FR2899768A1 - Food supplement, useful as antioxidant, to improve the organ response or prevent the oxidative stress and to reduce aging, comprises gamma-tocopherol, flavonoids, carnosic acid and carnosol - Google Patents

Food supplement, useful as antioxidant, to improve the organ response or prevent the oxidative stress and to reduce aging, comprises gamma-tocopherol, flavonoids, carnosic acid and carnosol Download PDF

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FR2899768A1
FR2899768A1 FR0603423A FR0603423A FR2899768A1 FR 2899768 A1 FR2899768 A1 FR 2899768A1 FR 0603423 A FR0603423 A FR 0603423A FR 0603423 A FR0603423 A FR 0603423A FR 2899768 A1 FR2899768 A1 FR 2899768A1
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extract
dietary supplement
tocopherol
supplement according
carnosol
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FR2899768B1 (en
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Caroline Quesnoit
Guillaume Olive
Poli Cecile Petrini
Appleton Geraldine Marchal
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JUVA SANTE SOC PAR ACTIONS SIM
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

Food supplement comprises gamma-tocopherol, flavonoids, carnosic acid and carnosol. ACTIVITY : Tranquilizer; Nootropic; Dermatological. MECHANISM OF ACTION : None given. No biological data given.

Description

La présente invention concerne un complément alimentaire améliorant laThe present invention relates to a dietary supplement improving the

réponse de l'organisme en réponse ou en prévention du stress oxydatif. D'une manière générale, un complément alimentaire (ou complément nutrition- nel) est un ensemble comestible destiné à compléter l'alimentation quotidienne d'un organisme humain en lui fournissant des nutriments ayant pour fonction de le renforcer ou d'atténuer, voire éliminer, un symptôme affectant celui-ci.  response of the body in response to or prevention of oxidative stress. In general, a dietary supplement (or nutritional supplement) is an edible set intended to supplement the daily diet of a human organism by providing nutrients whose function is to strengthen it or to reduce or eliminate , a symptom affecting this one.

