WO2016149979A1 - 蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置 - Google Patents

蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置 Download PDF

Info

Publication number
WO2016149979A1
WO2016149979A1 PCT/CN2015/077439 CN2015077439W WO2016149979A1 WO 2016149979 A1 WO2016149979 A1 WO 2016149979A1 CN 2015077439 W CN2015077439 W CN 2015077439W WO 2016149979 A1 WO2016149979 A1 WO 2016149979A1
Authority
WO
WIPO (PCT)
Prior art keywords
worm
strip
position adjusting
coil
dark area
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2015/077439
Other languages
English (en)
French (fr)
Inventor
张贯京
陈兴明
葛新科
张少鹏
方静芳
克里斯基捏⋅普拉纽克
古列莎⋅艾琳娜
波达别特⋅伊万
高伟明
梁昊原
梁艳妮
周荣
徐之艳
周亮
肖应芬
郑慧华
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shenzhen Qianhai AnyCheck Information Technology Co Ltd
E Techno Information Technologies Co Ltd
Bio Tech Academy China Co Ltd
Original Assignee
Shenzhen Qianhai AnyCheck Information Technology Co Ltd
E Techno Information Technologies Co Ltd
Bio Tech Academy China Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shenzhen Qianhai AnyCheck Information Technology Co Ltd, E Techno Information Technologies Co Ltd, Bio Tech Academy China Co Ltd filed Critical Shenzhen Qianhai AnyCheck Information Technology Co Ltd
Publication of WO2016149979A1 publication Critical patent/WO2016149979A1/zh
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection

