WO2015189274A1 - Ensemble de modules, dispositif de mesure, système et procédé d'analyse d'un échantillon de fluide - Google Patents

Ensemble de modules, dispositif de mesure, système et procédé d'analyse d'un échantillon de fluide Download PDF

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Publication number
WO2015189274A1
WO2015189274A1 PCT/EP2015/062947 EP2015062947W WO2015189274A1 WO 2015189274 A1 WO2015189274 A1 WO 2015189274A1 EP 2015062947 W EP2015062947 W EP 2015062947W WO 2015189274 A1 WO2015189274 A1 WO 2015189274A1
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WO
WIPO (PCT)
Prior art keywords
module
measurement device
modules
meter
previous
Prior art date
Application number
PCT/EP2015/062947
Other languages
English (en)
Inventor
Arthur Queval
Maxime ETTORI
Original Assignee
Qloudlab Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qloudlab Sa filed Critical Qloudlab Sa
Publication of WO2015189274A1 publication Critical patent/WO2015189274A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/028—Modular arrangements

Definitions

  • the present invention concerns a set of modules, a measurement device, a system and a method for the analysis of a fluid sample.
  • Point of care tests are personal diagnostic devices offering great advantages compare to traditional medical testing in laboratory. Indeed, they do not require complex procedure nor expensive facilities to be performed. They are designed in such way that the fluid sample (blood, tears, urine, saliva, etc ..) containing the parameter of interest (bacteria, viruses, chemical compounds, etc ..) can be directly inserted into the device without any pre-treatment.
  • Common pre-treatment used in traditional medical testing involves typically mixing the liquid sample with reagents, filtration, heating, etc....
  • fluid sample indicates a liquid sample, for example but in a non-limiting way, blood, urine, serum, blood plasma, saliva, secretions, tears, sweat, or a gas sample, for example but in a non-limiting way, breath.
  • optical transducers e.g. reflectometric, immunoturbidimetric, colorimetric transducers
  • electrical transducers e.g. amperometric, potentiometric, conductimetric transducers
  • mechanical transducers e.g.
  • This measurement device comprises in general a User Interface (Ul), electronic chips and circuitry to perform the
  • a casing In some cases, it comprises also a network circuitry (e.g. Bluetooth, WIFI, infrared etc .), and/or an internal power supply (e.g. a battery).
  • a network circuitry e.g. Bluetooth, WIFI, infrared etc .
  • an internal power supply e.g. a battery.
  • an additional light sensor as well as a light source are needed. This light sensor can be used on a broad part of the light spectrum or on narrow light wavelength range.
  • the analysis result can be asserted through direct eye observation (e.g. the control lines and result lines like for pregnancy tests).
  • direct eye observation e.g. the control lines and result lines like for pregnancy tests.
  • a third electrode can be used as a reference electrode to precisely measure the potential between the working electrode and the counter electrode.
  • Other electrodes can also be added, so as to improve the number of features of the test (e.g. check if a minimal sample volume is provided, check the haematocrit concentration, check the humidity, etc .).
  • optical measurement techniques have been widely used to perform analyte measurement, e.g. in lateral flow POCT.
  • Lateral flow POCT use a wicking membrane to put the sample of interest in contact with a specific reagent that produces an optical response proportional to concentration of the analyte of interest.
  • lateral flow POCT use a wicking membrane to put the sample of interest in contact with a specific reagent that produces an optical response proportional to concentration of the analyte of interest.
  • lateral flow POCT One of the most famous lateral flow POCT is the pregnancy test. Depending of the test, specific light sources and light receptors can be needed to perform the analysis.
  • amperometric POCT is the most used
  • the differences for glucose test measurement systems manufactured by different companies are mainly about the test strip, not about the meter.
  • the differences in the meter are mainly about changes in software, design and electric layout more than changes in the electronic circuitry embedded within the meter.
  • test strip incompatibility from one meter manufacturer to another is not optimal. This can be troublesome in a case of test strip shortage, or when traveling in countries where other test strips are sold. This product high fragmentation is the consequence of a highly regulated market, in which each company had developed a specific combination of test and meters in compliance with local healthcare regulatory administration.
