WO2016028357A1 - Traitement de la peau sèche présentant un aspect écaillé par une composition topique et procédés de fabrication de celle-ci - Google Patents

Traitement de la peau sèche présentant un aspect écaillé par une composition topique et procédés de fabrication de celle-ci Download PDF

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Publication number
WO2016028357A1
WO2016028357A1 PCT/US2015/034039 US2015034039W WO2016028357A1 WO 2016028357 A1 WO2016028357 A1 WO 2016028357A1 US 2015034039 W US2015034039 W US 2015034039W WO 2016028357 A1 WO2016028357 A1 WO 2016028357A1
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WO
WIPO (PCT)
Prior art keywords
topical preparation
skin
butter
ashy
around
Prior art date
Application number
PCT/US2015/034039
Other languages
English (en)
Inventor
Christian D. PASCAL
Original Assignee
Pascal Christian D
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/462,627 external-priority patent/US9078839B1/en
Priority claimed from US14/723,974 external-priority patent/US20150258013A1/en
Priority claimed from US14/724,006 external-priority patent/US20150258014A1/en
Application filed by Pascal Christian D filed Critical Pascal Christian D
Publication of WO2016028357A1 publication Critical patent/WO2016028357A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A61K8/585—Organosilicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin

Definitions

  • the present disclosure relates generally to a topical composition for treating skin ashiness. More particularly, the present disclosure relates to a topical preparation for treating ashy skin and a method of manufacture thereof.
  • Ashy skin is commonly found on arms, elbows, lower legs, knees and heels. Ashy skin is generally dry skin that has a dull, white or gray appearance.
  • creams and lotions intended for moisturizing ashy skin have titanium dioxide, which dries to a light powder leaving a whitish residue on the areas where ashy skin is a problem.
  • These creams and lotions are emulsions, that is, two- phase mixtures of water with oils and fats that require surfactants to stabilize the mixture, preventing the water and fats from separating into separate phases.
  • the fats and fat derivatives are also solids with high melting temperatures so that a residue remains when the water evaporates.
  • surfactants and high-melting fats also leave a gray to white residue that adds to the ashy appearance.
  • creams and lotion may be suitable for moisturizing, or for general use, they would not be as suitable for the purposes of the present disclosure as disclosed hereafter.
  • An aspect of an example embodiment in the present disclosure is to provide a topical preparation for treating ashy skin that does not leave a visible residue. Accordingly, the present disclosure provides a topical preparation that lacks hydrophilic ingredients that leave a white residue on the skin surface when the preparation is absorbed into the skin.
  • Another aspect of an example embodiment in the present disclosure is to provide a topical preparation for treating ashy skin that is easily absorbed by the skin. Accordingly, the present disclosure provides a topical preparation that is a liquid or liquefies at around skin surface temperature, so that the preparation is a liquid when topically applied allowing for easy absorption by the skin.
  • a further aspect of an example embodiment in the present disclosure is to provide a topical preparation for treating ashy skin that liquefies upon application to skin surface. Accordingly, the present disclosure provides a topical preparation that has a plurality of ingredients, each ingredient a liquid or having a melting point around skin surface temperature, so that the topical preparation is a liquid after application to the skin.
  • Yet another aspect of an example embodiment in the present disclosure is to provide a topical preparation for treating ashy skin that is lipophilic and single phase. Accordingly, the present disclosure provides a topical preparation that has a plurality of lipophilic, hydrophobic, substantially anhydrous ingredients, all ingredients in a single phase without requiring a surfactant to form an emulsion.
  • Yet a further aspect of an example embodiment in the present disclosure is to provide a topical preparation for treating ashy skin that is in physically stable form, having a consistent melting point. Accordingly, the present disclosure provides a topical preparation formed by tempering, so that crystallization is controlled by cooling to minimize polymorphism, which creates varying melting temperatures.
  • the present disclosure describes a topical preparation for treating ashy skin and a method of manufacture thereof.
  • the topical preparation is a single phase, hydrophobic, lipophilic preparation comprising plant-based butters that have a melting point around the temperature of the skin surface. The melting point of the mixture is stabilized by a tempering process.
