WO2016108412A1 - Appareil d'analyse hématologique - Google Patents

Appareil d'analyse hématologique Download PDF

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Publication number
WO2016108412A1
WO2016108412A1 PCT/KR2015/011415 KR2015011415W WO2016108412A1 WO 2016108412 A1 WO2016108412 A1 WO 2016108412A1 KR 2015011415 W KR2015011415 W KR 2015011415W WO 2016108412 A1 WO2016108412 A1 WO 2016108412A1
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WO
WIPO (PCT)
Prior art keywords
blood
sample
dilution
module
analysis
Prior art date
Application number
PCT/KR2015/011415
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English (en)
Korean (ko)
Inventor
한경자
Original Assignee
가톨릭대학교 산학협력단
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Publication of WO2016108412A1 publication Critical patent/WO2016108412A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/06—Investigating concentration of particle suspensions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/06—Investigating concentration of particle suspensions
    • G01N15/0656—Investigating concentration of particle suspensions using electric, e.g. electrostatic methods or magnetic methods
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/39—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/012—Red blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/016—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/018—Platelets

Definitions

  • the present invention relates to a blood cell analysis device, and more particularly, to a blood cell analysis device having an improved structure to improve management efficiency such as blood analysis efficiency and quality control.
  • CBC Complete Blood Cell Count
  • the CBC test is one of the most basic blood tests with various clinical indications, from diagnosis, treatment and follow-up of the disease. This test can be used to identify information on three different types of cells (blood cells) in the blood: red blood cells, white blood cells, and platelets.
  • an automatic hematology analyzer (automatic hematology analyzer) that automatically measures the number of individual blood cells in a volume after proper dilution of blood is widely used.
  • Numerical information on blood cells can also be obtained by using a hemocytometer to measure cell numbers, but automated hemocytometers are more widely used because they can measure various indicators besides numerical information. .
  • the blood cell test apparatus according to the prior art as described above has used a plurality of devices (usually 5 or more) in a large hospital because the number of samples to be processed per one device is relatively small.
  • Quality control refers to all means of managing analytical values within a certain confidence range through statistical processing to ensure accuracy and precision of analytical results.
  • This quality control requires the same reliability of the analysis results of each device, and therefore requires the inspection of each device by using separate reagents on a daily basis or by using a patient sample.
  • the present invention has been made to solve the above problems, it is to provide a blood cell analysis device that can increase the efficiency of blood analysis efficiency and quality control at the same time.
  • Another object of the present invention is to provide a blood cell analysis device that can increase the space utilization efficiency.
  • the dilution module is mixed with the blood sample and the dilution for sample analysis;
  • a plurality of optical analysis modules for dividing and introducing the same sample sample extracted from the dilution module into a predetermined amount, respectively, and dividing and analyzing the sample sample with each optical analysis device;
  • a split inlet means for dividing the sample sample into the plurality of optical analysis modules.
  • the dilution module may include dilution tanks provided in a number corresponding to the optical analysis modules; A plurality of blood side connecting pipes for fluidly connecting the respective dilution tanks and the blood extraction needles so that the blood samples can be dividedly introduced into the dilution tanks; And a plurality of vacuum modules for introducing the blood sample into the blood-side connecting tube through the respective blood extraction needles.
  • the dividing inlet means connects each dilution tank and each optical analysis module to enable fluid flow and one-to-one correspondence so that the sample sample accommodated in each dilution tank can be divided into each optical analysis module and introduced. It is preferable to include a plurality of analysis-side connecting tube.
  • the dilution module comprises: a dilution tank of the single unit; A single unit blood side connecting tube for fluidly connecting the dilution tank and a single unit of blood extraction needle so that the blood sample can be dividedly introduced into the dilution tank; And a single unit vacuum module for allowing the blood sample to enter the blood side connecting tube through the blood extraction needle.
  • the dividing inlet means fluidly connects the dilution tank of each single unit and each optical analysis module so that the sample sample contained in the dilution tank of the single unit can be divided into the optical analysis modules and introduced. It is also possible to include a; a plurality of analysis side connecting pipe to be made.
  • the split inlet means is one connecting tube and the connecting tube connected to the dilution tank of the single unit so that the sample sample contained in the dilution tank of the single unit can be divided into each optical analysis module and introduced.
  • it may include a plurality of branch pipes branched from and connected to each optical analysis module.