  • a single meter arranged to be connected to two or more consumable test strips is known.
  • the test strips share the same dimension and their electrical layout is designed to be compatible with a single meter. Therefore, several test strips can be used with a single meter.
  • WO1 109431 5 describes a sensor port of a measurement device, this sensor port being configured to receive a plurality of test strips having different sizes, shapes and/or electrode configurations. However, this port is not configured for receiving new and future test strips, having
  • US6773671 describes a measurement device with one test port for receiving test strips.
  • the test port is configured to receive a plurality of test strips and to recognise the inserted test strips.
  • WO0005581 describes a measurement device with a plurality of ports for medical measurement modules configured for receiving
  • Each disposable cartridge is automatically calibrated with respect to measurements to be made once connected to the
  • these aims are achieved by means of a set of modules for the analysis of a fluid sample, each module comprising - a meter port, configured for cooperating with a module port of a measurement device, so as to connect a module of this set to the
  • an insertion slit configured for receiving a test strip arranged for receiving the fluid sample
  • the meter port is the same for all the modules of the set
  • each module comprises a module identification unit for identifying the module when the module is connected to the measurement device.
  • This module identification unit is configured to identify the module itself and not the test strip. The identification is performed once the module is connected to the measurement device. In a preferred embodiment, the identification is performed before inserting the test strip in the insertion slit of the module.
  • At least one module of the set comprises at least two insertion slits, each insertion slit being configured for receiving only one test strip. In another embodiment, at least one module of the set comprises only one insertion slit, this insertion slit being configured for receiving only a test strip.
  • At least one module of the set comprises only one insertion slit, this insertion slit being configured for receiving at least two test strips of different type.
  • At least one module of the set comprises a ring, e.g. a magnetic ring, arranged to be plugged into the measurement device, so as to mechanically connect the module to the measurement device.
  • a ring e.g. a magnetic ring
  • At least one module of the set comprises indexation means, so as to providing mechanical adjustment between the module and the measurement device.
  • the module comprises a module ring (not necessarily magnetic) comprising at least two fingers
  • the meter comprises a bayonet ring comprising at least two notches, the notches being arranged to cooperate with the fingers in a bayonet-like fashion.
  • At least one module of the set is an active module (i.e. it comprises at least one sensor, e.g. an optical sensor, a mechanical sensor, an electrical sensor, an electromechanical sensor, etc., and/or a processing unit arranged to execute a software sent by the measurement device, so as to perform a measurement on the fluid sample on the test strip inserted in the module), and at least one module of the set is a passive module (i.e. devoid of sensors and/or devoid of processing unit).
  • an active module i.e. it comprises at least one sensor, e.g. an optical sensor, a mechanical sensor, an electrical sensor, an electromechanical sensor, etc., and/or a processing unit arranged to execute a software sent by the measurement device, so as to perform a measurement on the fluid sample on the test strip inserted in the module
  • a passive module i.e. devoid of sensors and/or devoid of processing unit
  • At least one module of the set comprises a movable clipping cover configured to define with a planar upper surface of the module the insertion slit and to be clipped over the module so as to contact the module on a part of this planar surface and on a lateral surface of the module.
  • this movable clipping cover allows to easily access contaminated parts of the clipping cover and/or of the module for an efficient disinfection.
  • the present invention concerns also a measurement device for the analysis of a fluid sample, comprising
  • a module port configured for cooperating with the meter port of a module of the set of modules according to the invention, so as to connect the measurement device to the module
  • a connecting unit arranged for allowing the measurement device to be wireless and/or wired connected with an external device
  • module identification unit arranged to identify the module when the module is connected to the measurement device.
  • the measurement device comprises a sensing unit, this sensing unit comprising at least two of the following sensors: optical sensor, mechanical sensor, electrical sensor, electromechanical sensor performing amperometric and/or coulometric measurements so as to allow the measurement device to perform at least two different medical tests.
  • the measurement device comprises:
  • a memory storing a software that can be executed by the processing unit in order to execute a measurement on the fluid sample on the test strip of a module connected to this measurement device, and/or to process this measurement so as to deduce analysis results.
