WO2016026580A1 - Compositions de dioxyde de zircone stabilisées produites par un processus de fusion et destinées à être utilisées dans des applications dentaires, et articles dentaires comprenant les compositions de dioxyde de zircone stabilisées - Google Patents

Compositions de dioxyde de zircone stabilisées produites par un processus de fusion et destinées à être utilisées dans des applications dentaires, et articles dentaires comprenant les compositions de dioxyde de zircone stabilisées Download PDF

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WO2016026580A1
WO2016026580A1 PCT/EP2015/001719 EP2015001719W WO2016026580A1 WO 2016026580 A1 WO2016026580 A1 WO 2016026580A1 EP 2015001719 W EP2015001719 W EP 2015001719W WO 2016026580 A1 WO2016026580 A1 WO 2016026580A1
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dental
stabilized zirconia
cubic stabilized
cubic
composition
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PCT/EP2015/001719
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English (en)
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WO2016026580A8 (fr
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Berthold Reusch
David Figge
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Pritidenta Gmbh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/802—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics
    • A61K6/822—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics comprising rare earth metal oxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/802—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics
    • A61K6/818—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics comprising zirconium oxide

Definitions

  • the present invention relates to cubic stabilized zirconia compositions produced by a melting process for use in dental applications.
  • the dental application may be a chair- side medical treatment.
  • the invention also relates to novel dental articles comprising said cubic stabilized zirconia compositions.
  • Preferred dental articles are crowns, bridges, inlays, onlays, veneers, facings, crown frameworks, bridged frameworks, implants, abutments, copings or orthodontic appliances.
  • the invention relates to a process for the production of a dental article comprising cubic stabilized zirconia compositions produced by a melting process.
  • yttria-stabilized tetragonal zirconia polycrystalline ( ⁇ - ⁇ ) ceramic materials are used to produce high strength frameworks for dental prostheses (e.g. single units up to large bridges with 14 units).
  • These zirconia based dental applications are typically generated by CAD/CAM technologies using a powder metallurgical generated pre-fired ceramic blank.
  • a dental article is milled out of a pre-sintered zirconia mill blank. Since these materials are crystalline, after milling of the framework, the materials have to be densified in a second step in a dental furnace, normally at temperatures of from 1350°C to 1540°C dependent on the used starting powder.
  • This process for the preparation of dental articles from yttria-stabilized tetragonal zirconia polycrystalline ( ⁇ - TZP) ceramic materials is complex and time-consuming.
  • Yttria-stabilized tetragonal zirconia polycrystalline ( ⁇ - ⁇ ) ceramic materials may be used in the classical time-consuming dental medical treatments.
  • the classical dental medical treatment comprises multiple costly treatments, at least a first treatment for taking an impression, integrating a temporary dental article, e.g. a temporary crown, expensive fabrication of a final dental article by dental technicians in a dental laboratory, and a further treatment for removing the temporary dental article and integrating the final dental article.
  • chair-side applications involve only one dental medical treatment, wherein in a first step an individually adapted dental article, e.g. a crown, onlay or inlay is milled out of a preform by means of CAD/CAM in the dental practice for the patient.
  • the individually adapted dental article is subjected to the dense sintered stage in a high temperature sintering oven and directly integrated in the first and only visit of the patient to the dentist.
  • dental materials must allow the dentist to produce and use the fully-anatomically formed dental article, e.g. a crown, during one visit of the patient with the aid of a computer, particularly with the help of CAD/CAM procedures, after gathering the data via e.g. an oral scanner.
  • Y-TZP yttria-partially-stabilized tetragonal zirconia polycrystalline
  • EP 2 045 222 A1 describes high-strength yttria-containing zirconia sintered bodies obtainable from zirconia powder, which comprise zirconia containing from 2 to 4 mol% yttria.
  • this dental material is not suitable for chair- side applications since carrying out the sintering step, which is necessary for obtaining the final dental article, lasts several hours. Thus, the chair-side application in the dental practice would take too long.
  • Another commonly used dental material is lithium disilicate glass ceramic. This dental material allows also chair-side applications. However, the production process of dental articles from this dental material requires recrystallization of the crude dental restoration taking about 30 minutes during the treatment in the dental practice.
  • translucency can be described as the gradient between transparent and opaque. Enamel and dentin have varying degrees of translucency. A high translucency is therefore a desired property of dental materials where esthetic matters.
  • lithium disilicate glass ceramic materials are commonly used for the production of dental articles - especially for chairside applications- such as crowns, inlays, onlays and veneers.
  • the translucency of lithium disilicate glass ceramic materials is up to 50% what is close to natural teeth.
