WO2016022927A1 - Détection d'oligosaccharides - Google Patents

Détection d'oligosaccharides Download PDF

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Publication number
WO2016022927A1
WO2016022927A1 PCT/US2015/044222 US2015044222W WO2016022927A1 WO 2016022927 A1 WO2016022927 A1 WO 2016022927A1 US 2015044222 W US2015044222 W US 2015044222W WO 2016022927 A1 WO2016022927 A1 WO 2016022927A1
Authority
WO
WIPO (PCT)
Prior art keywords
oligosaccharides
amount
sulfated
reducing end
biomarker
Prior art date
Application number
PCT/US2015/044222
Other languages
English (en)
Inventor
Brett E. Crawford
Jillian R. Brown
Roger Lawrence
Original Assignee
Biomarin Pharmaceutical Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomarin Pharmaceutical Inc. filed Critical Biomarin Pharmaceutical Inc.
Publication of WO2016022927A1 publication Critical patent/WO2016022927A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, e.g. Konjac gum, Locust bean gum, Guar gum
    • G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Abstract

La présente invention concerne des procédés de détection d'oligosaccharides dans un échantillon biologique. Dans des exemples spécifiques, l'échantillon biologique provient d'un individu souffrant d'un trouble associé à une accumulation anormale de glycosaminoglycane.
PCT/US2015/044222 2014-08-08 2015-08-07 Détection d'oligosaccharides WO2016022927A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462035320P 2014-08-08 2014-08-08
US62/035,320 2014-08-08

Publications (1)

Publication Number Publication Date
WO2016022927A1 true WO2016022927A1 (fr) 2016-02-11

Family

ID=55264634

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/044222 WO2016022927A1 (fr) 2014-08-08 2015-08-07 Détection d'oligosaccharides

Country Status (1)

Country Link
WO (1) WO2016022927A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070161074A1 (en) * 2005-12-27 2007-07-12 Daiichi Pharmaceutical Co., Ltd. Diagnostic method of mucopolysaccharidoses
US20130216742A1 (en) * 2011-10-25 2013-08-22 Steven Edward DeMartino Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
US20130217056A1 (en) * 2009-01-02 2013-08-22 Zacharon Pharmaceuticals, Inc. Quantification of non-reducing end glycan residual compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070161074A1 (en) * 2005-12-27 2007-07-12 Daiichi Pharmaceutical Co., Ltd. Diagnostic method of mucopolysaccharidoses
US20130217056A1 (en) * 2009-01-02 2013-08-22 Zacharon Pharmaceuticals, Inc. Quantification of non-reducing end glycan residual compounds
US20130216742A1 (en) * 2011-10-25 2013-08-22 Steven Edward DeMartino Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
KODAMA, C. ET AL.: "Liquid-Chromatographic Determination Of Urinary Glycosaminoglycans For Differential Diagnosis Of Genetic Mucopolysaccharidoses.", CLIN. CHEM., vol. 32, no. 1, 1986, pages 30 - 34 *
MINAMI, R. ET AL.: "Characterization of keratan sulfate isolated from liver affected by Morquio syndrome.", TOHUKU J. EXP. MEP., vol. 139, 1983, pages 321 - 326 *
VOLPI, N. ET AL.: "Plasmatic dermatan sulfate and chondroitin sulfate determination in mucopolysaccharidoses.", J PHARM BIOMED ANAL., vol. 85, November 2013 (2013-11-01), pages 40 - 45, XP028709834, DOI: doi:10.1016/j.jpba.2013.06.026 *
WHITMAN, KM. ET AL.: "An improved method for the structural profiling of keratan sulfates: analysis of keratan sulfates from brain and ovarian tumors.", GLYCOBIOLOGY., vol. 9, no. 3, 1999, pages 285 - 291 *

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