WO2016149981A1 - 基于光反射的生物标志物检测用光谱位置调整装置 - Google Patents

基于光反射的生物标志物检测用光谱位置调整装置 Download PDF

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Publication number
WO2016149981A1
WO2016149981A1 PCT/CN2015/077442 CN2015077442W WO2016149981A1 WO 2016149981 A1 WO2016149981 A1 WO 2016149981A1 CN 2015077442 W CN2015077442 W CN 2015077442W WO 2016149981 A1 WO2016149981 A1 WO 2016149981A1
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WIPO (PCT)
Prior art keywords
strip
light reflection
position adjusting
section
coil
Prior art date
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Ceased
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PCT/CN2015/077442
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English (en)
French (fr)
Inventor
张贯京
陈兴明
葛新科
张少鹏
方静芳
克里斯基捏⋅普拉纽克
古列莎⋅艾琳娜
波达别特⋅伊万
高伟明
梁昊原
梁艳妮
周荣
徐之艳
周亮
肖应芬
郑慧华
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Shenzhen Qianhai AnyCheck Information Technology Co Ltd
E Techno Information Technologies Co Ltd
Bio Tech Academy China Co Ltd
Original Assignee
Shenzhen Qianhai AnyCheck Information Technology Co Ltd
E Techno Information Technologies Co Ltd
Bio Tech Academy China Co Ltd
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Application filed by Shenzhen Qianhai AnyCheck Information Technology Co Ltd, E Techno Information Technologies Co Ltd, Bio Tech Academy China Co Ltd filed Critical Shenzhen Qianhai AnyCheck Information Technology Co Ltd
Publication of WO2016149981A1 publication Critical patent/WO2016149981A1/zh
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection

Definitions

  • the present invention relates to the field of biomarker detection, and more particularly to a spectral position adjustment device for detecting biomarkers based on light reflection.
  • Biomarker refers to a biochemical indicator that can label changes or possible changes in the structure, function, organization, cell and subcellular structure or function of a system, and has a very wide range of uses. Biomarkers can be used for disease diagnosis, for judging disease staging, or for assessing the safety and efficacy of new drugs or new therapies in the target population.
  • Surface plasmon resonance technology SPR (Surface) is commonly used when detecting biomarkers Plasmon Resonance), which uses a physical optical phenomenon caused by total reflection connection of metal film/liquid surface interface to analyze biomolecular interactions, and measures the concentration of biomarkers by infrared light combined with SPR technology. For details, refer to the paper “Surface Plasma”.
  • the present invention provides a spectral position adjusting device for detecting a biomarker based on light reflection capable of acquiring reflected light of a biomarker and adjusting a spectral position of the reflected light of the biomarker.
  • a spectral position adjusting device for detecting biomarkers based on light reflection comprising a strip, a mirror, a gear, a shaft, a coil and a magnet, the mirror being disposed on the strip
  • Upper end of the strip is hingedly fixed, and a rack structure engaged with the gear is opened on the strip
  • the gear is rotatably fixed on the shaft
  • the coil is fixed on the
  • the magnet is adjacent to the coil such that it can be rotated about the axis by the action of the magnet after energization into the coil.
  • the coil extends out of the gear body.
  • the spectral position adjusting device for detecting a biomarker based on light reflection is further provided with a balancing device on the gear, and the balancing device and the coil are distributed in the Said on both sides of the gear.
  • the balancing device is a closed loop coil.
  • the strip includes a straight line segment and a bent portion, and the mirror is fixed to the straight line
  • the bending segment comprises a horizontal segment and a vertical segment, and the rack structure is disposed on the vertical segment.
  • the mirror is distributed along the extending direction of the straight line segment of the strip.
  • the present invention further includes a spring, and the strip is supported by the spring.
  • the spring is fixed at one end and the other end is connected to the horizontal section of the bent section of the strip
  • the spring can also be placed in another position, in particular the spring is fixed at one end and the other end is connected to the hinged fixed end of the strip.
  • the magnet is selected from a very high magnetic neodymium magnet to ensure that the coil can be magnetized after being energized.
  • the large magnetic field force can drive the gears to rotate around the axis.
  • the spring is fixed at one end and the other end is connected to the hinged fixed end of the strip. That is, the spring is moved from the position given in the drawing to the end near the hinge of the slat.
  • the shaft is fixed to the holder.
  • the magnet is a neodymium magnet, and the magnet has a strip shape or a circular arc shape.
  • the gear can be fixedly mounted on the outer ring of the bearing, and then the bearing is fixed on the shaft, so that the gear can rotate around the shaft under low resistance; however, the bearing gear can also be directly used when selecting the gear. Simply fix it on the shaft. At the same time, other methods existing can be adopted for this problem, and will not be enumerated here.