  • the optical sensor of the measurement device comprises a light source and/or an image acquisition unit arranged to be connected to its processing unit.
  • the measurement device comprises a bayonet ring comprising at least two meter indexation means, e.g. notches, each meter indexation mean being arranged to cooperate with a corresponding module indexation mean of a ring of the module in a bayonet-like fashion.
  • the measurement device comprises:
  • a base plate comprising second internal electrical connections arranged to cooperate with the first internal electrical connections
  • a ring e.g. the described bayonet ring, configured to be placed between the housing and the base plate and allowing the connection of the measurement device with a module
  • the present invention concerns also a system for the analysis of a fluid sample, comprising
  • the system comprises an external device, arranged to be connected to the measurement device.
  • This external device can be arranged to communicate with a network.
  • a memory storing a software that can be executed by the processing unit in order to execute a measurement on the fluid sample on the test strip of a module connected to this measurement device, and/or to process this measurement so as to deduce analysis results.
  • the external device comprises at least one display unit for displaying said analysis results.
  • the system according to the invention is arranged for performing at least one of the following analysis of the fluid sample on the test strip:
  • the present invention concerns also a method for the analysis of a fluid sample comprising:
  • the method comprises:
  • the method comprises:
  • the method comprises:
  • the method comprises:
  • the method comprises:
  • the module directly comprises a memory storing the set of instructions that can be executed by a processing unit of the module, in order to execute a measurement on the fluid sample on the test strip.
  • this set of instructions is stored in an external memory, connected to the module.
  • Fig. 1 shows a view of an embodiment of a system for the analysis of a fluid sample according to the invention.
  • Fig. 2 shows a view of another embodiment of a system for the analysis of a fluid sample according to the invention.
  • Fig. 3 shows a view of an embodiment of a measurement device for the analysis of a fluid sample according to the invention.
  • Fig. 4 shows a flow chart of an embodiment of the module identification process.
  • Fig. 5 shows a perspective view of an embodiment of the module connected to the measurement device according to the invention.
  • Fig. 6 shows another perspective and exploded view of the embodiment of Fig. 5 of the module and of the measurement device according to the invention.
  • Fig. 7 shows another perspective and exploded view of the embodiment of Fig. 5 of the module and of the measurement device according to the invention.
  • Figs. 8a and 8b show an exploded section view respectively a bottom view of an embodiment of the measurement device according to the invention.
  • Fig. 9 shows a section view of the measurement device of Figs. 8a and 8b.
  • Figs. 10a and 10b show a section view of a possible connection between the measurement device and the module according to the invention.
  • Figs. 1 1 a and 1 1 b show a top view respectively a section view of an embodiment of a module according to the invention and suitable for measuring e.g. a lipid panel.
  • Fig. 12 shows a section view of an existing solution for measuring a lipid panel.
  • Fig. 1 shows a view of an embodiment of a system 1000 for the analysis of a fluid sample according to the invention.
  • This system 1000 comprises a module 10, a measurement device or meter 20, an external device 40, which can be e.g. and in a non-limiting way a smartphone, a wearable computer (e.g. computer-glasses), a PDA, a tablet, a computer, etc.
  • the external device 40 is arranged to communicate with a network or cloud 50.
  • the module 10 can be active (i.e. it comprises at least one sensor, e.g. an optical sensor, a mechanical sensor, an electrical sensor, an electromechanical sensor, etc., and/or a processing unit arranged to execute a software sent by the measurement device, so as to perform a
  • active and passive modules 10 are powered by the measurement device 20.
  • the module 10 is arranged to receive a test strip (not illustrated in Fig. 1) in its insertion slit 13.
  • the module 10 comprises a meter port 12 arranged to cooperate with the module port 22 of the measurement device 20, so as to connect the module 10 to the measurement device 20.
  • the connection is both electrical and mechanical.
  • the measurement device 20 is arranged to be connected to the external device 40.
  • the connection can be a wireless and/or a wired connection.
  • the measurement device 20 is Dust and Waterproof according to the norm IP68.
