WO2016005400A1 - Dispositif de surveillance et de stimulation nerveuse - Google Patents

Dispositif de surveillance et de stimulation nerveuse Download PDF

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Publication number
WO2016005400A1
WO2016005400A1 PCT/EP2015/065511 EP2015065511W WO2016005400A1 WO 2016005400 A1 WO2016005400 A1 WO 2016005400A1 EP 2015065511 W EP2015065511 W EP 2015065511W WO 2016005400 A1 WO2016005400 A1 WO 2016005400A1
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WO
WIPO (PCT)
Prior art keywords
nerve
spike
cuff
chemical
chemical sensor
Prior art date
Application number
PCT/EP2015/065511
Other languages
English (en)
Inventor
Amir EFTEKHAR
Christofer Toumazou
Original Assignee
Vagonyx Limited
Lind, Robert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vagonyx Limited, Lind, Robert filed Critical Vagonyx Limited
Publication of WO2016005400A1 publication Critical patent/WO2016005400A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A61N1/0556—Cuff electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4029—Detecting, measuring or recording for evaluating the nervous system for evaluating the peripheral nervous systems
    • A61B5/4041—Evaluating nerves condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/685—Microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2505/00—Evaluating, monitoring or diagnosing in the context of a particular type of medical care
    • A61B2505/05—Surgical care
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/028—Microscale sensors, e.g. electromechanical sensors [MEMS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A61B2562/046—Arrangements of multiple sensors of the same type in a matrix array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/686—Permanently implanted devices, e.g. pacemakers, other stimulators, biochips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
    • A61B5/6877—Nerve
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4148—Integrated circuits therefor, e.g. fabricated by CMOS processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • G01N33/4836—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures using multielectrode arrays