  • the meshing manner of the gear and the rack can also be replaced by a similar meshing method, for example, changing the gear to a worm wheel, fixing the coil to the worm wheel, and replacing the rack structure on the strip with a worm or
  • the worm structure relies on the meshing transmission of the worm and the worm to complete the adjustment of the slat and the mirror thereon;
  • the gear can also be replaced by a nut, and the coil is fixed on the nut, and the rack structure on the strip is replaced by a thread.
  • a rod or the like such that the coil is rotated by the nut under the action of the magnet, thereby driving the threaded rod and the strip to move, thereby adjusting the position or/and the angle of the strip and the mirror above it.
  • the spectral position adjusting device for detecting biomarkers based on light reflection adopts the above technical solution, and the technical effect is as follows: since the present invention adopts a strip plate fixed with a mirror and fixes one end of the strip, the other end thereof Through the spring support, a rack structure is arranged on the strip and meshed with the gear, and a magnet is arranged near the coil fixed on the gear to input a current into the coil (or change the current flowing into the coil) And direction), due to the principle of electromagnetic induction, the coil generates a magnetic field, which interacts with the magnetic field generated by the magnet. Under this action, the coil drives the gear to rotate around the shaft, thereby driving the strip to move and changing the angle of the mirror on the strip.
  • the adjustment process is very simple and reliable, and is very easy to operate.
  • High sensitivity, easy and quick change of biomarker surface plasmon resonance technology inspection process The infrared illumination of the biomarker in the test reflects the spectral position information of the light, thereby obtaining valid information of the biomarker in the test.
  • FIG. 1 is a schematic view showing the overall structure of a spectral position adjusting device for detecting a biomarker based on light reflection according to the present invention
  • FIG. 2 is a schematic view showing the use state of a spectral position adjusting device for detecting a biomarker based on light reflection according to the present invention.
  • a spectral position adjusting device for detecting biomarkers based on light reflection comprising a strip 2, a spring 4, a gear 7, a coil 9 and a magnet 10, and a strip 2
  • a strip 2 One end is fixed in an articulated manner, the other end is fixedly connected to the rack 6 , and a gear 7 is arranged beside the rack 6 .
  • the gear 7 is engaged with the rack 6 , and the gear 7 is rotatably fixed on the shaft 8 .
  • the strip 2 can be arranged as two parts of a fixed connection, one part is a straight section 21, the other part is a bending section 22, and the straight section 21
  • One end is fixed by an articulation, and the other end is fixedly connected with the bending section 22, and the straight section 21 is at a certain angle with the horizontal direction (generally, an acute angle is mostly), and the mirror 3 is fixed on the straight section 21,
  • Infrared light for reflection detection of the biomarker the bending section 22 is bent at a 90 degree, the horizontal part is fixedly connected with the straight section, and the vertical part is fixed to the rack 6, and of course, the vertical section Set the rack structure on the rack and Off section 22 is provided integrally structure, comparatively speaking, a rack configuration in the vertical portion of the bent section 22, i.e., one-piece structure made in the production, installation and use more convenient.
  • the rack structure on the strip 2 or the fixed rack 6 is in meshing state with the gear 7.
  • the gear 7 When the gear 7 is rotated by an external force, the rack structure or the rack 6 on the strip 2 follows the gear 7 Rotate and rotate to drive the strip 2 to move.
  • a closed coil 9 is attached to the gear 7, which extends 9 out of the body of the gear 7 and extends outwardly a distance, with a fixed magnet 10 placed next to the coil 9. A part of the coil 9 overlaps with the magnet 10, so that when a current is applied to the coil 9, the coil 9 in the closed state forms a closed loop, and when there is current in the closed loop, it is itself charged.
  • the magnetic field generates a magnetic field, and the magnetic field generated by the coil 9 and the magnetic field of the magnet 10 interact with each other. At this time, changing the magnitude/direction of the current flowing into the coil 9 can change the strength of the magnetic field generated by the coil 9 and the direction of the magnetic field. Since the magnitude and direction of the magnetic field generated by the magnet 10 are fixed, when the magnitude and/or direction of the current in the coil 9 is changed, the coil 9 is rotated by the magnetic field of the magnet 10, since the coil 9 is fixed.
  • a spring 4 is attached to the strip 2, and the other end of the spring 4 is fixed to set an initial position so that the spring 4 In this initial position, the entire device is at a zero point, and when it is necessary to adjust the horizontal angle of the mirror 3, the spring force of the spring 4 can be utilized to make the mirror 3 easier to return to the initial position.