  • the measurement device 20 is compatible with a given set 100 of modules 10, each module performing a particular medical test with a particular technology.
  • each module 10 of the set of modules 100 comprises: - a meter port 12, configured for cooperating with a module port 22 of th measurement device 20, so as to connect the module 10 to the measurement device 20,
  • an insertion slit 13 configured for receiving a test strip 30 arranged for receiving a fluid sample (not illustrated).
  • the meter port 12 is the same for all the modules 10 of the set 100, but the insertion slit 13 is different for at least some modules 10 of the set 100.
  • the insertion slits 13', 13" and 13"' of the three modules are different.
  • each module 10 of the set 100 comprises:
  • it comprises also additional electrical sensors (e.g. impedance sensors, electrochemical cells, amperometric sensors, potentiometric sensors, conductimetric sensors, etc .).
  • additional electrical sensors e.g. impedance sensors, electrochemical cells, amperometric sensors, potentiometric sensors, conductimetric sensors, etc .
  • the meter port 12 comprises also light sources (e.g. LED, OLED, etc ..) and/or light receptors or image acquisition unit (e.g. CMOS, CCD, photodiodes, etc .).
  • the meter port 12 has a shape and/or dimensions and/or electrodes configuration configured to match the module port 22 of the meter 20 (e.g. if the module port 22 is a female connector, the meter port 12 is a male connector and vice-versa).
  • the meter port 12 ensures that the module 10 and the meter 20 are mechanically and electrically linked in a known configuration, while providing precise mechanical adjustment between the two parts.
  • the module 10 comprises an indexation notch 1 50, arranged to cooperate with an indexation finger 250 of the measurement device 20, visible on Fig. 6.
  • This embodiment is not limitative, and any other indexation means can be used.
  • the meter port 12 of the module 10 comprises meter electrical connections 120, arranged to cooperate with module electrical connections 220 of the module port 22 of the meter 20, visible on Fig. 6.
  • the module 10 comprises a ring, e.g. a magnetic ring, arranged to be plugged into the measurement device 20, so as to mechanically connect the module 10 to the
  • the ring is a magnetic or magnetisable ring, or a ring made of a ferromagnetic alloy, arranged to cooperate with one or more magnets (not illustrated), e.g. permanent magnets, on the measurement device 20.
  • Figs. 10a and 10b show a section view of another possible connection between the measurement device 20 and the module 10 according to the invention.
  • the measurement device 20 comprises a bayonet ring 223.
  • This bayonet ring 223 comprises at least two meter indexation means 251 , 251 ' (e.g. two notches on Figs. 10a and 10b), each notch being configured for cooperating with a respective module indexation mean 1 51 (e.g. a finger on Figs. 10a and 10b) of a module ring 19 of the module 10.
  • a respective module indexation mean 1 51 e.g. a finger on Figs. 10a and 10b
  • the module 10 is first plugged in the measurement device 20 so that the module ring 19 is inserted in the meter ring 223 and module indexation means 1 51 are inserted in the corresponding meter indexation means 251 , 251 '.
  • the module 10 is then rotated around its central axis so that module indexation means 1 51 engage in the in the corresponding meter indexation means so as to allow a stable connection between the two parties 10, 20.
  • the module 10 comprises a module status indicator 1 5, e.g. a LED, arranged to indicate the status of the module 10.
  • the status of the module 10 can comprise: the detection of the module 10, the proceedings of a measurement (or test), the end of a measurement, the failure of a measurement, etc.
  • the status of the module 10 is indicated by the color of the LED. In another embodiment, it is indicated by a sequence of flickering of the LED.
  • the module 10 has a single slit 13 that is designed to precisely match one test strip design 30. Accordingly, in this embodiment, each test strip 30 is inserted into a specific module 10 that needs to be connected to the meter 20.
  • the module 10' comprises multiple strip insertion slit 13' to 13"'.
  • each test strip of a set has the same dimensions and the appropriate electric connection layout, allowing each test strip 30 to be inserted in a unique strip insertion slit 13.
  • the meter 20 has access to some information from the module 10, e.g. and in a non-limitative way its lot number, serial number, product family number, manufacturing date, etc.
