, pepper: 5 parts, licorice: 4 parts, Chuanbei powder: 2 parts, dried tangerine peel: 3 parts, yellow wine: 10 parts.
  • the present invention also provides a preparation method of a traditional Chinese medicine composition for promoting health promotion of asthma in children, which comprises the following steps:
  • step C the filtrate CC formed in step C is decocted and concentrated to a quarter of the filtrate CC, and then the gelatin and yellow wine are melted to form a decoction DD;
  • Dissolved rock sugar take out the rock sugar according to the predetermined amount, stir the rock sugar and water in a ratio of 2:1, dissolve it by heating, keep the micro-boiling (110 °C ⁇ 115 °C), and refine to a preset concentration to form a rock sugar liquid EE. spare;
  • the water content in the rock sugar EE in the step E is 22%.
  • the relative density of the decoction FF in step F is 1.4 g/l.
  • the invention adopts the synergistic action of the ginseng, the red jujube, the astragalus, the gelatin, the rock sugar, the asparagus, the rehmannia, the coltsfoot, the psoralen, the salvia, the pepper, the licorice, the chuanbei powder, the tangerine peel and the yellow wine.
  • the effect of clearing away heat and detoxifying, phlegm dampness, moistening the lungs and removing phlegm, relieving cough and relieving asthma can significantly improve the symptoms of asthma, relieve the pain of asthma patients, protect against the suffering of asthma, and improve the quality of life of patients; Children with less severe asthma attacks can achieve the effect of curing asthma.
  • the invention provides a traditional Chinese medicine composition for promoting the health of asthma in children, wherein the traditional Chinese medicine composition is composed of the following parts by weight:
  • Radix Pseudostellariae sweet, slightly bitter, and sexually flat; into the heart, spleen, lung three menstrual; with qi and spleen and nourishing yin and fluid; for temper weakness, stomach yin deficiency, less food Body tired and thirsty tongue dry; Taizishen can also be used for lung deficiency, dry cough, dry throat, sticky qi and yin deficiency and palpitations and insomnia.
  • Jujube with the effect of strengthening the spleen and stomach: for those who are weak in the spleen and stomach, diarrhea and burnout, eat seven red dates a day, or share it with Codonopsis and Atractylodes, which can supplement the Qi and spleen and stomach, and increase appetite and diarrhea. Efficacy At the same time, red dates also have the effect of nourishing blood and soothe the nerves.
  • Astragalus membranaceus has the effect of tonifying the qi, solidifying the phlegm, diuretic, purulent and sore muscles; for qi deficiency, lack of food, sputum, stagnation, self-sweating, stagnation, stagnation, long-term collapse, And heat inside and quench your thirst.
  • the biggest effect of Astragalus membranaceus is qi, so it is of great benefit to asthma, but the single-flavored Astragalus membranaceus is not enough for the treatment of asthma, and the compound is used for the purpose of radical cure.
  • Ejiao flesh and blood, has the effect of nourishing yin, moistening dryness, nourishing blood and nourishing blood; it is used for lung dryness, cough, dizziness, palpitations, upset and sleeplessness.
  • the main component of rock sugar is sucrose, which can be decomposed into glucose and fructose. Therefore, when taking tonic and supplements, rock sugar is better than cotton sugar.
  • rock sugar is better than cotton sugar.
  • the sugar candy is very sweet, its nature is relatively calm. It is not suitable for leaving moisture, oysters and heat. No brown sugar can cause mildew.
  • Rehmannia with the effect of nourishing yin and tonifying the kidney, and purifying the marrow; through the simmering of the slag, the slag is filtered, and the smoldering is concentrated into a cream. Those who have insufficient yin blood are suitable for taking it regularly.
  • Buguzhi has the effect of tonifying the kidney and benefiting the spleen; it is used for deficiency of kidney yang, coldness of the lower yuan, cold pain in the lower back and knees, and kidney incontinence.
  • Zhigancao has the effects of replenishing spleen and replenishing qi, clearing away heat and detoxifying, relieving cough, relieving pain and relieving pain, and reconciling various medicines; it is used for coughing, fatigue, fatigue, palpitations, shortness of breath and sore swollen poison.
  • Chuanbei powder has the effects of clearing away heat and detoxifying, relieving phlegm and relieving cough, dispersing and eliminating phlegm; it is used for wind-heat cough, phlegm cough, lung phlegm and sore.
  • Chenpi has the effects of regulating qi and dampness, relieving phlegm and relieving cough, and strengthening the spleen and stomach.
  • the tangerine peel also has the effect of clearing collaterals, relieving qi and promoting blood circulation, and is used for stasis and cough.
  • Yellow wine hot, more suitable for winter drinking after heating.
  • Yellow rice wine contains a lot of protein, B vitamins, calcium, phosphorus, selenium, etc., as well as a certain amount of sugar, organic acids and amino acids.
  • Rice wine is often used in medicinal purposes. For example, it can be used for soaking gelatin cream, which can be used to taste, while warming and promoting blood circulation. A small amount of drinking yellow wine is harmless to the body.
  • ⁇ can be understood as the chronic inflammation of the bronchus in the remission period, the sputum is blocked in the bronchus, and the bronchial stenosis, the patient feels that the breathing is not smooth; if the external environmental factors are induced, the bronchial inflammation is intensified and the asthma attack is caused. At the same time, it will also affect the blood operation and form a situation of sputum.
  • the ginseng in the drug component can effectively improve the symptoms of dryness, cough, dryness and phlegm, help qi and spleen, nourish yin and spleen; red dates help spleen and stomach; jaundice can be effective Invigorating gas and solid table, diuretic detoxification, help to qi; Ejiao, can effectively improve lung dryness, cough, dizziness, help to nourish yin, moisten dryness, nourish blood; rock sugar can effectively stop thirst and phlegm, help Zhongzhongyi Qi; Tiandong can effectively improve the symptoms of dryness and dryness of the lungs, cough, sputum, thirst and insomnia, which is conducive to nourishing yin and fluid, moistening the lungs and clearing the heart; rehmannia can effectively improve the symptoms of yin and blood deficiency, help to nourish yin and kidney , the essence of the marrow; the winter flower can effectively improve the symptoms of new long-term
  • Rice wine is often used in medicinal purposes, such as in gelatin cream.