  • the above specific process is as follows: when a current is supplied to the coil 9, a magnetic field is generated in the coil, and under the action of the magnet 10, the coil 9 rotates around the shaft 8 under the action of the magnetic field interaction, and the gear 7 also starts to rotate, the strip plate
  • the rack structure on the 2 or the fixedly mounted rack 6 rises/falls under the rotation of the gear 7, thereby driving the strip 2 as a whole to rise/fall, and when the strip 2 starts to rise/fall, it also starts to stretch/
  • the compression spring 4 when the strip 2 and the mirror 3 above it are required to return to the initial position or the desired set position, when the corresponding change in the magnitude or direction of the current flowing into the coil 9, the strip 2 follows When the upper rack structure or the rack 6 is correspondingly moved, the spring 4 can correspondingly provide a contraction force or a tensile force, so that the strip 2 can be more sensitive and quickly restored to the initial with the assistance of the force of the spring 4. Location or desired location.
  • one end is fixed on the bending section 22, and the other end is fixed in a corresponding position (for example, a platform or a frame, etc.).
  • Fig. 1 one end of the strip 2 is hingedly fixed, and various hinge devices including hinges, hinge balls and the like can be used here, and the hinge fixing method can be adopted, that is, only the strip 2 can be ensured to be supported around the support point. 1 Rotate with low friction.
  • the shape of the magnet 10 is exemplified in the figure, and the magnet 10 is disposed in the vertical direction (this direction is an intuitive direction in the drawing, and the specific orientation of the object is not limited thereto), and the N pole is set. And the S pole is reasonably distributed, so that the coil 9 can move between the N pole and the S pole of the magnet 10 within the range of the magnetic field of the magnet 10, and for the magnet 10, it is arranged in an arc shape as shown in the figure. Corresponding to the direction of rotation of the coil 9, it is possible to exert a relatively wide influence on the coil 9.
  • the shape of the magnet 10 is not limited thereto, and the use of a strip magnet U-shaped magnet or other existing-shaped magnets can also satisfy the above-mentioned use requirements, and will not be described one by one.
  • a balancing device 5 is fixed on the gear 7, and the balancing device 5 is mounted on the gear 7.
  • the position is corresponding to the coil 9, that is, the balance device 5 and the coil 9 are respectively located on both sides of the gear, and the two are at the same level, which play a certain balance between each other.
  • the balancing device 5 is arranged in a coil shape so as to partially extend out of the gear 7, so that the weight of the balancing device 5 can be reduced, and at the same time, the balancing device 5 can also raise the position of the coil 9 under the action of the lever by its own gravity.
  • the shaft 8 in Fig. 1 it can be fixed by the bracket 11, in the embodiment given in Fig. 1, the fixed end of the strip 2, the fixed end of the spring 4 and the fixing of the bracket 11 are Supporting platforms, such as bench-top work platforms or support platforms placed on racks, however, a rack or enclosure can be added to secure the entire unit to the rack or enclosure.
  • the rotatably fixed manner of the gear 7 on the shaft 8 can be solved by the prior art.
  • the gear 7 can be placed on the outer ring of the bearing so that it can rotate around the bearing and then The inner ring of the bearing is fixed on the shaft 8 to fix the shaft 8 on the bracket 11; in addition, the gear 7 can also directly use the bearing gear to directly fix it on the shaft 8; other existing methods of rotating connection, such as articulation It is within the scope of the present invention that the gear 7 can be rotationally fixed.
  • FIG. 2 is a schematic view showing the use state of the spectral position adjusting device for detecting biomarkers based on light reflection according to the present invention.
  • the detection liquid containing no biomarker can be used first, and the infrared light pair detection is used.
  • the device is irradiated, and its reflected light is irradiated onto the mirror 3 in the direction shown in FIG. 2, reflected by the mirror 3, and then enters the spectrum receiving device 12, and the infrared light reflected by the mirror 3 is received by the spectrum receiving device 12. And determining the position of the dark region of the spectrum.
  • the spectral position adjusting device for detecting the biomarker based on the light reflection is set to the initial position, and correspondingly, the band formed at the spectral receiving device 12 in the state.
  • the dark region in the light region and the strip light region also correspondingly serve as an initial position.
  • the reflected light of the infrared light changes that is, the infrared light that is irradiated onto the mirror 3 of the present invention changes, and after being reflected by the spectrum receiving device 12, Transmitting infrared light changes, the spectrum formed on the receiving apparatus 12 will be transmitted in the spectral changes, the position of the dark areas formed therefrom will be shifted relative to the initial position.
  • the incident light is the infrared reflected light of the detected object, and the emitted light is the light actually received by the spectrum receiving device 12, and the dark region of the spectrum formed on the spectrum receiving device 12 is required.