Definitions

  • the present invention relates to the field of biomarker detection, and more particularly to a spectral dark zone position adjustment device for biomarker detection.
  • Biomarker refers to a biochemical indicator that can label changes or possible changes in the structure, function, organization, cell and subcellular structure or function of a system, and has a very wide range of uses. Biomarkers can be used for disease diagnosis, for judging disease staging, or for assessing the safety and efficacy of new drugs or new therapies in the target population.
  • Surface plasmon resonance technology SPR (Surface) is commonly used when detecting biomarkers Plasmon Resonance), which uses a physical optical phenomenon caused by total reflection connection of metal film/liquid surface interface to analyze biomolecular interactions, and measures the concentration of biomarkers by infrared light combined with SPR technology. For details, refer to the paper “Surface Plasma”.
  • the present invention provides a spectral dark area position adjusting device for detecting a worm-gear biomarker capable of acquiring reflected light of a biomarker and adjusting a spectral position of the reflected light of the biomarker.
  • a spectral dark zone position adjusting device for detecting a worm-gear biomarker, comprising a strip plate, a mirror, a meshing worm and a worm wheel, a shaft, a coil and a magnet.
  • the mirror is disposed on the strip
  • the strip is hingedly fixed at one end
  • the worm is fixed on the strip
  • the worm wheel is rotatably disposed on the shaft
  • the coil and the worm wheel are A fixed connection, the magnet being adjacent to the coil such that after energization into the coil it is capable of rotational movement about the shaft under the action of the magnet.
  • the strip includes a straight line segment and a bent portion, and the mirror is fixed at In the straight section, the bending section comprises a horizontal section and a vertical section, and the worm is disposed on a vertical section of the bending section.
  • the spectral dark area position adjusting device for detecting the worm-and-worm biomarker in the present invention is further defined as a manner of fixing the worm on the strip, wherein the worm is fixed in a vertical direction to the vertical portion of the bent portion. Straight paragraph.
  • the spectroscopic dark area position adjusting device for worm-and-worm biomarker detection in the present invention is further defined as a manner in which the mirror is disposed on the strip, and the mirror is disposed along the extending direction of the straight section of the strip.
  • the present invention further includes a spring, and the strip is supported by the spring.
  • the spring is fixed at one end and the other end is opposite to the strip The horizontal section of the bend section is connected.
  • the spring is fixed at one end and the other end is opposite to the strip Hinged fixed end connection.
  • the coil extends beyond the worm wheel body as a further limitation of the position of the coil on the worm wheel.
  • a balancing device is further disposed on the worm wheel, and the balancing device and the coil are distributed in the Describe the sides of the worm gear.
  • the spectral dark area position adjusting device for detecting a worm gear type biomarker in the present invention is further defined as a shape for the balance device and a shaft, the balance device being a closed loop coil, and the shaft fixing On the stand.
  • the shaft is fixed to the bracket.
  • the magnet is a neodymium magnet, and the shape thereof may be an arc shape or a strip shape.
  • the spectral dark area position adjusting device for detecting the worm-and-worm biomarker in the present invention is further defined as a relationship between the worm and the strip, and the worm and the strip are integrated, but are not limited thereto. Alternatively, a separate worm can be used to secure it to the slats.
  • the worm wheel can be fixed on the outer ring of the bearing, and then the bearing is fixed on the shaft, so that the worm wheel can rotate around the shaft under low resistance; however, the bearing gear can also be directly used when selecting the worm wheel. Simply fix it on the shaft. At the same time, other methods existing can be adopted for this problem, and will not be enumerated here.
  • a similar meshing mode can be used for replacement, for example, the worm gear is replaced by a gear, the coil is fixed on the gear, and the worm or worm structure on the strip is replaced with a rack structure.
  • the worm wheel can also be replaced by a nut, and the coil is correspondingly fixed on the nut, and the worm on the strip is replaced with A threaded rod or the like, such that the coil is rotated by the nut under the action of the magnet, thereby driving the threaded rod and the strip to move, thereby adjusting the position or/and the angle of the strip and the mirror above it.
  • the spectral position adjusting device for detecting biomarkers of the present invention adopts the above technical solution, and brings the technical effect: since the present invention adopts a strip plate fixed with a mirror, and one end of the strip is fixed, and the other end passes through the spring. Support, a worm is arranged on the strip and meshed with the worm wheel, a magnet is arranged near the coil fixed on the worm wheel, and a current is supplied to the coil (or the magnitude and direction of the current flowing into the coil), Due to the principle of electromagnetic induction, the coil generates a magnetic field, which interacts with the magnetic field generated by the magnet.
  • the coil drives the worm wheel to rotate around the axis, thereby driving the strip to move, changing the angle of the mirror on the strip, thereby changing the infrared ray.
  • the incident/exit angle controls the position of the dark region formed by the relevant infrared light on the spectrum receiving device, and acquires relevant information of the biomarker in the detection.
  • the adjustment process is very simple and reliable, and is very easy to operate, has high sensitivity, and can Convenient and quick change of biomarker surface plasmon resonance technology
  • the infrared illumination of the marker reflects the spectral position information of the light to obtain valid information of the biomarker in the test.
  • FIG. 1 is a schematic view showing the overall structure of a spectral dark area position adjusting device for detecting a worm-and-worm biomarker according to the present invention
  • FIG. 2 is a schematic structural view of a second embodiment of a spectral dark area position adjusting device for detecting a worm-and-worm biomarker according to a second embodiment of the present invention
  • Fig. 3 is a schematic view showing the use state of the spectral dark area position adjusting device for detecting the worm-and-worm biomarker of the present invention.
  • a spectral dark zone position adjusting device for detecting a worm-and-worm biomarker including a strip 2, a mirror 3.
  • the spring 4, the worm wheel 7, the coil 9 and the magnet 10, one end of the strip 2 is fixed in an articulated manner, the other end is fixedly connected with a worm 6, and a worm wheel 7 is provided beside the worm 6, the worm wheel 7 and the worm 6
  • the worm wheel 7 is rotatably fixed on the shaft 8, and the shaft 8 is fixed on the bracket 11.
  • the strip 2 can be set as two parts of a fixed connection, and a part is a straight line.
  • Section 21, another part is a bending section 22, one end of which is fixed in an articulated manner, and the other end of which is fixedly connected with the bending section 22, and the straight section 21 is at an angle with the horizontal direction (generally In the straight line segment 21, a mirror 3 is fixed on the straight line segment 21 for reflecting the infrared light when detecting the biomarker.
  • the bent portion 22 is bent at a 90-degree angle, and the horizontal portion is fixedly connected with the straight line segment, and the vertical portion thereof is vertically connected.
  • a worm-like structure capable of meshing with the worm wheel (a spiral structure of the worm meshing with the worm wheel 7 ) is disposed thereon, so that the worm wheel 7 can Maintaining meshing with the worm structure of the vertical section.
  • the worm structure on the strip 2 or the fixed worm 6 is in meshing state with the worm wheel 7.
  • the worm wheel 7 is rotated by an external force
  • the worm structure or the worm 6 on the strip 2 rotates with the rotation of the worm wheel 7.
  • the strip 2 is moved.
  • a closed coil 9 is fixed on the worm wheel 7, the coil 9 extending out of the body of the worm wheel 7 and extending outwardly a distance, and a fixed magnet 10 is arranged beside the coil 9.
  • a portion of the coil 9 overlaps the magnet 10, so that when a current is applied to the coil 9, the coil 9 in the closed state forms a closed loop, and when there is current in the closed loop, it is itself in electromagnetic induction.
  • the magnetic field generated by the coil 9 and the magnetic field of the magnet 10 interact with each other.
  • changing the magnitude/direction of the current flowing into the coil 9 can change the strength of the magnetic field generated by the coil 9 and the direction of the magnetic field due to The magnitude and direction of the magnetic field generated by the magnet 10 is fixed.
  • the coil 9 is rotated by the magnetic field of the magnet 10, since the coil 9 is fixed at On the worm wheel 7, therefore, when the coil 9 starts to rotate, the worm wheel 7 rotates as the coil 9 rotates, and the worm wheel 7 meshes with the worm structure or the worm 6 on the strip 2, thus the strip
  • the worm structure or the worm 6 on the 2 moves with the rotation of the worm wheel 7 (the rotation movement with the hinge point as the axis in the figure), and finally the strip 2 also moves with the change of the current in the coil 9, for the strip
  • the plate 2 because its straight section 21 is fixed in an articulated manner, the angle between the straight section 21 of the strip 2 and the horizontal direction when the strip 2 changes as the current flowing through the coil 9 changes. It will also change accordingly, and the angle between the mirror 3 fixed to the strip 2 and the horizontal direction will also change, and the angle of the reflected light on the strip will also change.
  • one end of the strip 2 is hingedly fixed, and a plurality of hinge devices including hinges, hinged balls, and the like can be used to be hingedly fixed at the support point 1 by means of hinged fixing means, that is, only the strip is required to be secured.