  • the topical preparation is applied to skin having an ashy appearance and is absorbed into the top layers without leaving a white residue.
  • a method of preparing a topical preparation for treatment of ashy skin can comprise selecting a plurality of essentially anhydrous lipophilic ingredients, said ingredients limited to plant-derived butters, said plant-derived butters further limited by having the property of melting around 37 degrees Centigrade; producing a molten butter base by melting with a heat source at least one selected plant-derived butter at around 58 degrees Centigrade until the butter base is in a molten state, at which point the heat source is removed; cooling the molten butter base by mixing additional plant-derived butters and a liquid fatty acid into the molten butter base at low shear, forming an anhydrous slurry, the addition of said additional butters and liquid fatty acid slowly cooling the slurry in a controlled manner, controlling crystallization in the slurry and further controlling polymorphism in the slurry, producing polymorphs having a melting point around 37 degrees Centigrade, the slurry cooling into a semi-solid state; and
  • the step of mixing a polysiloxane into said mixture at low shear until completely blended can include the step of mixing petrolatum into said mixture at low shear until a desire finished viscosity is achieved, the concentration of petrolatum in the preparation not exceeding four percent.
  • the butter base can be a mixture of mango butter and shea butter, the mango butter concentration a reciprocal of the shea butter concentration in the butter base.
  • FIG. 1 is a method of preparing a topical preparation for treatment of ashy skin, according to one or more embodiments.
  • a treatment for ashy skin also know as keratinized dehydrated disorder, xerosis or watosis.
  • the treatment is a topical preparation that is transparent, non-greasy feeling and readily absorbed by the skin.
  • the topical preparation is not an oil in water emulsion nor a water in oil emulsion, but it is a completely lipophilic, single-phase homogenous mixture having no added water, no aqueous solutions and no polar components.
  • the lipophilic, single-phase homogenous composition provides an essentially non-irritating topical preparation.
  • the preparation is substantially absorbed by the skin, giving a non-greasy perception and appearance, transparent and without residue because it is a single-phase mixture without surfactants, emulsifiers, dispersing agents, whiteners, brighteners and water-soluble compounds.
  • Surfactants, emulsifiers, dispersing agents, whiteners, brighteners and water-soluble compounds produce a solid white residue on the skin when the water in a two-phase emulsion system evaporates, leaving these components on the skin as the lipophilic components of the two-phase emulsion system are absorbed into the skin.
  • the white residue on the skin contributes to the ashy appearance.
  • the composition of the present disclosure is a one-phase lipophilic composition, lacking these compounds, provides a residue-free topical
  • the topical preparation for treating ashy skin comprises a prime base comprising of a butter base, aloe butter, avocado butter and caprylic acid.
  • the topical preparation further comprises the prime base and a polysiloxane.
  • the polysiloxane is dimethicone.
  • the polysiloxane is cyclomethicone.
  • the topical preparation for treating ashy skin comprises a prime base comprising a butter base, aloe butter, avocado butter, caprylic acid and an essential oil, and dimethicone.
  • composition of the topical preparation is choosing the ingredients that melt close to skin temperature so that the preparation is liquid when applied and readily absorbable by the skin.
  • the process of forming the mixture includes a tempering step described hereinbelow that creates a liquid prime base close to skin temperature.
  • the topical preparation has a viscosity that ranges from a lotion to cream or ointment.
  • the viscosity is selectively increased by adding petrolatum, up to four percent by weight to the preparation.
  • the butter base is preferably mango butter.
  • part or all the mango butter may be substituted with shea butter.
  • the range of mango butter in the butter base is zero to one hundred percent, shea butter constituting the remainder of the butter base.
  • some or all of the shea butter may be substituted with cocoa butter.
  • the range of butter base in the topical preparation is preferably 47 to 52 percent, targeting around 50 percent.
  • the polysiloxane is around 2 percent.
  • the range of aloe butter is around 22 to 25, preferably around 23.5.
  • the range of avocado butter is around 17 to 20, preferably about 18.6.
  • the range of caprylic acid is around 2 to 3 percent preferably about 2.5.
