WO2016063265A3 - Formulação tópica para o tratamento de infeções na pele ou mucosas, método de preparação e seus usos - Google Patents
Formulação tópica para o tratamento de infeções na pele ou mucosas, método de preparação e seus usos Download PDFInfo
- Publication number
- WO2016063265A3 WO2016063265A3 PCT/IB2015/058245 IB2015058245W WO2016063265A3 WO 2016063265 A3 WO2016063265 A3 WO 2016063265A3 IB 2015058245 W IB2015058245 W IB 2015058245W WO 2016063265 A3 WO2016063265 A3 WO 2016063265A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- skin
- treating
- infections
- mucosae
- bromelain
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/22—Cysteine endopeptidases (3.4.22)
- C12Y304/22033—Fruit bromelain (3.4.22.33), i.e. juice bromelain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A61L2300/254—Enzymes, proenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Inorganic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A presente divulgação insere-se no domínio da terapêutica de infeções na pele ou suas mucosas e diz respeito ao uso da bromelaína isolada ou com agentes antimicrobianos para inibir, reduzir ou tratar biofilmes em infeções derivadas da presença deste mecanismo de patogenicidade. Esta aplicação pretende usufruir da ação enzimática da bromelaína para destruir os biofilmes e permitir a penetração dos antifúngicos, potenciando, deste modo, a sua ação local no foco da infeção, tratando e reduzindo os sintomas. A presente divulgação pode ser utilizada na área farmacêutica para o tratamento de infeções, em cremes, loções, géis, ou ampolas para a aplicação local na pele ou mucosas. Foram desenvolvidas formulações com capacidade de manter a estabilidade da enzima e dos restantes componentes ativos com boas características para aplicação na pele ou mucosas, em particular a vagina, promovendo, deste modo, a eficácia e a aceitabilidade do produto final.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15/521,403 US20170304411A1 (en) | 2014-10-24 | 2015-10-26 | Topical formulation for treating skin or mucosal infections, preparation method and uses thereof |
EP15805257.1A EP3210619A2 (en) | 2014-10-24 | 2015-10-26 | Topical formulation for treating skin or mucosal infections, preparation method and uses thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PT108004 | 2014-10-24 | ||
PT10800414 | 2014-10-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2016063265A2 WO2016063265A2 (pt) | 2016-04-28 |
WO2016063265A3 true WO2016063265A3 (pt) | 2016-06-16 |
Family
ID=54783955
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2015/058245 WO2016063265A2 (pt) | 2014-10-24 | 2015-10-26 | Formulação tópica para o tratamento de infeções na pele ou mucosas, método de preparação e seus usos |
Country Status (3)
Country | Link |
---|---|
US (1) | US20170304411A1 (pt) |
EP (1) | EP3210619A2 (pt) |
WO (1) | WO2016063265A2 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112021022632A2 (pt) * | 2019-05-10 | 2022-01-04 | Locus Ip Co Llc | Composições e métodos para tratar condições pulmonares relacionadas a biofilmes |
JP7428842B1 (ja) | 2023-03-29 | 2024-02-06 | artience株式会社 | 活性エネルギー線硬化型インキ、その製造方法、および印刷物 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0358500A1 (en) * | 1988-09-08 | 1990-03-14 | The Public Health Laboratory Service Board | Method and composition for the treatment and prevention of viral infections |
WO1995023614A1 (en) * | 1994-03-01 | 1995-09-08 | E.R. Squibb & Sons, Inc. | Enzymatic debridement compositions and methods |
US5560910A (en) * | 1994-08-26 | 1996-10-01 | Crandall; Wilson T. | Topical anti-inflammatory composition and method |
US20040151716A1 (en) * | 2003-02-03 | 2004-08-05 | Hamer Richard A. | Material and method for treating microbial mediated dermatological conditions |
US20070275045A1 (en) * | 2006-02-28 | 2007-11-29 | Evans Robin D | Composition for the treatment of warts and molluscum contagiosum |