  • the effects of clearing away heat and detoxifying, dampness and dispersing, moistening the lungs and removing phlegm and relieving cough and relieving asthma can significantly improve the symptoms of asthma, alleviate the pain of asthma patients, and avoid the suffering of asthma.
  • the quality of life of the patient; for children with mild disease and less severe asthma attacks, the effect of curing asthma can be achieved.
  • Radix Pseudostellariae 10 ⁇ 12 parts, red dates: 10 ⁇ 12 parts, Astragalus: 8 ⁇ 9 parts, Ejiao: 8 ⁇ 9 parts, rock sugar: 7 ⁇ 9 parts, Asparagus: 7 ⁇ 9 parts, Rehmannia: 2 ⁇ 3 parts , Coltsfoot flower: 5 ⁇ 7 servings, psoralen: 5 ⁇ 7 servings, Salvia: 5 ⁇ 6 servings, pepper: 3 ⁇ 5 servings, Zhigancao: 3 ⁇ 4 servings, Chuanbei powder: 2 ⁇ 3 servings, dried tangerine peel : 2 ⁇ 4, yellow wine: 8 ⁇ 10 copies.
  • Radix Pseudostellariae 12 servings, red dates: 12 servings, astragalus: 8 servings, donkey-hide gelatin: 8 servings, rock sugar: 8 servings, asparagus: 8 servings, rehmannia: 2 servings, coltsfoot flower: 6 servings, psoralen: 6 servings, Salvia: 6 parts, pepper: 3 parts, licorice: 3.2 parts, Chuanbei powder: 2 parts, dried tangerine peel: 2.4 parts, yellow wine: 8 parts.
  • Radix Pseudostellariae 10 parts, red dates: 10 parts, astragalus: 9 parts, donkey-hide gelatin: 9 parts, rock sugar: 9 parts, asparagus: 8 parts, rehmannia: 3 parts, coltsfoot flower: 5 parts, psoralen: 6 parts, Salvia: 6 parts, pepper: 3 parts, licorice: 3.2 parts, Chuanbei powder: 2 parts, dried tangerine peel: 2.4 parts, yellow wine: 10 parts.
  • Radix Pseudostellariae 10 parts, red dates: 12 parts, astragalus: 8 parts, donkey-hide gelatin: 8 parts, rock sugar: 8 parts, asparagus: 8 parts, rehmannia: 2 parts, coltsfoot flower: 5 parts, psoralen: 7 parts, Salvia: 5 parts, pepper: 5 parts, licorice: 3.2 parts, Chuanbei powder: 2 parts, dried tangerine peel: 4 parts, yellow wine: 10 parts.
  • Radix Pseudostellariae 12 parts, 10 red dates, 9 yellow peony, 8 gelatin, 9 sugar, 9 winter, 3 rehmannia, 7 coltsfoot, 5 psoralen, 6 salvia, 5 pepper, 3 parts of licorice, 3 parts of Chuanbei powder, dried tangerine peel 4, 9 pieces of yellow wine.
  • Radix Pseudostellariae 12 parts, red dates: 10 parts, astragalus: 8 parts, donkey-hide gelatin: 8 parts, rock sugar: 9 parts, asparagus: 9 parts, rehmannia: 2 parts, coltsfoot flower: 7 parts, psoralen: 5 parts, Salvia: 6 parts, pepper: 3 parts, licorice: 3 parts, Chuanbei powder: 2 parts, dried tangerine peel: 3, yellow wine: 10 parts.
  • Radix Pseudostellariae 10 parts, red dates: 10 parts, astragalus: 8 parts, donkey-hide gelatin: 8 parts, rock sugar: 8 parts, asparagus: 8 parts, rehmannia: 2 parts, coltsfoot flower: 6 parts, psoralen: 6 parts, Salvia: 6 parts, pepper: 3 parts, licorice: 3.2 parts, Chuanbei powder: 2 parts, dried tangerine peel: 2.4 parts, yellow wine: 10 parts.
  • Radix Pseudostellariae 10 parts, red dates: 11 parts, astragalus: 9 parts, donkey-hide gelatin: 8 parts, rock sugar: 8 parts, asparagus: 8 parts, rehmannia: 2 parts, coltsfoot flower: 6 parts, psoralen: 6 parts, Salvia: 6 parts, pepper: 3 parts, licorice: 3.2 parts, Chuanbei powder: 2 parts, dried tangerine peel: 2 parts, yellow wine: 10 parts.
  • Radix Pseudostellariae 11 servings, red dates: 12 servings, astragalus: 8 servings, donkey-hide gelatin: 8 servings, rock sugar: 7 servings, asparagus: 8 servings, rehmannia: 2 servings, coltsfoot flower: 6 servings, psoralen: 6 servings, Salvia: 5 parts, pepper: 4 parts, licorice: 3 parts, Chuanbei powder: 2 parts, dried tangerine peel: 2.4 parts, yellow wine: 8 parts.
  • Radix Pseudostellariae 11 servings, red dates: 12 servings, astragalus: 8 servings, donkey-hide gelatin: 8 servings, rock sugar: 7 servings, asparagus: 9 servings, rehmannia: 3 servings, coltsfoot flower: 5 servings, psoralen: 6 servings, Salvia: 5 parts, pepper: 4 parts, licorice: 3 parts, Chuanbei powder: 2 parts, dried tangerine peel: 2.4 parts, yellow wine: 8 parts.
  • Radix Pseudostellariae 11 servings, red dates: 12 servings, astragalus: 8 servings, donkey-hide gelatin: 8 servings, rock sugar: 9 servings, asparagus: 9 servings, rehmannia: 3 servings, coltsfoot flower: 5 servings, psoralen: 6 servings Salvia: 6 parts, pepper: 5 parts, licorice: 4 parts, Chuanbei powder: 2 parts, dried tangerine peel: 3 parts, yellow wine: 10 parts.
  • step C the filtrate CC formed in step C is decocted and concentrated to a quarter of the filtrate CC, and then the gelatin and yellow wine are melted to form a decoction DD;
  • Dissolved rock sugar take the rock sugar according to the ratio of the rock sugar corresponding to each traditional Chinese medicine component in step A.