  • the meter 20 comprises a module identification unit (not illustrated) allowing the meter 20 to identify which module 10 is plugged in the meter 20.
  • the module identification unit can be a resistance of known value that will be measured by an ADC of the meter processor unit 28 (illustrated in Fig. 3).
  • the processor unit can use then a one-entry look-up table that links a module 10, or a set of modules 100, to a resistance value.
  • a tolerance range can be defined in this look-up table to take into account the deviation in manufactured resistances (e.g. 10 kOhm ⁇ 1 %).
  • the module identification unit comprises a second processor unit and/or non-volatile memory (e.g. an EEPROM), not illustrated.
  • This processor unit can access the module's memory directly or via an active component within the module 10.
  • the module identification is performed by accessing a memory of the module, then at least one electric connection is needed to power the chip comprising the memory and read/write it.
  • a one- wire communication protocol only one wire is needed whereas with I2C communication protocol four wires are needed (i.e. SCL, SDA, Vin and GND).
  • I2C communication protocol four wires are needed (i.e. SCL, SDA, Vin and GND).
  • the meter and/or the module comprises optical components
  • the meter and/or the module comprises optical components
  • total cholesterol, HDL, LDL, triglycerides total cholesterol, HDL, LDL, triglycerides.
  • the elements that can be tested in the fluid sample by the meter 20 thanks to the previously listed measurement techniques are e.g. and in a non-limiting way: bacteria, viruses, chemical compounds, glucose, lactate, cholesterol, INR, ureic acid measurement, troponin, hematocrit, RBC, WBC, pH.
  • Fig. 3 shows a view of an embodiment of a measurement device 20 for the analysis of a fluid sample according to the invention. It comprises an external housing 21 , and an electrical circuitry 23, which comprises a sensor unit 26 (comprising e.g. an impedance spectroscopy sensor, two or three electrochemical cells, amperometric sensor, potentiometric sensor, conductimetric sensor, etc .), a processor unit 28, and a communication unit 24 arranged to electrically connect the meter 20 to an external device 40.
  • the communication unit 24 comprises a wireless network unit (e.g. Bluetooth, Wifi, Zigbee, IR, etc.) if the communication between the meter 20 and the external device is a wireless communication.
  • the communication unit 24 comprises a connector (e.g. jack, USB, power-plug, etc.) if the communication between the meter 20 and the external device is a wired communication.
  • a wireless network unit e.g. Bluetooth, Wifi, Zigbee, IR,
  • the measurement device 20 comprises also a module port 22, i.e. a connection mechanism allowing the measurement device 20 to be connected to the meter port 12 of the module 10.
  • the measurement device 20 is devoid of a display, and the results of the analysis are displayed on a display unit of the external device 40.
  • the results of the analysis are displayed on a display unit of the external device 40.
  • measurement device 20 comprises a display unit.
  • the measurement device 20 is devoid of a communication unit allowing a communication with a network or a cloud, and this communication is performed through the communication unit of the external device 40.
  • the measurement device 20 comprises a communication unit comprising a network unit (e.g. Bluetooth, Wifi, Zigbee, IR, etc.), and/or a link connector (e.g. jack, USB, power-plug, etc.).
  • a network unit e.g. Bluetooth, Wifi, Zigbee, IR, etc.
  • a link connector e.g. jack, USB, power-plug, etc.
  • the measurement device 20 comprises an image acquisition device (e.g. CMOS, CCD camera, etc., see e.g.
  • a light source i.e. LED, OLED, etc.
  • the module port 22 and the meter port 12 are designed in such way that when a module 10 is plugged into the meter 20, the module 10 and the meter 20 are physically linked in a known configuration, while providing precise mechanical adjustment between the two parts.
  • fasteners like bolts, screws, clips and/or magnets (electromagnetic or permanent magnets type) can be used.
  • the meter 20 can be powered by an internal battery (e.g. a AAA battery) or by an external power supply. If it is battery powered, the meter design must maximized battery-life. Possible meter designs to increase battery-life are for example designing a meter 20 without display and/or using ultra-low power chips only.
  • the measurement device 20 comprises a power button 280, e.g. a ON/OFF button.