  • a disadvantage for the chairside application is the half-hour recrystallization firing after milling.
  • Another dental material is cubic stabilized polycrystalline zirconia produced by powder metallurgic processes.
  • the translucency of cubic yttria-full-stabilized polycrystalline zirconia produced by powder metallurgic processes is also adjustable. However, this dental material has also only a translucency of up to 50%.
  • EP 2 045 222 A1 describes high-strength yttria-containing zirconia sintered bodies obtainable from zirconia powder, which comprises zirconia containing from 2 to 4 mol% yttria and has a total light transmittance ranging from 41 % to 46%, when it has a thickness of 1 mm.
  • the strong unreal color of white zirconia is connected with advantages and disadvantages for the esthetics and thus for the production of teeth replacement applications. There are certain possibilities to deal with the strong unreal color of yttria- stabilized tetragonal zirconia polycrystalline ( ⁇ ) ceramic materials.
  • the most common method is to "hide" the zirconia under either a layer of stain or liner.
  • feldspar ceramics are used to realize the highest possible esthetic results.
  • One disadvantage of this method is that this technology requires a skilled and experienced dental technician.
  • a further disadvantage is that the preparation of the materials is very time consuming and costly due to several firing steps.
  • Another method is to entail shading the zirconium oxide in the pre-sintered stage, e.g. by immersing the whole framework or a single crown into a coloring liquid, or by painting the same.
  • One disadvantage of this method is that the resulting frameworks or crowns have a reduced translucency.
  • this method is also time-consuming and costly and can only be carried out by a skilled and experienced dental technician.
  • Fig. 1 is a scheme disclosing the workflow for the preparation of a preform from cubic stabilized zirconia compositions produced by a Skull melting process.
  • Fig. 2 is a scheme disclosing the principle of CAD/CAM machining for cubic stabilized zirconia compositions produced by a Skull melting process.
  • Fig. 3 is a photograph showing a crown exemplifying a finished milled dental article.
  • Fig. 4 is a photograph showing a crown exemplifying a finished milled dental article.
  • Fig. 5 is a photograph showing a crown exemplifying a finished milled dental article.
  • Fig. 6 is a photograph showing a three part bridge exemplifying a finished milled dental article.
  • the present invention relates to a cubic stabilized zirconia composition produced by a melting process for use in dental applications.
  • the present invention relates to the use of a cubic stabilized zirconia composition produced by a melting process in dental applications.
  • the invention relates to the cubic stabilized zirconia composition for the above-mentioned use, wherein the composition has been produced by means of a Skull melting process. In another embodiment, the invention relates to the cubic stabilized zirconia composition for the above-mentioned use, wherein the composition comprises:
  • the cubic stabilized zirconia composition for the above-mentioned use comprises:
  • the invention relates to the cubic stabilized zirconia composition for the above-mentioned use, wherein the composition further comprises from 0.1 to 6 wt.% coloring oxides and/or coloring pigments, or mixtures thereof.
  • the coloring oxides in the cubic stabilized zirconia composition for the above-mentioned use are oxides of transition metals or oxides of rare-earth elements.
  • the coloring oxides in the cubic stabilized zirconia composition for the above-mentioned use are selected from the group consisting of iron oxide (Fe 2 0 3 ), cerium oxide (Ce0 2 ) and praseodymium oxide (Pr 2 C>3).
  • the preferred embodiments of the cubic stabilized zirconia compositions produced by a melting process mentioned above apply accordingly to any purpose-related products for dental applications, to any use for dental applications, to any dental articles, to any chair-side medical treatments and to any processes for the production of a dental article comprising a cubic stabilized zirconia composition according to the present invention as described herein.
  • the invention relates to the cubic stabilized zirconia composition for the above-mentioned use, wherein the dental application is a dental restoration.
  • the invention relates to the cubic stabilized zirconia composition for the above-mentioned use, wherein the dental application is a preform, preferably a single-colored or multicolored preform (tooth-similar geometry), particularly preferred a dental milling block, a disc or a prefab.
  • the invention relates to the cubic stabilized zirconia composition for the above-mentioned use, wherein the preform comprises a holder.
  • the invention relates to the cubic stabilized zirconia composition for the above-mentioned use, wherein the dental application is a chair-side application.
  • the invention relates to a dental article comprising a cubic stabilized zirconia composition as defined herein.
  • the dental article is a shaped dental article.
  • the dental article is a crown, a bridge, an inlay, an onlay, a veneer, a facing, a crown and bridged framework, an implant, an abutment, a coping or an orthodontic appliance.
  • the dental article is a crown.