  • the rock sugar and water are stirred and mixed according to the ratio of 2:1, dissolved by heating, and kept slightly boiling (110 ° C ⁇ 115 ° C) , refining to a preset concentration to form a rock sugar liquid EE standby;
  • step E the dissolved sugar is refined to a preset concentration of 22% water content in the rock sugar liquid, and the visual effect is dripping into beads; in step F, the rock sugar liquid EE is added to the concentrated decoction DD, and the heating is continued; Stir constantly to form decoction FF; the relative density of decoction FF is 1.4 g/l, the intuitive effect can be achieved with a thin stick to provoke "summer hanging flag, winter hanging silk".
  • Cure The clinical symptoms disappear and do not recur within one year.
  • the treatment results taking the drug for a course of treatment in January, the lighter one course of treatment, the severe two to three courses of cure.
  • the effective rate is 98.5%
  • the cure rate is 40%
  • the improvement rate is 58.5%.
  • Case 1 Patient Wang, female, 9 years old. Visited in October 2009, asthma recurred for 5 years, especially in winter and spring, frequent One episode in January and February, after treatment is invalid. In the past 1 week, asthma has not been done, and I want to take Chinese medicine for conditioning. Symptoms at the time of diagnosis: face color Shaohua, movement is asthma, anorexia, pale red tongue, thin and greasy fur, weak pulse. The card is a spleen qi deficiency, and the phlegm is stopped. Expelling tonic lung spleen, accompanied by kidney and qi, phlegm. The prescription of the present invention is administered, and the ointment is made according to the law. The morning and evening rushing 1-2 spoons, taking 2 months, the number of asthma attacks is reduced, the symptoms are relieved during the attack; the continuous use of 3 years of treatment; after 3 years of follow-up, no recurrence.
  • Case 2 Patient Chen, male, 5 and a half years old. In January 2010, the patient had milk thistle since childhood, and cough and asthma appeared after 1 and a half years of consumption of milk. After the fall, it occurred two to three times a year. At the time of the attack, there was an acute asthma in the night, a chicken squeak in the throat, a sticky sputum in the morning, a sneezing, a runny nose, a nasal itching, a stuffy nose, and often spontaneous sweating, a poor appetite, a stool, and a night stun. . Symptoms at the time of diagnosis: pale complexion, weight loss, pale nasal mucosa, clear secretions, no swelling of the tonsils.
