WO2016037698A1 - Antioxidant food composition in gel form - Google Patents

Antioxidant food composition in gel form Download PDF

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Publication number
WO2016037698A1
WO2016037698A1 PCT/EP2015/001807 EP2015001807W WO2016037698A1 WO 2016037698 A1 WO2016037698 A1 WO 2016037698A1 EP 2015001807 W EP2015001807 W EP 2015001807W WO 2016037698 A1 WO2016037698 A1 WO 2016037698A1
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extract
composition according
content
composition
pomegranate
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PCT/EP2015/001807
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French (fr)
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Constant THOMAOGLOU
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Thomaoglou Constant
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Publication of WO2016037698A1 publication Critical patent/WO2016037698A1/en

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/231—Pectin; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention relates to the field of cancer prevention and, more specifically, to a specific gel composition for oral administration.
  • Cancer is a disease characterized by an abnormally large cell proliferation (tumor) within a normal tissue of the body, in such a way that the survival of the latter, comes from it. to be threatened.
  • the cells of this tumor generally derive from the same clone; which clone is comparable to the cancer initiating cell which has acquired certain characteristics allowing it to divide indefinitely.
  • metastases some tumor cells are likely to migrate into the body and thus form what is called metastases.
  • Cancer is a general term for a disease for which certain cells of an organism exhibit abnormal behavior characterized by:
  • Cells associated with cancer are referred to as "cancerous” or “tumoral” and can form a malignant tumor (a neoplasm) or spread through the body.
  • the risk factors for cancer are multiple and can be internal (familial, spontaneous mutation, etc.), and / or external (diet, exposure to infectious agents or carcinogens or conditions such as irradiation, etc. .).
  • FIREPLACE REMPLACEMENT (RULE 26) If the impact of internal factors is not negligible, especially with hormonal or epigenetic factors; scientific studies associate only 5 to 10% of cancer cases with genetic factors, 25 to 30% for smoking, 30 to 35% for diets (including alcohol), 15 to 20% for infections, and 10 to 25% to other factors (ionizing radiation, stress, physical activity, environmental pollution).
  • Fruit and vegetable consumption has been shown to have a protective effect on cancers of the upper aerodigestive tract (esophagus, oral cavity, larynx and pharynx), cancers of the stomach and lungs (for fruits only). It should also be noted that fruits and vegetables, which are low in calories, contribute to the maintenance of normal body weight and the prevention of overweight and obesity.
  • the inventors have now developed a food composition in gel form, which comprises at least:
  • the inventors have been able to demonstrate that such a food composition, intended for oral intake, despite its very high antioxidant content could be in the form of a gel.
  • the inventors have observed that because of its gelled form, the bioavailability of curcumin present in the composition is significantly improved.
  • FIRE REPLACEM ENT (RULE 26) which daily intake is obviously necessary to produce its preventive effects over time.
  • turmeric (Curcuma longa) is a perennial rhizomatous herbaceous plant of the genus Turmeric of the family Zingiberaceae native to southern Asia. He has been known in the West since ancient times and described by Dioscorides in his Materia Medica.
  • Turmeric is recognized in the West for its antioxidant properties by which it helps the body fight against stress and maintain the effectiveness of natural defenses. It has also been used for a very long time as an anti-inflammatory by Indian Ayurvedic medicine and is probably the strongest natural anti-inflammatory identified to date.
  • curcumin The active ingredient of turmeric, curcumin, is thus the subject of active research. This molecule is able to inhibit in vitro the growth of a very large number of xancers: colon, liver, stomach, ovaries, breast, leukemia among others.
  • the extract used turmeric corresponds to the rhizome of the latter which comprises from 0.5 to 3% by weight of curcominoids distributed between curcumin (0.4 to 2.2%), demethoxycurcumin (0, 1 to 1% ).
  • the content of the composition according to the invention in extract of turmeric rhizome is between 1 and 3%, preferably between 1.5 and 2%.
  • the Japanese Sophora or Styphnolobium japonicum, is a tree species of the family Fabaceae.
  • the flower of the latter has the particularity to include flavonoids in quantity, which consist mainly of quercetin, rutin, isorhamnetin
  • FLEI LLE OF REM PLACEM ENT (REG 26) and kaempferol.
  • One of the first benefits of these molecules is their antioxidant activity, able to neutralize free radicals responsible for part of the aging and alteration of the body.
  • the Sophora flower from Japan has the advantage of containing up to 15 to 20% rutin.
  • the content of the composition according to the invention in Sophora flower extract from Japan is between 1 and 3%, preferably between 1.5 and 2%.
  • Pomegranate is the fruit of the pomegranate tree, Punica granat, which belongs to the family Lythraceae and is found over a wide geographical area stretching from western Asia to central Asia. . The latter is thus a good source of dietary fiber, folate, and also a very good source of: vitamin C.
  • the pomegranate aril contains in addition flavanols (or catechins) and; flavanol dimers (procyanidols), as well as a large number of particularly effective polyphenols, to which presumably its beneficial effects on health can be attributed.
  • the content of the composition according to the invention in pomegranate extract is between 2 and 10%, preferably between 3 and 7%, or between 4 and 6%.
  • this pomegranate extract we prefer to use pomegranate juice.
  • the tea tree also called tea, like the infusion of its leaves, is a species of shrubs from the family of theaeeae. It is native to the Far East and is widely grown for its leaves which, once dried and more or less oxidized, are used for the preparation by infusion of this essential drink.
  • Green tea is a particular variety of tea related to the preparation of tea leaves once harvested. Green tea is in fact a tea with very little oxidation during its manufacture, which allows to keep intact its properties.
  • green tea The properties of green tea are multiple: rich in tannins, it is these antioxidant polyphenols that give tea its aroma and bitter taste. Green tea also contains vitamin C. But what sets green tea apart is
  • FIRE I LLE OF REM PLACEM ENT (RULE 26) it contains a catechin called epigallocatechin EPGC or epigallocatechin-3-gallate (EGCG).
  • EPGC has properties far more powerful than those of a simple antioxidant.
  • Green tea (green because unfermented) contains ten times more EPGC than black tea and 2.5 times more than Oolong tea.
  • caffeine theine
  • Tea also contains teaanne, a glutamate-like amino acid that has a soothing effect that inhibits the caffeine's hypertensive effect.