  • a power button 280 e.g. a ON/OFF button.
  • a connectivity status indicator 240 e.g. a LED ring, for indicating if the connection between the measurement device 20 and the external device 40 has been correctly performed.
  • the measurement device 20 comprises a meter status indicator unit 25, comprising in this case some LEDs, e.g. five LEDs, at an end of the measurement device 20.
  • the shape of the measurement device 20 allows a user to easily handle measurement device 20 and connect the module 10.
  • a first part of the measurement device 20 has a shape substantially cylindrical (see e.g. left part of the measurement device 20 in Fig. 5), and a second part of the measurement device 20 has a shape substantially flared (see e.g. right part of the measurement device 20 in Fig. 5).
  • the dimensions of the measurement device 20 allow the measurement device 20 to be portable.
  • the total length of the measurement device 20 is comprised between 80 mm and 180 mm, preferably between 90 mm and 1 50 mm.
  • the diameter of the substantially cylindrical part of the measurement device 20 is comprised between 25 mm and 35 mm, e.g.
  • the diameter of the substantially flared part of the measurement device 20 is comprised between 30 mm and 60 mm, e.g. 45 mm. In another embodiment, the diameter of the substantially cylindrical part of the measurement device 20 is comprised between 35 mm and 50 mm, e.g. 45 mm. In one embodiment, the weight of the measurement device 20 is comprised between 40 g and 1 50 g, preferably between 60 g and 140 g.
  • the end of the measurement device 20 opposite to the end receiving the module is made of aluminum.
  • the aluminum is anodized (e.g. a colored or natural anodization, i.e. an anodization conferring a color to the aluminum, respectively holding the original color of the aluminum).
  • the substantially flared part of the measurement device 20 is made of titanium.
  • the titanium is anodized (e.g. a colored or natural anodization).
  • substantially flared part of the measurement device 20 is made of a nonmagnetic material or alloy.
  • the part of the measurement device 20 near the module port 22 e.g. the part 212 on Fig. 9 is made of polymer, for example but in a non limiting way, PEEK, PET, ABS, PC, ABS-PC or POM.
  • This polymeric part ensures the possibility of using a wireless communication protocol (WiFI, ZigBee, Bluetooth, 2G, 3G, 4G, EDGE etc ..) emitted from the communication unit 24 of the measurement device 20 to the external device 40.
  • the module port 22 of the meter 20 is designed in such way that an external module 10 can be easily plugged in to the meter 20, making the meter 20 and the module 10 reversibly physically linked.
  • connection is not only mechanical, but also electrical thanks to the module port 22 and meter port 12.
  • This electric connection between the module port 22 and the meter port 12 can be used, e.g. and in a non- limiting way, for:
  • the meter is used with an external device 40, e.g. and in a non-limiting way a smartphone, a wearable computer (e.g. computer-glasses), a PDA, a tablet, a computer, etc.
  • the meter must be used with this external device 40.
  • Connecting the meter 20 to an external device 40 offers numerous advantages, e.g. and in a non-limiting way:
  • the network communication protocol of the external device 40 can be GSM or any other communication protocol suitable for data transmission (i.e. WiFi, ZigBee, Bluetooth, 2G, 3G, 4G, EDGE etc .).
  • the results of the fluid sample analysis can then be send from a patient site to a general practitioner (GP), or to a secured online platform (e.g. a secured cloud).
  • GP general practitioner
  • a secured online platform e.g. a secured cloud
  • the external device operating system allows designing advanced user interface to enhance user experience.
  • the external device 40 comprises at least one processor, and a memory storing a software that can be executed by this processor, this software comprising portions of code for a
  • the module 10 is properly identified by the meter 20.
  • the meter 20 runs the correct set of instructions needed for the sample measurement and analysis.
  • the external device software access the result of a known test, e.g. via internet, and provide the appropriate data integration inside the external device software environment.
  • This integration can be used to send the data to a person (e.g. GP) or to a third party company (e.g. a secured cloud storage).