  • the invention relates to a chair-side medical treatment comprising the following steps: (a) intra-oral measuring of the area requiring treatment in the mouth of the patient or of a model or a replica of this area outside the patient's mouth with the aid of a conventional 3D imaging device,
  • the present invention relates to the use of a cubic stabilized zirconia composition as defined herein for the production of a dental article, preferably of a crown.
  • the present invention relates to a process for the production of a dental article comprising a cubic stabilized zirconia composition as. defined herein comprising the following steps:
  • a cubic stabilized zirconia composition means a cubic fully- stabilized zirconia composition.
  • the term “dental application” means any application or use in the dental or orthodontic field, especially a dental restoration, a preform, e.g. a dental milling block, a disc or a prefab for application in dental clinics (Chair side) or dental laboratories.
  • the dental restoration, the preform, the dental milling block, the disc and the prefab may be monochromatic and/or multilayered.
  • the term "dental article” means any article which can or is to be used in the dental or orthodontic field, especially for producing of or as dental restoration, a tooth model and parts thereof.
  • dental articles include crowns, bridges, inlays, onlays, veneers, facings, copings, crown frameworks, bridged frameworks, implants, abutments, orthodontic appliances (e.g. brackets, buccal tubes, cleats and buttons) and parts thereof.
  • a dental article should not contain components which are detrimental to the patient's health and thus be free of hazardous and toxic components being able to migrate out of the dental article.
  • the term “dental restoration” means any dental restorative material used to restore the function, integrity and morphology of missing tooth structure.
  • preform means any piece of a material, which has been preformed for further use, e.g. for use in a dental CAD/CAM machine, especially a dental milling block, a disc or a prefab.
  • the term "dental milling block” means a solid block (3-dim article) of a material from which a dental article or a dental restoration can or is to be machined.
  • a dental milling block may have a size of about 20 mm to about 30 mm in two dimensions, e.g. may have a diameter in that range, and may be of a certain length in a third dimension.
  • a block for making a single crown may have a length of about 15 mm to about 30 mm, and a block for making bridges may have a length of about 40 mm to about 80 mm.
  • a typical size of a block as it is used for making a single crown has a diameter of about 24 mm and a length of about 19 mm.
  • a typical size of a block as it is used for making bridges has a diameter of about 24 mm and a length of about 58 mm.
  • a dental milling block may also have the shape of a cube, a cylinder or a cuboid. Larger mill blocks may be advantageous if more than one crown or bridge should be manufactured out of one blank.
  • the diameter or length of a cylindric or cuboid shaped mill block may be in a range of about 100 to about 200 mm, with a thickness being in the range of about 10 to about 30 mm.
  • the term "disc” means a disc (3-dim article) of a material from which a dental article or a dental restoration can or is to be machined.
  • prefab means any preformed body resembling the tooth geometry.
  • the terms "chair-side application” or “chair-side medical treatment” mean that in a first step a crude dental article, e.g. a crown, onlay, inlay is milled out of a preform by means of a CAD/CAM machine, e.g. out of a dental milling block, or a disc in the dental practice.
  • the crude dental article is individually adapted in the dental practice to obtain a final dental article.
  • the individual adaptation of the crude dental article depends on the dental material and may comprise for example only polishing or a short-term heat treatment of about 30 minutes.
  • the dental article can be used directly and be inserted into the mouth of the patient in the first and only dentist's visit of the patient.
  • Chair-side applications or chair-side medical treatments may encompass surgical or therapeutic procedures to be conducted by a dentist.
  • the term "fully-anatomical form" as an attribute of a dental article means that this dental article has already the final dimensions for insertion into the mouth of the patient or must only be minimally readjusted, e.g. subsequently cut, e.g. for the production of an optimal chew level.
  • CAD/CAM milling machine means any CAD/CAM milling machine, preferably a usual, particularly a commercially available CAD/CAM milling machine.
  • VITA dental color means the gradual 16 VITA classical A1-D4 shade guide serving to accurately determining tooth shade and the 32 3D-master shade guide VITA basic colors.
  • the arrangement of the shades in the VITA classical family of shades is as follows: A1 , A2, A3, A4 (reddish-brownish), B1 , B2, B3, B4 (reddish- yellowish), C1 , C2, C3, C4 (greyish shades), D2, D3, D4 (reddish-grey).
  • Cubic stabilized zirconia compositions produced by a melting process for the novel use in dental applications
  • the problem underlying the present invention was to provide alternative artificial compositions having a high translucency, preferably a higher translucency than known dental materials, which are suitable for use in dental applications that provide for example for translucent dental articles. Besides a high natural-like translucency a high flexural strength, a simple and quick manual aftercare and a good millability with usual dental CAD/CAM-machines are important. It has now been found that this problem is solved by the use of cubic stabilized zirconia compositions produced by a melting process in dental applications.