Definitions

  • Nerve stimulating and monitoring device Field of the invention This invention relates to the field of nerve monitoring devices and nerve stimulating devices, more specifically but not restricted to, nerve cuffs and intraneural electrodes.
  • FIG. 1 illustrates a cross section of a nerve (1 ).
  • the nerve contains a plurality of fascicles (2).
  • Each fascicle forms a bundle of axons which can carry electrochemical signals toward organs.
  • Each fascicle is surrounded by a layer of tissue called a perineurium (3).
  • An interfascicular space (4) is provided between the fascicles and the nerve is surrounded by a layer of connective tissue called epineurium (5).
  • nerves can carry signals from sensory neurons to the central nervous system and those nerves are referred to as afferent nerves.
  • Other nerves can carry signals from the central nervous system to muscles and organs and those nerves are referred to as efferent nerves.
  • a third type of nerve can contain both afferent and efferent axons.
  • An electrochemical signal travelling along an axon is also referred to as an action potential.
  • the action potential travels down an axon, the electric potential difference across the cell membranes of the axon changes. The changes are caused by the opening and closing of Na + and K + gated ion channels.
  • Na + channels open and Na + moves into the axon, causing depolarization.
  • the K + channels open and K + moves out of the axon, causing repolarization.
  • a device for detecting impulses within a nerve comprising a support for securing to the epineurium of the nerve, at least one spike extending from said support and arranged to penetrate the perineurium, and at least one chemical sensor arranged on a surface of the at least one spike.
  • the spike may further be arranged to carry an electric signal for stimulating at least part of the nerve.
  • the dimensions of the chemical sensor may be chosen to correspond to the dimensions of a fascicle within the nerve and the position of the chemical sensor may be chosen such that the chemical sensor is in direct contact with the fascicle when the spike is entered in to the nerve.
  • the device may comprise a plurality of chemical sensors attached to the at least one spike for interfacing a corresponding plurality of fascicles and may further comprise a reference chemical sensor attached to a part of the device remote from the at least one spike.
  • the device may further comprise a reference electrode.
  • the chemical sensors may be sensitive to one of: K + , Na + , CI " and H + .
  • the device may comprise a plurality of spikes arranged along a helical path or arranged along a linear path parallel to the longitudinal axis of the nerve.
  • the support may be a nerve cuff and may a flexible material for wrapping the nerve cuff around the nerve.
  • the cuff may comprise two substantially rigid sections connected to each other by a hinge.
  • the device may further comprise a processor connected to the at least one chemical sensor which is arranged to process the chemical signal.
  • the processor may further be arranged to send a signal to the spike and the signal may be arranged to be sent to the spike depending on the measured chemical signal in a closed-loop control system.
  • Figure 1 illustrates a cross section of a nerve
  • Figure 2 shows a perspective view of a nerve with a nerve cuff
  • Figure 3 shows a perspective view of a nerve with a detail of a nerve cuff
  • Figures 4 a) and b) show a perspective view of two spikes
  • Figure 5 shows a perspective view of a nerve with a nerve cuff
  • Figure 6 shows a perspective view of an open nerve cuff with spikes
  • Figure 7 shows a perspective view of a nerve cuff with spikes in an open state and Figure 7a) shows the nerve cuff in a closed state.
  • a means for both stimulating a nerve and detecting activity of the nerve may be carried out in response to a detected activity of the nerve or the stimulation may be carried out without first detecting a signal.
  • Detection of an activity of a nerve may be carried out by a means for detecting an action potential travelling along an axon.
  • One way of detecting an action potential is detecting a change in concentration of Na + and K + ions in a portion of the nerve.
  • a second way of detecting an action potential is detecting electrical activity with an electrode, whereby the electrode is arranged to estimate the potential difference between the inside and the outside of the axons.
  • the stimulation may be carried out by a means for applying a voltage difference to a portion of the nerve or injecting current into a portion of the nerve.
  • a first embodiment is illustrated in Figs. 2 and 3.
  • a substantially cylindrical nerve cuff 21 partially or completely surrounds a portion of the length of the nerve 1 .
  • the parts of the nerve corresponding to the parts of the nerve shown in Fig. 1 are indicated with the same reference numerals.
  • the cuff follows the perimeter of the nerve such that there is a direct contact between the cuff and the nerve.
  • the cuff may be made of a flexible material such that the cuff can be wrapped around a nerve when putting the cuff in place.
  • a plurality of arrays of pointed spikes 22, 23 are provided on the inside 24 of the cuff and extend from the cuff into the nerve.
  • An array of spikes is illustrated in more detail on Fig. 3.
  • the arrays are connected to contacts 25 which can carry an electrical signal to or from the spikes.
