WO2016118038A1 - Implant en titane à surface poreuse et procédé de formation de cette dernière - Google Patents

Implant en titane à surface poreuse et procédé de formation de cette dernière Download PDF

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Publication number
WO2016118038A1
WO2016118038A1 PCT/RU2015/000031 RU2015000031W WO2016118038A1 WO 2016118038 A1 WO2016118038 A1 WO 2016118038A1 RU 2015000031 W RU2015000031 W RU 2015000031W WO 2016118038 A1 WO2016118038 A1 WO 2016118038A1
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WO
WIPO (PCT)
Prior art keywords
implant
titanium
increase
forming
chemical etching
Prior art date
Application number
PCT/RU2015/000031
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English (en)
Russian (ru)
Inventor
Илья Юльевич ФРИДМАН
Сергей Александрович КИСЕЛЕВ
Павел Александрович ЗАБУРСКИЙ
Андрей Викторович ОЛЕНИН
Original Assignee
Общество с ограниченной ответственностью "Альфа Биотех"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Общество с ограниченной ответственностью "Альфа Биотех" filed Critical Общество с ограниченной ответственностью "Альфа Биотех"
Priority to PCT/RU2015/000031 priority Critical patent/WO2016118038A1/fr
Publication of WO2016118038A1 publication Critical patent/WO2016118038A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/06—Titanium or titanium alloys
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C22/00—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals
    • C23C22/05—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions
    • C23C22/06—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions using aqueous acidic solutions with pH less than 6

Definitions

  • the invention relates to medicine, namely to dentistry, and can be used to form the surface of dental titanium implants in order to ensure further successful integration of the implant into bone tissue.
  • TiUnite from Nobel Biocare
  • NanoTechTM developed by Alpha-Bio Tes
  • SLActive from Straumann. All of them are more osteoconductive than osteinductive.
  • TiUnite technology implies a process when, under the action of electrolysis, the released gas in the titanium oxide layer creates pores and thereby increases the thickness of the oxide layer itself and, as a result, the total surface area of the implant.
  • Alpha-Bio Tes in turn, has developed an NanoTecTM surface that is exceptional in micromechanical and biological properties.
  • the NanoTecTM surface is the result of a multi-stage process, which essentially consists in sandblasting the implant body with a titanium oxide powder consisting of particles from 20 to 40 microns in size followed by double thermal acid etching to achieve microporosity from 1 to 5 microns in size.
  • Straumann developed the SLActive implant surface, during the formation of which the titanium implant body is sandblasted, acid-etched and then washed with water using a nitrogen atmosphere, which leads to the formation of a hydroxylated, chemically active layer on the surface of the implant body with hydrophilic properties.
  • This hydrophilic surface is designed to optimize the formation of a new bone structure around the implant due to its potentiated ability to retain a blood clot in the peri-implant region during its retraction.
  • the present invention is the formation of the surface of the dental implant, ensuring the successful integration of the implant into the bone tissue.
  • the problem is solved by achieving a technical result - creating such an outer surface of the implant, which provides optimal conditions for protein adhesion due to the technologically formed maximum possible surface area of the implant and the three-level structure of the formed microcavities: less than 1 micron (nanoscale), 1-5 micron (microscale) and 20-40 microns (macro level).
  • the achievement of the specified technical result is achieved as a result of the implementation of the method of forming the surface of the dental implant, including bead blasting of the titanium implant with aluminum oxide and subsequent chemical etching, in which the chemical etching is carried out using an acid composition containing sulfuric and hydrochloric acids diluted in a 50% concentration, within 20 minutes at a temperature of the solution from 22 to 25 ° C and illumination from 0.25 to 0.4 lux and simultaneous exposure to ultrasound with a power of 45 7 to 50 7 erg / s.
  • titanium implants are used, made of technically pure titanium, for example, titanium of grades VT 1-0 and BT 1-00 (GOST 19807-91) or of “commercially pure” titanium of four grades (Grade 1-4 ASTM, ISO) or titanium alloy Ti-6AI-4V (ASTM, ISO), subjected to preliminary bead-blasting with aluminum oxide (Al 2 0 3 ).
  • titanium implants of Alpha BIO company (Israel) can be used. Preliminary shot blasting is necessary for texturing the titanium surface in preparation for etching to achieve the desired etching result. In this case, the roughness size, etching carried out after bead-blasting, and the subsequent ultrasonic washing do not affect the result of subsequent modification by the proposed method.
  • the titanium implant is placed in an ultrasonic bath, where it is etched in a mixture of hydrochloric (hydrochloric acid OSCH 20-4 GOST 14261-77, and 26-4 GOST 14261-77) and sulfuric acid (sulfuric acid OSCH 11-5 (very pure) GOST 14262-78 (mass fraction of the main substance 95.6%)) in equal proportions diluted with distilled water in a 50% concentration.
  • Etching is carried out within 20 minutes. at a temperature solution from 22 to 25 ° C and illumination from 0.25 to 0.4 lux (lux) and the simultaneous exposure to ultrasound with a power of 45 7 to 50 7 erg / s.
  • a modified implant surface is formed having a three-level structure of microcavities:
  • pores with a size range from 1-5 nm to 200 nm and a maximum in the region of 50 nm provide the ability to sorb proteins in larger quantities than known analogues, providing the induction of bone morphogenetic proteins necessary for osseointegration;
  • the implant surface formed by the proposed method provides the creation of optimal conditions for protein adhesion by forming the maximum possible surface area of the implant having a three-level structure of microcavities.
  • the set of characteristics inherent in the implant surface obtained by the proposed method provides its osteinductive and osteoconductive properties, which, in turn, ensures successful osseointegration of bone tissue during implantation. Since the retraction of a blood clot on a titanium implant occurs more slowly in the region of pores having a size of less than 1 micron, the retraction of the entire clot does not occur simultaneously, since the farther the clot is located from the wound surface, the weaker its retraction. This prevents the development of such complications as epithelial ingrowth and the formation of a bone pocket around the cervical part of the implant.
  • FIG. 1 micrographs of the implant surface formed by the method according to the invention, photo of the Microanalysis Laboratory of the Skolkovo Technopark:
  • Fig. 2 microphotographs of the surface of the implant obtained by Antozhir (Anthogyr), France: a) a 150-fold increase, b) a 500-fold increase, c) a 1000-fold increase, d) a 2,500-fold increase, e) - increase 10 4 , e) increase 4x10 4 , g) - increase 8x10 4 , h) - increase 5,000 times;
  • Fig. 5 is a micrograph of the NanoTec surface of the Alpha Bio Tes ATID implant (magnification 4x10 4 );
  • Fig. 6 is a photomicrograph of a Nobel Wüsage TiUnite surface (enlarged
  • Fig. 7 is a micrograph of the surface of the SLA of Straumann Wüsage (magnification 2x10 4 );
  • Fig. 8 shows the results of spectral analysis of the surface of an ATID implant
  • Fig. 9 shows the results of spectral analysis of the ICE implant surface
  • Fig. 10 shows the results of spectral analysis of the surface of an SPI implant
  • Fig. 11 shows the results of spectral analysis of the surface of a DFI implant
  • Fig. 12 shows the results of spectral analysis of the surface of a Mirell implant
  • Fig. 14 shows the results of spectral analysis of the surface of the SIN implant.
  • the implant surface obtained by the method according to the invention is more structured than the implant surfaces of known analogues.
  • Titanium implants were subjected to acid etching in a mixture of hydrochloric and sulfuric acids, mixed in equal proportions and diluted with distilled water in a 50% concentration. Etching was carried out for 20 minutes. at a solution temperature of 24 ° ⁇ and illumination of 0.4 lux with simultaneous exposure to ultrasound with a power of 50 7 erg / s.
  • a modified implant surface was formed having a three-level structure of microcavities (see Fig. 1).