  • the magnitude or/and direction of the current flowing into the coil 9 is changed, and the intensity or/and direction of the magnetic field generated by the closed coil 9 also changes with the transmission, such that Since the magnet 10 acts, the coil 9 drives the gear 7 to rotate (the coil 9 is relatively easy to move under the magnetic force of the magnet 10 under the balanced braking action of the balancing device 5), and the gear 7 drives the teeth on the strip 2
  • the strip structure or the rack 6 moves, the strip 2 also starts to move, and the angle of the mirror 3 with the horizontal direction changes with the movement of the strip 2, so that the incident angle of the incident light irradiated onto the mirror 3 changes, correspondingly
  • the exit angle also changes, and the angle at which the emitted light is incident on the spectrum receiving device 12
  • the position of the dark area also changes, that is, according to the magnitude or/and direction of the current flowing into the coil 9, the position of the dark area formed on the spectrum receiving device 12 is controlled correspondingly, and the position and the change of the dark area are changed.
  • the change in current in coil 9 yields the required measurement information.
  • the implementation of the present invention is not limited to the above-described embodiments, for example, the gear 7 in which the movement of the strip 2 is realized and the rack structure or the rack 6 on the strip 2 engaged therewith may be mutually
  • the meshed turbine, the worm or the socket-mounted nut and the screw are integrally replaced, and the parts to be modified are modified as needed, and those skilled in the art and other common knowledge in the field of the existing mechanical field are known.
  • the above-mentioned changes can be easily made by the field personnel; further, in the present invention, the position of the spring 4 is not limited to the position shown in the drawing, and it can also be moved to the vicinity of the support point 1, so that the spring 4 functions. The effect may be better.

