WO2016061210A3 - Novel viruses found in rattus norvegicus and uses thereof - Google Patents

Novel viruses found in rattus norvegicus and uses thereof Download PDF

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Publication number
WO2016061210A3
WO2016061210A3 PCT/US2015/055510 US2015055510W WO2016061210A3 WO 2016061210 A3 WO2016061210 A3 WO 2016061210A3 US 2015055510 W US2015055510 W US 2015055510W WO 2016061210 A3 WO2016061210 A3 WO 2016061210A3
Authority
WO
WIPO (PCT)
Prior art keywords
nrhv
rattus norvegicus
found
animal
rhv
Prior art date
Application number
PCT/US2015/055510
Other languages
French (fr)
Other versions
WO2016061210A2 (en
Inventor
W. Ian Lipkin
Amit Kapoor
Meera BHAT
Cadhla FIRTH
Phenix-Lan QUAN
Original Assignee
The Trustees Of Columbia University In The City Of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Trustees Of Columbia University In The City Of New York filed Critical The Trustees Of Columbia University In The City Of New York
Publication of WO2016061210A2 publication Critical patent/WO2016061210A2/en
Publication of WO2016061210A3 publication Critical patent/WO2016061210A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24221—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention is directed to novel hepatotropic hepaciviruses isolated in Norway rats (Rattus norvegicus), designated NrHV-1 or RHV-rn-NY01 and NrHV-2 or RHV-rn-NY02, and isolated nucleic acids sequences and polypeptides thereof. The invention also relates to antibodies against antigens from NrHV- 1 or NrHV-2 found in Rattus norvegicus. The invention also relates to iRNAs which target nucleic acid sequences of NrHV- 1 or NrHV-2 found in Rattus norvegicus. The invention is related to methods for detecting the presence or absence of NrHV-1 or NrHV-2 found in Rattus norvegicus in an animal. The invention is also related to immunogenic compositions for inducing an immune response against NrHV-1 or NrHV-2 in an animal. The invention is also related to a cell culture system and a laboratory animal to model human hepatitis C virus (HCV).
PCT/US2015/055510 2014-10-14 2015-10-14 Novel viruses found in rattus norvegicus and uses thereof WO2016061210A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462063780P 2014-10-14 2014-10-14
US62/063,780 2014-10-14

Publications (2)

Publication Number Publication Date
WO2016061210A2 WO2016061210A2 (en) 2016-04-21
WO2016061210A3 true WO2016061210A3 (en) 2016-05-12

Family

ID=55747546

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/055510 WO2016061210A2 (en) 2014-10-14 2015-10-14 Novel viruses found in rattus norvegicus and uses thereof

Country Status (1)

Country Link
WO (1) WO2016061210A2 (en)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020119447A1 (en) * 1994-02-14 2002-08-29 John N. Simons Non-a,non-b,non-c,non-c,non-d,non-e hepatitis reagents and methods for their use
US7244585B1 (en) * 1999-06-04 2007-07-17 The Board Of Regents Of The University Of Texas System 3′ Sequence of the GB virus B (GBV-B) genome
US20070214517A1 (en) * 2004-02-13 2007-09-13 Ceres, Inc. Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
US7473772B2 (en) * 2002-07-03 2009-01-06 The Board Of Regents Of The University Of Texas System Chimeric GB virus B (GBV-B)
US20110289610A1 (en) * 2008-07-15 2011-11-24 Noboru Maki Hcv/gbv-b chimeric virus
US20120159672A1 (en) * 2004-02-06 2012-06-21 Nickolai Alexandrov Sequence-determined DNA fragments and corresponding polypeptides encoded thereby

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020119447A1 (en) * 1994-02-14 2002-08-29 John N. Simons Non-a,non-b,non-c,non-c,non-d,non-e hepatitis reagents and methods for their use
US7244585B1 (en) * 1999-06-04 2007-07-17 The Board Of Regents Of The University Of Texas System 3′ Sequence of the GB virus B (GBV-B) genome
US7473772B2 (en) * 2002-07-03 2009-01-06 The Board Of Regents Of The University Of Texas System Chimeric GB virus B (GBV-B)
US20120159672A1 (en) * 2004-02-06 2012-06-21 Nickolai Alexandrov Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
US20070214517A1 (en) * 2004-02-13 2007-09-13 Ceres, Inc. Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
US20110289610A1 (en) * 2008-07-15 2011-11-24 Noboru Maki Hcv/gbv-b chimeric virus

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DREXLER, JF ET AL.: "Evidence for Novel Hepaciviruses in Rodents.", PLOS PATHOGENS., vol. 9, no. 6, 20 June 2013 (2013-06-20), pages e1003438-1 - e1003438-1, XP055279324 *
FIRTH, C ET AL.: "Detection of Zoonotic Pathogens and Characterization of Novel Viruses Carried by Commensal Rattus norvegicus in New York City.", MBIO., vol. 5, no. 5, 14 October 2014 (2014-10-14), pages e01933 - 14, XP055279327 *
KAPOOR, A ET AL.: "Identification of Rodent Homologs of Hepatitis C Virus and Pegiviruses.", MBIO., vol. 4, no. 2, 9 April 2013 (2013-04-09), pages e00216-1 - 13, XP055279314 *

Also Published As

Publication number Publication date
WO2016061210A2 (en) 2016-04-21

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