  • the plate 2 can be rotated around the support point 1 with a low frictional force.
  • a spring 4 is attached to the strip 2, and the other end of the spring 4 is fixed to set an initial position so that the spring 4 In this initial position, the entire device is at a zero point, and when it is necessary to adjust the horizontal angle of the mirror 3, the spring force of the spring 4 can be utilized to make the mirror 3 easier to return to the initial position.
  • the spring 4 can correspondingly provide a contraction force or a tensile force, so that the slat 2 can be more sensitively and quickly returned to the initial position or required with the assistance of the force of the spring 4. position.
  • FIG. 1 shows a first embodiment thereof, as shown in FIG. 1, which is placed close to the support point 1 so that one end is fixed to the strip 2 and the other end is fixed.
  • the spring 4 is disposed near the hinge fixing point of the strip 2, and can cooperate with the support point 1 to support the strip 2, but in this case, since the spring 4 is relatively close to the support point 1, Under the action of the lever, the spring 4 receives the slat 2 as a fulcrum, and the gravity of the slat 2 is large.
  • the principle of the lever is thus formed.
  • the position of the strip 2 can be changed, and the angle of the mirror 2 fixed thereto and 2 can be changed, thereby making the adjustment of the entire device more sensitive and easy to control.
  • FIG. 2 is a schematic structural view of a second embodiment of a spectral dark area position adjusting device for detecting a worm-gear biomarker according to the present invention with respect to a spring setting position thereof, as shown in the figure, in this embodiment, the spring 4 is to be set.
  • the spring 4 In the position where the strip 2 is close to the worm 6, for example, one end of the spring 4 can be connected to the horizontal section of the bent section 22 of the strip 2, and the other end can be fixed. In this state, the spring 4 is relatively far from the support point 1.
  • the spring 4 and the support point 1 tend to give the strip 2 support at both ends of the strip 2, and the adjustment sensitivity of the strip 2 is slightly lower than that of the spring in Fig. 1 .
  • the weight of the worm 6 can be appropriately increased, thereby increasing the overall weight of the slat 2, or using a lighter spring 4, that is, a suitable ratio of the weight of the selected spring 4 to the worm 6 is made such that
  • the worm wheel 7 is rotated, the worm 6 meshing therewith can sensitively move with the worm wheel 7, that is, it is better to ensure that the worm wheel 7 can realize the rotating action under the hindrance of low resistance, and avoid the friction between the worm wheel 7 and the worm 6 Large, making the device as a whole difficult Day use.
  • the shape of the magnet 10 is exemplified in the figure, and the magnet 10 is disposed in the vertical direction (this direction is an intuitive direction in the drawing, and the specific orientation of the object is not limited thereto), and the N pole is set. And the S pole is reasonably distributed, so that the coil 9 can move between the N pole and the S pole of the magnet 10 within the range of the magnetic field of the magnet 10, and for the magnet 10, it is arranged in an arc shape as shown in the figure. Corresponding to the direction of rotation of the coil 9, it is possible to exert a relatively wide influence on the coil 9.
  • the shape of the magnet 10 is not limited thereto, and the use of a strip magnet U-shaped magnet or other existing-shaped magnets can also satisfy the above-mentioned use requirements, and will not be described one by one.
  • a balancing device 5 is fixed on the worm wheel 7, and the balancing device 5 is mounted.
  • the worm wheel 7 its position should correspond to the coil 9, that is, the balance device 5 and the coil 9 are respectively located on both sides of the worm wheel, and the two are at the same level, which play a certain balance between each other.
  • the balancing device 5 can be arranged in a coil shape, and can be partially extended out of the worm wheel 7, so that the weight of the balancing device 5 can be reduced, and at the same time, the balancing device 5 can also be used for the coil 9 under the action of the lever by its own gravity.
  • the position height plays a good balance.
  • the coil 9 is moved upward/down by the magnetic field force of the magnet 10 (only the orientation in the figure, the actual direction is not limited thereto), the coil 9 is only operated by the balancing device 5. It is necessary to overcome the small force to get rid of the static state of movement. Similarly, when the coil 9 needs to be adjusted to the initial position, it is only necessary to overcome the small resistance, that is, the access coil 9 does not need to be greatly changed.
  • the current in the middle can achieve the position adjustment of the coil 9.
  • the shaft 8 of Figures 1 and 2 it can be fixed by the bracket 11, in the embodiment given in Figure 1 of the present invention, the fixed end of the strip 2, the fixing of the spring 4 and the fixing of the bracket 11 They are all supported platforms, such as a bench-top work platform or a support platform placed on the rack.
  • a rack or casing can be added to fix the whole device to the frame or the casing.
  • the rotatable fixing manner of the worm wheel 7 on the shaft 8 can be solved by the prior art.
  • the worm wheel 7 can be placed on the outer ring of the bearing so that it can rotate around the bearing, and then The inner ring of the bearing is fixed on the shaft 8 to fix the shaft 8 on the bracket 11; in addition, the worm wheel 7 can also directly use the bearing gear and directly fix it on the shaft 8; in addition, other existing methods of rotating connection It is within the scope of the present invention to enable the worm wheel 7 to be rotatably fixed, such as hinged, socketed, and the like.
  • the detection liquid containing no biomarker may be used first, and the detecting device may be performed using infrared light. Irradiating and illuminating the reflected light onto the mirror 3 in the direction shown in FIG. 2, reflecting through the mirror 3, entering the spectrum receiving device 12, and receiving the infrared light reflected by the mirror 3 by the spectrum receiving device 12, and Determining the position of the dark region of the spectrum.
  • the spectral position adjusting device for detecting the biomarker of the present invention is set to an initial position, and correspondingly, the strip-shaped optical region formed at the spectral receiving device 12 in the state and The dark region in the band-shaped region also corresponds to the initial position.
  • the antibody in the detection device absorbs the antigen due to the presence of the biomarker in the detection, and the reflection of the irradiated infrared light is detected.
  • Spectrum receiving means 12 is formed in the transmission spectrum will also change the position of the dark areas formed therefrom will be shifted relative to the initial position.
  • the incident light is the infrared reflected light of the detected object
  • the emitted light is the light actually received by the spectrum receiving device 12, and the dark region of the spectrum formed on the spectrum receiving device 12 is required.
  • the magnitude or/and direction of the current flowing into the coil 9 is changed, and the intensity or/and direction of the magnetic field generated by the closed coil 9 also changes with the transmission.
  • the coil 9 drives the worm wheel 7 to rotate (the coil 9 is relatively easy to move under the magnetic force of the magnet 10 under the balanced braking action of the balancing device 5), and the worm wheel 7 drives the strip 2
  • the slat 2 also starts to move, and the angle of the mirror 3 with the horizontal direction changes with the movement of the slat 2, so that the incident angle of the incident light irradiated onto the mirror 3 changes, correspondingly
  • the exit angle also changes, and the angle at which the emitted light is incident on the spectrum receiving device 12 also changes, so that infrared rays reflected by the detecting object are formed on the spectrum receiving device 12.
  • the position of the dark region is also changed, that is, according to the magnitude or/and direction of the current flowing into the coil 9, the position of the dark region formed on the spectrum receiving device 12 is controlled correspondingly, and the position of the dark region is changed and passed.
  • the change in current into the coil 9 yields the required measurement information.
  • the worm-and-worm type transmission mode of the present invention For the worm-and-worm type transmission mode of the present invention, during the use of the device, since a current is supplied to the coil 9 or the magnitude of the current flowing therein is changed, a magnetic field is generated in the coil 9 or the magnetic field generated by the coil 9 is changed. Then, the magnet 10 causes the coil 9 to move, and then the coil 9 drives the worm wheel 7 to move, that is, in the worm gear combination, the worm wheel 7 is used as the power source to drive the worm 6 to move, and the worm of the conventional worm gear is used as the active member.
  • the transmission efficiency of the worm gear in this case is relatively low, and the transmission is a speed increasing transmission, from the perspective of the invention, this will make the slat 2 connected to the worm 6 obtain A higher sensitivity makes adjustment of the entire device easier and more sensitive.
  • the lead angle of the worm 6 is greater than the equivalent friction angle between the meshing teeth, otherwise the worm gear will be self-locking and cannot be used.
  • the magnet 10 it is arranged in an arc shape as shown in the drawing so as to correspond to the direction of rotation of the coil 9, which can exert a relatively wide influence on the coil 9.
  • the shape of the magnet 10 is not limited thereto, and the use of a strip magnet U-shaped magnet or other existing-shaped magnets can also satisfy the above-mentioned use requirements, and will not be described one by one.
  • the implementation of the present invention is not limited to the above-described embodiments, for example, the worm gear 7 in which the movement of the strip 2 and the worm structure or the worm 6 on the strip 2 engaged therewith can be engaged with each other.
  • the turbine, the worm or the socket-mounted nut and the screw are integrally replaced, and the parts to be modified are modified as needed, and are well-known to those skilled in the art and other fields in common with the existing mechanical field. These changes can be made very easily.