ARRIERE PLAN DE L'INVENTION Le stress oxydatif est aujourd'hui reconnu par la communauté scientifique comme un état physiologique perturbé qui est directement relié à plus de 200 maladies, qui vont des troubles cardiovasculaires, à la dégénéres- cence maculaire liée à l'âge en passant par les maladies de Parkinson et d'Alzheimer. Le stress oxydatif se définit par la surproduction de radicaux libres (ou espèces oxygénées réactives) par rapport aux défenses antioxydantes de l'organisme. Le 2.0 stress oxydatif est également considéré par la communauté scientifique comme un des principaux mécanismes responsables du vieillissement. L'ensembie de la population est concernée par le stress oxydatif car les facteurs favorisant la surproduc- 25 tion de radicaux libres sont nombreux et courants : expo- sition au soleil, stress psychologique, tabagisme, pollu- tion, surcharge pondérale, alimentation pro-oxydante (surconsommation de sucres simples, aliments riches en mauvais cholestérol LDL)... 30 L'alimentation est une source importante d'antioxydants pour permettre de lutter contre le stress oxydatif. Les fruits et légumes sont les aliments les plus antioxydants, c'est pourquoi il est généralement conseillé de manger cinq fruits et légumes par jour. Tou- 35 tefois, les études nutritionnelles montrent que la plu- 2 part des personnes n'atteignent pas ce seuil recommandé : d'après l'enquête INCA 1998 et 1999 et le Baromètre Santé Nutrition 2002, 60 % des français mangent moins de une portion et demi de fruits et moins de deux portions de légumes par jour. Cette sous-consommation de fruits et légumes est donc un handicap en terme de prévention de maladies. En effet l'étude SU.VI. MAX a démontré que la consommation d'antioxydants à des doses nutritionnelles permettait de réduire chez les hommes la mortalité de 37% et le risque de cancer de 31%. Or, il suffit d'une perturbation dje notre mode de vie (événement stressant, émotion forte, régime) pour que notre organisme n'arrive plus à produire suffisamment de défenses antioxydantes pour lutter contre l'augmentation de la production de radicaux libres. Ajoutée à une consommation insuffisante de fruits et légumes, une telle perturbation ou tout simplement l'adoption d'un mode de vie peu sain (habiter dans une grande ville polluée, être stressé(e) par son travail, avoir une alimentation désé- quilibrée) peut donc très facilement occasionner l'apparition d'un stress oxydatif et donc accélérer le processus de vieillissement. Certains compléments alimentaires antioxydants ont été lancés ces dernières années mais la mesure de leur pouvoir antioxydant révèle qu'ils apportent finale-ment une faible dose d'antioxydants par rapport aux fruits et aux légumes. De plus les apports en antioxydants doivent être variés et ne pas se limiter à deux, trois ou quatre molécules antioxydantes (comme c'est le cas dans de nombreux produits actuellement sur le marché) afin de ne pas perturber les équilibres redox internes et éviter ainsi le développement du stress oxydatif. OBJET DE L'INVENTION Il serait donc intéressant de disposer d'un nou- veau moyen facile à utiliser favorisant le maintien ou le 3 retour à un équilibre interne entre la production de radicaux libres et le niveau de défenses antioxydantes afin d'éviter de développer un stress oxydatif. DESCRIPTION DETAILLEE DE L'INVENTION A cet effet, on prévoit selon l'invention, un complément alimentaire comprenant du gamma-tocophérol, des flavonoïdes, de l'acide carnosique et du carnosol. Le gamma-tocophérol est une des formes existantes de la vitamine E dans l'alimentation, tout comme l'alpha- I0 tocophérol. La vitamine E est un puissant antioxydant. Toutefois c'est le rapport alpha-tocophérol sur gamma-tocophérol qui pilote l'action antioxydante. Or il s'avère que la quasi-totalité des compléments alimentaires apportant de la vitamine E le font sous forme 15 d'alpha-tocophérol, ce qui crée un déséquilibre dans l'organisme. Les recherches scientifiques ont montré qu'augmenter la proportion de gamma-tocophérol par rapport à l'alpha-tocophérol permettait de mieux prévenir les maladies cardiovasculaires. 20 L'intérêt des flavonoïdes est double car d'une part les flavonoïdes neutralisent directement les radicaux libres et d'autre part ils agissent en synergie avec les vitamines C et E dans la neutralisation des radicaux libres. En effet les vitamines C et E donnent un électron 25 aux radicaux libres afin de les stabiliser. Mais ensuite ces vitamines C et E se retrouvent sous forme oxydée et ne peuvent plus lutter contre les radicaux libres. Les flavonoïdes permettent de régénérer sous forme réduite les vitamines C et E afin de continuer à lutter contre 30 les radicaux libres. Selon un mode de réalisation particulier, le complément alimentaire comprend : - de l'acide carnosique et du carnosol, - des oligo-proanthocyanidines, 35 - du gamma-tocophérol, 4 - des catéchines et biflavanes. Les oligo-proanthocyanidines sont des flavonoïdes dont l'activité antioxydante est 50 fois supérieure à celle des vitamines C et E. L'acide carnosique et le car- nosol sont de puissants antioxydants qui viennent renforcer l'action des