  • Jianpi Xiaoke Dingchuan treatment the child was asthmatic, and the morning sputum disappeared, but there was still spontaneous sweating, Nazeng, two stools, and the child with night sputum was scared.
  • the prescription of the present invention was administered, and the ointment was made according to the law, and it was taken for three months.
  • Case 3 Patient Wu, male, 14 years old. At the first clinic on January 13, 2012, the child was diagnosed with a cold due to a cold at the age of three or four. Every time he was wet and sultry, he would have a lingering stagnation. He often sent to the hospital for emergency treatment in the middle of the night. Symptoms at the time of diagnosis: shortness of breath, chest tightness, snoring in the throat, not lying down, nasal congestion, fine veins, thin greasy fur, reddish tongue. After Xuansu lung gas, clearing away heat and phlegm, the disease was relieved after sputum and sputum, and there was occasional snoring in the throat, but it could relieve itself and disappear. The patient was given conditioning, taking three months, sometimes inadvertently catching a cold, and did not cause asthma; and taking a one-year course of treatment; after 2 years of follow-up, no recurrence was observed.

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Abstract

一种用于治疗儿童哮喘的中药组合物及其制备方法。所述中药组合物由以下重量份的原料制成：太子参5-15，红枣5-12，黄芪4-10，阿胶4-10，冰糖4-10，天冬4-10，熟地0.8-3.5，款冬花4-7.5，补骨脂4-7，丹参4-7.5，花椒2-6，甘草2-5，川贝母0.5-3.5，陈皮0.5-4.5，黄酒7-13。所述中药组合物能用于治疗儿童哮喘。

Description

用于儿童哮喘健康促进的中药组合物及其制备方法
技术领域
本发明涉及医学技术领域，尤其涉及一种用于儿童哮喘健康促进的中药组合物及其制备方法。
背景技术
支气管哮喘是最常见的慢性呼吸道疾病之一，哮喘患者的常见症状是发作性的喘息、气急、胸闷、咳嗽等症状，少数患者还有胸痛的症状。随着经济的飞速发展，人们的生活环境发生了巨大改变，哮喘的发病率有了上升的趋势。西药治疗哮喘，常常使用抗生素，致使患者的耐药性逐年增加，治疗效果越来越差，而且还存在滥用镇咳药的现象。而中药因为具有作用温和、起效持久的功效，能够明显改善哮喘症状，减轻了哮喘患者的病痛，免于哮喘病的折磨，提高了患者的生活质量；对于病程轻、哮喘发作不严重的儿童，可以达到治愈哮喘的效果。
发明内容
本发明的目的在于提供一种用于儿童哮喘健康促进的中药组合物及其制备方法，作用温和、起效持久，能够明显改善哮喘症状；对于病程轻、哮喘发作不严重的儿童，可以达到治愈哮喘的效果。
为实现上述目的，本发明提供一种用于儿童哮喘健康促进的中药组合物，所述中药组合物由以下重量份组成：
太子参：5~15份，红枣：5~12份，黄芪：4~10份，阿胶：4~10份，冰糖：4~10份，天冬：4~10份，熟地：0.8~3.5份，款冬花：4~7.5份，补骨脂：4~7份，丹参：4~7.5份，花椒：2~6份，炙甘草：2~5份，川贝粉：0.5~3.5份，陈皮：0.5~4.5，黄酒：7~13份。
优选地，所述中药组合物由以下重量份组成：
太子参：10~12份，红枣：10~12份，黄芪：8~9份，阿胶：8~9份，冰糖：7~9份，天冬：7~9份，熟地：2~3份，款冬花：5~7份，补骨脂：5~7份，丹参：5~6份，花椒：3~5份，炙甘草：3~4份，川贝粉：2~3份，陈皮：2~4，黄酒：8~10份。
优选地，所述中药组合物由以下重量份组成：
太子参：12份，红枣：12份，黄芪：8份，阿胶：8份，冰糖：8份，天冬：8份，熟地：2份，款冬花：6份，补骨脂：6份，丹参：6份，花椒：3份，炙甘草：3.2份，川贝粉：2份，陈皮：2.4份，黄酒：8份。
优选地，所述中药组合物由以下重量份组成：
太子参：10份，红枣：10份，黄芪：9份，阿胶：9份，冰糖：9份，天冬：8份，熟地：3份，款冬花：5份，补骨脂：6份，丹参：6份，花椒：3份，炙甘草：3.2份，川贝粉：2份，陈皮：2.4份，黄酒：10份。
优选地，所述中药组合物由以下重量份组成：
太子参：10份，红枣：12份，黄芪：8份，阿胶：8份，冰糖：8份，天冬：8份，熟地：2份，款冬花：5份，补骨脂：7份，丹参：5份，花椒：5份，炙甘草：3.2份，川贝粉：2份，陈皮：4份，黄酒：10份。
优选地，所述中药组合物由以下重量份组成：
太子参：12份，红枣10份，黄芪9份，阿胶8份，冰糖9份，天冬9份，熟地3份，款冬花7份，补骨脂5份，丹参6份，花椒5份，炙甘草3份，川贝粉3份，陈皮4，黄酒9份。