  • the dilution module includes a plurality of dilution tanks; A plurality of blood side connecting pipes for fluidly connecting the dilution tank and the blood extraction needle of the single unit so that the blood sample can be divided into the dilution tank; A single unit vacuum module for introducing the blood sample into the blood side connecting tube through the blood extraction needle; And selective connection means for allowing the blood extraction needle of the single unit to be selectively connected to the plurality of blood side connection tubes.
  • the selective connecting means includes a solenoid valve configured to selectively communicate any one of the vacuum module of the single unit and the blood-side connecting tubes.
  • the optical analysis modules include an analysis tank radially arranged along the circumferential direction and the sample sample is introduced therein, and each optical analysis device includes light sources disposed on a central axis of the array of the analysis tanks. It is preferable to make.
  • each sample sample is introduced into the optical analysis module in the state divided by the split inflow means.
  • the analysis of blood can be performed by dividing the analysis time, thereby reducing the analysis time, thereby improving the efficiency of blood analysis, and by using a single device to test the use of multiple devices, quality control The benefits of improving the efficiency of the product are derived.
  • FIG. 1 is a block diagram of a blood cell analysis apparatus according to an embodiment of the present invention.
  • FIG. 2 is a view for explaining the configuration and operation principle of an embodiment of the present invention.
  • FIG. 3 is a view for explaining an example of the arrangement structure of an embodiment of the present invention.
  • FIG. 4 is a view for explaining the configuration and operating principle of the blood cell analysis apparatus according to another embodiment of the present invention.
  • FIG. 5 is a view for explaining the configuration and operating principle of the blood cell analysis apparatus according to another embodiment of the present invention.
  • FIG. 6 is a view for explaining the configuration and operating principle of the blood cell analysis apparatus according to another embodiment of the present invention.
  • FIG. 1 is a block diagram of a blood cell analysis apparatus according to an embodiment of the present invention
  • Figure 2 is a view for explaining the configuration and operation principle of an embodiment of the present invention
  • Figure 3 is an example of a layout structure of an embodiment of the present invention A diagram for explaining.
  • the blood cell analysis apparatus is used for the Complete Blood Cell Count (CBC) test, which is one of the methods for testing blood, and includes a dilution module 1 and an optical analysis module 2. And split inlet means.
  • CBC Complete Blood Cell Count
  • a specific diluent is used together for reasons of smoothness of analysis or efficiency of analysis, depending on a subject required for the analysis, ie, red blood cells, white blood cells, platelets, and the like.
  • a subject required for the analysis ie, red blood cells, white blood cells, platelets, and the like.
  • the specific diluent corresponds to a well-known material, further description thereof will be omitted.
  • the dilution module 1 is a portion in which a blood sample to be analyzed and a sample analysis diluent are mixed with each other, and as shown in FIG. 2, includes a dilution tank 11.
  • the dilution module 1 may be implemented in various ways, but in this embodiment, a plurality of dilution tanks 11 and blood-side connecting tubes 12 provided in a number corresponding to the optical analysis modules 2. And vacuum modules 14.
  • each of the dilution tanks 11 the same blood sample is divided into and flows through the plurality of blood extraction needles 13 and the blood side connection pipes 12 by the action of the respective vacuum modules 14, and the divided flows in this way.
  • the prepared blood sample, the sample sample (S) formed by mixing with the diluent of the dilution tank (11) is introduced into the plurality of optical analysis module (2).
  • the dilution module 1 employed in this embodiment includes dilution tanks 11 provided in a number corresponding to the optical analysis modules 2.
  • the same blood sample is divided into each of the dilution tanks 11, and the present embodiment includes a plurality of blood side connecting pipes 12 and a plurality of vacuum modules 14 to implement such a split inflow. Is done.
  • Each blood-side connection tube 12 connects each of the dilution tanks 11 and the blood extraction needles 13 so that fluid flow is possible, so that blood samples may be divided into each of the dilution tanks 11 and flow into the dilution tanks 11. do.
  • Each vacuum module 14 for example, by the selective opening and closing of the flow path by the solenoid valve, the blood sample can be introduced into each blood side connecting tube 12 through the blood extraction needle (13).
  • a blood sample that is analyzed is divided into a plurality of dilution modules 1 and flows into a plurality of sample samples (S). ) Are each introduced.
  • Each optical analysis module 2 includes an analysis tank 20 for analyzing the sample sample S.
  • the analysis tank 20 includes a sheath fluid in which the sample sample S is surrounded. It may be made to include a rapid forming portion 22 for forming the rapids 23 to be placed in the center of the "rapid") so that the cells are optically analyzed one by one.
  • the sample sample (S) is introduced into the analysis tank 20 in the course of the flow of the rapids 23, the sample sample (S) is sucked up with the rapids 23, and elongate thinly. As the blood cells of the sample sample S are aligned along the elongated direction, targeting of the blood cells by the optical analyzer 24 to be described later is smoothly performed.