oligo-proanthocyanidines dans la lutte contre les radicaux libres et la régénération des formes actives des vitamines C et E. De préférence, le complément alimentaire com- prend : - un extrait sec de romarin contenant de l'acide carnosique et du carnosol, - un extrait sec de raisin contenant des oligoproanthocyanidines, - un extrait de soja contenant du gamma-tocophérol, - un extrait sec de myrtille contenant des catéchines et biflavanes. L'extrait de myrtille apporte également de la 2.0 vitamine C. La vitamine C est hydrophile donc elle exerce son activité antioxydante principalement en milieu aqueux. La vitamine E est lipophile et exerce donc son action antioxydante en milieu lipidique. Les oligoproanthocyanidines complètent donc de manière intéres- 25 sante dans un complément alimentaire les vitamines C et E car leur action antioxydante s'exerce à la fois en milieu aqueux et milieu lipidique. L'intérêt des extraits de raisin, myrtille et ro-marin réside également dans le fait qu'en tant que subs- 30 tance naturelle non purifiée ils apportent de nombreux composés antioxydants qui ne se limitent pas à ceux cités précédemment. C'est cet apport de nombreux antioxydants qui permet d'agir sur de multiples chaînes d'oxydoréduction de l'organisme et ainsi d'induire un équilibre 35 entre production de radicaux libres et défenses antioxy- dantes de manière générale dans tout l'organisme. De préférence, le complément alimentaire comprend un extrait de thé vert, un extrait d'acérola, de l'acide ascorbique, du sélénium et du zinc. 5 Les extraits de thé vert et d'acérola, l'acide ascorbique, le sélénium et le zinc sont des composés antioxydants qui viennent renforcer l'action antioxydante du complément alimentaire. L'action antioxydante du complément alimentaire est mesurée grâce au test CRAC et garantit au minimum 2000 unités ORAC. Cette preuve de l'efficacité de ce complément alimentaire est importante car d'une part de nombreux autres compléments alimentaires antioxydants actuellement commercialisés ont en réalité un faible pou- voir antioxydant. D'autre part des nutritionnistes américains conseillent de consommer entre 3000 et 5000 unités ORAC par jour afin de limiter le vieillissement de l'organisme et de prévenir le stress oxydatif. Or l'alimentation des Français n'apporte que 1500 unités CRAC chaque jour. Donc le complément alimentaire ci-dessus est un moyen efficace de lutter contre le stress oxydatif puisque son action antioxydante en complément de l'alimentation est prouvée. D'autres caractéristiques et avantages de l'in- vention ressortiront à la lecture de la description qui suit d'un mode de réalisation particulier non limitatif de l'invention. Le complément alimentaire conforme à l'invention comprend un extrait sec de soja, de raisin, de myrtille et de romarin. L'extrait de soja est garanti non OGM et dosé entre 18 et 21 de gamma-tocophérol environ. L'extrait sec de raisin est du marc de raisin présenté sous forme de poudre obtenue par pulvérisation du marc séché et tamisage de la poudre obtenue.  BACKGROUND OF THE INVENTION Oxidative stress is now recognized by the scientific community as a disrupted physiological condition that is directly related to more than 200 diseases, ranging from cardiovascular disorders, to age-related macular degeneration. going through Parkinson's and Alzheimer's diseases. Oxidative stress is defined by the overproduction of free radicals (or reactive oxygen species) in relation to the antioxidant defenses of the body. Oxidative stress is also considered by the scientific community as one of the main mechanisms responsible for aging. The whole population is affected by oxidative stress because the factors promoting the overproduction of free radicals are numerous and common: exposure to the sun, psychological stress, smoking, pollution, overweight, diet oxidative (overconsumption of simple sugars, foods rich in bad LDL cholesterol) ... Food is an important source of antioxidants to help fight against oxidative stress. Fruits and vegetables are the most antioxidant foods, so it is generally advisable to eat five fruits and vegetables a day. However, nutritional studies show that most people do not reach this recommended threshold: according to the CNIB 1998 and 1999 survey and the 2002 Health Nutrition Barometer, 60% of French people eat less than one person. serving and a half of fruit and less than two servings of vegetables a day. This under-consumption of fruits and vegetables is therefore a handicap in terms of disease prevention. Indeed the study SU.VI. MAX has shown that the consumption of antioxidants at nutritional levels reduces mortality in men by 37% and cancer risk by 31%. However, it suffices to disrupt our lifestyle (stressful event, strong emotion, diet) so that our body can no longer produce enough antioxidant defenses to fight against the increase in the production of free radicals. Added to an insufficient consumption of fruit and vegetables, such a disruption or simply the adoption of an unhealthy lifestyle (living in a large polluted city, being stressed by one's work, having an unbalanced diet ) can very easily cause the onset of oxidative stress