US20110182874A1 (en) * | 2009-11-23 | 2011-07-28 | Prothera, Inc. | Compositions and methods comprising serratia peptidase for inhibition and treatment of biofilms related to certain conditions |
US20110243918A1 (en) * | 2009-08-25 | 2011-10-06 | Thornton Joseph P | Topical medication for the treatment of hemorrhoids and method of use |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4361551A (en) * | 1979-11-05 | 1982-11-30 | Riker Laboratories, Inc. | Method of enzymatic debridement |
US5939090A (en) * | 1996-12-03 | 1999-08-17 | 3M Innovative Properties Company | Gel formulations for topical drug delivery |
US7241456B2 (en) * | 2002-10-25 | 2007-07-10 | Australian Importers Ltd. | Formulations for topical delivery of bioactive substances and methods for their use |
US20050281806A1 (en) * | 2004-06-16 | 2005-12-22 | Collegium Pharmaceutical, Inc., Delaware | Compositions for topical enzymatic debridement |
JP5782603B2 (ja) * | 2008-10-30 | 2015-09-24 | クリーンウェル,リミティド ライアビリティ カンパニー | 抗菌発泡性石鹸 |
US8557237B2 (en) * | 2009-01-13 | 2013-10-15 | Mindfulnessfyb, Inc. | Crème comprising encapsulated bromelain for the skin, specifically for inhibiting ingrown hair |
WO2012049544A1 (en) * | 2010-10-15 | 2012-04-19 | Sulur Subramaniam Vanangamudi | A medicinal fusidic acid cream made using sodium fusidate and incorporating a biopolymer, a hydrocortisone acetate as a corticosteroid, and clotrimazole as an antifungal agent, and a process to make it |
PL2734216T3 (pl) * | 2011-07-20 | 2018-12-31 | Mediwound, Ltd. | Ekstrakt proteolityczny z bromelainy do leczenia schorzeń tkanki łącznej |
-
2015
- 2015-10-26 EP EP15805257.1A patent/EP3210619A2/en not_active Withdrawn
- 2015-10-26 WO PCT/IB2015/058245 patent/WO2016063265A2/pt active Application Filing
- 2015-10-26 US US15/521,403 patent/US20170304411A1/en not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0358500A1 (en) * | 1988-09-08 | 1990-03-14 | The Public Health Laboratory Service Board | Method and composition for the treatment and prevention of viral infections |
WO1995023614A1 (en) * | 1994-03-01 | 1995-09-08 | E.R. Squibb & Sons, Inc. | Enzymatic debridement compositions and methods |
US5560910A (en) * | 1994-08-26 | 1996-10-01 | Crandall; Wilson T. | Topical anti-inflammatory composition and method |
US20040151716A1 (en) * | 2003-02-03 | 2004-08-05 | Hamer Richard A. | Material and method for treating microbial mediated dermatological conditions |
US20070275045A1 (en) * | 2006-02-28 | 2007-11-29 | Evans Robin D | Composition for the treatment of warts and molluscum contagiosum |
US20110243918A1 (en) * | 2009-08-25 | 2011-10-06 | Thornton Joseph P | Topical medication for the treatment of hemorrhoids and method of use |
US20110182874A1 (en) * | 2009-11-23 | 2011-07-28 | Prothera, Inc. | Compositions and methods comprising serratia peptidase for inhibition and treatment of biofilms related to certain conditions |
Non-Patent Citations (3)
Title |
---|
NGUYEN UYEN T ET AL: "DNase I and proteinase K impair Listeria monocytogenes biofilm formation and induce dispersal of pre-existing biofilms", INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, ELSEVIER BV, NL, vol. 187, 4 July 2014 (2014-07-04), pages 26 - 32, XP029013073, ISSN: 0168-1605, DOI: 10.1016/J.IJFOODMICRO.2014.06.025 * |
PAVAN RAJENDRA ET AL: "Properties and therapeutic application of bromelain: a review.", BIOTECHNOLOGY RESEARCH INTERNATIONAL 2012, vol. 2012, 976203, 2012, pages 1 - 6, XP002753417, ISSN: 2090-3146, DOI: 10.1155/2012/976203 * |
SILVA JULIANA ET AL: "Antifungal activity of bromelain in Candida pre-formed biofilms", ANTIMICROBIAL RESEARCH - ICAR2012, LISBON (PORTUGAL) 21-23 NOVEMBER 2012, THE BOOK OF ABSTRACTS: PAGE 272, November 2012 (2012-11-01), pages 272, XP055244889 * |
Also Published As
Publication number | Publication date |
---|---|
EP3210619A2 (en) | 2017-08-30 |
US20170304411A1 (en) | 2017-10-26 |
WO2016063265A2 (pt) | 2016-04-28 |
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