优选地，所述中药组合物由以下重量份组成：
太子参：12份，红枣：10份，黄芪：8份，阿胶：8份，冰糖：9份，天冬：9份，熟地：2份，款冬花：7份，补骨脂：5份，丹参：6份，花椒：3份，炙甘草：3份，川贝粉：2份，陈皮：3，黄酒：10份。
优选地，所述中药组合物由以下重量份组成：
太子参：10份，红枣：10份，黄芪：8份，阿胶：8份，冰糖：8份，天冬：8份，熟地：2份，款冬花：6份，补骨脂：6份，丹参：6份，花椒：3份，炙甘草：3.2份，川贝粉：2份，陈皮：2.4份，黄酒：10份。
优选地，所述中药组合物由以下重量份组成：
太子参：10份，红枣：10份，黄芪：8份，阿胶：8份，冰糖：8份，天冬：8份，熟地：2份，款冬花：6份，补骨脂：6份，丹参：6份，花椒：3份，炙甘草：3.2份，川贝粉：2份，陈皮：2.4份，黄酒：10份。
优选地，所述中药组合物由以下重量份组成：
太子参：11份，红枣：10份，黄芪：9份，阿胶：8份，冰糖：8份，天冬：8份，熟地：2份，款冬花：6份，补骨脂：6份，丹参：6份，花椒：3份，炙甘草：3.2份，川贝粉：3份，陈皮：3份，黄酒：9份。
优选地，所述中药组合物由以下重量份组成：
太子参：11份，红枣：12份，黄芪：8份，阿胶：8份，冰糖：7份，天冬：8份，熟地：2份，款冬花：6份，补骨脂：6份，丹参：5份，花椒：4份，炙甘草：3份，川贝粉：2份，陈皮：2.4份，黄酒：8份。
优选地，所述中药组合物由以下重量份组成：
太子参：11份，红枣：12份，黄芪：8份，阿胶：8份，冰糖：7份，天冬：9份，熟地：3份，款冬花：5份，补骨脂：6份，丹参：5份，花椒：4份，炙甘草：3份，川贝粉：2份，陈皮：2.4份，黄酒：8份。
优选地，所述中药组合物由以下重量份组成：
太子参：11份，红枣：12份，黄芪：8份，阿胶：8份，冰糖：9份，天冬：9份，熟地：3份，款冬花：5份，补骨脂：6份，丹参：6份，花椒：5份，炙甘草：4份，川贝粉：2份，陈皮：3份，黄酒：10份。
此外，为实现上述目的，本发明还提供一种用于儿童哮喘健康促进的中药组合物的制备方法，所述制备方法包含以下步骤：
A、将太子参、红枣、黄芪、天冬、熟地、款冬花、补骨脂、丹参、花椒、炙甘草、川贝粉、陈皮加入8-10倍体积的水浸泡40分钟后煎煮，水开后煎煮35-40分钟，倒出煎液AA；
B、向煎液AA中加入3-4倍体积的水，煎煮 15-25分钟，倒出煎液BB；
C、将煎液AA和煎液BB混匀，静置澄清10-15分钟，吸取上清液，过滤形成滤液CC备用；
D、将步骤C中形成的滤液CC煎煮浓缩至滤液CC的四分之一后加入阿胶、黄酒融化，形成煎液DD；
E、溶解冰糖：按预定的量取出冰糖，冰糖和水按2:1的配比搅拌混合，加热溶解，保持微沸（110℃~115℃），炼至预设定的浓度形成冰糖液EE备用；
F、将步骤E形成的冰糖液EE加入步骤D形成的煎液DD，继续加热熬炼；并不断搅拌，至预设定的浓度形成煎液FF，将所述煎液FF分装于洁净干燥灭菌的大口容器中，冷却后加盖密闭备用。
优选地，所述步骤E中冰糖液EE中的含水量为22%。
优选地，步骤F中所述煎液FF的相对密度为1.4 g/l。
本发明以太子参、红枣、黄芪、阿胶、冰糖、天冬、熟地、款冬花、补骨脂、丹参、花椒、炙甘草、川贝粉、陈皮、黄酒为药物组份，通过它们协同作用起到清热解毒、祛湿散结、润肺化痰、止咳平喘的功效，能够明显改善哮喘症状，减轻了哮喘患者的病痛，免于哮喘病的折磨，提高了患者的生活质量；对于病程轻、哮喘发作不严重的儿童，可以达到治愈哮喘的效果。
具体实施方式
下面结合具体实施例对本发明做进一步的详细说明，以下实施例是对本发明的解释，本发明并不局限于以下实施例。
本发明提供的用于儿童哮喘健康促进的中药组合物，所述中药组合物由以下重量份组成：
太子参：5~15份，红枣：5~12份，黄芪：4~10份，阿胶：4~10份，冰糖：4~10份，天冬：4~10份，熟地：0.8~3.5份，款冬花：4~7.5份，补骨脂：4~7份，丹参：4~7.5份，花椒：2~6份，炙甘草：2~5份，川贝粉：0.5~3.5份，陈皮：0.5~4.5，黄酒：7~13份。
在上述组份中，太子参，味甘、微苦、性平；入心、脾、肺三经；具有补气益脾和养阴生津的功效；用于脾气虚弱、胃阴不足、食少体倦和口渴舌干；太子参还可用于肺虚燥咳、咽干痰粘、气阴不足和心悸失眠。
红枣，具有健脾益胃的功效：对于脾胃虚弱、腹泻和倦怠无力的人，每日吃红枣七颗，或与党参、白术共用，能补中益气、健脾胃，达到增加食欲、止泻的功效; 同时红枣还具有养血安神的功效。
黄芪，具有补气固表、利尿托毒、排脓和敛疮生肌的功效；用于气虚乏力、食少便溏、中气下陷、表虚自汗、痈疽难溃、久溃不敛、和内热消渴。黄芪最大的功效是补气，所以对哮喘病是有很大的好处，但是单味的黄芪药材对于哮喘病的冶疗是不够的，用复方达到根治的目的。
阿胶，血肉有情之品，具有滋阴、润燥、补血和养血的功效；用于肺燥咳嗽、眩晕心悸、心烦不眠。
冰糖，味甘、性平；归脾、肺经；具有补中益气、止渴化痰，通常认为冰糖最为滋补。冰糖的主要成分是蔗糖，可分解为葡萄糖及果糖等；因此，在服用补药、补品时冰糖比绵白糖为佳，如煎制各种膏滋药、蒸煮白木耳、烧煮龙眼（桂圆）汤时，常用冰糖，而取其补益的功效。冰糖虽甚甘甜，但性质比较平和，不宜留湿、生痰、化热，无红糖可致温热的弊端。
天冬，味甘、苦、性寒；归肺、肾经；具有养阴生津、润肺清心的功效；用于肺燥干咳、虚劳咳嗽、津伤口渴、心烦失眠、内热消渴、和白喉。
熟地，具有滋阴补肾、生精益髓的功效；通过熟地煎熬去渣过滤，稳火煎熬浓缩成膏，凡阴血不足者都适合经常服用。
款冬花，辛、微苦，温；具有润肺下气、止咳化痰的功效；用于新久咳嗽、喘咳痰多和咳嗽咳血。
补骨脂，具有补肾益脾的功效；用于肾阳不足、下元虚冷、腰膝冷痛和肾不纳气等。
丹参，苦性、微寒;归心、心包、肝经；丹参具有祛瘀活血、养血安神的功效；用于烦热、精神不佳和心悸不眠。
花椒，味辛，温；用于邪气咳逆、寒湿痹痛。可作膏药。
炙甘草，具有补脾益气、清热解毒、祛痰止咳、缓急止痛、调和诸药的功效；用于咳嗽痰多、倦怠乏力、心悸气短和痈肿疮毒。
川贝粉，具有清热解毒、化痰止咳、散结消痈的功效；用于风热咳嗽、痰火咳嗽、肺痈和疮毒。