  • Fig. 4 shows a flow chart of an embodiment of the module identification process. Two different cases are presented here, one in which the module 10 is connected for the first time to the meter 20, and the other one in which the module 10 has already been plugged into the meter 20.
  • the meter must identify the module ID as well as the proper set of instruction necessary to perform the measurement with the meter 20.
  • the identification of the module is performed by the module identification units within the meter 20 and the module 10.
  • the meter 20 can comprise a look-up table comprising a list of module identification codes and its corresponding module models or types. In case the module model is unknown, the meter 20 is connected to the external device 40 to search for the module type. The module type can be found by providing the module identification code.
  • the external device 40 downloads the module type linked to its identification code and updates its internal lookup table with this information.
  • the external device 40 can download also the set of instructions that the meter 20 will use for measuring the module 10 plugged in. Once the set of instruction are downloaded into the external device non-volatile memory, the user can use the meter 20 even if the external device 40 has no more internet
  • the set of instruction is transmitted from the external device 40 to the meter 20 each time a measurement must be performed.
  • the set of instructions is written into a non-volatile memory of the meter 20, so as to reduce the analysis time.
  • the meter 20 recognize the module 10 from its identification code and reuse the set of instruction that has been previously downloaded in the external device non-volatile memory. In one embodiment, the meter reuse the set of instructions written in the meter non-volatile memory.
  • Figs. 8a and 8b show an exploded section view respectively a bottom view of an embodiment of the measurement device 20 according to the invention.
  • the measurement device 20
  • the central basket 210 comprises a central basket 210 comprising the electronic circuit 23.
  • the electronic circuit 23 is configured for being inserted into the basked 210, i.e. its size and form are arranged so as it can be received by the basket 210.
  • This central basket 210 is inserted into a housing which advantageously can comprise two parties, i.e. a top part 21 1 and a bottom part 212.
  • the two parties 21 1 , 212 are two distinct and separated pieces configured to be connected. In another embodiment, they belong to a same body.
  • the bottom part 212 can be made of a material allowing the transmission of any electromagnetic signal from the communication unit 24 of the measurement device 20 to an external device 40.
  • the bottom part 212 can be made of a polymer.
  • the bottom part 212 of the housing cooperates with a bayonet ring 223, however this embodiment is not limited to a bayonet ring and any other connection means (e.g. a magnetic ring, etc.) could be used.
  • the reference 21 5 on Fig. 8a indicates a meter recharging port, e.g. a USB port.
  • the port is a USB C-type port.
  • the port 21 5 belongs to the electronic circuit 23.
  • the measurement device 20 comprises first internal electrical connections 213 on the electronic circuit 23, arranged to cooperate with corresponding second internal electrical connections 220 of a holder plate 221 of the module port 22, so as to create an electrical connection internal to the measurement device 20.
  • the holder plate 221 defines an opening arranged to receive a screw 222. This screw 222 cooperates with the nut 214 on the central basket
  • the two parts of the housing are assembled and maintain all the described parties of the measurement device 20 together (i.e. the housing, the central basket, the connection ring, the base plate).
  • the two parts of the housing are assembled and maintain all the described parties of the measurement device 20 together (i.e. the housing, the central basket, the connection ring, the base plate).
  • the two parts of the housing are assembled and maintain all the described parties of the measurement device 20 together (i.e. the housing, the central basket, the connection ring, the base plate).
  • the two parts of the housing are assembled and maintain all the described parties of the measurement device 20 together (i.e. the housing, the central basket, the connection ring, the base plate).
  • the main advantage of the measurement device 20 illustrated in Figs. 8a, 8b and 9 is that only one screw 222 is sufficient for assembling all the illustrated parties. The disassembling is simpler as well, therefore the after-sale service can be performed in a simpler and more efficient way. Moreover, this screw 222 allows the measurement device 20 to be not only more rigid, but also waterproof thanks to the sandwiched structure, i.e. the housing 21 1, 212 sandwiched between the basket 210 and the plate 221 . Finally, the screw 222 allows the internal electrical connection between the electronic circuit 23 and the module port 22.
  • Fig. 12 shows a section view of an existing solution for measuri a lipid panel.