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dentistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Mechanical Engineering (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne le domaine de la médecine et plus particulièrement de la stomatologie et peut être utilisée pour former la surface d'implants dentaires en titane pour assurer une intégration subséquente d'un implant dans le tissu osseux. A cet effet, on propose un procédé de formation de la surface d'un implant dentaire qui comprend le grenaillage d'un implant en titane avec de l'oxyde d'aluminium puis l'attaque chimique qui se distingue en ce que l'attaque chimique s'effectue au moyen d'une composition d'acide contenant des acides sulfurique et chlorhydrique dilués dans des proportions de 50 % de concentration pendant 20 min. à une température de la solution entre 22 et 25°C et une luminosité de 0,25 à 0,4 lx et une action simultanée des ultrasons à une puissance entre 457 et 507 erg/s. La surface de l'implant formée au moyen du procédé de l'invention permet de créer les conditions optimales pour l'adhérence des protéines grâce à la formation d'une surface maximale possible de l'implant et d'une structure à trois niveaux des micro-cavités qui se forment.
PCT/RU2015/000031 2015-01-21 2015-01-21 Implant en titane à surface poreuse et procédé de formation de cette dernière WO2016118038A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/RU2015/000031 WO2016118038A1 (fr) 2015-01-21 2015-01-21 Implant en titane à surface poreuse et procédé de formation de cette dernière

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PCT/RU2015/000031 WO2016118038A1 (fr) 2015-01-21 2015-01-21 Implant en titane à surface poreuse et procédé de formation de cette dernière

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WO2016118038A1 true WO2016118038A1 (fr) 2016-07-28

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11357600B2 (en) 2014-12-16 2022-06-14 Nobel Biocare Services Ag Dental implant

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2202984C1 (ru) * 2002-02-26 2003-04-27 Абдуллаев Фикрет Мавлудинович Стоматологический имплантат
US7144428B2 (en) * 2000-09-19 2006-12-05 Eduardo Aldecoa Anitua Method for surface treatment of implants or prosthesis made of titanium or other materials
EP2054093B1 (fr) * 2006-08-22 2012-11-21 Thommen Medical Ag Implant, notamment implant dentaire

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7144428B2 (en) * 2000-09-19 2006-12-05 Eduardo Aldecoa Anitua Method for surface treatment of implants or prosthesis made of titanium or other materials
RU2202984C1 (ru) * 2002-02-26 2003-04-27 Абдуллаев Фикрет Мавлудинович Стоматологический имплантат
EP2054093B1 (fr) * 2006-08-22 2012-11-21 Thommen Medical Ag Implant, notamment implant dentaire

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11357600B2 (en) 2014-12-16 2022-06-14 Nobel Biocare Services Ag Dental implant
US11918434B2 (en) 2014-12-16 2024-03-05 Nobel Biocare Services Ag Dental implant

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