  • the present invention in one aspect, relates to a cubic stabilized zirconia composition produced by a melting process for use in dental applications.
  • the melting process is a Skull melting process.
  • Cubic stabilized zirconia compositions produced by a melting process are preferably monocrystalline.
  • cubic stabilized zirconia compositions produced by a melting process are suitable for use in dental applications. Furthermore, it has been uncovered that these materials having a significantly higher translucency than known dental materials allow contrary to expectations a simplified production of dental articles.
  • cubic stabilized zirconia compositions produced by a melting process are transparent or translucent having a color closely resembling the color of natural teeth.
  • cubic stabilized zirconia compositions produced by a melting process suitable for use in dental applications, also in chair-side medical treatments.
  • cubic stabilized zirconia compositions produced by a melting process comprising from 5 wt.% to 35 wt.% yttrium oxide, preferably from 18 wt.% to 30 wt.% yttrium oxide, can be wet grinded with usual dental CAD/CAM-machines.
  • dental CAD/CAM-machines can be wet grinded with usual dental CAD/CAM-machines.
  • bench type dental CAD/CAM-machines may be used.
  • a significant advantage of the cubic stabilized zirconia compositions produced by a melting process are their good mechanical properties, chemical resistance and biocompatibility, which are necessary characteristics for teeth replacement materials.
  • Single-crystalline cubic zirconia is known as a material for the production of gemstones and known for having a high translucency.
  • Cubic zirconia for use in the production of gemstones is produced by the Skull melting process as described below requiring heating at a temperature of 2000 °C or higher.
  • EP 2 045 222 A1 describes that the translucent zirconia obtained as a sintered body must be subjected to cutting in order to impart a desired shape thereto.
  • the Skull melting process has been considered as unsuitable for use in industrial processes. Since for dental applications larger amounts of the respective dental materials are needed, EP 2 045 222 A1 may have kept the skilled person from using endsintered cubic zirconia for dental applications. For the reasons outlined above, it was not foreseeable that a cubic stabilized zirconia composition produced by a melting process is suitable for use in dental applications and allows simplification of the production of dental articles.
  • the present invention relates to the use of a cubic stabilized zirconia composition produced by a melting process in dental applications.
  • cubic stabilized zirconia compositions can be used in dental applications directly without a sintering process. This applies surprisingly also in case of addition of coloring oxides and/or coloring pigments.
  • the cubic stabilized zirconia compositions produced by a melting process as described herein for use in the present invention consists of up to 97 wt.% of cubic single crystals.
  • the cubic stabilized zirconia compositions produced by a melting process as described herein for use in the present invention may contain monoclinic crystals.
  • the cubic stabilized zirconia compositions comprise up to 3 wt.% monoclinic crystals.
  • the cubic stabilized zirconia composition for the use described herein comprises:
  • the sum of all components of the cubic stabilized zirconia compositions described herein is less than or equal to 100 wt%.
  • the cubic stabilized zirconia composition for the use described herein comprises:
  • the cubic stabilized zirconia composition for the use described herein comprises:
  • the cubic stabilized zirconia composition for the above-mentioned use comprises:
  • the cubic stabilized zirconia composition for the use described herein is consisting of:
  • the cubic stabilized zirconia composition for the use described herein is consisting of:
  • the cubic stabilized zirconia composition for the use described herein is consisting of:
  • the cubic stabilized zirconia composition for the above-mentioned use is consisting of:
  • the cubic stabilized zirconia composition for the use described herein comprises from 64 wt.% to 94 wt.% zirconium oxide based on the total weight of the cubic stabilized zirconia composition, e.g. from 63 wt.% to 93 wt.%, from 62 wt.% to 92 wt.%, from 61 wt.% to 91 wt.%, from 60 wt.% to 90 wt.%, from 55 wt.% to 85 wt.%, or from 50 wt.% to 80 wt.%.
  • the cubic stabilized zirconia composition for the use described herein comprises from 85 wt.% to 90 wt.% zirconium oxide.
  • the cubic stabilized zirconia composition for the use described herein comprises from 6 wt.% to 34 wt.% yttrium oxide based on the total weight of the cubic stabilized zirconia composition, e.g. from 7 wt.% to 30 wt.%, from 8 wt.% to 25 wt.%, from 8 wt.% to 20 wt.%, from 9 wt.% to 20 wt.%, from 10 wt.% to 20 wt.%, or from 12 wt.% to 18 wt.%.