  • the content of the composition according to the invention in green tea extract is between 1 and 5%, preferably between 2 and 4%, or between 2.5 and 3%.
  • a liquid green tea extract preferably a concentrated green tea extract which will comprise from 15 to 45% of dry matter, preferably from 25 to 35% by weight. dry matter.
  • the one that is cultivated is a perennial monocotyledonous vegetable plant whose bulbs, with an odor and a strong taste, are often used as a condiment in cooking.
  • a head of garlic is made up of several garlic cloves or garlic:
  • Various studies show that regular consumption of a clove of garlic (3 g) per day would reduce by half the risk of cancer of the stomach, colon and rectum. This action would result in particular from the alliine, which is a sulfoxide and which is a derivative of cysteine.
  • the alliinase enzyme When fresh garlic is crushed or chopped, this alliin is converted by the alliinase enzyme into allicin which is responsible for the aroma of fresh garlic.
  • the content of the composition according to the invention in garlic bulb extract is between 0.01 and 0.5%, preferably between 0.01 and 0.05%.
  • the content of the composition according to the invention in broccoli extract is between 1 and 5%, preferably between 2 and 4%, or between 2.5 and 3%.
  • this broccoli extract it will be preferred to use a dry extract, and especially an atomized extract.
  • this atomized extract comprises particles having a diameter of less than 1 ⁇ .
  • Vitamin B 6 is involved in the metabolism of homocysteine whose deficiency causes a significant decrease in tone. In connection with the nervous system, vitamin B 6 also participates in the biosynthesis of serotonin and its recommended daily intake (RDA) is 1.4 mg according to the directive 2008/100 / CE.
  • RDA recommended daily intake
  • the composition according to the invention has a vitamin B 6 content is between 0.01 and 0.05%, preferably between 0.01 and 0.03%. This proportion is adapted so that the setting of the composition according to the invention is close to the AJR without risking (too) exceed it.
  • “Gelling agent” means an agent which makes it possible to give the composition according to the invention the consistency of a gel.
  • Such agents are well known to those skilled in the art and include gum arabic (or gum acacia), xanthan gum, gelatin, pectin, alginates, carrageenans, or agar agar.
  • the content of gelling agent of the composition according to the invention is dependent on the gelling agent used and can be simply adapted by those skilled in the art. It is typically greater than 0.1%, 0.5% and less than 10% or 5%.
  • composition according to the invention may further comprise different constituents with antioxidant or stimulating properties.
  • selenium which belongs to the family of chalcogenes, of symbol Se and atomic number 34 is preferably added to the latter.
  • Selenium is a trace element constituting selenoproteins including the intracellular principaDantioxidant, glutathione peroxidase. It is found in kidneys of pork, beef, garlic, fish and molluscs. Western nutrition largely meets the daily needs of this element, but it is impossible to predict body levels of selenium from dietary intake because its use and retention are dependent on the presence of folic acid, vitamin B12 and negatively affected by the presence of homocysteine.
  • the selenium used will be in the form of a yeast extract (eg Saccharomyces cerevisiae) enriched in selenium. This enrichment corresponds to a concentration of the order of 1500 to 3000 g of selenium per gram of extract.
  • yeast extract eg Saccharomyces cerevisiae
  • selenium present in this extract is in the form of seleniomethionine and is in the form of a dry extract.
  • the content of the composition according to the invention has a content of yeast extract enriched with selenium between between 0.1 and 0.5%, preferably between 0.1 and 0.3%.
  • composition according to the invention will further preferably comprise vitamin B 9 which is essential for limiting cognitive decline and for preventing the onset of age-related pathologies such as Alzheimer's disease.
  • the recommended daily intake (AIR) of vitamin B is 200 ⁇ g according to Directive 2008/100 / EC.
  • the composition according to the invention has a vitamin B 9 content between 0.001 and 0.005%, preferably between 0.001 and 0.003%. This proportion is adapted so that the setting of the composition according to the invention is close to the AIR without risking to (excessively) exceed it.
  • the composition according to the invention may furthermore comprise acidifiers, among which citric acid.
  • the acidifying content of the composition according to the invention may reach 2%, but will preferably be less than or equal to 1%.
  • composition according to the invention may comprise at least one sweetener.
  • sweeteners include, among others, sucralose, stevia extract, xylitol, aspartame, glucose syrup, fructooligosaccharide syrup, maltitol powder or syrup, acesulfame potassium, fructooligosaccharide and sodium cyclamate.
  • composition according to the invention will also comprise at least one preservative.
  • preservatives mention may be made of potassium sorbate, sodium benzoate or ascorbyl palmitate (antioxidant).
  • composition according to the invention may comprise a texturing agent such as glycerine.
  • a second subject of the invention relates to a pod containing the composition in gel form according to the invention.
  • the user can simply consume the required dose and, if desired, combine or dissolve in a glass of water.
  • a third object according to the invention corresponds to the use of a composition as described above for the prevention of pathologies associated with oxidative damage due to free radicals, such as cancers, in a subject.
  • cancer oral cancer or cancer of the digestive tract is preferably meant.

Abstract

The present invention relates to a food composition in gel form including at least a turmeric rhizome extract, a Sophora japonica flower extract, a pomegranate extract, a green tea extract, a garlic bulb extract, a broccoli extract, vitamin B6 and a gelling agent. The invention also relates to a capsule including a composition of this kind in gel form and to the use of a composition of this kind for preventing diseases associated with oxidative damage due to free radicals such as cancers.

Description

COMPOSITION ALIMENTAIRE ANTIOXYDANTE SOUS FORME DE GEL ANTIOXIDIZING FOOD COMPOSITION IN THE FORM OF GEL
La présente demande internationale revendique la priorité de la demande de brevet Français FR 14/02031 déposée en date du 11 septembre 2015 et dont le contenu est incorporée à celui de la présente demande internationale par référence. The present international application claims the priority of the French patent application FR 14/02031 filed on September 11, 2015 and the contents of which are incorporated in the present international application by reference.
Domaine de L'invention  Field of the invention
La présente invention concerne le domaine de la prévention du cancer et, plus spécifiquement, une composition sous forme de gel spécifique et destinée à une prise orale.  The present invention relates to the field of cancer prevention and, more specifically, to a specific gel composition for oral administration.