and thus accelerate the aging process. Some antioxidant dietary supplements have been launched in recent years, but the measure of their antioxidant power reveals that they ultimately provide a low dose of antioxidants compared to fruits and vegetables. In addition, the antioxidant intake must be varied and not be limited to two, three or four antioxidant molecules (as is the case in many products currently on the market) so as not to disturb the internal redox equilibrium and thus avoid the development of oxidative stress. OBJECT OF THE INVENTION It would therefore be advantageous to have a new easy-to-use means for maintaining or returning to an internal balance between the production of free radicals and the level of antioxidant defenses in order to avoid developing oxidative stress. DETAILED DESCRIPTION OF THE INVENTION For this purpose, there is provided according to the invention, a dietary supplement comprising gamma-tocopherol, flavonoids, carnosic acid and carnosol. Gamma-tocopherol is one of the existing forms of vitamin E in the diet, as is alpha-I-tocopherol. Vitamin E is a powerful antioxidant. However, it is the alpha-tocopherol ratio on gamma-tocopherol that drives the antioxidant action. However, it turns out that almost all food supplements providing vitamin E do so in the form of alpha-tocopherol, which creates an imbalance in the body. Scientific research has shown that increasing the proportion of gamma-tocopherol relative to alpha-tocopherol can better prevent cardiovascular disease. The interest of flavonoids is twofold because on the one hand flavonoids directly neutralize free radicals and on the other hand they act synergistically with vitamins C and E in the neutralization of free radicals. Indeed vitamins C and E give an electron 25 to free radicals to stabilize them. But then these vitamins C and E are found in oxidized form and can no longer fight against free radicals. Flavonoids make it possible to regenerate in reduced form vitamins C and E in order to continue to fight against free radicals. According to a particular embodiment, the dietary supplement comprises: carnosic acid and carnosol, oligo-proanthocyanidines, gamma-tocopherol, catechins and biflavans. Oligo-proanthocyanidins are flavonoids with antioxidant activity 50 times higher than vitamins C and E. Carnosic acid and carsonol are powerful antioxidants that enhance the action of oligo-proanthocyanidins in the fight against against free radicals and the regeneration of the active forms of vitamins C and E. Preferably, the food supplement comprises: - a dry extract of rosemary containing carnosic acid and carnosol, - a dry extract of grapes containing oligoproanthocyanidins, - a soybean extract containing gamma-tocopherol, - a bilberry dry extract containing catechins and biflavans. The blueberry extract also brings 2.0 vitamin C. Vitamin C is hydrophilic so it exerts its antioxidant activity mainly in aqueous medium. Vitamin E is lipophilic and therefore exerts its antioxidant action in a lipidic medium. Oligoproanthocyanidins thus complement vitamin C and E in a dietary supplement because their antioxidant action is exercised both in an aqueous medium and in a lipidic medium. The interest of grape, blueberry and ro-marine extracts also lies in the fact that, as a natural unpurified substance, they provide numerous antioxidant compounds which are not limited to those mentioned above. It is this contribution of numerous antioxidants which makes it possible to act on multiple oxidoreduction chains of the organism and thus to induce a balance between production of free radicals and antioxidant defenses generally throughout the body. . Preferably, the dietary supplement comprises green tea extract, acerola extract, ascorbic acid, selenium and zinc. 5 Extracts of green tea and acerola, ascorbic acid, selenium and zinc are antioxidant compounds that enhance the antioxidant action of the dietary supplement. The antioxidant action of the food supplement is measured using the CRAC test and guarantees at least 2000 ORAC units. This proof of the effectiveness of this dietary supplement is important because on the one hand many other antioxidant food supplements currently marketed have in fact a low antioxidant power. On the other hand American nutritionists advise to consume between 3000 and 5000 ORAC units per day in order to limit the aging of the body and to prevent oxidative stress. But the diet of the French brings only 1500 CRAC units each day. So the food supplement above is an effective way to fight against oxidative stress since its antioxidant action in addition to food is proven. Other characteristics and advantages of the invention will become apparent on reading the following description of a particular non-limiting embodiment of the invention. The food supplement according to the invention comprises a dry extract of soy, grape, blueberry and rosemary. The soy extract is guaranteed non-GMO and dosed between 18 and 21 gamma-tocopherol approximately. The dry grape extract is grape pomace presented in the form of a powder obtained by spraying the dried pomace and sieving the powder obtained.