  • the cubic stabilized zirconia composition for the use described herein comprises from 10 wt. % to 15 wt.% yttrium oxide.
  • the cubic stabilized zirconia composition for the use described herein further comprises up to 3 wt.% hafnium oxide, preferably up to 2 wt.% hafnium oxide, particularly preferred up to 1 wt.% hafnium oxide.
  • the cubic stabilized zirconia composition for the use described herein further comprises from 0.01 wt.% to 6 wt.% coloring oxides and/or coloring pigments and mixtures thereof.
  • the cubic stabilized zirconia composition may be single- colored or multicolored.
  • the cubic stabilized zirconia composition for the use described herein comprises from 0.01 wt.% to 5.5 wt.% coloring oxides and/or coloring pigments, e.g. from 0.01 wt.% to 5.0 wt.%, from 0.01 wt.% to 4.5 wt.%, from 0.01 wt.% to 4.0 wt.%, from 0.02 wt.% to 3.5 wt.%, from 0.01 wt.% to 3.0 wt.%, or from 0.01 wt.% to 2.5 wt.%.
  • the cubic stabilized zirconia composition for the use described herein comprises from 0.01 wt.% to 0.5 wt.% coloring oxides and/or coloring pigments
  • the coloring pigments may be doped spinels.
  • the coloring oxides in the cubic stabilized zirconia composition for the use described herein are oxides of transition metal elements or oxides of rare-earth elements.
  • Exemplary coloring oxides include but are not limited to oxides of transition metal elements such as iron, e.g., Fe 2 03; titanium, e.g. Ti0 2 ; copper, e.g. CuO; chromium, e.g. Cr 2 O3, cobalt, e.g. Co 2 O3; nickel, manganese, e.g. Mn0 2 ; selenium, silver, indium, gold, vanadium, e.g. V 2 O 5 ; and oxides of rare earth elements as lanthanum; cerium, e.g.
  • transition metal elements such as iron, e.g., Fe 2 03; titanium, e.g. Ti0 2 ; copper, e.g. CuO; chromium, e.g. Cr 2 O3, cobalt, e.g. Co 2 O3; nickel, manganese, e.g. Mn0 2 ; selenium, silver, indium, gold, vanadium, e.g. V 2 O
  • Ce0 2 or Ce 2 03l praseodymium e.g. Pr 2 0 3 ; neodymium; samarium; europium, e.g.
  • EU2O3 gadolinium; terbium; dysprosium; holmium, e.g. Ho 2 0 3 ; erbium, e.g. Er 2 03, thulium, e.g.Tu 2 O3; ytterbium, Yt 2 03; and mixtures thereof.
  • the coloring oxides may be added in the form of an oxide, metal organic compound, nitrate or oxalate of the metal or rare earth metal to the respective composition, which is used as a starting material to obtain a pre-colored starting powder.
  • the coloring oxides in the cubic stabilized zirconia composition for the use described herein are selected from the group consisting of iron oxide (Fe 2 O 3 ), cerium oxide (Ce0 2 ) and praseodymium oxide (Pr 2 03).
  • iron oxide (Fe 2 0 3 ) in the amounts described above to the cubic stabilized zirconia composition results in a teeth color ranging from light to dark yellow.
  • cerium oxide (CeO 2 ) in the amounts described above to the cubic stabilized zirconia composition results in a teeth color from light to dark yellow-orange.
  • praseodymium oxide (Pr 2 0 3 ) in the amounts described above to the cubic stabilized zirconia composition results in a teeth color from light to dark amber.
  • the cubic stabilized zirconia composition for the use described herein may comprise further additives such as e.g. fluorescent agents.
  • fluorescent agents include but are not limited to phosphorous oxide, titanium oxide, tin oxide and mixtures thereof.
  • the cubic stabilized zirconia composition for the above-mentioned use comprises from 1 wt.% to 10 wt.% fluorescent agents, e.g. from 2 wt.% to 8 wt.%, from 3 wt% to 7 wt.% or from 4 wt% to 6 wt.%.
  • cubic stabilized zirconia composition for the use described herein is consisting of:
  • cubic stabilized zirconia composition for the use described herein is consisting of:
  • zirconium oxide (ZrO 2 )
  • cubic stabilized zirconia composition for the use described herein is consisting of:
  • the cubic stabilized zirconia composition for the use described herein is consisting of: 89.98 wt.% zirconium oxide (ZrO2),
  • the cubic stabilized zirconia compositions as described herein have an opacity ranging from 30% to 100%, preferably from 40% to 100%, particularly preferred from 50% to 100%, e.g. at a thickness of 2.7 mm, preferably at a thickness of 1 mm Opacity can be determined according to common determination methods, e.g. by means of a colorimeter.