Art antérieur de l'invention  Prior art of the invention
Le cancer est une maladie caractérisée par une prolifération cellulaire (tumeur) Anormalement importante au sein d'un tissu normal de l'organisme, de telle manière que la survie de ce dernier, en vient . à être menacée. Les cellules de cette tumeur dérivent en général toutes d'un même clone ; lequel clone est assimilable à la cellule initiatrice de cancer qui a acquis certaines caractéristiques lui permettant de se diviser indéfiniment. En fonction de l'évolution de la maladie, certaines cellules tumorales sont susceptibles de migrer dans l'organisme et de former ainsi ce que l'on appelle des métastases.  Cancer is a disease characterized by an abnormally large cell proliferation (tumor) within a normal tissue of the body, in such a way that the survival of the latter, comes from it. to be threatened. The cells of this tumor generally derive from the same clone; which clone is comparable to the cancer initiating cell which has acquired certain characteristics allowing it to divide indefinitely. Depending on the evolution of the disease, some tumor cells are likely to migrate into the body and thus form what is called metastases.
Le terme « Cancer » est un terme général qui désigne une maladie pour lesquelles certaines cellules d'un organisme adoptent un comportement anormal caractérisé par :  The term "Cancer" is a general term for a disease for which certain cells of an organism exhibit abnormal behavior characterized by:
• une capacité proliférative qui n'est plus limitée (croissance à l'infini) ; • a proliferative capacity that is no longer limited (growth to infinity);
• la disparition du phénomène d'apoptose (mort cellulaire); • the disappearance of the phenomenon of apoptosis (cell death);
• et l'acquisition d'un pouvoir invasif et de production de métastases.  • and the acquisition of invasive power and the production of metastases.
Les cellules associées à un cancer sont qualifiées de « cancéreuses » ou « tumorales » et elles peuvent former une tumeur maligne (un néoplasme) ou se propager à travers le corps.  Cells associated with cancer are referred to as "cancerous" or "tumoral" and can form a malignant tumor (a neoplasm) or spread through the body.
Les facteurs de risques au cancer sont multiples et peuvent être internes (familial, mutation spontanée, etc.), et/ou externes (alimentation, exposition à des agents infectieux ou à des substances cancérigènes ou à des conditions telles que l'irradiation, etc.).  The risk factors for cancer are multiple and can be internal (familial, spontaneous mutation, etc.), and / or external (diet, exposure to infectious agents or carcinogens or conditions such as irradiation, etc. .).
FEU I LLE DE REM PLACEMENT (RÈG LE 26) Si l'impact des facteurs internes n'est pas négligeable, avec notamment dés facteurs hormonaux ou épigénétiques ; des études scientifiques n'associent que 5 à 10 % des cas de cancer à des facteurs génétiques contre 25 à 30 % au tabagisme, 30 à 35 % aux régimes alimentaires (dont l'alcool), 15 à 20 % aux infections, et 10 à 25 % aux autres facteurs (rayons ionisants, stress, activités physique, pollution de l'environnement). FIREPLACE REMPLACEMENT (RULE 26) If the impact of internal factors is not negligible, especially with hormonal or epigenetic factors; scientific studies associate only 5 to 10% of cancer cases with genetic factors, 25 to 30% for smoking, 30 to 35% for diets (including alcohol), 15 to 20% for infections, and 10 to 25% to other factors (ionizing radiation, stress, physical activity, environmental pollution).
Durant la dernière décennie, plusieurs types de cancers semblent en augmentation, si dans certains cas cette progression est facilement liée à des facteurs de risqué identifiés (tabac, alcool, polluants industriels reconnus cancérigènes, obésité,, sédentarité, exposition au soleil) dans certains cas il est difficile d'attribuer à des facteurs précis l'augmentation observée. L'amélioration des outils de diagnostic et le vieillissement de la population expliquent une part importante de la progression de l'incidence de certains cancers. À l'inverse une étude de l'Institut de veille sanitaire montre que les cancers.de l'estomac, de l'œsophage (chez l'homme), du col de l'utérus et le lymphome hodgkinien ont régressé entre 1980 et 2000.  During the last decade, several types of cancers seem to be increasing, if in some cases this progression is easily linked to identified risk factors (tobacco, alcohol, recognized carcinogenic industrial pollutants, obesity, inactivity, sun exposure) in certain cases. it is difficult to attribute the observed increase to specific factors. The improvement of diagnostic tools and the aging of the population explain a large part of the increase in the incidence of certain cancers. Conversely, a study conducted by the French Institute for Public Health Surveillance shows that cancers of the stomach, esophagus (in humans), the cervix and Hodgkin's lymphoma have declined between 1980 and 2000 .
La doublé prise de conscience actuelle de cette forte incidence du cancer associée à notre mode de vie moderne ont amené à une réflexion visant à adapter notre mode de vie en vue de mieux se prémunir contre cette maladie.  The current double awareness of this high incidence of cancer associated with our modern lifestyle has led to a reflection to adapt our way of life to better guard against this disease.
Ces dernières années, il est apparu que le cancer, ou tout du moins certains cancers, touchait avec une moindre incidence certaines sous-populations. Si cette moindre sensibilité a pu parfois s'expliquer par des causes internes (génétiques), des causes externes et notamment alimentaires l'ont parfois expliquées.  In recent years, it has become apparent that cancer, or at least some cancers, has a lower incidence of certain sub-populations. Although this lesser sensitivity could sometimes be explained by internal (genetic) causes, external and especially food causes have sometimes explained it.
Il est ainsi apparu que la consommation de fruits et légumes exerce un effet protecteur probable sur les cancers des voies aérodigestives supérieures (œsophage, cavité buccale, larynx et pharynx), les cancers de l'estomac et du poumon (pour les fruits seulement). A noter en outre que, les fruits et légumes, faibles en calories, participent au maintien d'un poids corporel normal et à la prévention du surpoids et de l'obésité.  Fruit and vegetable consumption has been shown to have a protective effect on cancers of the upper aerodigestive tract (esophagus, oral cavity, larynx and pharynx), cancers of the stomach and lungs (for fruits only). It should also be noted that fruits and vegetables, which are low in calories, contribute to the maintenance of normal body weight and the prevention of overweight and obesity.