  • the spikes have different lengths and thereby extend to different parts of the nerve.
  • a particular spike may penetrate one or more fascicles and the interfascicular space.
  • Fig. 2 illustrates that nerve electrical monitoring electrodes may be provided as a band 26 or as pads 27 distributed around the inside of the nerve cuff.
  • Two embodiments of spikes 23 are illustrated in Figures 4 a) and b).
  • the end of a spike which is connected to the cuff is larger than the opposite end of the spike, which has a sharp tip for entering the spike into nerve tissue.
  • the embodiments illustrated in Figs. 4 a) and b) have a conical shape.
  • the spikes are, for example, between 0.1 and 3mm in length, depending upon the size of the nerve. The size is selected depending on the nerve to minimise damage to the nerve.
  • the sensing area may be along substantially the whole surface of the spike, as illustrated in Fig. 4 a) as portion 27, or consisting of one or more sensing areas 27 which cover only a small part of the total spike surface and which are distributed along the spike surface as illustrated in Fig. 4 b). Examples of dimensions of the sensing areas are in the order of tens of micrometers, such as 30 ⁇ 30 ⁇ " ⁇ .
  • the sensing areas are connected to contacts 25 for carrying signals to and from the sensing areas.
  • the sensing membrane 27 is a membrane deposited on the surface of a metal contact on the spike. These can be ISFET-type, capacitive-type or direct open circuit potential membranes. Two types of electrochemical sensors may be used: potentiostatic, which control a DC bias and measuring current, or potentiometric, which passively measure the potential- without forcing a bias potential or current. Potentiometric sensors are well suited for in-vivo sensing.
  • ISFET Ion-Selective Field Effect Transistor
  • ISFETs may be used for pH measurements but can also be made sensitive to specific ions by the deposition of an appropriate ionophore into a polymer membrane. If the ISFETs are sensitive to specific ions they are referred to as ChemFETs. The ionophore facilitates selective ion transfer.
  • a further option is an extendable planar version of an ISFET which has a separate sensing area and a coupled transistor. In this way, the sensing area is not restricted by the size of the transistor and can be made smaller. The transistor gate is then coupled to this in external recording circuitry.
  • CMOS complementary metal-oxide-semiconductor
  • membranes For measurements of pH within the nerve the inventors have appreciated that there are the following options for membranes including, but not limited to Iridium Oxide, Silicon Oxide, Silicon Nitride and Aluminium Oxide.
  • Several other membranes may be attached, including ionic conductive polymers, plasticized polyvinyl chloride (PVC), ion- conductive inorganic crystals, biological ionophores, and enzymes.
  • PVC plasticized polyvinyl chloride
  • Most of these membranes can be manufactured using one of several technologies including thin-film deposition, electrochemical processes and dip-coating.
  • a spike as illustrated in Fig. 4b) provides sufficient spatial and temporal resolution to detect action potentials in individual fascicles.
  • a particular sensing membrane 27 may be positioned on the spike such that it can be interfaced with a particular fascicle. The spike can be used to send an electronic signal into the nerve.
  • the electrical stimulation and chemical sensing may be carried out simultaneously because electrical signal would not interfere with the chemical sensing membrane.
  • a platinum reference electrode may be provided within the cuff or an additional chemical sensor may be provided outside the cuff.
  • the calibration measurements from the reference electrode or external chemical sensor can be compared with the measurements from the chemical sensors on the spike before or after amplification of the signals.
  • Figs. 5 and 6 illustrate an alternative arrangement of spike electrodes wherein the spikes (23) are distributed around the cuff such that, when wrapped around a nerve, rows of spikes are arranged along a helical path. As shown in Fig. 6, when the cuff is not wrapped around a nerve and laid out flat, the spikes are arranged in multiple substantially linear rows. The inventors have appreciated that this allows for an easier insertion into the nerve when the cuff is wrapped around the nerve.
  • Figs. 7 and 7a illustrate another embodiment of a cuff, wherein the spikes 23 are embedded in a semi-rigid cuff surface 21 .
  • the cuff illustrated in Figs. 7 and 7a consists of two halves forming a cylinder when joined together. The cylinder is opened up along its longitudinal axis and one or more hinges 28 allows the opening and closing of the cuff. Spikes can be placed in any convenient arrangement to minimize damage to the nerve.
  • the arrangement shown in Fig. 7a is a substantially linear row of spikes along the longitudinal axis of the cylinder.
  • a further embodiment is where the spikes are supported by a structure which does not form a cylinder when attached to the nerve.
  • the spikes may be supported by a substantially flat surface connected to a means for attaching the surface to the nerve, for example one or more rings.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physiology (AREA)
  • Electrotherapy Devices (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)