  • the cubic stabilized zirconia compositions as described herein have a translucency ranging from 60% to 100%, preferably from ranging 70% to 100%, particularly preferred ranging from 80% to 100%, e.g. at a thickness of 1 mm.
  • the cubic stabilized zirconia composition is produced by the Skull melting process and has a translucency of 70% at a thickness of 1 mm.
  • Translucency can be determined according to common determination methods, e.g. by means of a spectrophotometer.
  • the cubic stabilized zirconia compositions as described herein have a Moh's hardness ranging from 6 to 9 (corresponding to a Vickers hardness ranging from 795 to 2060), preferably from 7 to 9 (corresponding to a Vickers hardness ranging from 1120 to 2060).
  • Moh's hardness can be determined according to common determination methods, e.g. as described by G.V. Samsonov (Ed.) in Handbook of the physicochemical properties of the elements, IFI-Plenum, New York, USA, 1968.
  • the cubic stabilized zirconia compositions produced by a melting process are commercially available, or can be obtained by melting processes known to the skilled person.
  • K. Nassau reviews the Skull melting technique used to produce cubic zirconia and summarizes the technical data for cubic zirconia and its distinguishing characteristics (K. Nassau, Gems & Gemology, Spring 1981 , 9-19).
  • methods for the preparation of cubic stabilized zirconia compositions produced by a melting process are described in GB 1 373 888 A, US 2,996,369, US 3,984,524, and US 4,153,469.
  • the starting materials for the preparation of the cubic stabilized zirconia compositions produced by a melting process are commercially available.
  • the cubic stabilized zirconia compositions can be prepared by providing a starting powder composition comprising an oxide powder mixture of pure monoclinic zirconium oxide.
  • a precipitated pure monoclinic zirconium oxide may be used.
  • This starting powder composition may comprise hafnium oxide.
  • Y 2 O 3 yttrium oxide
  • metallic zirconium is added, e.g. from 3 wt.% to 10 wt.%.
  • coloring agents such as the metal oxides and rare earth oxides described herein are added to obtain pre-colored or multicolored cubic stabilized zirconia compositions.
  • the coloring oxides may be added in the form of an oxide of the metal or rare earth metal.
  • a metal organic compound, nitrate or oxalate of the metal or rare earth metal may be added.
  • the starting powder composition mixture is subject to high temperature melting at temperatures ranging from 2700 °C to 3200 °C, preferably at temperatures ranging from 2.800 °C to 2900 °C for 1 to 10 hours, preferably using the Skull melting process.
  • the cubic stabilized zirconia compositions produced by this melting process are isolated according to common methods.
  • the cubic stabilized zirconia composition for the above-mentioned use has been produced using the Skull melting process or the Stockbarger process. Accordingly, the cubic stabilized zirconia composition is based on a molten single monocrystalline, single-colored or multicolored cubic, or cubic and partially tetragonal zirconia phase.
  • the cubic stabilized zirconia composition for the above-mentioned use has been produced by means of a Skull melting process.
  • Dental applications and processes for their production have been produced by means of a Skull melting process.
  • Dental applications in terms of the present invention comprise any application or use in the dental or orthodontic field, especially the use in a dental restoration, in a preform, preferably in a single-colored and/or multicolored preform, or in a chair-side application.
  • the invention relates to the cubic stabilized zirconia composition as defined herein for use in a dental application, wherein the dental application is a dental restoration.
  • the dental application is a preform.
  • the preform may be single- colored or multicolored.
  • the preform may comprise one or more layers of cubic stabilized zirconia compositions as described herein of the same or different colors.
  • the dental application is a multicolored multilayered preform.
  • the dental application is a translucent multicolored multilayered preform. Multicolored preforms may be obtained by joining one or more layers of cubic stabilized zirconia compositions of different colors together using joining technologies well-known to the skilled persons.
  • the preform may have a tooth-similar geometry.
  • the preform is a dental milling block, a disc or a prefab.
  • the dental restoration, the dental milling block, the preform and the disc may be monochromatic and/or multilayered.
  • the preform e.g. the dental milling block, the disc and the prefab, may contain a holder for fixing the preform in the grinding machine.
  • the holder is a clamping possibility (step) or an adapter.
  • the preform e.g. the dental milling block, the disc or the prefab does not contain any holder.
  • Multicolored preforms may be obtained by joining one or more layers of cubic stabilized zirconia compositions of different colors together using joining technologies well-known to the skilled persons.