陈皮，具有理气燥湿、化痰止咳和健脾和胃的功效；陈皮还具有通络化痰、顺气活血的功效，用于痰滞咳嗽等症。
黄酒，性热，加热后更适合冬天饮用。黄酒中含大量蛋白质、B族维生素、钙、磷、硒等，以及一定量的糖、有机酸和氨基酸。黄酒常配药用，如用于泡阿胶膏，可去味，同时温经，促进血液循环的作用。少量饮用黄酒对身体无害。
由于哮喘病的发作常常由患者自身因素和外界环境因素所引起的，患者自身因素是由患者的肺、脾、肾三脏的功能降低造成的，而外界环境因素常常是由于患者的饮食不当、过度疲劳和休息不足等因素引起的。《医宗必读•喘》曰：“良由痰火郁于内，风寒束于外”。这里的“痰”可以理解为缓解期存在的支气管慢性炎症，痰阻塞在支气管处，而支气管狭窄，患者感到呼吸不顺畅；如果再加上外界环境因素的诱发，支气管炎症加剧从而导致哮喘发作。同时也会影响血液运行，形成痰瘀交结的局面。
哮喘缓解期的治疗应以调养肺、脾、肾三脏为主，《景岳全书•喘促》曾指出：“此等证候，当倦倦以元气为念，必使元气渐充，庶可望其渐愈。”即只有通过扶正固本，才能使“元气渐充”，达到根治哮喘的目的。冬天的时候利用膏方调养、进食补药达到治疗内脏器官的效果。膏方又称膏滋，是我国传统的滋补、祛除疾病、延年益寿制剂之一。
服用上述药物，药物组份中的太子参能够有效改善肺燥咳嗽、咽干痰粘的症状，有助于补气益脾、养阴生津；红枣，有助于健脾益胃；黄芪能够有效补气固表、利尿排毒，有助于补气；阿胶，能够有效改善肺燥咳嗽、眩晕，有助于滋阴、润燥、养血；冰糖能够有效止渴化痰，有利于补中益气；天冬能够有效改善肺燥干咳、虚劳咳嗽、津伤口渴和心烦失眠等症状，有利于养阴生津、润肺清心；熟地能够有效改善阴血不足症状，有助于滋阴补肾、生精益髓；款冬花能够有效改善新久咳嗽、喘咳痰多和劳嗽咳血等症状，有助于润肺下气、止咳化痰；补骨脂能够有效改善肾阳不足、下元虚冷和腰膝冷痛等症状，有助于补肾益脾；丹参能够有效改善烦热、精神不佳和心悸不眠等症状，有助于祛瘀活血、养血安神；花椒能够有效改善邪气咳逆、寒湿痹痛，有助于调关节、耐寒署，可作膏药；炙甘草能够有效改善脾胃虚弱、倦怠乏力、心悸气短、咳嗽痰多和痈肿疮毒等症状，有助于补脾益气、清热解毒、祛痰止咳；川贝粉能够有效改善风热咳嗽、痰火咳嗽和肺痈疮毒等症状，有助于清热解毒、化痰止咳和散结消痈；陈皮能够有效改善痰滞咳嗽等症状，有助于理气燥湿、化痰止咳和健脾和胃；黄酒含大量蛋白质、B族维生素、钙、磷、硒等，以及一定量的糖、有机酸和氨基酸。黄酒常配药用，如用于泡阿胶膏。通过上述药物组份的协同作用起到清热解毒、祛湿散结、润肺化痰和止咳平喘的功效，能够明显改善哮喘症状，减轻了哮喘患者的病痛，免于哮喘病的折磨，提高了患者的生活质量；对于病程轻、哮喘发作不严重的儿童，可以达到治愈哮喘的效果。
实施例1
用于儿童哮喘健康促进的中药组合物的组分如下：
太子参：10~12份，红枣：10~12份，黄芪：8~9份，阿胶：8~9份，冰糖：7~9份，天冬：7~9份，熟地：2~3份，款冬花：5~7份，补骨脂：5~7份，丹参：5~6份，花椒：3~5份，炙甘草：3~4份，川贝粉：2~3份，陈皮：2~4，黄酒：8~10份。
实施例2
用于儿童哮喘健康促进的中药组合物的组分如下：
太子参：12份，红枣：12份，黄芪：8份，阿胶：8份，冰糖：8份，天冬：8份，熟地：2份，款冬花：6份，补骨脂：6份，丹参：6份，花椒：3份，炙甘草：3.2份，川贝粉：2份，陈皮：2.4份，黄酒：8份。
实施例3
用于儿童哮喘健康促进的中药组合物的组分如下：
太子参：10份，红枣：10份，黄芪：9份，阿胶：9份，冰糖：9份，天冬：8份，熟地：3份，款冬花：5份，补骨脂：6份，丹参：6份，花椒：3份，炙甘草：3.2份，川贝粉：2份，陈皮：2.4份，黄酒：10份。
实施例4
用于儿童哮喘健康促进的中药组合物的组分如下：
太子参：10份，红枣：12份，黄芪：8份，阿胶：8份，冰糖：8份，天冬：8份，熟地：2份，款冬花：5份，补骨脂：7份，丹参：5份，花椒：5份，炙甘草：3.2份，川贝粉：2份，陈皮：4份，黄酒：10份。
实施例5
用于儿童哮喘健康促进的中药组合物的组分如下：
太子参：12份，红枣10份，黄芪9份，阿胶8份，冰糖9份，天冬9份，熟地3份，款冬花7份，补骨脂5份，丹参6份，花椒5份，炙甘草3份，川贝粉3份，陈皮4，黄酒9份。
实施例6
用于儿童哮喘健康促进的中药组合物的组分如下：
太子参：12份，红枣：10份，黄芪：8份，阿胶：8份，冰糖：9份，天冬：9份，熟地：2份，款冬花：7份，补骨脂：5份，丹参：6份，花椒：3份，炙甘草：3份，川贝粉：2份，陈皮：3，黄酒：10份。
实施例7
用于儿童哮喘健康促进的中药组合物的组分如下：
太子参：10份，红枣：10份，黄芪：8份，阿胶：8份，冰糖：8份，天冬：8份，熟地：2份，款冬花：6份，补骨脂：6份，丹参：6份，花椒：3份，炙甘草：3.2份，川贝粉：2份，陈皮：2.4份，黄酒：10份。
实施例8
用于儿童哮喘健康促进的中药组合物的组分如下：
太子参：11份，红枣：10份，黄芪：9份，阿胶：8份，冰糖：8份，天冬：8份，熟地：2份，款冬花：6份，补骨脂：6份，丹参：6份，花椒：3份，炙甘草：3.2份，川贝粉：3份，陈皮：3份，黄酒：9份。
实施例9
用于儿童哮喘健康促进的中药组合物的组分如下：
太子参：10份，红枣：11份，黄芪：8份，阿胶：9份，冰糖：8份，天冬：7份，熟地：3份，款冬花：6份，补骨脂：6份，丹参：6份，花椒：3份，炙甘草：3.2份，川贝粉：2份，陈皮：2.4份，黄酒：10份。
实施例10
用于儿童哮喘健康促进的中药组合物的组分如下：
太子参：10份，红枣：11份，黄芪：9份，阿胶：8份，冰糖：8份，天冬：8份，熟地：2份，款冬花：6份，补骨脂：6份，丹参：6份，花椒：3份，炙甘草：3.2份，川贝粉：2份，陈皮：2份，黄酒：10份。
实施例11
用于儿童哮喘健康促进的中药组合物的组分如下：
太子参：10份，红枣：11份，黄芪：9份，阿胶：8份，冰糖：8份，天冬：8份，熟地：2份，款冬花：6份，补骨脂：6份，丹参：6份，花椒：3份，炙甘草：3.2份，川贝粉：2份，陈皮：2.4份，黄酒：10份。
实施例12