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

一种用于生物标志物检测的光谱暗区位置调节装置包括条板(2)、镜子(3)、相互啮合着的蜗杆(6)与蜗轮(7)、轴(8)、线圈(9)以及磁铁(10)，所述的镜子(3)设置在条板(2)上，条板(2)一端铰接固定，蜗杆(6)固定在条板(2)上，蜗轮(7)可转动的设置在轴(8)上，线圈(9)与蜗轮(7)固定连接，磁铁(10)靠近线圈(9)，使得向线圈(9)中通电后其能够在磁铁(10)的作用下绕轴(8)旋转运动。该装置能够方便、快捷的改变生物标志物表面等离子共振技术检查过程中检测物中生物标志物的红外照射反射光线的光谱位置，从而获取检测物中生物标志物的有效信息。

Description

蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置
技术领域
本发明涉及生物标志物检测领域，更具体的说涉及生物标志物检测用光谱暗区位置调节装置。
背景技术
生物标志物（Biomarker）是指可以标记系统、器官、组织、细胞及亚细胞结构或功能的改变或可能发生的改变的生化指标，具有非常广泛的用途。生物标志物可用于疾病诊断、判断疾病分期或者用来评价新药或新疗法在目标人群中的安全性及有效性。在检测生物标志物时，常用到表面等离子共振技术SPR（Surface Plasmon Resonance），即利用金属膜/液面界面光的全反射连接引起的一种物理光学现象来分析生物分子相互作用，并通过红外光结合SPR技术测量生物标志物浓度，具体可参照论文“表面等离子共振技术在生物医学中的应用”，以及论文“表面等离子体共振免疫传感器在蛋白质检测中的应用及其研究进展”—《分析化学》2010年第七期1052-1059，然而，在测量过程中，怎样能够更加准确的获取检测生物标志物的红外光的特征光谱位置信息，从而获取待测物中生物标志物的相关信息，是摆在众多生物医学领域学家面前的一道难题。
发明内容
为了解决上述技术问题，本发明提供一种能够获取生物标志物的反射光线，并调整生物标志物反射光光谱位置的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置。
本发明为解决上述技术问题所采用的技术方案为：蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，包括条板、镜子、相互啮合着的蜗杆与蜗轮、轴、线圈以及磁铁，所述的镜子设置在条板上，所述的条板一端铰接固定，所述蜗杆固定在所述条板上，所述的蜗轮可转动的设置在轴上，所述的线圈与所述的蜗轮固定连接，所述的磁铁靠近所述线圈，使得向所述线圈中通电后其能够在所述磁铁的作用下绕所述轴旋转运动。
对于本发明中的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，作为针对条板结构的进一步改进式设置，所述的条板包括直线段和弯折段，所述的镜子固定在所述的直线段上，所述的弯折段包括水平段和竖直段，所述的蜗杆设置在所述弯折段的竖直段上。
对于本发明中的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，作为蜗杆在条板上固定方式的进一步限定，所述的蜗杆以竖直方向固定在所述的弯折段的竖直段上。
对于本发明中的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，作为镜子在条板上设置方式的进一步限定，所述的镜子沿所述条板的直线段的延伸方向设置。
对于本发明中的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，作为进一步的设置，本发明还包括弹簧，所述的条板由所述弹簧支撑。
对于本发明中的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，作为针对弹簧的设置位置的一种可选的实施例，所述的弹簧一端固定，另一端与所述条板的弯折段的水平段连接。
对于本发明中的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，作为针对弹簧的设置位置的一种可选的实施例，所述的弹簧一端固定，另一端与所述条板的铰接固定端连接。
对于本发明中的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，作为针对线圈在蜗轮上固定位置的进一步的限定，所述的线圈延伸出所述的蜗轮本体。
对于本发明中的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，作为进一步的设置，在所述的蜗轮上还设有平衡装置，所述的平衡装置与所述的线圈分布在所述蜗轮的两侧。
对于本发明中的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，作为针对平衡装置的形状以及轴的设置进一步限定，所述的平衡装置为闭合的环状线圈，所述的轴固定在支架上。
对于本发明中的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，作为进一步限定，所述的轴固定在支架上。
对于本发明中的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，作为针对磁铁的进一步限定，所述的磁铁为钕磁铁，其形状可选弧形或条形。
对于本发明中的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，作为针对蜗杆与条板关系进一步限定，所述的蜗杆与所述的条板为一体式结构，但并不局限于此，也可选用单独的蜗杆，将其固定在条板上。
本发明中，可将蜗轮固定的套在轴承的外圈上，然后将轴承固定在轴上，使得蜗轮可在低阻力下围绕轴旋转运动；但是，在应用选择蜗轮时也可直接选用轴承齿轮，直接将其固定在轴上即可。同时，针对该问题，还可采用现有的其它方式，在此不再一一列举。
本发明中，对于蜗轮蜗杆的啮合方式，还可以选用类似的啮合方式进行替换，例如：将蜗轮换为齿轮，将线圈固定在齿轮上，将条板上的蜗杆或蜗杆结构替换为齿条结构或齿条，依靠齿轮和齿条的啮合传递，完成对条板及其上面的镜子的调节；还可将蜗轮替换为螺母，相应的将线圈固定在螺母上，将条板上的蜗杆换成螺纹杆或类似结构，使得线圈在磁铁的作用下通过带动螺母旋转，进而带动螺纹杆、条板进行运动，从而调整条板及其上面的镜子的位置或/和角度。