  • the color of multicolored preforms may be modified e.g. by heat treatment in order to lighten the original cubic stabilized zirconia composition.
  • a preform e.g. a dental milling block, a disc or a prefab
  • the cubic stabilized zirconia composition as defined herein is cutted and milled out of the rough molten pieces of cubic stabilized zirconia composition.
  • Preforms for example dental milling blocks, discs or prefabs, can be generated in any requested geometries.
  • a holder for example a metal or polymer holder, can be fixed on the preform of cubic stabilized zirconia composition by common fixing techniques.
  • the fixing of the preform includes but is not limited to using glue, e.g. a two-part epoxy glue.
  • the invention in another aspect, relates to a dental restoration comprising a cubic stabilized zirconia composition as described herein.
  • the dental application is a chair-side application.
  • the invention relates to a preform comprising the cubic stabilized zirconia composition as described herein.
  • the preform is a single-colored or multicolored preform.
  • the preform is a dental milling block, a disc or a prefab.
  • the preform comprises a holder.
  • Dental articles and processes for their production comprises many time-consuming steps.
  • a dental milling block is cutted out of the rough molten pieces of lithium disilicate glass ceramic material.
  • a crude dental article or dental restoration is grinded out from the dental milling block, a disc or prefab using any commercially available CAD/CAM milling machine.
  • a final step which takes about 30 minutes, the crude dental article has to be recrystallized in order to yield the final dental article or dental restoration.
  • the crude dental article may be polished.
  • a dental article for example of a crown
  • cubic stabilized polycrystalline zirconia produced by a powder metallurgic process requires complex processing.
  • powder of cubic stabilized polycrystalline zirconia produced by a powder metallurgic process is pressed and pre-sintered in order to allow dry milling to obtain a pre-fired zirconia milling block.
  • a dental article is milled out of a pre-sintered zirconia milling block. The dental article is only obtained after a final sintering step.
  • the present invention relates to a process for the production of a dental article comprising a cubic stabilized zirconia composition as defined herein comprising the following steps:
  • One particular advantage of the process of the invention over a process for the production of a dental article, wherein a lithium disilicate glass ceramic material is used as starting material is that the recrystallization step of the crude dental article, which takes about 30 minutes, is not required.
  • the process of the invention has surprisingly several advantages over a process, wherein cubic stabilized polycrystalline zirconia produced by a powder metallurgic process is used as starting material.
  • the starting material can be processed in a final-sintered state.
  • wet grinding with conventional CAD/CAM machines is surprisingly possible.
  • the crude dental article is grinded out by wet grinding. Consequently, the process of the invention allows unexpectedly an accelerated and simplified production of a dental article.
  • any commercially available CAD/CAM milling machine may be used precluded that said machine has the option to be run with water as a coolant.
  • the milling of the cubic stabilized zirconia composition is comparable to the grinding of feldspar ceramic and can be carried out using common techniques.
  • the dental article or dental restoration can be easily removed from the frame dental CAD/CAM machine.
  • the so obtained "crude” dental article or dental restoration may be finished by polishing the surface thereof.
  • the "crude” dental article or dental restoration or a part thereof may also be treated with commercially available stain materials, glaze materials or veneering material.
  • the present invention relates to a dental article comprising a cubic stabilized zirconia composition as described herein.
  • the dental article consists of a cubic stabilized zirconia composition as described herein. In one embodiment, the invention relates to a shaped dental article.
  • Preferred dental articles are crowns, bridges, inlays, onlays, veneers, facings, crown frameworks, bridged frameworks, implants, abutments, copings or orthodontic appliances.
  • a crown comprising a cubic stabilized zirconia composition as defined herein.
  • a cubic stabilized zirconia composition as defined herein allows a simplified chair-side dental medical treatment using any CAD/CAM milling machines, preferably any commercially available CAD/CAM milling machines and accelerates the chair-side dental medical treatment by up to 20 minutes.
  • the present invention relates to a chair-side medical treatment comprising the following steps:
  • the crude dental article which is obtained as a result of process step (d) has already the fully anatomically form of the desired dental article.
  • a cubic stabilized zirconia composition produced by a melting process for use in dental applications.
  • the cubic stabilized zirconia composition for use of embodiment 1 wherein the composition has been produced by means of a Skull melting process.
  • the cubic stabilized zirconia composition for use of embodiment 1 or 2 wherein the composition comprises:
  • yttrium oxide from 5 wt.% to 35 wt.% yttrium oxide, preferably from 18 wt.% to 30 wt.% yttrium oxide.