En outre, il est apparu qu'une alimentation riche en fibres (céréales complètes, fruits, légumes, légumineuses) étaient associée à un moindre risque de développer un cancer colorectal (niveau de preuve probable).  In addition, it was found that a diet high in fiber (whole grains, fruits, vegetables, legumes) was associated with a lower risk of developing colorectal cancer (probable level of evidence).
FEU ILLE DE REMPLACEMENT (RÈGLE 26) Au-delà de ces généralités, certains composants ont pu être associés à des actions anticancéreuses comme le curcuma (du fait de la curcumine). FIRE REPLACEMENT ISLAND (RULE 26) Beyond these generalities, certain components could be associated with anticancer actions such as turmeric (because of curcumin).
Partant de ces résultats différents compléments alimentaires à vocation préventive à rencontre du cancer ont été développés, soit sous forme de poudre, soit sous forme de gélules.  On the basis of these results, various dietary supplements with a preventive function against cancer have been developed, either in the form of powder or in the form of capsules.
Descriptif de l'invention  Description of the invention
Les inventeurs ont maintenant mis au point une composition alimentaire sous forme de gel, laquelle comprend au moins :  The inventors have now developed a food composition in gel form, which comprises at least:
un extrait de rhizome de curcuma ;  an extract of turmeric rhizome;
- un extrait de fleurs de Sophora du Japon ;  - an extract of Sophora flowers from Japan;
- un extrait de grenade ;  - a pomegranate extract;
- un extrait de thé vert ;  - green tea extract
- un extrait de bulbe d'ail ;  - an extract of bulb of garlic;
- un extrait de brocoli ;  - an extract of broccoli;
- de la vitamine B6 ; et  - vitamin B6; and
- un agent gélifiant.  a gelling agent.
Les inventeurs ont pu mettre en évidence qu'une telle composition alimentaire, destinée à une prise orale, malgré sa teneur en antioxydants très élevée pouvait se trouver sous forme de gel.  The inventors have been able to demonstrate that such a food composition, intended for oral intake, despite its very high antioxidant content could be in the form of a gel.
En outre, et de façon inattendue, les inventeurs ont pu observer que du fait de sa forme gélifiée, la biodisponibilité de la curcumine présente au sein de la composition s'en trouve très nettement améliorée.  In addition, and unexpectedly, the inventors have observed that because of its gelled form, the bioavailability of curcumin present in the composition is significantly improved.
L'avantage d'une telle forme étant qu'elle a montré une perturbation nettement moindre du transit chez ses utilisateurs qu'une composition sous forme de poudre.  The advantage of such a form is that it has shown a significantly lower disturbance of transit in its users than a composition in powder form.
De surcroît, les utilisateurs l'ont consommé bien plus facilement qu'une composition sous forme de gélule, associée plus fortement à Une forme « médicale » et donc à la maladie.  In addition, the users consumed it much more easily than a composition in capsule form, associated more strongly with a "medical" form and therefore with the disease.
Finalement, les utilisateurs ont appréciés les qualités organoleptiques de la composition selon l'invention, ce qui a grandement facilité sa prise quotidienne,  Finally, the users appreciated the organoleptic qualities of the composition according to the invention, which greatly facilitated its daily intake,
FEU ILLE DE REMPLACEM ENT (RÈGLE 26) laquelle prise quotidienne est bien évidemment nécessaire pour produire ses effets préventifs avec le temps. FIRE REPLACEM ENT (RULE 26) which daily intake is obviously necessary to produce its preventive effects over time.
Pour ce qui est des composants de celle-ci, on trouve tout d'abord le curcuma (Curcuma longa) est une plante herbacée rhizomàteuse vivace du genre Curcuma de la famille des Zingibéracées originaire du sud de l'Asie. Il est connu en Occident depuis l'Antiquité et décrit par Dioscoride dans ses Materia Medica.  In terms of its components, turmeric (Curcuma longa) is a perennial rhizomatous herbaceous plant of the genus Turmeric of the family Zingiberaceae native to southern Asia. He has been known in the West since ancient times and described by Dioscorides in his Materia Medica.
Le curcuma est reconnu en Occident pour ses propriétés antioxydantes par lesquelles il aide l'organisme à lutter contre le stress et à maintenir l'efficacité' des défenses naturelles. Il est également utilisé depuis très longtemps comme anti- inflammatoire par la médecine ayurvédique indienne et c'est probablement l'anti- inflammatoire naturel le plus puissant identifié à ce jour.  Turmeric is recognized in the West for its antioxidant properties by which it helps the body fight against stress and maintain the effectiveness of natural defenses. It has also been used for a very long time as an anti-inflammatory by Indian Ayurvedic medicine and is probably the strongest natural anti-inflammatory identified to date.
' Maintenant, il a été mis en évidence qu'il peut jouer aussi un rôle dans la prévention du cancer et à âge égal, les Indiens ont huit fois moins de cancers du poumon que les Occidentaux, neuf fois moins de cancers du côlon, 5 fois moins de cancers du sein et jusqu'à dix fois moins de cancers du rein. Un des éléments pouvant expliquer cette différence pourrait être attribuable à leur consommation élevée de curcuma, laquelle est en moyenne de 1,5 à 2 g de curcuma par jour (l'équivalent d'un quart à une demi-cuillère à café). ' Now it has been shown that it can also play a role in cancer prevention and at the same age, Indians have eight times less lung cancer than Westerners, nine times less colon cancer, 5 times fewer breast cancers and up to ten times fewer kidney cancers. One of the factors that may explain this difference could be attributable to their high consumption of turmeric, which averages 1.5 to 2 g of turmeric per day (the equivalent of a quarter to a half a teaspoon).
: Le principe actif du curcuma, la curcumine, est ainsi l'objet de recherches actives. Cette molécule se montre capable d'inhibe in vitro la croissance d'un très grand nombre dexancers : côlon, foie, estomac, ovaires, sein, leucémie entre autres.  : The active ingredient of turmeric, curcumin, is thus the subject of active research. This molecule is able to inhibit in vitro the growth of a very large number of xancers: colon, liver, stomach, ovaries, breast, leukemia among others.
: L'extrait utilisé de curcuma correspond au rhizome de ce dernier qui comprend de 0,5 à 3% en poids de curcominoïdes répartis entre la curcumine (0,4 à 2,2%), la déméthoxycurcumine (0, 1 à 1%).  The extract used turmeric corresponds to the rhizome of the latter which comprises from 0.5 to 3% by weight of curcominoids distributed between curcumin (0.4 to 2.2%), demethoxycurcumin (0, 1 to 1% ).