  • the essential oil has both therapeutic and fragrance properties.
  • the range of essential oil is 1 to 4 percent preferably about 3.4 percent.
  • the range of essential oil is 0 to 0.5, preferably 0.5 percent. Table 1 lists the ingredients of one example embodiment and Table 1 A lists the ingredients of another example embodiment containing the preferred amounts.
  • Table 2 shows another example embodiment that does not have an essential oil, the topical preparation for treatment of ashy skin of an individual that has sensitivity to perfumes and essential oils.
  • Table 2A shows a further example embodiment that does not have an essential oil, Table 2 A listing the preferred amounts.
  • Table 3 below shows a further example embodiment with an essential oil providing a fragrance to the preparation.
  • Table 4 below shows a further example embodiment with an antioxidant, tocopherol, also known as Vitamin E, which encourages skin healing and reduces scarring, preferably at around 1 percent.
  • tocopherol also known as Vitamin E
  • FIG. 1 is an outline of a method according to one or more embodiments.
  • a plurality of lipophilic ingredients are selected (101 ).
  • Plant- derived butter(s) is melted using a heat source (102).
  • a determination is made as to whether the butter base has reached a molten state (103).
  • the heat source is used to melt the butter until the butter base is in the molten state and then the heat source is removed (104).
  • Additional plant-derived butters and a liquid fatty acid are mixed into the molten butter base at low shear, forming an anhydrous slurry (105).
  • the addition of additional butters and liquid fatty acid is performed to control cooling the mixture (106), controlling polymorphism in the slurry.
  • a determination is made as to whether the slurry mixture has cooled into a semisolid state (107).
  • a polysiloxane is mixed into the mixture at low shear (108) until completely blended (109) thereby forming an essentially anhydrous, lipophilic topical preparation for treatment of ashy skin that is ready to apply (1 10).
  • a method of preparing an example embodiment of the topical preparation for treatment of ashy skin comprises selecting a plurality of lipophilic ingredients having the property of being in a liquid, molten state at around 37 degrees
  • a molten butter base is produced by melting with a heat source at least one plant-derived butter at around 58 degrees Centigrade until the butter base is in a molten state, at which point the heat source is removed.
  • the plant-derived butter is mango butter
  • the plant-derived butter is shea butter.
  • the butter base is a mixture of mango butter and shea butter.
  • the butter base comprises cocoa butter.
  • cocoa butter is combined with mango butter and shea butter.
  • tempering The step of heating the butter base to temperature above the melting point and removing heat is referred to as tempering.
  • the heating step followed by a controlled cooling step has never been applied to the preparation of topical preparations, because topical preparations are generally two-phase emulsions and not single-phase mixtures.
  • the unique selection of ingredients coupled with the tempering step produces the preparation that has the unique characteristics that are particularly effective in treating ashy skin, such as no residue from hydrophilic materials, liquid state at skin temperature and moisturizing ingredients that treat dry skin.
  • the butter base is heated to above the melting point to insure that all crystal forms of the fat are melted.
  • Fats exist in nature in many polymorphic forms and the crystalline phase plays a large role in properties such as melting point, appearance and texture.
  • Additional plant-derived butters, a liquid fatty acid and an essential oil are mixed into the molten butter base at low shear, forming an anhydrous slurry of a prime base.
  • the addition of said additional butters and liquid fatty acid slowly cools the mixture in a controlled manner, controlling polymorphism in the slurry, the slurry cooling into a semi-solid state.
  • the additional plant-derived butters further comprise aloe butter and avocado butter.
  • the fatty acid is caprylic acid.
  • the essential oil is benzoin essential oil.
  • a polysiloxane is added to the prime base mixture at low shear until completely blended, forming an essentially anhydrous, lipophilic topical preparation for treatment of ashy skin.
  • the preferred polysiloxane is dimethicone, and in a further example embodiment, the polysiloxane is cyclomethicone.
  • tocopherol is added at low shear before the prime base solidifies.
  • petrolatum is added to the mixture after the polysiloxane, mixing at low shear until a desired finished viscosity is achieved.
  • concentration of petrolatum does not exceed four percent.