本发明用于生物标志物检测的光谱位置调整装置采用上述技术方案，带来的技术效果为：由于本发明采用了固定有镜子的条板，并将条板一端进行固定，其另一端通过弹簧支撑，在条板上设置了蜗杆，并使其与蜗轮啮合，在蜗轮上固定着的线圈附近设有磁铁，在向线圈中通入电流（或改变通入线圈中电流的大小和方向），由于电磁感应原理，线圈产生磁场，该磁场与磁铁产生的磁场相互作用，在此作用下线圈带动蜗轮围绕轴转动，进而带动条板进行运动，改变条板上的镜子的角度，从而改变红外线的入射/出射角度，控制相关红外光线在光谱接收装置上所形成的暗区的位置，获取检测物中的生物标志物的相关信息，该调节过程十分简洁可靠，且非常容易操作，灵敏度高，能够方便、快捷的改变生物标志物表面等离子共振技术检查过程中检测物中生物标志物的红外照射反射光线的光谱位置信息，从而获取检测物中生物标志物的有效信息。
附图说明
图1为本发明蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置的整体结构示意图；
图2为本发明蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置关于其弹簧设置位置的第二种实施例的结构示意图；
图3为本发明蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置的使用状态示意图。
具体实施方式
为使本发明实施例的目的、技术方案和优点更加清楚，下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚地描述，显然，所描述的实施例是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
图1为本发明蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置的整体结构示意图，如图所示，蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，包括条板2、镜子3、弹簧4、蜗轮7、线圈9和磁铁10，条板2的一端以铰接的方式固定，另一端与一个蜗杆6固定连接，在蜗杆6的旁边设置有一个蜗轮7，蜗轮7与蜗杆6处于啮合状态，蜗轮7可转动的固定在轴8上，轴8固定在支架11上，为了方便在条板2上固定蜗杆6，可将条板2设置为固定连接的两部分，一部分为直线段21，另一部分为弯折段22，直线段21的一端采用铰接的方式固定，其另一端与弯折段22固定连接，并使得直线段21与水平方向呈一定的夹角（一般情况下以锐角居多），在直线段21上固定有镜子3，用于反射检测生物标志物时的红外光线，弯折段22呈90度折弯状，其水平部分与直线段固定连接，其竖直部分固定蜗杆6，当然，也可以在该竖直段做成圆柱形，并在其上面设置能够与蜗轮啮合着的蜗杆状结构（即可与蜗轮7啮合的蜗杆的螺旋结构），使得蜗轮7能与该竖直段的蜗杆结构保持啮合状态。
条板2上的蜗杆结构或固定着的蜗杆6与蜗轮7处于啮合状态，当蜗轮7在外力的作用下转动时，条板2上的蜗杆结构或蜗杆6随着蜗轮7的转动而转动，从而带动条板2发生运动。为了控制/调节蜗轮7的转动，在蜗轮7上固定一个闭合的线圈9，该线圈9要延伸出蜗轮7的本体，并向外延伸一段距离，在线圈9旁边设置一个固定着的磁铁10，线圈9的一部分与磁铁10重叠，这样以来，当向线圈9上通入电流时，处于闭合状态的线圈9形成一个闭合的回路，当这个闭合的回路中有电流通过时，其自身在电磁感应作用下产生磁场，线圈9产生的磁场与磁铁10的磁场相互之间发生作用力，此时，改变通入线圈9中的电流大小/方向可以改变线圈9所产生的磁场强度以及磁场方向，由于磁铁10所产生的磁场的大小和方向是固定的，因此，当改变线圈9中的电流大小和/或方向时，在磁铁10的磁场的作用下，线圈9发生转动，由于线圈9是固定在蜗轮7上的，因此，在线圈9开始转动时，蜗轮7随着线圈9转动而转动，蜗轮7与条板2上的蜗杆结构或蜗杆6啮合，因此条板2上的蜗杆结构或蜗杆6随着蜗轮7的转动而运动（图中为以其铰接点为轴的旋转运动），最终条板2也会随着线圈9中电流的变化而运动，对于条板2，由于其直线段21是以铰接的方式固定着的，因此，在条板2随着线圈9中通入电流的变化而变化时，条板2的直线段21与水平方向的夹角也将随之而改变，进而，固定在条板2上的镜子3与水平方向的夹角也便随着改变，其上面的反射光线的角度也会随之而改变。
本发明中，条板2的一端是铰接固定着的，此处可采用包括合页、铰接球等在内的多种铰接装置及铰接固定方式在支撑点1处铰接固定，即只需确保条板2能够绕支撑点1以较低的摩擦力旋转即可。
如图1所示，为了进一步提高条板2上的镜子3的水平夹角的调节灵敏度，在条板2上连接一个弹簧4，弹簧4的另一端固定，设定一个初始位置，使得弹簧4在该初始位置时整个装置处于一个零点，当需要调整镜子3的水平夹角时，可借助弹簧4的弹力，使得镜子3更加容易回复至初始位置。上述具体过程表现为：当向线圈9中通入电流，线圈中产生磁场，在磁铁10的作用下，线圈9在磁场交互的作用力下绕轴8转动，同时蜗轮7也开始转动，条板2上的蜗杆结构或固定安装的蜗杆6在蜗轮7的转动下上升/下降，进而带动条板2整体上升/下降，在条板2开始上升/下降时，其同时也开始拉伸/压缩弹簧4，当需使条板2及其上面的镜子3回复至初始位置或所需设定的位置时，当相应的改变通入线圈9中的电流大小或方向，条板2在随着其上面的蜗杆结构或蜗杆6相应的运动时，弹簧4能够相应的提供收缩力或拉伸力，使得条板2能够在弹簧4的作用力的协助下更加灵敏、快速的回复至初始位置或所需位置。
对于弹簧4位置的设置，图1给出了其第一种实施例，如图1所示，即将其设置在靠近支撑点1处，使其一端固定在条板2上，另一端固定，这种状态下，弹簧4设置在靠近条板2的铰接固定点处，能与支撑点1共同起到对条板2的支撑作用，但这种情况下，由于弹簧4离支撑点1比较近，在杆杠作用下，弹簧4作为支点所承受条板2的重力较大，同时，在设定条板2及其上面固定的镜子3的初始位置后，因此而形成的杠杆作用原理使得在条板2另一端施加一个较小的力时即可改变条板2的位置，并改变2及其上面固定着的镜子3的角度，从而使得整个装置的调节变得更加灵敏，易于控制。