: Avantageusement, la teneur de la composition selon l'invention en extrait de rhizome de curcuma est comprise entre 1 et 3%, de préférence entre 1,5 et 2%.  Advantageously, the content of the composition according to the invention in extract of turmeric rhizome is between 1 and 3%, preferably between 1.5 and 2%.
Le Sophora du Japon, ou Styphnolobium japonicum, est une espèce d'arbre de la famille des Fabaceae.  The Japanese Sophora, or Styphnolobium japonicum, is a tree species of the family Fabaceae.
La fleur de ce dernier présente la particularité de comprendre des flavonoïdes en quantité, lesquels consistent principalement en la quercétine, la rutine, l'isorhamnétine  The flower of the latter has the particularity to include flavonoids in quantity, which consist mainly of quercetin, rutin, isorhamnetin
FEUI LLE DE REM PLACEM ENT (RÈG LE 26) et le kaempférol. Un des premiers bienfaits de ces molécules consistent en leur activité antioxydante, à même de neutraliser les radicaux libres responsables pour partie du vieillissement et de l'altération de l'organisme. La fleur de Sophora du Japon présente l'avantage de renfermer jusqu'à 15 à 20% de rutine. FLEI LLE OF REM PLACEM ENT (REG 26) and kaempferol. One of the first benefits of these molecules is their antioxidant activity, able to neutralize free radicals responsible for part of the aging and alteration of the body. The Sophora flower from Japan has the advantage of containing up to 15 to 20% rutin.
Avantageusement, la teneur de la composition selon l'invention en extrait de fleur de Sophora du Japon est comprise entre 1 et 3%, de préférence entre 1,5 et 2%.  Advantageously, the content of the composition according to the invention in Sophora flower extract from Japan is between 1 and 3%, preferably between 1.5 and 2%.
La grenade, quant à elle, est le fruit du grenadier, ou Punica granat m, qui appartient à la famille des Lythracées et que l'on trouve sur un large domaine géographique qui s'étend de l'Asie occidentale à l'Asie centrale. Cette dernière est ainsi une bonne source de fibres alimentaires, de folate, et également une très bonne source de: vitamine C. L'arille de la grenade contient en outre des flavanols (ou catéchines) et des; dimères de flavanols (des procyanidols), de même qu'un grand nombre de polyphénols particulièrement efficaces et auxquels on peut vraisemblablement attribuer ses effets bénéfiques pour la santé.  Pomegranate is the fruit of the pomegranate tree, Punica granat, which belongs to the family Lythraceae and is found over a wide geographical area stretching from western Asia to central Asia. . The latter is thus a good source of dietary fiber, folate, and also a very good source of: vitamin C. The pomegranate aril contains in addition flavanols (or catechins) and; flavanol dimers (procyanidols), as well as a large number of particularly effective polyphenols, to which presumably its beneficial effects on health can be attributed.
Tous ces composants contribuent à doter le jus de grenade de propriétés antioxydantes des plus intéressantes.  All these components contribute to providing pomegranate juice with some of the most interesting antioxidant properties.
. Avantageusement, la teneur de la composition selon l'invention en extrait de grenade èst comprise entre 2 et 10%, de préférence entre 3 et 7%, voir entre 4 et 6%. Maintenant, cet pour ce qui est de cet extrait de grenade, on préférera utiliser le jus de grenade.  . Advantageously, the content of the composition according to the invention in pomegranate extract is between 2 and 10%, preferably between 3 and 7%, or between 4 and 6%. Now, for this pomegranate extract, we prefer to use pomegranate juice.
Le théier (Camellia sinensis), appelé aussi thé, comme l'infusion de ses feuilles, est Une espèce d'arbustes de là famille des Théaeées. Il est originaire d'Extrême-Orient et est largement cultivé pour ses feuilles qui, une fois séchées et plus ou moins oxydées, servent à la préparation par infusion de cette boisson incontournable.  The tea tree (Camellia sinensis), also called tea, like the infusion of its leaves, is a species of shrubs from the family of theaeeae. It is native to the Far East and is widely grown for its leaves which, once dried and more or less oxidized, are used for the preparation by infusion of this essential drink.
Le thé vert correspond à une variété particulière de thé liée à la préparation des feuilles de thé une fois récoltées. Le thé vert est en fait un thé très peu oxydé lors de sa fabrication, laquellè permet de conserver ainsi intactes ses propriétés.  Green tea is a particular variety of tea related to the preparation of tea leaves once harvested. Green tea is in fact a tea with very little oxidation during its manufacture, which allows to keep intact its properties.
. Les propriétés du thé vert sont multiples : riche en tanins, ce sont ces polyphénols antioxydants qui donnent au thé son arôme et son goût amer particulier. Le thé vert contient également de la vitamine C. Mais ce qui démarque le thé vert des autres, c'est  . The properties of green tea are multiple: rich in tannins, it is these antioxidant polyphenols that give tea its aroma and bitter taste. Green tea also contains vitamin C. But what sets green tea apart is
FEU I LLE DE REM PLACEM ENT (RÈG LE 26) qu'il contient une catéchine nommée épigallocatéchine EPGC ou encore épigallocatéchine-3-gallate (EGCG). L'EPGC possède des propriétés bien plus puissantes que celles d'un simple antioxydant. Le thé vert (vert car non fermenté) contient ainsi dix fois plus d'EPGC que le thé noir et 2,5 fois plus que le thé Oolong. Quant au taux de caféine (théine), il est semblable à celui du thé noir soit 20-90 mg par tasse mais ses effets excitants sont atténués par la présence des tanins. Le thé contient également de la théanjne, un acide aminé analogue au glutamate, qui a un effet apaisant qui inhibe l'effet hypertenseur de la caféine. FIRE I LLE OF REM PLACEM ENT (RULE 26) it contains a catechin called epigallocatechin EPGC or epigallocatechin-3-gallate (EGCG). EPGC has properties far more powerful than those of a simple antioxidant. Green tea (green because unfermented) contains ten times more EPGC than black tea and 2.5 times more than Oolong tea. As for the caffeine (theine), it is similar to that of black tea is 20-90 mg per cup but its exciting effects are mitigated by the presence of tannins. Tea also contains teaanne, a glutamate-like amino acid that has a soothing effect that inhibits the caffeine's hypertensive effect.