L'extrait sec de myrtille contient 25% d'anthocyanidines et a été obtenu par une méthode d'extraction hydroalcoolique (alcool/eau dans un rapport 80 : 20) du fruit de la plante.  The bilberry dry extract contains 25% anthocyanidins and was obtained by a hydroalcoholic extraction method (alcohol / water ratio 80:20) of the fruit of the plant.

L'extrait sec de romarin est obtenu à partir des feuilles de romarin avec de l'éthanol à 30%. Le complément alimentaire comprend en outre un extrait de thé vert, un extrait d'acérola, du sélénium sous forme de levure de sélénium, du zinc sous forme de sulfate de zinc, de l'acide ascorbique, du sorbitol et du stéarate de magnésium. Le complément alimentaire comprend, en poids, en-viron . - 23% d'extrait sec de romarin - 4 % d'extrait sec de raisin, - 3% de gamma-tocophérol, - 2% d'extrait sec de myrtille, - 12% d'extrait de thé vert, - 3% de sulfate de zinc, - 3% de levure de sélénium, - 2% d'extrait d'acérola, - 2% d'acide ascorbique, - 43% de sorbitol, - 2% de stéarate de magnésium. Plus précisément, le complément alimentaire se présente ici sous la forme d'un comprimé de 650 mg. La composition de ce comprimé est de : - 150 mg d'extrait sec de romarin mg d'extrait sec de raisin, - 18,35 mg de gamma-tocophérol - 15 mg d'extrait sec de myrtille - 80 mg d'extrait de thé vert - 21 mg de sulfate de zinc - 18,75 mg de levure de sélénium - 15 mg d'extrait d'acérola 20 25 30 35 7 - 12,85 mg d'acide ascorbique - 281,05 mg de sorbitol - 13 mg de stéarate de magnésium. Une posologie adaptée à une grande part des cas est de 2 comprimés par jour. Les différents constituants se présentent sous forme de poudres qui sont mélangées en tamisant dans l'ordre . - la moitié du sorbitol, - les autres composants à l'exception du stéarate de magnésium, - le reste du sorbitol, - le stéarate de magnésium. Bien entendu, l'invention n'est pas limitée au mode de réalisation décrit et on peut y apporter des va-riantes de réalisation sans sortir du cadre de l'invention tel que défini par les revendicationsä En particulier, la composition du complément alimentaire peut être différente de celle décrite et ne pas comporter par exemple d'extrait de thé vert, d'extrait d'acérola, du sélénium sous forme de levure de sélénium, du zinc sous forme de sulfate de zinc, de l'acide ascorbique, du sorbitol et du stéarate de magnésium... Ces composants peuvent être supprimés ou remplacer par des com- posants équivalents. Le gamma-tocophérol, les oligoproanthocyanidines, les catéchines et biflavanes et l'acide carnosique peuvent en outre être fournis par d'autres ingrédients que le soja, le marc de raisin, la myrtille et le romarin. Le complément alimentaire peut incorporer d'autres flavonoïdes que ceux décrits. Le complément alimentaire peut se présenter sous d'autres formes galéniques et par exemple sous forme de gélules, la composition du complémentaire pouvant alors incorporer un excipient.  The dry extract of rosemary is obtained from rosemary leaves with 30% ethanol. The dietary supplement further comprises green tea extract, acerola extract, selenium in the form of selenium yeast, zinc in the form of zinc sulphate, ascorbic acid, sorbitol and magnesium stearate. The dietary supplement comprises, by weight, approximately. - 23% dry rosemary extract - 4% dry grape extract, - 3% gamma-tocopherol, - 2% bilberry dry extract, - 12% green tea extract, - 3% zinc sulphate, - 3% selenium yeast, - 2% acerola extract, - 2% ascorbic acid, - 43% sorbitol, - 2% magnesium stearate. More specifically, the dietary supplement is here in the form of a 650 mg tablet. The composition of this tablet is: - 150 mg dry extract of rosemary mg dry extract of grapes, - 18.35 mg of gamma-tocopherol - 15 mg of dry extract of blueberry - 80 mg of extract of green tea - 21 mg of zinc sulphate - 18.75 mg of selenium yeast - 15 mg of acerola extract 20 25 30 35 7 - 12.85 mg of ascorbic acid - 281.05 mg of sorbitol - 13 mg of magnesium stearate. A dosage adapted to a large part of the cases is 2 tablets per day. The various constituents are in the form of powders which are mixed by sieving in order. - half of the sorbitol, - the other ingredients with the exception of magnesium stearate, - the rest of the sorbitol, - the magnesium stearate. Of course, the invention is not limited to the embodiment described and it is possible to provide variations thereto without departing from the scope of the invention as defined by the claims In particular, the composition of the dietary supplement may be different from that described and not include, for example, green tea extract, acerola extract, selenium in the form of selenium yeast, zinc in the form of zinc sulphate, ascorbic acid, sorbitol and magnesium stearate ... These components can be removed or replaced with equivalent components. Gamma-tocopherol, oligoproanthocyanidines, catechins and biflavans and carnosic acid may additionally be provided by other ingredients than soybean, grape marc, bilberry and rosemary. The dietary supplement may incorporate other flavonoids than those described. The dietary supplement may be in other galenic forms and for example in the form of capsules, the composition of the supplement can then incorporate an excipient.