  • the rapid flow 23 and the sample sample S are illustrated as being divided by the main body 21 to facilitate understanding, but the rapid flow 23 is in contact with the sample sample S. It will be said to be formed to surround the sample sample S in a state.
  • the sample sample S is irradiated by an optical analysis device such as a laser 24 after passing through the main body 21.
  • the optical analysis device employed in the optical analysis module 2 can be implemented in various ways, but the laser 24 is employed in this embodiment. As the sample sample S is irradiated with the laser 24, the analysis and counting of blood, particularly white blood cells, may be performed.
  • an optical analyzer 25 is provided on the opposite side of the laser 24 centering on the analysis tank.
  • the trajectory that reaches the optical analyzer 25 by refraction or the like after the laser 24 is irradiated to the sample sample S is illustrated as a straight line for convenience, but it is generally bent by about 15 degrees.
  • the plurality of optical analysis modules 2 are preferably arranged radially along the circumferential direction in order to increase the efficiency of space utilization.
  • the light source of each optical analysis device is arranged on the center axis of the arrangement of the analysis tanks 20 to enable optimization of space utilization.
  • the split inlet means for dividing the sample sample into each optical analysis module 2 can be implemented in various ways, as will be described later.
  • the respective dilution tanks 11 and each It is configured to include a plurality of analysis side connectors (3) connecting the analysis tank (20) fluidly and one-to-one correspondence.
  • the analysis side connecting pipe (3) is a method for implementing a hydraulic device such as a known fluid circuit, and the like, each sample sample (S) accommodated in each dilution tank (11) the optical analysis module (2) It acts as a mediator by dividing into.
  • the blood cell analysis apparatus having the above-described configuration divides and analyzes a specific blood sample into one piece of equipment and then collects the analysis values to complete analysis of the specific blood sample, and then re-creates another specific blood sample. By having a mechanism to analyze with the instrument, it is possible to further increase the analysis efficiency.
  • the blood cell analysis device comprising a dilution module 1, a plurality of optical analysis modules 2 and a split inlet means, the sample to be analyzed is divided into the dilution module 1 After being introduced, each sample sample (S) is separated by the split inlet means and then separately analyzed after entering the optical analysis module (2), so that the analysis of blood can be divided and performed.
  • the efficiency of quality control can be derived.
  • reference numeral 4 is a known resistance measuring means for measuring the size and number of blood cells in a manner using an electrical impedence, that is, an electrical resistance principle. It is common to use with the device.
  • FIG. 4 is a view for explaining the configuration and operating principle of the blood cell analysis apparatus according to another embodiment of the present invention.
  • the configuration of the dilution module 100 and the split inlet means is different from the above-described embodiment and thus has a difference in function.
  • the configuration for supplying and diluting blood is used as a single unit, and the structure in which the diluted sample sample is divided into the optical analysis module and adopted is adopted, and thus the configuration is simpler than that of the embodiment described above.
  • the dilution module 100 employed in the present embodiment includes a dilution tank of a single unit, a blood side connection pipe 120 of a single unit, and a vacuum module 140 of a single unit.
  • the plurality of analysis side connectors are formed.
  • a blood sample is extracted from one blood extraction needle 130 connected to a blood sample and mixed with the diluent through one dilution module 100, and then the mixed sample sample is mixed with each optical.
  • connection tube 301 is connected to the dilution tank of the single unit, and a plurality of branch tubes 302 are branched from the connection tube 301 and connected to each optical analysis module, thereby providing a sample. Allow the sample to be split and analyzed.
  • FIG. 6 is a view for explaining the configuration and operation principle of the blood cell analysis apparatus according to another embodiment of the present invention.
  • the embodiment shown in this figure has a structure in which the dilution module includes a plurality of dilution tanks 401 and a plurality of blood side connecting tubes 402, while the vacuum module 403 has a single unit adopted. .
  • the present embodiment includes a plurality of dilution tanks 401 and a plurality of blood side connecting tubes 402 to enable quick and accurate analysis of the sample sample, while simplifying the configuration of the blood sample supply side. While at the same time enabling rapid supply of blood samples.
  • the present embodiment includes a single unit of the vacuum module 403 for introducing a blood sample into the blood-side connecting tubes 402 through the blood extraction needle 405,
  • the blood extraction needle 405 of a single unit comprises an optional connecting means 406 for selectively connecting to the plurality of blood side connecting tubes 402.
  • the selective contact means for example, can be implemented in the same configuration as the solenoid valve 406, to enable a vacuum action by the vacuum module 403 on any one side of the plurality of blood side connection pipe 402. .
  • This selective connection means can further increase the supply efficiency of the blood sample to the dilution module side, thereby further increasing the blood analysis efficiency according to the present embodiment.