Là encore, tous ces composants contribuent à doter le thé vert de propriétés antioxydantes puissantes et adaptées à prévenir les dommages des stress oxydatifs.  Here again, all these components contribute to providing green tea with powerful antioxidant properties that are suitable for preventing damage from oxidative stress.
Avantageusement, la teneur de la composition selon l'invention en extrait de thé vert est comprise entre 1 et 5%, de préférence entre 2 et 4%, voir entre 2,5 et 3%. Maintenant, et pour ce qui est de cet extrait de thé vert, on préférera utiliser un extrait liquide de thé vert, de préférence un extrait de thé vert concentré lequel comprendra de 15 à 45% de matière sèche, de préférence de 25 à 35% de matière sèche.  Advantageously, the content of the composition according to the invention in green tea extract is between 1 and 5%, preferably between 2 and 4%, or between 2.5 and 3%. Now, and for this green tea extract, it will be preferable to use a liquid green tea extract, preferably a concentrated green tea extract which will comprise from 15 to 45% of dry matter, preferably from 25 to 35% by weight. dry matter.
Pour l'ail, celui qui est cultivé (Allium sativum) est une plante potagère vivace monocotylédone dont les bulbes, à l'odeur et au goût fort, sont souvent employés comme condiment en cuisine. Une tête d'ail se compose de plusieurs caïèux ou gousses d'ail: Différentes études établissent que la consommation régulière d'une gousse d'ail (3 g) par jour réduirait de moitié le risque de cancer de l'estomac, du colon ét du rectum. Cette action résulterait notamment de l'alliine, qui est un sulfoxyde et qui constitue un dérivé de la cystéine. Lorsque de l'ail frais est écrasé ou haché, cet alliine est convertit par l'enzyme alliinase en allicine qui est responsable de l'arôme de l'ail frais.  For garlic, the one that is cultivated (Allium sativum) is a perennial monocotyledonous vegetable plant whose bulbs, with an odor and a strong taste, are often used as a condiment in cooking. A head of garlic is made up of several garlic cloves or garlic: Various studies show that regular consumption of a clove of garlic (3 g) per day would reduce by half the risk of cancer of the stomach, colon and rectum. This action would result in particular from the alliine, which is a sulfoxide and which is a derivative of cysteine. When fresh garlic is crushed or chopped, this alliin is converted by the alliinase enzyme into allicin which is responsible for the aroma of fresh garlic.
En outre, du fait de sa composition en alliine (près de 0,5 à 1,3% dans le bulbe) qui a des propriétés de captage du radical hydroxyle, l'ail s'est révélée avoir des propriétés antioxydantes très intéressantes. Maintenant, celles-ci sont également associées pour partie aux flavonoïdes et au tocophérol que le bulbe d'ail renferme en quantités.  In addition, because of its composition of alliine (nearly 0.5 to 1.3% in the bulb) which has properties of capturing the hydroxyl radical, garlic has been found to have very interesting antioxidant properties. Now, these are also associated in part with flavonoids and tocopherol that the bulb of garlic contains in quantities.
Avantageusement, la teneur de la composition selon l'invention en extrait de bulbe d'ail est comprise entre 0,01 et 0,5%, de préférence entre 0,01 et 0,05%.  Advantageously, the content of the composition according to the invention in garlic bulb extract is between 0.01 and 0.5%, preferably between 0.01 and 0.05%.
FEU ILLE DE REM PLACEM ENT (RÈGLE 26) Maintenant, et pour ce qui est de cet extrait de bulbe d'ail, on préférera utiliser un extrait sec, avantageusement désodorisé. FIRELIGHT OF REM PLACEM ENT (RULE 26) Now, and for this garlic bulb extract, it will be preferred to use a dry extract, advantageously deodorized.
Eri liën avec le brocoli (Brassica oleracea var. italica), il s'agit d'une variété de chou qui est originaire du sud de l'Italie. Le brocoli présente une tige centrale ferme ramifiée en petits bouquets qui, à la floraison, sont parsemés de minuscules fleurs jaunes. Habituellement de couleur vert foncé à vert sauge, le brocoli peut aussi être blanc ou pourpre (violacé).  Eri lien with broccoli (Brassica oleracea var., Italica), it is a variety of cabbage that is native to southern Italy. Broccoli has a firm central stem branched into small bunches that, at bloom, are dotted with tiny yellow flowers. Usually dark green to sage green, broccoli can also be white or purple (purplish).
Pour ce qui est de ses propriétés, il bénéficie d'une action préventive du cancer (et principalement le cancer du côlon) grâce aux fibres et aux composés soufrés et d'autres antioxydants : indoles, sulforaphane, glutathion, quercétine, β-carotène, brocoline (alcaloïde typique du brocoli) : ces substances ont la propriété de neutraliser certains composés toxiques présents dans l'organisme (radicaux libres).  In terms of its properties, it benefits from a preventive action against cancer (and mainly colon cancer) thanks to fibers and sulfur compounds and other antioxidants: indoles, sulforaphane, glutathione, quercetin, β-carotene, brocoline (alkaloid typical of broccoli): these substances have the property of neutralizing certain toxic compounds present in the body (free radicals).
Avantageusement, la teneur de la composition selon l'invention en extrait de brocoli ëst comprise entre 1 et 5%, de préférence entre 2 et 4%, voir entre 2,5 et 3%. Maintenant, et pour ce qui est de cet extrait de brocoli, on préférera utiliser un extrait sec, et surtout un extrait atomisé. Typiquement, cet extrait atomisé comprend des particules présentant un diamètre inférieur à 1 μπι.  Advantageously, the content of the composition according to the invention in broccoli extract is between 1 and 5%, preferably between 2 and 4%, or between 2.5 and 3%. Now, and as for this broccoli extract, it will be preferred to use a dry extract, and especially an atomized extract. Typically, this atomized extract comprises particles having a diameter of less than 1 μπι.
La vitamine B6, elle, intervient dans le métabolisme de l'homocystéine dont la carence entraîne une baisse importante de la tonicité. En lien avec le système nerveux, la vitamine B6 participe également à la biosynthèse de la sérotonine et son apport journaliér recommandé (AJR) est de 1,4 mg selon la directive 2008/100/CE. Vitamin B 6 is involved in the metabolism of homocysteine whose deficiency causes a significant decrease in tone. In connection with the nervous system, vitamin B 6 also participates in the biosynthesis of serotonin and its recommended daily intake (RDA) is 1.4 mg according to the directive 2008/100 / CE.