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Abstract

一种基于光反射的生物标志物检测用光谱位置调整装置，包括条板(2)、镜子(3)、齿轮(7)、轴(8)、线圈(9)以及磁铁(10)，镜子(3)设置在条板(2)上，条板(2)一端铰接固定，在条板(2)上开设有与齿轮(7)啮合的齿条结构，齿轮(7)可转动的固定在轴(8)上，线圈(9)固定在齿轮(7)上，磁铁(10)靠近线圈(9)，使得向线圈(9)中通电后其能够在磁铁(10)的作用绕轴(8)旋转运动。该装置能够方便、快捷的改变生物标志物表面等离子共振技术检查过程中检测物中生物标志物的红外照射反射光线的光谱位置，从而获取检测物中生物标志物的有效信息。

Description

基于光反射的生物标志物检测用光谱位置调整装置
技术领域
本发明涉及生物标志物检测领域，更具体的说涉及基于光反射的生物标志物检测用光谱位置调整装置。
背景技术
生物标志物（Biomarker）是指可以标记系统、器官、组织、细胞及亚细胞结构或功能的改变或可能发生的改变的生化指标，具有非常广泛的用途。生物标志物可用于疾病诊断、判断疾病分期或者用来评价新药或新疗法在目标人群中的安全性及有效性。在检测生物标志物时，常用到表面等离子共振技术SPR（Surface Plasmon Resonance），即利用金属膜/液面界面光的全反射连接引起的一种物理光学现象来分析生物分子相互作用，并通过红外光结合SPR技术测量生物标志物浓度，具体可参照论文“表面等离子共振技术在生物医学中的应用”，以及论文“表面等离子体共振免疫传感器在蛋白质检测中的应用及其研究进展”—《分析化学》2010年第七期1052-1059，然而，在测量过程中，怎样能够更加准确的获取检测生物标志物的红外光的特征光谱位置信息，从而获取待测物中生物标志物的相关信息，是摆在众多生物医学领域学家面前的一道难题。
发明内容
为了解决上述技术问题，本发明提供一种能够获取生物标志物的反射光线，并调整生物标志物反射光光谱位置的基于光反射的生物标志物检测用光谱位置调整装置。
本发明为解决上述技术问题所采用的技术方案为：基于光反射的生物标志物检测用光谱位置调整装置，包括条板、镜子、齿轮、轴、线圈以及磁铁，所述的镜子设置在条板上，所述的条板一端铰接固定，在所述条板上开设有与所述齿轮啮合的齿条结构，所述的齿轮可转动的固定在轴上，所述的线圈固定在所述的齿轮上，所述的磁铁靠近所述线圈，使得向所述线圈中通电后其能够在所述磁铁的作用绕所述轴旋转运动。
对于本发明中的基于光反射的生物标志物检测用光谱位置调整装置，作为进一步的设置，所述的线圈延伸出所述的齿轮本体。
对于本发明中的基于光反射的生物标志物检测用光谱位置调整装置，作为进一步的设置，在所述的齿轮上还设有平衡装置，且所述的平衡装置与所述的线圈分布在所述齿轮的两侧。
对于本发明中的基于光反射的生物标志物检测用光谱位置调整装置，作为平衡装置的一种优选方案，所述的平衡装置为闭合的环状线圈。
对于本发明中的基于光反射的生物标志物检测用光谱位置调整装置，作为针对条板的进一步优化，所述的条板包括直线段和弯折段，所述的镜子固定在所述的直线段上，所述的弯折段包括水平段和竖直段，所述的齿条结构设置在所述的竖直段上。
对于本发明中的基于光反射的生物标志物检测用光谱位置调整装置，作为进一步的设置，所述的镜子沿所述条板的直线段的延伸方向分布。
对于本发明中的基于光反射的生物标志物检测用光谱位置调整装置，作为进一步的设置，本发明还包括弹簧，所述的条板由所述弹簧支撑。
对于本发明中的基于光反射的生物标志物检测用光谱位置调整装置，作为弹簧固定位置的进一步的设置，所述的弹簧一端固定，另一端与所述条板的弯折段的水平段连接，但是同时，弹簧还可以设置在另一个位置，具体为所述的弹簧一端固定，另一端与所述条板的铰接固定端连接。
对于本发明中的基于光反射的生物标志物检测用光谱位置调整装置，作为针对磁铁的最优可选方案，所述的磁铁选用极高磁性的钕磁铁，确保线圈在通电后能够受到磁铁较大的磁场力，从而能够带动齿轮一起围绕轴转动。
对于本发明中的基于光反射的生物标志物检测用光谱位置调整装置，作为针对弹簧对条板支撑位置的设计方案，所述的弹簧一端固定，另一端与所述条板的铰接固定端连接，即将弹簧从附图中给出的位置移动至靠近条板铰接的端部。
对于本发明中的基于光反射的生物标志物检测用光谱位置调整装置，作为进一步的设置，所述的轴固定在支架上。
对于本发明中的基于光反射的生物标志物检测用光谱位置调整装置，作为进一步的设置，所述的磁铁为钕磁铁，磁铁的形状为条形或圆弧形。
本发明中，可将齿轮固定的套在轴承的外圈上，然后将轴承固定在轴上，使得齿轮可在低阻力下围绕轴旋转运动；但是，在应用选择齿轮时也可直接选用轴承齿轮，直接将其固定在轴上即可。同时，针对该问题，还可采用现有的其它方式，在此不再一一列举。