Abstract

La présente invention concerne un dispositif de détection d'impulsions à l'intérieur d'un nerf, le dispositif comprenant un support de fixation à l'épinèvre du nerf, au moins une pointe s'étendant à partir dudit support, disposée de façon à pénétrer dans le périnèvre et au moins un capteur chimique disposé sur une surface de l'au moins une pointe.
PCT/EP2015/065511 2014-07-08 2015-07-07 Dispositif de surveillance et de stimulation nerveuse WO2016005400A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1412137.0 2014-07-08
GB1412137.0A GB2528070B (en) 2014-07-08 2014-07-08 Nerve stimulating and monitoring device

Publications (1)

Publication Number Publication Date
WO2016005400A1 true WO2016005400A1 (fr) 2016-01-14

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PCT/EP2015/065511 WO2016005400A1 (fr) 2014-07-08 2015-07-07 Dispositif de surveillance et de stimulation nerveuse

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WO (1) WO2016005400A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170020403A1 (en) * 2015-07-24 2017-01-26 Korea Institute Of Science And Technology Neural probe array of high performance and for minimized damage of neuron
WO2018065868A1 (fr) 2016-10-04 2018-04-12 Ecole Polytechnique Federale De Lausanne (Epfl) Implant formant électrode intrafasciculaire
US20180125427A1 (en) * 2016-11-10 2018-05-10 Korea Institute Of Science And Technology Planar neural probe structure and its assembly structure for chronic implantation

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2563651A (en) * 2017-06-22 2018-12-26 Galvani Bioelectronics Ltd Nerve stimulation and monitoring device
US11745010B2 (en) 2017-12-21 2023-09-05 Galvani Bioelectronics Limited Nerve stimulation device for current steering
EP3727563A1 (fr) 2017-12-21 2020-10-28 Galvani Bioelectronics Limited Dispositif de stimulation nerveuse pour une stimulation unidirectionnelle et une orientation du courant
BR112021005243A2 (pt) * 2018-09-21 2021-06-15 Teralytic Inc. plataforma de fusão de sensores multimodal, extensível, para sensoriamento remoto de terreno proximal

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US4969468A (en) * 1986-06-17 1990-11-13 Alfred E. Mann Foundation For Scientific Research Electrode array for use in connection with a living body and method of manufacture
US5634462A (en) * 1993-10-15 1997-06-03 Case Western Reserve University Corrugated inter-fascicular nerve cuff method and apparatus
WO2008007065A2 (fr) * 2006-07-10 2008-01-17 Imperial Innovations Limited Procédé et dispositif de mesure de l'activité dans le système nerveux périphérique
WO2011057276A2 (fr) * 2009-11-09 2011-05-12 University Of Utah Research Foundation Interface neurale optico-électrique tridimensionnelle pénétrante pour stimulation sélective et enregistrement
GB2487416A (en) * 2011-01-21 2012-07-25 Dna Electronics Ltd Chemical Sensor

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US8024022B2 (en) * 2005-05-25 2011-09-20 Alfred E. Mann Foundation For Scientific Research Hermetically sealed three-dimensional electrode array
US7991475B1 (en) * 2005-06-08 2011-08-02 The Regents Of The University Of California High density micromachined electrode arrays useable for auditory nerve implants and related methods
US9622671B2 (en) * 2012-03-20 2017-04-18 University of Pittsburgh—of the Commonwealth System of Higher Education Monitoring and regulating physiological states and functions via sensory neural inputs to the spinal cord

Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
US4969468A (en) * 1986-06-17 1990-11-13 Alfred E. Mann Foundation For Scientific Research Electrode array for use in connection with a living body and method of manufacture
US5634462A (en) * 1993-10-15 1997-06-03 Case Western Reserve University Corrugated inter-fascicular nerve cuff method and apparatus
WO2008007065A2 (fr) * 2006-07-10 2008-01-17 Imperial Innovations Limited Procédé et dispositif de mesure de l'activité dans le système nerveux périphérique
WO2011057276A2 (fr) * 2009-11-09 2011-05-12 University Of Utah Research Foundation Interface neurale optico-électrique tridimensionnelle pénétrante pour stimulation sélective et enregistrement
GB2487416A (en) * 2011-01-21 2012-07-25 Dna Electronics Ltd Chemical Sensor

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170020403A1 (en) * 2015-07-24 2017-01-26 Korea Institute Of Science And Technology Neural probe array of high performance and for minimized damage of neuron
US10206597B2 (en) * 2015-07-24 2019-02-19 Korea Institute Of Science And Technology Neural probe array of high performance and for minimized damage of neuron
WO2018065868A1 (fr) 2016-10-04 2018-04-12 Ecole Polytechnique Federale De Lausanne (Epfl) Implant formant électrode intrafasciculaire
US20180125427A1 (en) * 2016-11-10 2018-05-10 Korea Institute Of Science And Technology Planar neural probe structure and its assembly structure for chronic implantation
US10653329B2 (en) * 2016-11-10 2020-05-19 Korea Institute Of Science And Technology Planar neural probe structure and its assembly structure for chronic implantation

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GB201412137D0 (en) 2014-08-20
GB2528070A (en) 2016-01-13

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