De préférence, la composition selon l'invention présente une teneur en vitamine B6 est comprise entre 0,01 et 0,05%, de préférence entre 0,01 et 0,03%. Cette proportion est adaptée de sorte que la prise de la composition selon l'invention se rapproche de l'AJR sans risquer de (trop) l'excéder. Preferably, the composition according to the invention has a vitamin B 6 content is between 0.01 and 0.05%, preferably between 0.01 and 0.03%. This proportion is adapted so that the setting of the composition according to the invention is close to the AJR without risking (too) exceed it.
Par agent gélifiant, on entend un agent qui permette de donner à la composition selon l'invention la consistance d'un gel.  "Gelling agent" means an agent which makes it possible to give the composition according to the invention the consistency of a gel.
De tels agents sont bien connus de l'homme du métier et comprennent notamment la gomme arabique (ou gomme d'acacia), la gomme xanthane, la gélatine, la pectine, les alginates, les carraghénanes, ou encore l'agar-agar.  Such agents are well known to those skilled in the art and include gum arabic (or gum acacia), xanthan gum, gelatin, pectin, alginates, carrageenans, or agar agar.
FEUI LLE DE REM PLACEM ENT (RÈGLE 26) La combinaison de gomme arabique et de gomme xanthane a montré, en lien avec la composition selon l'invention, une grande facilité de prise pour l'utilisateur et une assimilation rapide. FEUI LLE OF REM PLACEM ENT (RULE 26) The combination of gum arabic and xanthan gum has shown, in connection with the composition according to the invention, a great ease of grip for the user and rapid assimilation.
La teneur en agent gélifiant de la composition selon l'invention est dépendante de l'agent gélifiant utilisé et peut être simplement adaptée par l'homme du métier. Elle est typiquement supérieure à 0, 1% voir 0,5% et inférieure à 10% voir 5%.  The content of gelling agent of the composition according to the invention is dependent on the gelling agent used and can be simply adapted by those skilled in the art. It is typically greater than 0.1%, 0.5% and less than 10% or 5%.
La composition selon l'invention pourra en outre comprendre différents constituants bénéficiant de propriétés antioxydantes ou stimulatrices.  The composition according to the invention may further comprise different constituents with antioxidant or stimulating properties.
On ajoutera ainsi de préférence à cette dernière du sélénium, qui appartient à la famille des chalcogènes, de symbole Se et de numéro atomique 34.  Thus selenium, which belongs to the family of chalcogenes, of symbol Se and atomic number 34 is preferably added to the latter.
Le sélénium est un oligo-élément constituant des sélénoprotéines dont fait partie le principaDantioxydant intracellulaire, la glutathion peroxydase. On en trouve dans les rognons de porc ourde bœuf, l'ail, le poisson et les mollusques. La nutrition occidentale satisfait largement les besoins quotidiens en cet élément mais il est impossible de prédire les concentrations corporelles de sélénium à partir de l'apport nutritionnel parce que son utilisation et sa rétention sont dépendantes de la présence d'acide folique, de vitamine B12 et négativement affectées par la présence d'homocystéine.  Selenium is a trace element constituting selenoproteins including the intracellular principaDantioxidant, glutathione peroxidase. It is found in kidneys of pork, beef, garlic, fish and molluscs. Western nutrition largely meets the daily needs of this element, but it is impossible to predict body levels of selenium from dietary intake because its use and retention are dependent on the presence of folic acid, vitamin B12 and negatively affected by the presence of homocysteine.
Le sélénium utilisé se trouvera sous la forme d'un extrait de levure (ex. Saccharomyces cerevisiae) enrichi en sélénium. Cet enrichissement correspond à une concentration de l'ordre de 1 500 à 3 000 g de sélénium par gramme d'extrait.  The selenium used will be in the form of a yeast extract (eg Saccharomyces cerevisiae) enriched in selenium. This enrichment corresponds to a concentration of the order of 1500 to 3000 g of selenium per gram of extract.
Il est a noter: que le sélénium présent dans cet extrait se trouve sous la forme de séléniométhionine et se présente sous la forme d'un extrait sec.  It should be noted that the selenium present in this extract is in the form of seleniomethionine and is in the form of a dry extract.
Avantageusement, la teneur de la composition selon l'invention présente une teneur en extrait de levure enrichi en sélénium comprise entre est comprise entre 0,1 et 0,5%, de préférence entre 0, 1 et 0,3%.  Advantageously, the content of the composition according to the invention has a content of yeast extract enriched with selenium between between 0.1 and 0.5%, preferably between 0.1 and 0.3%.
La composition selon l'invention comprendra en outre de préférence de la vitamine B9 qui est essentiel pour limiter le déclin cognitif et palier à l'apparition de pathologies 'liées à l'âge comme la maladie d'Alzheimer. L'apport journalier recommandé (AIR) en vitamine B est de 200 μg selon la directive 2008/100/CE. The composition according to the invention will further preferably comprise vitamin B 9 which is essential for limiting cognitive decline and for preventing the onset of age-related pathologies such as Alzheimer's disease. The recommended daily intake (AIR) of vitamin B is 200 μg according to Directive 2008/100 / EC.
FEU I LLE DE REM PLACEMENT (RÈG LE 26) De préférence, la composition selon l'invention présente une teneur en vitamine B9 comprise entre est comprise entre 0,001 et 0,005%, de préférence entre 0,001 et 0,003%. Cette proportion est adaptée de sorte que la prise de la composition selon l'invention se rapproche de l'AIR sans risquer de (trop) l'excéder. La composition selon l'invention pourra comprendre en outre des acidifiants, parmi lesquels l'acide citrique. FIREPLACE REMPLACEMENT (RULE 26) Preferably, the composition according to the invention has a vitamin B 9 content between 0.001 and 0.005%, preferably between 0.001 and 0.003%. This proportion is adapted so that the setting of the composition according to the invention is close to the AIR without risking to (excessively) exceed it. The composition according to the invention may furthermore comprise acidifiers, among which citric acid.