本发明中，对于齿轮和齿条的啮合方式，还可以选用类似的啮合方式进行替换，例如：将齿轮换为蜗轮，将线圈固定在蜗轮上，将条板上的齿条结构替换为蜗杆或蜗杆结构，依靠蜗轮蜗杆的啮合传递，完成对条板及其上面的镜子的调节；还可将齿轮替换为螺母，相应的将线圈固定在螺母上，将条板上的齿条结构换成螺纹杆或类似结构，使得线圈在磁铁的作用下通过带动螺母旋转，进而带动螺纹杆、条板进行运动，从而调整条板及其上面的镜子的位置或/和角度。
本发明基于光反射的生物标志物检测用光谱位置调整装置采用上述技术方案，带来的技术效果为：由于本发明采用了固定有镜子的条板，并将条板一端进行固定，其另一端通过弹簧支撑，在条板上设置了齿条结构，并使其与齿轮啮合，在齿轮上固定着的线圈附近设有磁铁，在向线圈中通入电流（或改变通入线圈中电流的大小和方向），由于电磁感应原理，线圈产生磁场，该磁场与磁铁产生的磁场相互作用，在此作用下线圈带动齿轮围绕轴转动，进而带动条板进行运动，改变条板上的镜子的角度，从而改变红外线的入射/出射角度，控制相关红外光线在光谱接收装置上所形成的暗区的位置，获取检测物中的生物标志物的相关信息，该调节过程十分简洁可靠，且非常容易操作，灵敏度高，能够方便、快捷的改变生物标志物表面等离子共振技术检查过程中检测物中生物标志物的红外照射反射光线的光谱位置信息，从而获取检测物中生物标志物的有效信息。
附图说明
图1为本发明基于光反射的生物标志物检测用光谱位置调整装置的整体结构示意图；
图2为本发明基于光反射的生物标志物检测用光谱位置调整装置的使用状态示意图。
具体实施方式
为使本发明实施例的目的、技术方案和优点更加清楚，下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚地描述，显然，所描述的实施例是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
图1为本发明的整体结构示意图，如图所示，基于光反射的生物标志物检测用光谱位置调整装置，包括条板2、弹簧4、齿轮7、线圈9和磁铁10，条板2的一端以铰接的方式固定，另一端与齿条6固定连接，在齿条6的旁边设置有一个齿轮7，齿轮7与齿条6处于啮合状态，齿轮7可转动的固定在轴8上，轴8固定在支架11上，为了方便在条板2上固定齿条6，可将条板2设置为固定连接的两部分，一部分为直线段21，另一部分为弯折段22，直线段21的一端采用铰接的方式固定，其另一端与弯折段22固定连接，并使得直线段21与水平方向呈一定的夹角（一般情况下以锐角居多），在直线段21上固定有镜子3，用于反射检测生物标志物时的红外光线，弯折段22呈90度折弯状，其水平部分与直线段固定连接，其竖直部分固定齿条6，当然，也可以在该竖直段上设置齿条结构，将齿条与弯折段22设置成一体结构，相比较而言，在弯折段22的竖直部分上设置齿条结构，即做成一体式的结构在制作、安装以及使用时会更加方便。
条板2上的齿条结构或固定着的齿条6与齿轮7处于啮合状态，当齿轮7在外力的作用下转动时，条板2上的齿条结构或齿条6随着齿轮7的转动而转动，从而带动条板2发生运动。为了控制/调节齿轮7的转动，在齿轮7上固定一个闭合的线圈9，该线圈9要延伸出齿轮7的本体，并向外延伸一段距离，在与线圈9旁边设置一个固定着的磁铁10，线圈9的一部分与磁铁10重叠，这样以来，当向线圈9上通入电流时，处于闭合状态的线圈9形成一个闭合的回路，当这个闭合的回路中有电流通过时，其自身在电磁感应作用下产生磁场，线圈9产生的磁场与磁铁10的磁场相互之间发生作用力，此时，改变通入线圈9中的电流大小/方向可以改变线圈9所产生的磁场强度以及磁场方向，由于磁铁10所产生的磁场的大小和方向是固定的，因此，当改变线圈9中的电流大小和/或方向时，在磁铁10的磁场的作用下，线圈9发生转动，由于线圈9是固定在齿轮7上的，因此，在线圈9开始转动时，齿轮7随着线圈9转动而转动，齿轮7与条板2上的齿条结构或齿条6啮合，因此条板2上的齿条结构或齿条6随着齿轮7的转动而运动（图中为竖直方向运动），最终条板2也会随着线圈9中电流的变化而运动，对于条板2，由于其直线段21是以铰接的方式固定着的，因此，在条板2随着线圈9中通入电流的变化而变化时，条板2的直线段21与水平方向的夹角也将随之而改变，进而，固定在条板2上的镜子3与水平方向的夹角也便随着改变，其上面的反射光线的角度也会随之而改变。