用于儿童哮喘健康促进的中药组合物的组分如下：
太子参：12份，红枣：11份，黄芪：9份，阿胶：8份，冰糖：8份，天冬：8份，熟地：2份，款冬花：6份，补骨脂：6份，丹参：5份，花椒：4份，炙甘草：3份，川贝粉：2份，陈皮：2.4份，黄酒：10份。
实施例13
用于儿童哮喘健康促进的中药组合物的组分如下：
太子参：11份，红枣：12份，黄芪：8份，阿胶：8份，冰糖：7份，天冬：8份，熟地：2份，款冬花：6份，补骨脂：6份，丹参：5份，花椒：4份，炙甘草：3份，川贝粉：2份，陈皮：2.4份，黄酒：8份。
实施例14
用于儿童哮喘健康促进的中药组合物的组分如下：
太子参：11份，红枣：12份，黄芪：8份，阿胶：8份，冰糖：7份，天冬：9份，熟地：3份，款冬花：5份，补骨脂：6份，丹参：5份，花椒：4份，炙甘草：3份，川贝粉：2份，陈皮：2.4份，黄酒：8份。
实施例15
用于儿童哮喘健康促进的中药组合物的组分如下：
太子参：11份，红枣：12份，黄芪：8份，阿胶：8份，冰糖：9份，天冬：9份，熟地：3份，款冬花：5份，补骨脂：6份，丹参：6份，花椒：5份，炙甘草：4份，川贝粉：2份，陈皮：3份，黄酒：10份。
以上实施例1-15中的用于儿童哮喘健康促进的中药组合物均采用下述方法制备：
A、将太子参、红枣、黄芪、天冬、熟地、款冬花、补骨脂、丹参、花椒、炙甘草、川贝粉、陈皮加入8-10倍体积的水浸泡40分钟后煎煮，水开后煎煮35-40分钟，倒出煎液AA；
B、向煎液AA中加入3-4倍体积的水，煎煮 15-25分钟，倒出煎液BB；
C、将煎液AA和煎液BB混匀，静置澄清10-15分钟，吸取上清液，过滤形成滤液CC备用；
D、将步骤C中形成的滤液CC煎煮浓缩至滤液CC的四分之一后加入阿胶、黄酒融化，形成煎液DD；
E、溶解冰糖：按与步骤A中各中药组份相对应的冰糖配比量取出冰糖，冰糖和水按2:1的配比搅拌混合，加热溶解，保持微沸（110℃~115℃），炼至预设定的浓度形成冰糖液EE备用；
F、将步骤E形成的冰糖液EE加入步骤D形成的煎液DD，继续加热熬炼；并不断搅拌，形成煎液FF，将所述煎液FF分装于洁净干燥灭菌的大口容器中，冷却后加盖密闭备用。
步骤E中溶解冰糖炼至预设定的浓度为冰糖液中的含水量为22%，直观效果是滴水成珠；步骤F中冰糖液EE加入浓缩后的煎液DD，继续加热熬炼；并不断搅拌，形成煎液FF；煎液FF的相对密度1.4 g/l，直观效果达到用细棒挑起“夏天挂旗，冬天挂丝”即可。
临床疗效总结：
一、一般资料：共治疗病人53例，其中男性27例，女性26例；年龄5-10岁18例，10-13岁13例，13-16岁以上22例；病程最长者6年，最短者1.5年。
二、诊断标准：
1、症状：反复发作性胸闷、咳嗽，多伴有哮鸣音的呼气性呼吸困难，持续数分钟或数小时，可自行缓解。
2、体征：发作时胸廓膨胀，肋间隙饱满，听诊两肺有广泛的哮鸣音，并发感染时有湿罗音，心音减弱。个别有轻度肺气肿特征。
三、疗效评定标准：
1、治愈：临床症状消失，一年内不复发。
2、好转：临床症状减轻，发作次数明显减少。
四、治疗结果：服药一月为一疗程，轻者一疗程治愈，重者两至三疗程治愈。有效率98.5%，治愈率40%，好转率58.5%。
五、典型病例：
病例1：患者王某，女，9岁。2009年10月来诊，哮喘反复发作5年，以冬春为甚，频繁时 1-2月发作1次，历经治疗无效。近1周哮喘未作，想要服中药调理而求诊。来诊时的症状：面色少华，动则气喘，纳差，舌质淡红，苔薄白腻，脉弱。证属肺脾气虚，痰湿内停。治宜补益肺脾，佐以补肾纳气，化痰祛瘀。给予本发明方药服用，依法制成膏剂，每日早晚冲服1-2匙，服用2月，哮喘发作次数减少，发作时症状减轻；连续使用3年疗程；随访3年，未见复发。
病例2：患者陈某，男，5岁半。2010年1月来诊，患者自幼有奶癣，1岁半食用牛奶后出现咳喘，以后每年秋季发作二到三次。发作时夜间气急气喘，喉中鸡鸣声，晨起喉中有粘痰，喷嚏多，流涕，鼻痒、鼻塞，平时经常有自汗，胃纳欠佳，大便尚调，夜寐易惊。来诊时的症状：面色恍白，消瘦，鼻黏膜苍白，有清稀分泌物，扁桃体未见肿大。双肺闻及少许哮鸣音。胸片未见异常。舌质淡苔白，脉细。急性期健脾消咳定喘治疗后患儿喘平，晨起嚏涕均消失，但仍有自汗，纳增，二便调，夜寐易惊患儿身体偏瘦。给予本发明方药服用，依法制成膏剂，服用三个月，当年哮喘未发作，亦未有感冒等，自汗等现象亦均逐渐消失，后患儿家人述次年体质增强，哮喘发作次数明显减少；又连续服用2年疗程；随访3年，未见复发。
病例3：患者吴某，男，14岁。2012年1月13日初诊，患儿三、四岁时因感冒未愈，发为哮喘，每逢湿闷及秋冬季节，必发，缠绵不已，常于半夜送医院急诊。来诊时的症状：气急胸闷，喉间痰鸣，不能平卧，鼻塞，脉细，苔薄腻，舌质偏红。经宣肃肺气，清化痰热，祛邪通窍后病情缓解，喉间偶有痰鸣，但能自行缓解消失，喘急未再发作。给予该方调理，服用三个月，有时不慎感冒，亦未引发哮喘；又连续服用1年疗程；随访2年，未见复发。
上述病例证明该方能够在哮喘缓解期益肺、脾、肾三脏之气，进一步增强体质和改善免疫机制；此即“扶正固本”之道也，效果显著。还须指出，患者应根据个人情况，需在一段时间内坚持服用此方，才能不断巩固疗效；如若稍愈即停药，则将半途而废，难获全功。
以上仅为本发明的优选实施例，并非因此限制本发明的专利范围，凡是利用本发明说明书所作的等效结构或等效流程变换，或直接或间接运用在其他相关的技术领域，均同理包括在本发明的专利保护范围内。

Claims (15)

  1. 一种用于儿童哮喘健康促进的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    太子参：5~15份，红枣：5~12份，黄芪：4~10份，阿胶：4~10份，冰糖：4~10份，天冬：4~10份，熟地：0.8~3.5份，款冬花：4~7.5份，补骨脂：4~7份，丹参：4~7.5份，花椒：2~6份，炙甘草：2~5份，川贝粉：0.5~3.5份，陈皮：0.5~4.5，黄酒：7~13份。