图2为本发明蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置关于其弹簧设置位置的第二种实施例的结构示意图，如图所示，此种实施例下，要将弹簧4设置在条板2靠近蜗杆6的位置，例如，可将弹簧4一端与条板2的弯折段22的水平段连接，另一端予以固定，这种状态下，弹簧4距离支撑点1相对较远，此时弹簧4和支撑点1趋向于在条板2的两端给予条板2支撑，相比于图1中弹簧的设置位置，该种情况下条板2的调节灵敏度要稍低一些，对于此，可适当增加蜗杆6的重量，从而增加条板2的整体重量，或者选用质量较轻的弹簧4，即要使选用的弹簧4与蜗杆6的重量有一个合适的配比，使得在转动蜗轮7时，与其啮合着的蜗杆6能够灵敏的随着蜗轮7运动，即最好保证蜗轮7在低阻力阻碍下即可实现旋转动作，避免因蜗轮7和蜗杆6之间的摩擦力过大，致使装置整体难以调节使用。
如图1中所示，磁铁10的形状以图中为例，在竖直方向（此方向为图中直观方向，具体实物的设置方位并不局限于此）设置磁铁10，并使其N极和其S极合理分布，使得线圈9能够在磁铁10磁场的作用范围内，在磁铁10的N极和S极之间运动，对于磁铁10，将其设置成如图中所示的弧形，使其与线圈9的旋转方向相应，能够对线圈9产生较为宽广的影响。但磁铁10的形状并不局限于此，选用条形磁铁U形磁铁或者其它现有形状的磁铁也可满足上述使用要求，在此不再一一描述。为了使其能够产生足够强的磁场，最好使用钕磁铁，可以获得较强的磁场，使其能够强力的促使通电后的线圈9的运动。
进一步的，如图1以及图2中所示，为了提高线圈9在蜗轮7上的稳定性，并进一步提高线圈9的调节灵敏性，在蜗轮7上固定一个平衡装置5，该平衡装置5安装在蜗轮7上，其位置要与线圈9对应，即使得平衡装置5和线圈9分别位于蜗轮的两侧，并使其二者位于同一水平高度，彼此之间起到一定的平衡作用，在此，可以将平衡装置5设置成线圈状，可以使其部分延伸出蜗轮7，这样一来可以减轻平衡装置5的重量，同时，平衡装置5还可以借助自身重力，在杠杆作用下对线圈9的位置高度起到很好的平衡作用，即当线圈9受磁铁10的磁场力向上/下（仅指图中方位，实际方向不限于此）运动时，在平衡装置5的作用下，线圈9只需克服很小的力便可摆脱静止状态进行运动，同样的，当需将线圈9调整至初始位置时，只需克服较小的阻力即可实现，即无需大幅度变动通入线圈9中的电流即可实现对线圈9的位置调整。
对于图1以及图2中的轴8，可将其通过支架11进行固定，本发明图1所给出的实施例中，条板2的固定端部、弹簧4的固定处以及支架11的固定处均为具有支撑作用的平台，例如：台式的工作平台或者设置在机架上的支撑平台等，然而，也可以增设一个机架或者外壳，将整套装置固定在机架或外壳上。
本发明中，对于蜗轮7在轴8上的可转动的固定方式，可采用现有技术进行解决，例如，可采用将蜗轮7套在轴承的外圈上，使其可围绕轴承转动，然后将轴承的内圈固定在轴8上，将轴8固定在支架11上；另外，蜗轮7也可直接使用轴承齿轮，并将其直接固定在轴8上；另外，其它现有的转动连接的方式，如铰接、套接，等等能够实现蜗轮7可转动固定的均在本发明的可实施范围之内。
图3为本发明用于生物标志物检测的光谱位置调整装置的使用状态示意图，如图中所示，在使用时，可首先使用不含生物标志物的检测液，使用红外光对检测装置进行照射，并使其反射光按图2中所示的方向照射到镜子3上，经镜子3反射后，进入到光谱接收装置12，由光谱接收装置12接收经镜子3反射后的红外线光，并确定光谱暗区的位置，此种情况下，本发明用于生物标志物检测的光谱位置调整装置设定为初始位置，相应的，该状态下的光谱接收装置12处所形成的带状光区及带状光区中的暗区也相应的作为初始位置，当改变所测量的检测物时，由于检测物中生物标志物的存在，检测装置中的抗体对抗原吸收，检测照射的红外光的反射光发生变化，即照射到本发明镜子3上的红外光线发生变化，进而经其反射后，光谱接收装置12所接收到的红外光发生变化，其在光谱接收装置12上形成的光谱也随之发送变化，其所形成的暗区的位置也便会相对初始位置发生偏移。
参照图3，以其中的入射光线为所检测的检测物的红外反射光线，以其出射光为光谱接收装置12实际所接收的光线，当需对光谱接收装置12上形成的光谱的暗区位置进行调整，以获取进一步关于生物标志物的详细信息时，改变通入线圈9中的电流大小或/和方向，闭合着的线圈9所产生的磁场的强度或/和方向也随着发送变化，这样以来，在磁铁10的作用下，线圈9带动蜗轮7转动（在平衡装置5的平衡制动作用下线圈9比较容易在磁铁10的磁力作用下运动），进而蜗轮7带动条板2上的蜗杆结构或蜗杆6运动，条板2也开始运动，镜子3与水平方向的角度随着条板2的运动发生改变，如此以来，照射到镜子3上的入射光的入射角发生变化，相应的，出射角也发生变化，出射光照射到光谱接收装置12上的角度也发生变化，因此经过检测物反射的红外线在光谱接收装置12上形成的暗区的位置也会发生改变，即根据调整通入线圈9中电流的大小或/和方向，相应的控制光谱接收装置12上形成的暗区的位置，通过该暗区位置的改变以及通入线圈9中的电流的改变获得所需的测量信息。
对于本发明中的蜗轮蜗杆式的传动方式，在装置的使用过程中，由于是向线圈9中通入电流或改变通入其中电流的大小，使得线圈9中产生磁场或者改变其所产生的磁场，继而由磁铁10促使线圈9运动，再由线圈9带动蜗轮7运动，即，在蜗轮蜗杆组合中，是由蜗轮7为动力源带动蜗杆6运动的，与传统的蜗轮蜗杆的蜗杆作为主动件的方式不同，虽然此种情况的蜗轮蜗杆的传动效率比较低，且该传动为增速传动，但从本发明所趋向的角度来说，这反而会使得与蜗杆6连接着的条板2获得一个较高的灵敏度，使得整个装置的调节变得更为容易和灵敏。但是需要注意的是，要使蜗杆6的导程角大于啮合轮齿间的当量摩擦角，否则蜗轮蜗杆会出现自锁现象而无法使用。
对于磁铁10，将其设置成如图中所示的弧形，使其与线圈9的旋转方向相应，能够对线圈9产生较为宽广的影响。但磁铁10的形状并不局限于此，选用条形磁铁U形磁铁或者其它现有形状的磁铁也可满足上述使用要求，在此不再一一描述。为了使其能够产生足够强的磁场，最好使用钕磁铁，可以获得较强的磁场，使其能够强力的促使通电后的线圈9的运动。
需要特别说明的是，本发明的实施并不局限于上述的实施方式，例如，其中实现条板2运动的蜗轮7以及与其啮合的条板2上的蜗杆结构或蜗杆6，可以由相互啮合的涡轮、蜗杆或者可套接安装的螺母、螺杆进行整体替换，并相应的按需要将所需更改的部位进行修改即可，对于本领域技术人员以及结合现有的机械领域公知常识的其它领域人员均可十分容易的做出上述变动。
上面结合附图对本发明的具体实施方式作了详细说明，但是本发明并不限于上述实施方式，在本领域技术人员所具备的知识范围内，还可以在不脱离本发明宗旨的前提下作出各种变化。