La teneur en acidifiant de la composition selon l'invention pourra atteindre les 2%, mais sera préférentiellement inférieure ou égale à 1%.  The acidifying content of the composition according to the invention may reach 2%, but will preferably be less than or equal to 1%.
De même, la composition selon l'invention pourra comprendre au moins un édulcorant. A titre d'exemple de tels édulcorants, on pourra citer, entre autres, le sucralose, l'extrait .de stévia, le xylitol, l'aspartame, le sirop de glucose, le sirop de fructo-oligosaccharide, le maltitol en poudre ou en sirop, l'acésulfame de potassium, le fructooligosaccharide et le cyclamate de sodium.  Similarly, the composition according to the invention may comprise at least one sweetener. Examples of such sweeteners include, among others, sucralose, stevia extract, xylitol, aspartame, glucose syrup, fructooligosaccharide syrup, maltitol powder or syrup, acesulfame potassium, fructooligosaccharide and sodium cyclamate.
La composition selon l'invention comprendra en outre au moins un conservateur. A titre d'exemples de conservateurs, on pourra citer le sorbate de potassium, le benzoate de sodium ou le palmitate d'ascorbyle (antioxydant).  The composition according to the invention will also comprise at least one preservative. As examples of preservatives, mention may be made of potassium sorbate, sodium benzoate or ascorbyl palmitate (antioxidant).
Enfin, la composition selon l'invention pourra comprendre un agent texturant tel que la glycérine.  Finally, the composition according to the invention may comprise a texturing agent such as glycerine.
Un second objet de l'invention porte sur une dosette contenant la composition sous forme de gel selon l'invention.  A second subject of the invention relates to a pod containing the composition in gel form according to the invention.
L'utilisateur; -pourra ainsi consommer simplement la dose requise et, s'il le souhaite, l'associer ou la dissoudre dans un verre d'eau.  The user; and can simply consume the required dose and, if desired, combine or dissolve in a glass of water.
Un troisième objet selon l'invention correspond à l'utilisation d'une composition telle que décrite précédemment pour la prévention de pathologies associées à des dommages oxydatifs dus aux radicaux libres, tels que les cancers, chez un sujet.  A third object according to the invention corresponds to the use of a composition as described above for the prevention of pathologies associated with oxidative damage due to free radicals, such as cancers, in a subject.
Par cancer; on entend de préférence un cancer oral ou un cancer de l'appareil digestif.  By cancer; oral cancer or cancer of the digestive tract is preferably meant.
Les exemples ci-après sont fournis pour illustrer l'invention et ne doivent en aucun cas être considérés comme une limite à la portée de l'invention. The following examples are provided to illustrate the invention and should in no way be considered as a limit to the scope of the invention.
FEU I LLE DE REM PLACEMENT (RÈG LE 26) FIREPLACE REMPLACEMENT (RULE 26)

Claims

REVENDICATIONS
1. Une composition alimentaire sous forme de gel, laquelle comprend au moins : 1. A food composition in gel form, which comprises at least:
un extrait de rhizome de curcuma dont la teneur est comprise entre 1 et 3% ;  an extract of turmeric rhizome having a content of between 1 and 3%;
un extrait de fleurs de Sophora du Japon dont la teneur est comprise entre 1 et 3%;  an extract of Japanese Sophora flowers with a content of between 1 and 3%;
un extrait de grenade dont la teneur est comprise entre 2 et 10% ; un extrait de thé vert dont la teneur est comprise entre 1 et 5% ; un extrait de bulbe d'ail dont la teneur est comprise entre 0,01 et 0,5%;  a pomegranate extract whose content is between 2 and 10%; a green tea extract whose content is between 1 and 5%; an extract of garlic bulb whose content is between 0.01 and 0.5%;
un extrait de brocoli dont la teneur est comprise entre 1 et 5% ; de la vitamine B6 dont la teneur est comprise entre 0,01 et 0,05%; et  a broccoli extract with a content of between 1 and 5%; vitamin B6, the content of which is between 0.01 and 0.05%; and
un agent gélifiant dont la teneur est comprise entre 0,1 et 10%.  a gelling agent whose content is between 0.1 and 10%.
2. La composition selon la revendication 1, laquelle comprend en outre du sélénium sous la forme d'un extrait de levure enrichi en sélénium et dont la teneur est comprise entre 0,1 et 0,5%. 2. The composition according to claim 1, which further comprises selenium in the form of a yeast extract enriched with selenium and whose content is between 0.1 and 0.5%.
3. La composition selon l'une quelconque des revendications précédentes, dans laquelle l'extrait de grenade est un jus de grenade. The composition of any of the preceding claims, wherein the pomegranate extract is a pomegranate juice.
4. La composition selon l'une quelconque des revendications précédentes, dans laquelle l'extrait de bulbe d'ail est un extrait sec, avantageusement désodorisé. 4. The composition according to any one of the preceding claims, wherein the garlic bulb extract is a dry extract, advantageously deodorized.
5. La composition selon l'une quelconque des revendications précédentes, dans laquelle l'extrait de brocoli est un extrait sec, avantageusement atomisé. 5. The composition according to any one of the preceding claims, wherein the broccoli extract is a dry extract, advantageously atomized.
6. La composition selon l'une quelconque des revendications précédentes, dans laquelle l'agent gélifiant est choisi dans le groupe comprenant la gomme arabique, la gomme xanthane, la gélatine, la pectine, les alginates, les carraghénanes et Pagar-agar. 6. The composition according to any one of the preceding claims, wherein the gelling agent is selected from the group consisting of gum arabic, xanthan gum, gelatin, pectin, alginates, carrageenans and agar-agar.
7. La composition selon l'une quelconque des revendications précédentes, laquelle comprend en outre de la vitamine B9. The composition of any one of the preceding claims, which further comprises vitamin B9.
8. Une dosette contenant la composition selon l'une quelconque des revendications 1 à 7. 8. A pod containing the composition according to any one of claims 1 to 7.
9. Une composition selon l'une quelconque des revendications 1 à 7 destinée à la prévention de pathologies associées à des dommages oxydatifs dus aux radicaux libres tels que les cancers. 9. A composition according to any one of claims 1 to 7 for the prevention of pathologies associated with oxidative damage due to free radicals such as cancer.
PCT/EP2015/001807 2014-09-11 2015-09-08 Antioxidant food composition in gel form WO2016037698A1 (en)

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