WO2015172077A8 - Acides polygalacturoniques o-acétylés de haut poids moléculaire et leur utilisation en tant que vaccin polysaccharidique contre le vi - Google Patents

Acides polygalacturoniques o-acétylés de haut poids moléculaire et leur utilisation en tant que vaccin polysaccharidique contre le vi Download PDF

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Publication number
WO2015172077A8
WO2015172077A8 PCT/US2015/029979 US2015029979W WO2015172077A8 WO 2015172077 A8 WO2015172077 A8 WO 2015172077A8 US 2015029979 W US2015029979 W US 2015029979W WO 2015172077 A8 WO2015172077 A8 WO 2015172077A8
Authority
WO
WIPO (PCT)
Prior art keywords
molecular weight
high molecular
acetylated high
polysaccharide vaccine
polygalacturonic acids
Prior art date
Application number
PCT/US2015/029979
Other languages
English (en)
Other versions
WO2015172077A1 (fr
Inventor
Yawei Ni
Michael Springer
Original Assignee
Nanotherapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanotherapeutics, Inc. filed Critical Nanotherapeutics, Inc.
Priority to EP15723634.0A priority Critical patent/EP3140324A1/fr
Priority to CN201580023307.6A priority patent/CN106459225A/zh
Priority to AU2015255693A priority patent/AU2015255693A1/en
Priority to JP2016566668A priority patent/JP2017514961A/ja
Priority to CA2946900A priority patent/CA2946900A1/fr
Publication of WO2015172077A1 publication Critical patent/WO2015172077A1/fr
Publication of WO2015172077A8 publication Critical patent/WO2015172077A8/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0275—Salmonella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

La présente invention concerne des acides polygalacturoniques O-acétylés de haut poids moléculaire ou des sels pharmaceutiquement acceptables de ceux-ci, possédant au moins l'une des caractéristiques suivantes : (a) un poids moléculaire supérieur à 1 x 106 Da; (b) un degré de méthylation inférieur à environ 10 % par mole; et (c) une teneur en rhamnose interposé comprise entre environ 2 % et 15 % par mole, ces produits étant utilisables en tant qu'antigène Vi immunogène synthétique. La présente invention concerne en outre les procédés de préparation d'un acide polygalacturonique O-acétylé de haut poids moléculaire ou d'un sel pharmaceutiquement acceptables de celui-ci, des compositions pharmaceutiques et/ou des compositions vaccinales les comprenant, et les méthodes d'immunisation utilisant les produits décrits ci-dessus.
PCT/US2015/029979 2014-05-08 2015-05-08 Acides polygalacturoniques o-acétylés de haut poids moléculaire et leur utilisation en tant que vaccin polysaccharidique contre le vi WO2015172077A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP15723634.0A EP3140324A1 (fr) 2014-05-08 2015-05-08 Acides polygalacturoniques o-acétylés de haut poids moléculaire et leur utilisation en tant que vaccin polysaccharidique contre le vi
CN201580023307.6A CN106459225A (zh) 2014-05-08 2015-05-08 O‑乙酰化高分子量聚半乳糖醛酸及其作为Vi多糖疫苗的用途
AU2015255693A AU2015255693A1 (en) 2014-05-08 2015-05-08 O-acetylated high molecular weight polygalacturonic acids and their use as Vi polysaccharide vaccine
JP2016566668A JP2017514961A (ja) 2014-05-08 2015-05-08 Ｏ−アセチル化高分子ポリガラクツロン酸およびＶｉ多糖類ワクチンとしてのその利用
CA2946900A CA2946900A1 (fr) 2014-05-08 2015-05-08 Acides polygalacturoniques o-acetyles de haut poids moleculaire et leur utilisation en tant que vaccin polysaccharidique contre le vi

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461990493P 2014-05-08 2014-05-08
US61/990,493 2014-05-08

Publications (2)

Publication Number Publication Date
WO2015172077A1 WO2015172077A1 (fr) 2015-11-12
WO2015172077A8 true WO2015172077A8 (fr) 2016-01-28

Family

ID=53190060

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/029979 WO2015172077A1 (fr) 2014-05-08 2015-05-08 Acides polygalacturoniques o-acétylés de haut poids moléculaire et leur utilisation en tant que vaccin polysaccharidique contre le vi

Country Status (6)

Country Link
EP (1) EP3140324A1 (fr)
JP (1) JP2017514961A (fr)
CN (1) CN106459225A (fr)
AU (1) AU2015255693A1 (fr)
CA (1) CA2946900A1 (fr)
WO (1) WO2015172077A1 (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7022683B1 (en) 1998-05-13 2006-04-04 Carrington Laboratories, Inc. Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation
US5929051A (en) * 1998-05-13 1999-07-27 Carrington Laboratories, Inc. Aloe pectins

Also Published As

Publication number Publication date
AU2015255693A1 (en) 2016-11-03
EP3140324A1 (fr) 2017-03-15
WO2015172077A1 (fr) 2015-11-12
JP2017514961A (ja) 2017-06-08
CN106459225A (zh) 2017-02-22
CA2946900A1 (fr) 2015-11-12

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