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  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Optics & Photonics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne un appareil d'analyse hématologique. Selon la présente invention, l'appareil d'analyse hématologique comprend : un module de dilution dans lequel un échantillon de sang et une solution de dilution pour analyse d'échantillon sont mélangés l'un avec l'autre ; une pluralité de modules d'analyse optique dans lesquels chacun des mêmes échantillons extraits du module de dilution s'écoulent de manière divisée selon une quantité prédéterminée, et qui analysent de manière divisée les échantillons avec des dispositifs d'analyse optique respectifs ; et des moyens de division et d'écoulement d'entrée pour amener les échantillons à s'écouler de manière divisée dans une pluralité des modules d'analyse optique.
PCT/KR2015/011415 2014-12-29 2015-10-28 Appareil d'analyse hématologique WO2016108412A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2014-0191993 2014-12-29
KR1020140191993A KR101628578B1 (ko) 2014-12-29 2014-12-29 혈구 분석 장치

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KR101895760B1 (ko) * 2016-06-27 2018-09-06 (주)뉴옵틱스 혈구 분석 시스템 및 그의 제어방법
KR20230172221A (ko) 2022-06-15 2023-12-22 엔트온(주) 유체분석키트와 이를 이용한 유체분석측정기
KR20240072749A (ko) 2022-11-17 2024-05-24 엔트온(주) 유체분석기

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06148057A (ja) * 1992-11-02 1994-05-27 Hitachi Ltd 微粒子計測方法および装置
WO2003069421A2 (fr) * 2002-02-14 2003-08-21 Immunivest Corporation Procedes et algorithmes pour le comptage de cellules dans un cytometre peu onereux
JP2010243503A (ja) * 1998-10-15 2010-10-28 Particle Sizing Systems Inc 高分解能粒度分析を行うための自動希釈システム
JP2012068233A (ja) * 2010-08-25 2012-04-05 Arkray Inc 分析装置および分析方法
JP5248309B2 (ja) * 2005-03-31 2013-07-31 セドゥー ディアグノスチックス 血液分析用の光学装置、斯る装置を備えた分析装置

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06148057A (ja) * 1992-11-02 1994-05-27 Hitachi Ltd 微粒子計測方法および装置
JP2010243503A (ja) * 1998-10-15 2010-10-28 Particle Sizing Systems Inc 高分解能粒度分析を行うための自動希釈システム
WO2003069421A2 (fr) * 2002-02-14 2003-08-21 Immunivest Corporation Procedes et algorithmes pour le comptage de cellules dans un cytometre peu onereux
JP5248309B2 (ja) * 2005-03-31 2013-07-31 セドゥー ディアグノスチックス 血液分析用の光学装置、斯る装置を備えた分析装置
JP2012068233A (ja) * 2010-08-25 2012-04-05 Arkray Inc 分析装置および分析方法

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