Ainsi, selon une autre formulation, le complément 1 0 8 alimentaire peut comprendre, en poids, environ : - 20% d'extrait sec de romarin, - 7 d'extrait sec de raisin, - 3% de gamma-tocophérol, - 7% d'extrait sec de myrtille, - 8% d'extrait de thé vert, - 3% de sulfate de zinc, - 3% de levure de sélénium, - 2% d'extrait d'acérola, - 1% d'acide ascorbique, -44% de sorbitol, - 2% de stéarate de magnésium.  Thus, according to another formulation, the food supplement may comprise, by weight, approximately: - 20% of dry extract of rosemary, - 7 of dry grape extract, - 3% of gamma-tocopherol, - 7 % bilberry dry extract, - 8% green tea extract, - 3% zinc sulphate, - 3% selenium yeast, - 2% acerola extract, - 1% acid ascorbic acid, -44% sorbitol, - 2% magnesium stearate.

Claims (18)

REVENDICATIONS 1. Complément alimentaire comprenant du gamma-tocophérol, des flavonoïdes, de l'acide carnosique et du carnosol.  1. Food supplement comprising gamma-tocopherol, flavonoids, carnosic acid and carnosol. 2. Complément alimentaire selon la revendication 1, caractérisé en ce que le gamma-tocophérol est issu du soja.  2. Dietary supplement according to claim 1, characterized in that the gamma-tocopherol is derived from soy. 3. Complément alimentaire selon la revendication 1.0 1, caractérisé en ce que les flavonoïdes comprennent des oligo-proanthocyanidines.  3. Dietary supplement according to claim 1.0, characterized in that the flavonoids comprise oligo-proanthocyanidines. 4. Complément alimentaire selon la revendication 3, caractérisé en ce que les oligo-proanthocyanidines sont issues du raisin. 15  4. Dietary supplement according to claim 3, characterized in that the oligo-proanthocyanidines are derived from the grape. 15 5. Complément alimentaire selon la revendication 1, caractérisé en ce que les flavonoïdes comprennent des catéchines et biflavanes.  5. Dietary supplement according to claim 1, characterized in that the flavonoids comprise catechins and biflavans. 6. Complément alimentaire selon la revendication 5, caractérisé en ce que les catéchines et biflavanes 20 sont issues d'un extrait de myrtille.  6. Dietary supplement according to claim 5, characterized in that the catechins and biflavans are derived from a blueberry extract. 7. Complément alimentaire selon la revendication 1, caractérisé en ce que l'acide carnosique et le carnosol sont issus d'un extrait de romarin.  7. Dietary supplement according to claim 1, characterized in that the carnosic acid and carnosol are derived from a rosemary extract. 8. Complément alimentaire selon la revendication 2.5 1, comprenant un extrait de thé vert.  8. Food supplement according to claim 2.5 1, comprising a green tea extract. 9. Complément alimentaire selon la revendication 1, comprenant un extrait d'acérola.  The dietary supplement of claim 1 comprising an acerola extract. 10. Complément alimentaire selon la revendication 1, comprenant de l'acide ascorbique. 30  10. Dietary supplement according to claim 1, comprising ascorbic acid. 30 11. Complément alimentaire selon la revendication 1, comprenant du sélénium.  