  • Mango butter also known by the INCI (International Nomenclature of Cosmetic Ingredients) name as Mangifera Indica Seed Butter, is classified as a skin conditioner. Mango butter is extracted from the kernels of the mango, which grows in the tropical climates of the world and is rich in vitamins A, C and E. It is a natural sunscreen against ultraviolet rays. Mango butter melts close to skin temperature, but is a solid at room temperature. Mango butter is rich in oleic and stearic acids having a non-greasy feel and is easily absorbed into the skin.
  • INCI International Nomenclature of Cosmetic Ingredients
  • Shea butter (INCI name Butyrospermum Parkii Butter), which can be substituted for some or all the mango butter, has similar properties. Shea butter is extracted from the kernels of the fruit of the shea nut tree. Shea butter melts close to skin temperature, but is a soft semi-solid at room temperature. Shea has only two polymorphic forms at skin temperature so that is more stable than many other fats and amenable to the tempering process. It is a natural sunscreen.
  • Cocoa butter (INCI name Theobroma Cacao (Cocoa) Seed Butter), which can be substituted for some of the shea butter, has similar properties to shea and mango butters. Cocoa butter has multiple polymorphic forms, the more stable ⁇ form having a melting point close to skin temperature. Cocoa butter is amenable to the tempering process to produce the more stable polymorphic forms.
  • avocado butter (INCI name Persea Gratissima Butter) is produced by hydrogenating cold pressed avocado oil with other vegetable oils, creating a soft butter at room temperature. It is also a natural sunscreen.
  • Aloe butter (INCI name Aloe Barbadensis Leaf Butter) is an extract of aloe vera, aloe barbadensis, blended with other plant-based oils such as coconut oil. It is solid at room temperature, but melts on the skin.
  • Caprylic acid (octanoic acid, INCI name caprylic acid) is a hydrophobic, lipophilic organic acid that has antibacterial properties.
  • the essential oil is benzoin essential oil (benzoin oil, INCI name benzoin extract) is extracted from the resin of the Styrax benzoin tree. In addition to having a pleasant fragrance, it forms a protective film over skin.
  • benzoin essential oil are benzoic acid, cinnamic acids, benzyl benzoate, benzoic aldehyde, vanillin and coniferyl benzoate.
  • Dimethicone (INCI name dimethicone) also known as
  • polydimethylsiloxane is a polysiloxane, a silicone compound and is a moisturizer and skin protectant. It is a liquid at room temperature and body temperature.
  • Cyclomethicone (INCI name cyclomethicone) is a polysiloxane. Although it is water dispersible, it is essentially water-free, containing less than 250 ppm of water. It promotes absorption of oils into top layers of epidermis and quickly evaporates, allowing the oils to remain in the skin.
  • Tocopherol also known as Vitamin E, is an antioxidant and skin conditioner, which encourages skin healing and reduces scarring.
  • Petrolatum (INCI name petrolatum) is a mixture of non-straight chain solid and high boiling liquid hydrocarbons, extremely nonpolar and hydrophobic, lipophilic semi-solid.
  • a method for treating skin having an ashy appearance comprises applying a topical preparation of lipophilic compounds in an amount sufficient to cover a surface of ashy skin requiring treatment.
  • the topical preparation has a melting range around 37 degrees Centigrade and liquefies when it come in contact with the skin, the skin having a temperature at around 37 degrees
  • the topical preparation is substantially absorbable by a plurality of top layers of skin and diminishes the ashy appearance of the skin when applied to said surface.
  • the topical preparation leaves no visible solid residue when applied to the skin.
  • the topical preparation is occlusive, moisturizing the skin by retarding evaporation from the skin surface.
  • the topical preparation has natural sunscreen properties.
  • the preparation is applied at least daily.
  • the topical preparation has a viscosity greater than 5,000 cps at 25 degrees Centigrade and 5 rpm and it is a lotion at lower viscosity. Viscosity can be increased by the addition of petrolatum up to four percent so that the topical preparation has a viscosity of a cream or ointment when applied.
  • the topical preparation is applied to the surface of the skin on the limbs.
  • the topical preparation is used at least once daily on the elbows, knees, hands and feet where the skin has an ashy appearance, covering the surface.
  • the topical preparation melts around 37 degrees Centigrade becoming liquid at skin temperature.
  • the topical preparation is absorbable by a plurality of top layers of skin, the topical preparation moisturizing the top layers of skin, diminishing the ashy appearance of the skin when applied leaving no visible solid residue when applied to the skin.