  • Figs. 1 1 a and 1 1 b show a top view respectively a section view (in the plane y-z) of an embodiment of a module 10 according to the invention and suitable for measuring a lipid panel or in general any other
  • the movable clipping cover 17 defines the width of the insertion slit 13"" (i.e. the dimension of the insertion slit 13"" parallel to the axis y on Fig. 1 1 b) receiving the test strip 30"", by assuring the lateral guidance of the test strip 30"".
  • the movable clipping cover 17, in particular its zone 16, defines with an upper planar surface 160 of the module 10 the height of the insertion slit 13"" (i.e. the dimension of the insertion slit 13"" parallel to the axis z on Fig. 1 1 b) receiving the test strip 30"", by assuring the vertical guidance of the test strip 30"".
  • the movable clipping cover 17 defines as well the length of the insertion slit 13"" (i.e. the dimension of the insertion slit 13"" parallel to the axis x on Fig. 1 1 b) receiving the test strip 30"", as visible on Fig. 1 1 a.
  • the movable clipping cover 17 is configured to enter into contact with the module at a part of the planar surface 160 and at a lateral surface 162 of the module 10.
  • the movable clipping cover 17 can be connected to the module 10 by clipping or by any other kind of movable connection.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne un ensemble (100) de modules (10) utilisable en vue de l'analyse d'un échantillon de fluide, chaque module comprenant : un orifice de mesure (12), conçu pour coopérer avec un orifice pour module (22) d'un dispositif de mesure (20), de façon à relier un module (10) dudit ensemble (100) audit dispositif de mesure (20) ; une fente d'introduction (13), conçue pour recevoir une bandelette d'essai (30) agencée pour recevoir l'échantillon de fluide. L'orifice de mesure (12) est le même pour tous les modules (10) de l'ensemble (100), la fente d'introduction (13) est différente pour au moins certains modules (10) de l'ensemble (100). La présente invention concerne également un dispositif de mesure (20) comprenant : un orifice pour module (22), conçu pour coopérer avec l'orifice de mesure (12) d'un module (10) de l'ensemble (100) de modules ; et une unité de raccordement (24) agencée de manière à permettre le raccordement du dispositif de mesure (20) à un dispositif externe (40).
PCT/EP2015/062947 2014-06-10 2015-06-10 Ensemble de modules, dispositif de mesure, système et procédé d'analyse d'un échantillon de fluide WO2015189274A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH00874/14 2014-06-10
CH8742014 2014-06-10

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WO2015189274A1 true WO2015189274A1 (fr) 2015-12-17

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019147225A1 (fr) * 2018-01-24 2019-08-01 Hewlett-Packard Development Company, L.P. Détermination de propriétés fluidiques à partir d'impédances de fluide
US11478175B1 (en) 2021-10-20 2022-10-25 Paulus Holdings Limited Devices for collecting capillary blood and methods for same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000005581A1 (fr) 1998-07-21 2000-02-03 Diametrics Medical, Inc. Analyseur medical portatif a reponse immediate
US6773671B1 (en) 1998-11-30 2004-08-10 Abbott Laboratories Multichemistry measuring device and test strips
WO2011094315A1 (fr) 2010-01-28 2011-08-04 Abbott Diabetes Care Inc. Port de bandelette réactive universel

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000005581A1 (fr) 1998-07-21 2000-02-03 Diametrics Medical, Inc. Analyseur medical portatif a reponse immediate
US6773671B1 (en) 1998-11-30 2004-08-10 Abbott Laboratories Multichemistry measuring device and test strips
WO2011094315A1 (fr) 2010-01-28 2011-08-04 Abbott Diabetes Care Inc. Port de bandelette réactive universel

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019147225A1 (fr) * 2018-01-24 2019-08-01 Hewlett-Packard Development Company, L.P. Détermination de propriétés fluidiques à partir d'impédances de fluide
US11467116B2 (en) 2018-01-24 2022-10-11 Hewlett-Packard Development Company, L.P. Fluidic property determination from fluid impedances
US11478175B1 (en) 2021-10-20 2022-10-25 Paulus Holdings Limited Devices for collecting capillary blood and methods for same

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