  • composition for use of embodiment 3, wherein the composition further comprises from 0.1 to 6 wt.% coloring oxides and/or coloring pigments, or mixtures thereof.
  • Opacity Opacity at a thickness of 1 mm was measured with a spectrophotometer CM-600d manufactured by Konica Minolta by direct transmission coefficient (t c ) [%] for wavelengths ( ⁇ ) from 400 nm to 700 nm.
  • Translucency total light transmittance, [%]
  • Translucency [%] 100% - measured opacity [%]
  • Example 1 A crown comprising a cubic stabilized zirconia composition
  • a crown exemplifying a dental article has been prepared from a cubic stabilized zirconia composition produced by the Skull melting process consisting of 69.98 wt.% zirconium oxide (ZrO 2 ), 30 wt.% yttrium oxide (Y 2 O 3 ) and 0.02 wt.% iron oxide (Fe 2 O 3 ) using a CAD/CAM machine.
  • the dental article has a translucent light yellow color.
  • Example 2 A crown comprising a cubic stabilized zirconia composition
  • a crown exemplifying a dental article as shown in Figures 3 and 4 has been prepared from a cubic stabilized zirconia composition produced by the Skull melting process consisting of 79.98 wt.% zirconium oxide (ZrO 2 ), 20 wt.% yttrium oxide (Y 2 O 3 ) and 0.02 wt.% iron oxide (Fe 2 O 3 ) using a CAD/CAM machine.
  • the dental article has a translucent light yellow color. Moh's hardness: 8.6 (HV 1350)
  • the cubic stabilized zirconia compositions which are used in the present invention, can be obtained according to the following general process.
  • the following Example describes the preparation of a zirconia melt by means of the Skull melting process.
  • a transparent cubic stabilized zirconia composition consisting of 87.5 wt.% zirconium oxide and 12.5 wt.% yttrium oxide may be obtained.
  • a precipitated high-purity monoclinic zirconium oxide with a chemical purity of 99.99% and an yttrium oxide with a chemical purity of at least 99.9% are used as starting materials.
  • 995 g zirconium oxide powder and 143 g yttrium oxide powder are mixed in a Turbula T2 F mixer to obtain a powder mixture. Thereafter, the powder mixture is added to a crucible, which is equipped with several copper coolers. Before the melting process, 5 g metallic zirconium is locally added to the powder mixture, to take effect as local melting accelerator.
  • Melting is carried out in an electric RF field ranging from 30 to 40 kW at an oscillating frequency of 300 kHz.
  • the starting powder composition mixture is then subjected to high temperature melting at temperatures ranging from 2800 °C to 2900 °C until the powder composition mixture is completely molten.
  • the temperature can be measured indirectly by means of a pyrometer.
  • a monocrystalline material can be obtained by means of the Bridgeman process through zone cooling.
  • the cast helix is driven out of the oven with a velocity of 30 mm per hour.
  • water cooling contributes to cooling off the cast helix.
  • the cooling off process continues until a final temperature ranging from 80 °C to 90 °C is reached.
  • the RF field is switched off.
  • the monocrystalline cubic stabilized zirconia composition can be removed, cutted out by means of diamond saws and surface treated.
  • the monocrystalline cubic stabilized zirconia composition consisting of 87.5 wt.% zirconium oxide and 12.5 wt.% yttrium oxide, which can be obtained, for example by the process described above, can be used for the preparation of a dental article, preferably for the preparation of a crown.
  • the RF field has to be adapted since the resulting powder mixtures have another melting point. For example, if erbium oxide is added the melting point increases to 2850 °C and the required frequency increases to 500 kHz.

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  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Ceramic Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dental Preparations (AREA)

Abstract

La présente invention concerne des compositions de dioxyde de zircone stabilisées produites par un processus de fusion et destinées à être utilisées dans des applications dentaires. L'application dentaire peut être un traitement médical côté chaise. L'invention concerne également de nouveaux articles dentaires comprenant lesdites compositions de dioxyde de zircone stabilisées. Les articles dentaires préférés sont des couronnes, des bridges, des incrustations, des appositions, des facettes, des structures de couronne, des structures de bridge, des implants, des butées, des chapes ou des appareils orthodontiques. En outre, l'invention concerne un procédé pour la production d'un article dentaire comprenant les compositions de dioxyde de zircone stabilisées produites par un processus de fusion.
PCT/EP2015/001719 2014-08-22 2015-08-21 Compositions de dioxyde de zircone stabilisées produites par un processus de fusion et destinées à être utilisées dans des applications dentaires, et articles dentaires comprenant les compositions de dioxyde de zircone stabilisées WO2016026580A1 (fr)

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