11. Food supplement according to claim 1, comprising selenium. 12. Complément alimentaire selon la revendication 1, comprenant du zinc.  12. Dietary supplement according to claim 1, comprising zinc. 13. Complément alimentaire selon la revendication 35 1, comprenant du sorbitol. 10  13. A dietary supplement according to claim 1 comprising sorbitol. 10 14. Complément alimentaire selon la revendication 1, comprenant du stéarate de magnésium.  The dietary supplement of claim 1 comprising magnesium stearate. 15. Complément alimentaire selon la revendication 1, comprenant . - de l'acide carnosique et du carnosol, - des oligo-proanthocyanidines, - du gamma-tocophérol, - des catéchises et biflavanes.  Food supplement according to claim 1, comprising. carnosic acid and carnosol, oligo-proanthocyanidines, gamma-tocopherol, catechises and biflavans. 16. Complément alimentaire selon la revendication 15, comprenant : - un extrait sec de romarin contenant de l'acide carnosique et du carnosol, -un extrait sec de raisin contenant des oligoproanthocyanidines, - un extrait de soja contenant du gamma-tocophérol, - un extrait sec de myrtille contenant des catéchines et biflavanes.  16. Dietary supplement according to claim 15, comprising: - a dry extract of rosemary containing carnosic acid and carnosol, - a grape extract containing oligoproanthocyanidines, - a soy extract containing gamma-tocopherol, - a bilberry dry extract containing catechins and biflavans. 17. Complément alimentaire selon la revendication 16, comprenant : - un extrait de thé vert, - du sulfate de zinc, - de la levure de sélénium, -un extrait d'acérola, - de l'acide ascorbique, - du sorbitol, - du stéarate de magnésium.  17. Dietary supplement according to claim 16, comprising: a green tea extract, zinc sulphate, selenium yeast, an acerola extract, ascorbic acid, sorbitol, magnesium stearate. 18. Complément alimentaire selon la revendication 17, caractérisé en ce qu'il comprend, en poids, environ : - 23% d'extrait sec de romarin, - 4 % d'extrait sec de raisin, - 3% de gamma-tocophérol, - 2% d'extrait sec de myrtille, - 12% d'extrait de thé vert, - 3% de sulfate de zinc,11 - 3% de levure de sélénium, - 2% d'extrait d'acérola, - 2% d'acide ascorbique, -43% de sorbitol, - 2% de stéarate de magnésium.  18. Dietary supplement according to claim 17, characterized in that it comprises, by weight, approximately: - 23% dry rosemary extract, - 4% grape dry extract, - 3% gamma-tocopherol, - 2% bilberry dry extract, - 12% green tea extract, - 3% zinc sulphate, 11 - 3% selenium yeast, - 2% acerola extract, - 2% ascorbic acid, -43% sorbitol, -2% magnesium stearate.
FR0603423A 2006-04-14 2006-04-14 ANTIOXIDANT FOOD SUPPLEMENT COMPRISING OLIGOPROANTHOCYANIDES, GAMMA-TOCOPHEROL, CATECHINS AND BIFLAVANES, CARNOSIC ACID AND CARNOSOL Expired - Fee Related FR2899768B1 (en)

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WO2022018281A3 (en) * 2020-07-24 2022-03-10 Activ'inside Composition comprising a mixture of extracts of vitis vinifera and vaccinium angustifolium and probiotics to improve cognitive function

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