  2. 如权利要求1所述的用于儿童哮喘健康促进的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    太子参：10~12份，红枣：10~12份，黄芪：8~9份，阿胶：8~9份，冰糖：7~9份，天冬：7~9份，熟地：2~3份，款冬花：5~7份，补骨脂：5~7份，丹参：5~6份，花椒：3~5份，炙甘草：3~4份，川贝粉：2~3份，陈皮：2~4，黄酒：8~10份。
  3. 如权利要求1所述的用于儿童哮喘健康促进的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    太子参：12份，红枣：12份，黄芪：8份，阿胶：8份，冰糖：8份，天冬：8份，熟地：2份，款冬花：6份，补骨脂：6份，丹参：6份，花椒：3份，炙甘草：3.2份，川贝粉：2份，陈皮：2.4份，黄酒：8份。
  4. 如权利要求1所述的用于儿童哮喘健康促进的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    太子参：10份，红枣：10份，黄芪：9份，阿胶：9份，冰糖：9份，天冬：8份，熟地：3份，款冬花：5份，补骨脂：6份，丹参：6份，花椒：3份，炙甘草：3.2份，川贝粉：2份，陈皮：2.4份，黄酒：10份。
  5. 如权利要求1所述的用于儿童哮喘健康促进的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    太子参：10份，红枣：12份，黄芪：8份，阿胶：8份，冰糖：8份，天冬：8份，熟地：2份，款冬花：5份，补骨脂：7份，丹参：5份，花椒：5份，炙甘草：3.2份，川贝粉：2份，陈皮：4份，黄酒：10份。
  6. 如权利要求1所述的用于儿童哮喘健康促进的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    太子参：12份，红枣10份，黄芪9份，阿胶8份，冰糖9份，天冬9份，熟地3份，款冬花7份，补骨脂5份，丹参6份，花椒5份，炙甘草3份，川贝粉3份，陈皮4，黄酒9份。
  7. 如权利要求1所述的用于儿童哮喘健康促进的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    太子参：12份，红枣：10份，黄芪：8份，阿胶：8份，冰糖：9份，天冬：9份，熟地：2份，款冬花：7份，补骨脂：5份，丹参：6份，花椒：3份，炙甘草：3份，川贝粉：2份，陈皮：3，黄酒：10份。
  8. 如权利要求1所述的用于儿童哮喘健康促进的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    太子参：10份，红枣：10份，黄芪：8份，阿胶：8份，冰糖：8份，天冬：8份，熟地：2份，款冬花：6份，补骨脂：6份，丹参：6份，花椒：3份，炙甘草：3.2份，川贝粉：2份，陈皮：2.4份，黄酒：10份。
  9. 如权利要求1所述的用于儿童哮喘健康促进的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    太子参：11份，红枣：10份，黄芪：9份，阿胶：8份，冰糖：8份，天冬：8份，熟地：2份，款冬花：6份，补骨脂：6份，丹参：6份，花椒：3份，炙甘草：3.2份，川贝粉：3份，陈皮：3份，黄酒：9份。
  10. 如权利要求1所述的用于儿童哮喘健康促进的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    太子参：11份，红枣：12份，黄芪：8份，阿胶：8份，冰糖：7份，天冬：8份，熟地：2份，款冬花：6份，补骨脂：6份，丹参：5份，花椒：4份，炙甘草：3份，川贝粉：2份，陈皮：2.4份，黄酒：8份。
  11. 如权利要求1所述的用于儿童哮喘健康促进的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    太子参：11份，红枣：12份，黄芪：8份，阿胶：8份，冰糖：7份，天冬：9份，熟地：3份，款冬花：5份，补骨脂：6份，丹参：5份，花椒：4份，炙甘草：3份，川贝粉：2份，陈皮：2.4份，黄酒：8份。
  12. 如权利要求1所述的用于儿童哮喘健康促进的中药组合物，其特征在于，所述中药组合物由以下重量份组成：
    太子参：11份，红枣：12份，黄芪：8份，阿胶：8份，冰糖：9份，天冬：9份，熟地：3份，款冬花：5份，补骨脂：6份，丹参：6份，花椒：5份，炙甘草：4份，川贝粉：2份，陈皮：3份，黄酒：10份。
  13. 一种用于权利要求1所述的用于儿童哮喘健康促进的中药组合物的制备方法，其特征在于，所述制备方法包含以下步骤：
    A、将太子参、红枣、黄芪、天冬、熟地、款冬花、补骨脂、丹参、花椒、炙甘草、川贝粉、陈皮加入8-10倍体积的水浸泡40分钟后煎煮，水开后煎煮35-40分钟，倒出煎液AA；
    B、向煎液AA中加入3-4倍体积的水，煎煮15-25分钟，倒出煎液BB；
    C、将煎液AA和煎液BB混匀，静置澄清10-15分钟，吸取上清液，过滤形成滤液CC备用；
    D、将步骤C中形成的滤液CC煎煮浓缩至滤液CC的四分之一后加入阿胶、黄酒融化，形成煎液DD；
    E、溶解冰糖：按与步骤A中各中药组份相对应的冰糖配比量取出冰糖，冰糖和水按2:1的配比搅拌混合，加热溶解，保持微沸（110℃~115℃），炼至预设定的浓度形成冰糖液EE备用；
    F、将步骤E形成的冰糖液EE加入步骤D形成的煎液DD，继续加热熬炼；并不断搅拌，形成煎液FF，将所述煎液FF分装于洁净干燥灭菌的大口容器中，冷却后加盖密闭备用。
  14. 如权利要求13所述的用于儿童哮喘健康促进的中药组合物的制备方法，其特征在于，所述步骤E中冰糖液EE中的含水量为22%。
  15. 如权利要求13所述的用于儿童哮喘健康促进的中药组合物的制备方法，其特征在于，步骤F中所述煎液FF的相对密度为1.4 g/l。
PCT/CN2015/080423 2015-04-09 2015-05-30 用于治疗儿童哮喘的中药组合物及其制备方法 WO2016161698A1 (zh)

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