如图1所示，为了进一步提高条板2上的镜子3的水平夹角的调节灵敏度，在条板2上连接一个弹簧4，弹簧4的另一端固定，设定一个初始位置，使得弹簧4在该初始位置时整个装置处于一个零点，当需要调整镜子3的水平夹角时，可借助弹簧4的弹力，使得镜子3更加容易回复至初始位置。上述具体过程表现为：当向线圈9中通入电流，线圈中产生磁场，在磁铁10的作用下，线圈9在磁场交互的作用力下绕轴8转动，同时齿轮7也开始转动，条板2上的齿条结构或固定安装的齿条6在齿轮7的转动下上升/下降，进而带动条板2整体上升/下降，在条板2开始上升/下降时，其同时也开始拉伸/压缩弹簧4，当需使条板2及其上面的镜子3回复至初始位置或所需设定的位置时，当相应的改变通入线圈9中的电流大小或方向，条板2在随着其上面的齿条结构或齿条6相应的运动时，弹簧4能够相应的提供收缩力或拉伸力，使得条板2能够在弹簧4的作用力的协助下更加灵敏、快速的回复至初始位置或所需位置。
对于弹簧4位置的设置，可参照图1，将其一端固定在弯折段22上，另一端固定在相应的位置（例如平台或机架上等）。
在图1中，条板2的一端是铰接固定着的，此处可采用包括合页、铰接球等在内的多种铰接装置及铰接固定方式，即只需确保条板2能够绕支撑点1以较低的摩擦力旋转即可。
如图1中所示，磁铁10的形状以图中为例，在竖直方向（此方向为图中直观方向，具体实物的设置方位并不局限于此）设置磁铁10，并使其N极和其S极合理分布，使得线圈9能够在磁铁10磁场的作用范围内，在磁铁10的N极和S极之间运动，对于磁铁10，将其设置成如图中所示的弧形，使其与线圈9的旋转方向相应，能够对线圈9产生较为宽广的影响。但磁铁10的形状并不局限于此，选用条形磁铁U形磁铁或者其它现有形状的磁铁也可满足上述使用要求，在此不再一一描述。为了使其能够产生足够强的磁场，最好使用钕磁铁，可以获得较强的磁场，使其能够强力的促使通电后的线圈9的运动。
进一步的，如图1中所示，为了提高线圈9在齿轮7上的稳定性，并进一步提高线圈9的调节灵敏性，在齿轮7上固定一个平衡装置5，该平衡装置5安装在齿轮7上，其位置要与线圈9对应，即使得平衡装置5和线圈9分别位于齿轮的两侧，并使其二者位于同一水平高度，彼此之间起到一定的平衡作用，在此，可以将平衡装置5设置成线圈状，可以使其部分延伸出齿轮7，这样一来可以减轻平衡装置5的重量，同时，平衡装置5还可以借助自身重力，在杠杆作用下对线圈9的位置高度起到很好的平衡作用，即当线圈9受磁铁10的磁场力向上/下（仅指图中方位，实际方向不限于此）运动时，在平衡装置5的作用下，线圈9只需克服很小的力便可摆脱静止状态进行运动，同样的，当需将线圈9调整至初始位置时，只需克服较小的阻力即可实现，即无需大幅度变动通入线圈9中的电流即可实现对线圈9的位置调整。
对于图1中的轴8，可将其通过支架11进行固定，本发明图1所给出的实施例中，条板2的固定端部、弹簧4的固定端以及支架11的固定处均为具有支撑作用的平台，例如：台式的工作平台或者设置在机架上的支撑平台等，然而，也可以增设一个机架或者外壳，将整套装置固定在机架或外壳上。
本发明中，对于齿轮7在轴8上的可转动的固定方式，可采用现有技术进行解决，例如，可采用将齿轮7套在轴承的外圈上，使其可围绕轴承转动，然后将轴承的内圈固定在轴8上，将轴8固定在支架11上；另外，齿轮7也可直接使用轴承齿轮，将其直接固定在轴8上；其它现有的转动连接的方式，如铰接、套接，等等能够实现齿轮7可转动固定的均在本发明的可实施范围之内。
图2为本发明基于光反射的生物标志物检测用光谱位置调整装置的使用状态示意图，如图中所示，在使用时，可首先使用不含生物标志物的检测液，使用红外光对检测装置进行照射，并使其反射光按图2中所示的方向照射到镜子3上，经镜子3反射后，进入到光谱接收装置12，由光谱接收装置12接收经镜子3反射后的红外线光，并确定光谱暗区的位置，此种情况下，本发明基于光反射的生物标志物检测用光谱位置调整装置设定为初始位置，相应的，该状态下的光谱接收装置12处所形成的带状光区及带状光区中的暗区也相应的作为初始位置，当改变所测量的检测物时，由于检测物中生物标志物的存在，检测装置中的抗体对抗原吸收，检测照射的红外光的反射光发生变化，即照射到本发明镜子3上的红外光线发生变化，进而经其反射后，光谱接收装置12所接收到的红外光发送变化，其在光谱接收装置12上形成的光谱也随之发送变化，其所形成的暗区的位置也便会相对初始位置发生偏移。
参照图2，以其中的入射光线为所检测的检测物的红外反射光线，以其出射光为光谱接收装置12实际所接收的光线，当需对光谱接收装置12上形成的光谱的暗区位置进行调整，以获取进一步关于生物标志物的详细信息时，改变通入线圈9中的电流大小或/和方向，闭合的线圈9所产生的磁场的强度或/和方向也随着发送变化，这样以来，在磁铁10的作用下，线圈9带动齿轮7转动（在平衡装置5的平衡制动作用下线圈9比较容易在磁铁10的磁力作用下运动），进而齿轮7带动条板2上的齿条结构或齿条6运动，条板2也开始运动，镜子3与水平方向的角度随着条板2的运动发生改变，如此以来，照射到镜子3上的入射光的入射角发生变化，相应的，出射角也发生变化，出射光照射到光谱接收装置12上的角度也发生变化，因此经过检测物反射的红外线在光谱接收装置12上形成的暗区的位置也会发生改变，即根据调整通入线圈9中电流的大小或/和方向，相应的控制光谱接收装置12上形成的暗区的位置，通过该暗区位置的改变以及通入线圈9中的电流的改变获得所需的测量信息。