Claims (15)

  1. 蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，包括条板（2）、镜子（3）、相互啮合着的蜗杆（6）与蜗轮（7）、轴（8）、线圈（9）以及磁铁（10），所述的镜子（3）设置在条板（2）上，所述的条板（2）一端铰接固定，所述蜗杆（6）固定在所述条板（2）上，所述的蜗轮（7）可转动的设置在轴（8）上，所述的线圈（9）与所述的蜗轮（7）固定连接，所述的磁铁（10）靠近所述线圈（9），使得向所述线圈（9）中通电后其能够在所述磁铁（10）的作用下绕所述轴（8）旋转运动。
  2. 根据权利要求1所述的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，其特征在于：所述的条板（2）包括直线段（21）和弯折段（22），所述的镜子（3）固定在所述的直线段（21）上，所述的弯折段（22）包括水平段和竖直段，所述的蜗杆（6）设置在所述弯折段（22）的竖直段上。
  3. 根据权利要求2所述的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，其特征在于：所述的蜗杆（6）以竖直方向固定在所述的弯折段的竖直段上。
  4. 根据权利要求3所述的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，其特征在于：所述的镜子（3）沿所述条板（2）的直线段（21）的延伸方向设置。
  5. 根据权利要求1所述的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，其特征在于：还包括弹簧（4），所述的条板（2）由所述弹簧（4）支撑。
  6. 根据权利要求2所述的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，其特征在于：还包括弹簧（4），所述的条板（2）由所述弹簧（4）支撑。
  7. 根据权利要求5所述的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，其特征在于：所述的弹簧（4）一端固定，另一端与所述条板（2）的弯折段（22）的水平段连接。
  8. 根据权利要求5所述的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，其特征在于：所述的弹簧（4）一端固定，另一端与所述条板（2）的铰接固定端连接。
  9. 根据权利要求5所述的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，其特征在于：所述的线圈（9）延伸出所述的蜗轮（7）本体。
  10. 根据权利要求9所述的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，其特征在于：在所述的蜗轮（7）上还设有平衡装置（5），所述的平衡装置（5）与所述的线圈（9）分布在所述蜗轮（7）的两侧。
  11. 根据权利要求10所述的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，其特征在于：所述的平衡装置（5）为闭合的环状线圈。
  12. 根据权利要求1所述的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，其特征在于：所述的轴（8）固定在支架（11）上。
  13. 根据权利要求1所述的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，其特征在于：所述的磁铁（10）为钕磁铁。
  14. 根据权利要求13所述的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，其特征在于：所述的磁铁（10）的形状为弧形或条形。
  15. 根据权利要求1所述的蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置，其特征在于：所述的蜗杆（6）与所述的条板（2）为一体式结构。
PCT/CN2015/077439 2015-03-25 2015-04-24 蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置 Ceased WO2016149979A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201510131754.5A CN104792698B (zh) 2015-03-25 2015-03-25 蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置
CN201510131754.5 2015-03-25