  • the method of treatment further comprises spraying a silicone liquid over the topical preparation.
  • the silicone spray seals in moisture and protects the skin surface.
  • the silicone spray is essentially transparent and anhydrous, comprising ingredients that do not leave any visible white residue.
  • the silicone spray is used in conjunction with the topical preparation.
  • a preferred example embodiment of the spray is listed in Table 5 below.
  • the silicone spray includes an essential oil such as benzoin essential oil.
  • the silicone spray may also comprise a fragrance.
  • the spray includes at least one ingredient not described hereinabove.
  • Jojoba oil (INCI Name Simmondsia Chinensis (Jojoba) Seed Oil) is a moisturizer and is a clear liquid. Additionally, a fragrance ingredient in addition to the essential oil is possible within the concept.
  • the method of treatment further comprises a brown sugar scrub that comprises granular brown sugar, glycerin and other liquid ingredients that dry to a transparent or no residue.
  • the scrub exfoliates the skin where there is an ashy appearance, removing dead skin and any soap residue left from washing with other products.
  • the scrub is thoroughly rinsed off and the skin is patted dry. Once the skin is thoroughly dry, the topical preparation is applied followed by the silicone spray.
  • the topical preparation is used at least once daily on the effected skin areas.
  • the topical preparation is rubbed into the skin and is followed by spraying the silicone spray over the topical preparation.
  • the brown sugar scrub is used prior to apply the topical preparation to remove dead skin scales and soap residue that add to the ashy appearance.
  • the scrub is thoroughly rinsed off and the skin is patted dry. Once the skin is thoroughly dry, the topical preparation is applied followed by the silicone spray.
  • the topical preparation can be included in a kit that comprises the topical preparation, a brown sugar scrub for removing dead skin scales that add to the ashy appearance and a silicone spray mist for additional moisturization that forms a protective film after the mist evaporates.
  • a kit that comprises the topical preparation, a brown sugar scrub for removing dead skin scales that add to the ashy appearance and a silicone spray mist for additional moisturization that forms a protective film after the mist evaporates.
  • Another example embodiment of the topical preparation further comprises a skin-lightening agent.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne une préparation topique pour le traitement de la peau sèche présentant un aspect écaillé et un procédé de fabrication de ladite préparation. La préparation topique est une préparation lipophile hydrophobe monophasique, comprenant des beurres à base de plantes qui ont un point de fusion autour de la température de la surface de la peau. Le point de fusion du mélange est stabilisé par un procédé de revenu, qui minimise le polymorphisme (102-107). La préparation topique est appliquée sur de la peau ayant un aspect écaillé et elle est absorbée dans les couches supérieures sans laisser de résidus blanc. La préparation topique est translucide, non irritante et possède des propriétés naturelles d'écran solaire.
PCT/US2015/034039 2014-08-19 2015-06-03 Traitement de la peau sèche présentant un aspect écaillé par une composition topique et procédés de fabrication de celle-ci WO2016028357A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US14/462,627 2014-08-19
US14/462,627 US9078839B1 (en) 2013-09-10 2014-08-19 Treatment of ashy skin by a topical composition and methods of manufacture thereof
US14/724,006 2015-05-28
US14/723,974 2015-05-28
US14/723,974 US20150258013A1 (en) 2013-09-10 2015-05-28 Treatment of Ashy Skin by a Topical Composition and Methods of Manufacture Thereof
US14/724,006 US20150258014A1 (en) 2013-09-10 2015-05-28 Treatment of Ashy Skin by a Topical Composition and Methods of Manufacture Thereof

Publications (1)

Publication Number Publication Date
WO2016028357A1 true WO2016028357A1 (fr) 2016-02-25

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050058672A1 (en) * 2003-09-14 2005-03-17 Bioderm Research Baby Care Skin Protectant Compositions for Diaper Rash
US20120237593A1 (en) * 2010-09-15 2012-09-20 Synergy Pharmaceuticals Inc. Formulations of Guanylate Cyclase C Agonists and Methods of Use
US8343467B2 (en) * 2004-12-27 2013-01-01 Beiersdorf Ag Glycopyrrolate in cosmetic preparations

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050058672A1 (en) * 2003-09-14 2005-03-17 Bioderm Research Baby Care Skin Protectant Compositions for Diaper Rash
US8343467B2 (en) * 2004-12-27 2013-01-01 Beiersdorf Ag Glycopyrrolate in cosmetic preparations
US20120237593A1 (en) * 2010-09-15 2012-09-20 Synergy Pharmaceuticals Inc. Formulations of Guanylate Cyclase C Agonists and Methods of Use

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