需要特别说明的是，本发明的实施并不局限于上述的实施方式，例如，其中实现条板2运动的齿轮7以及与其啮合的条板2上的齿条结构或齿条6，可以由相互啮合的涡轮、蜗杆或者可套接安装的螺母、螺杆进行整体替换，并相应的按需要将所需更改的部位进行修改即可，对于本领域技术人员以及结合现有的机械领域公知常识的其它领域人员均可十分容易的做出上述变动；而且，本发明中，弹簧4的位置也并不局限于图中所示的位置，还可将其移动至支撑点1附近，这样弹簧4的作用效果可能会更好。
上面结合附图对本发明的具体实施方式作了详细说明，但是本发明并不限于上述实施方式，在本领域技术人员所具备的知识范围内，还可以在不脱离本发明宗旨的前提下作出各种变化。

Claims (15)

  1. 基于光反射的生物标志物检测用光谱位置调整装置，其特征在于：包括条板（2）、镜子（3）、齿轮（7）、轴（8）、线圈（9）以及磁铁（10），所述的镜子（3）设置在条板（2）上，所述的条板（2）一端铰接固定，在所述条板（2）上开设有与所述齿轮（7）啮合的齿条结构，所述的齿轮（7）可转动的固定在轴（8）上，所述的线圈（9）固定在所述的齿轮（7）上，所述的磁铁（10）靠近所述线圈（9），使得向所述线圈（9）中通电后其能够在所述磁铁（10）的作用下绕所述轴（8）旋转运动。
  2. 根据权利要求1所述的基于光反射的生物标志物检测用光谱位置调整装置，其特征在于：所述的线圈（9）延伸出所述的齿轮（7）本体。
  3. 根据权利要求2所述的基于光反射的生物标志物检测用光谱位置调整装置，其特征在于：在所述的齿轮（7）上还设有平衡装置（5），所述的平衡装置（5）与所述的线圈（9）分布在所述齿轮（7）的两侧。
  4. 根据权利要求3所述的基于光反射的生物标志物检测用光谱位置调整装置，其特征在于：所述的平衡装置（5）为闭合的环状线圈。
  5. 根据权利要求1所述的基于光反射的生物标志物检测用光谱位置调整装置，其特征在于：所述的条板（2）包括直线段（21）和弯折段（22），所述的镜子（3）固定在所述的直线段（21）上，所述的弯折段（22）包括水平段和竖直段，所述的齿条结构设置在所述弯折段（22）的竖直段上。
  6. 根据权利要求2所述的基于光反射的生物标志物检测用光谱位置调整装置，其特征在于：所述的条板（2）包括直线段（21）和弯折段（22），所述的镜子（3）固定在所述的直线段（21）上，所述的弯折段（22）包括水平段和竖直段，所述的齿条结构设置在所述弯折段（22）的竖直段上。
  7. 根据权利要求3所述的基于光反射的生物标志物检测用光谱位置调整装置，其特征在于：所述的条板（2）包括直线段（21）和弯折段（22），所述的镜子（3）固定在所述的直线段（21）上，所述的弯折段（22）包括水平段和竖直段，所述的齿条结构设置在所述弯折段（22）的竖直段上。
  8. 根据权利要求4所述的基于光反射的生物标志物检测用光谱位置调整装置，其特征在于：所述的条板（2）包括直线段（21）和弯折段（22），所述的镜子（3）固定在所述的直线段（21）上，所述的弯折段（22）包括水平段和竖直段，所述的齿条结构设置在所述弯折段（22）的竖直段上。
  9. 根据权利要求5所述的基于光反射的生物标志物检测用光谱位置调整装置，其特征在于：所述的镜子（3）沿所述条板（2）的直线段（21）的延伸方向分布。
  10. 根据权利要求9所述的基于光反射的生物标志物检测用光谱位置调整装置，其特征在于：还包括弹簧（4），所述的条板（2）由所述弹簧（4）支撑。
  11. 根据权利要求10所述的基于光反射的生物标志物检测用光谱位置调整装置，其特征在于：所述的弹簧（4）一端固定，另一端与所述条板（2）的弯折段（22）的水平段连接。
  12. 根据权利要求10所述的基于光反射的生物标志物检测用光谱位置调整装置，其特征在于：所述的弹簧（4）一端固定，另一端与所述条板（2）的铰接固定端连接。
  13. 根据权利要求1所述的基于光反射的生物标志物检测用光谱位置调整装置，其特征在于：所述的轴（8）固定在支架（11）上。
  14. 根据权利要求1所述的基于光反射的生物标志物检测用光谱位置调整装置，其特征在于：所述的磁铁（10）为钕磁铁。
  15. 根据权利要求14所述的基于光反射的生物标志物检测用光谱位置调整装置，其特征在于：所述的磁铁（10）的形状为弧形或条形。
PCT/CN2015/077442 2015-03-25 2015-04-24 基于光反射的生物标志物检测用光谱位置调整装置 Ceased WO2016149981A1 (zh)

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