Publications (1)

Publication Number Publication Date
WO2016149979A1 true WO2016149979A1 (zh) 2016-09-29

Family

ID=53557687

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2015/077439 Ceased WO2016149979A1 (zh) 2015-03-25 2015-04-24 蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置

Country Status (2)

Country Link
CN (1) CN104792698B (zh)
WO (1) WO2016149979A1 (zh)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0730241A2 (en) * 1990-05-08 1996-09-04 Symbol Technologies, Inc. Scanning arrangement
EP1081529A2 (en) * 1999-08-30 2001-03-07 PSC Scanning, Inc. Reflective dither spring
CN1844938A (zh) * 2006-05-12 2006-10-11 中国科学院上海微系统与信息技术研究所 一种基于微电子机械系统的光学电流传感器、制作及检测方法
CN201075777Y (zh) * 2007-08-31 2008-06-18 上海世科嘉车辆技术研发有限公司 后视镜单电机电动角度调节系统
CN201212871Y (zh) * 2008-04-30 2009-03-25 中国科学院金属研究所 薄膜材料动态弯曲疲劳性能测试系统
CN102967934A (zh) * 2012-12-04 2013-03-13 中国科学院苏州纳米技术与纳米仿生研究所 一种电磁驱动微镜
CN103528683A (zh) * 2013-10-25 2014-01-22 武汉大学 一种用于傅立叶变换红外光谱仪的动镜扫描装置
CN103984091A (zh) * 2013-11-21 2014-08-13 苏州浩创信息科技有限公司 一种扫描器摆镜装置
CN204462017U (zh) * 2015-03-25 2015-07-08 深圳市易特科信息技术有限公司 用于生物标志物检测的光谱暗区位置调节装置

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0730241A2 (en) * 1990-05-08 1996-09-04 Symbol Technologies, Inc. Scanning arrangement
EP1081529A2 (en) * 1999-08-30 2001-03-07 PSC Scanning, Inc. Reflective dither spring
CN1844938A (zh) * 2006-05-12 2006-10-11 中国科学院上海微系统与信息技术研究所 一种基于微电子机械系统的光学电流传感器、制作及检测方法
CN201075777Y (zh) * 2007-08-31 2008-06-18 上海世科嘉车辆技术研发有限公司 后视镜单电机电动角度调节系统
CN201212871Y (zh) * 2008-04-30 2009-03-25 中国科学院金属研究所 薄膜材料动态弯曲疲劳性能测试系统
CN102967934A (zh) * 2012-12-04 2013-03-13 中国科学院苏州纳米技术与纳米仿生研究所 一种电磁驱动微镜
CN103528683A (zh) * 2013-10-25 2014-01-22 武汉大学 一种用于傅立叶变换红外光谱仪的动镜扫描装置
CN103984091A (zh) * 2013-11-21 2014-08-13 苏州浩创信息科技有限公司 一种扫描器摆镜装置
CN204462017U (zh) * 2015-03-25 2015-07-08 深圳市易特科信息技术有限公司 用于生物标志物检测的光谱暗区位置调节装置

Also Published As

Publication number Publication date
CN104792698B (zh) 2019-06-14
CN104792698A (zh) 2015-07-22

Similar Documents

Publication Publication Date Title
CN204495749U (zh) 连续衍射分光与探测装置及顺序式x射线荧光光谱仪
CN102323240B (zh) 室内全自动brdf测量装置
CN102175650A (zh) 连续光谱双向反射分布函数测量装置
CN103940766A (zh) 农产品组织光学特性检测装置
CN104777137B (zh) 生物标志物检测用光谱位置调节装置
EP1870695A1 (en) Accelerated weathering device with optical slip ring
WO2016149981A1 (zh) 基于光反射的生物标志物检测用光谱位置调整装置
CN104596639B (zh) 一种用于半导体光源的远场三维强度的表征装置
CN116659564A (zh) 一种有机光电传感器的特性测试设备
WO2016149990A1 (zh) 螺旋升降式生物标志物检测用光谱位置调节装置
CN202255626U (zh) 一种光辐射安全测量系统
CN109001116B (zh) 一种入射狭缝调节机构及应用其的原子发射光谱仪
CN204536183U (zh) 用于生物标志物检测的光反射式光谱位置调整装置
CN110596054A (zh) 一种双向透射分布函数快速测量装置
CN204479459U (zh) 用于生物标志物检测的螺旋升降式光谱位置调节装置
CN204462017U (zh) 用于生物标志物检测的光谱暗区位置调节装置
CN119688257A (zh) 一种光学锥面镜生产用检测装置及方法
CN104246456B (zh) 光学测量装置
JP5455792B2 (ja) Ｘ線分析装置
CN204536918U (zh) 用于生物标志物检测的光谱位置调节装置
CN110859604A (zh) 智能验放一体机
JP3783400B2 (ja) モノクロメータ
CN104777136B (zh) 基于表面等离子共振技术的生物标志物检测方法与系统
CN104792698A (zh) 蜗轮蜗杆式生物标志物检测用光谱暗区位置调节装置
CN104749118B (zh) 变量干预式生物标志物浓度检测方法及装置

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 15885917

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 15885917

Country of ref document: EP

Kind code of ref document: A1