WO2015166379A3 - Nouvelles formes polymorphes de la vortioxétine et de ses sels pharmaceutiquement acceptables - Google Patents

Nouvelles formes polymorphes de la vortioxétine et de ses sels pharmaceutiquement acceptables Download PDF

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Publication number
WO2015166379A3
WO2015166379A3 PCT/IB2015/052904 IB2015052904W WO2015166379A3 WO 2015166379 A3 WO2015166379 A3 WO 2015166379A3 IB 2015052904 W IB2015052904 W IB 2015052904W WO 2015166379 A3 WO2015166379 A3 WO 2015166379A3
Authority
WO
WIPO (PCT)
Prior art keywords
vortioxetine
pharmaceutically acceptable
acceptable salts
polymorphic forms
novel polymorphic
Prior art date
Application number
PCT/IB2015/052904
Other languages
English (en)
Other versions
WO2015166379A2 (fr
Inventor
Venkat Raman JAYARAMAN
Sanjiv Tomer
Piyush Rana
Kamlesh Kanzariya
Sunit Kumar
Nilav PATEL
Manoj Borsaniya
Sudhir Shah
Anand THIRUNAVAKARASU
Original Assignee
Alembic Pharmaceuticals Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alembic Pharmaceuticals Limited filed Critical Alembic Pharmaceuticals Limited
Priority to EP15785569.3A priority Critical patent/EP3137083A2/fr
Priority to CA2940097A priority patent/CA2940097A1/fr
Priority to AU2015254949A priority patent/AU2015254949A1/en
Priority to US15/304,929 priority patent/US10071092B2/en
Publication of WO2015166379A2 publication Critical patent/WO2015166379A2/fr
Publication of WO2015166379A3 publication Critical patent/WO2015166379A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Abstract

La présente invention concerne des formes polymorphes de la vortioxétine et de ses sels pharmaceutiquement acceptables. La présente invention concerne, plus précisément, de nouvelles formes cristallines de la vortioxétine ou de ses sels pharmaceutiquement acceptables. De plus, la présente invention concerne également une forme amorphe du bromhydrate de vortioxétine et un co-précipité amorphe stable du bromhydrate de vortioxétine associé à des excipients pharmaceutiquement acceptables.
PCT/IB2015/052904 2014-04-28 2015-04-21 Nouvelles formes polymorphes de la vortioxétine et de ses sels pharmaceutiquement acceptables WO2015166379A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP15785569.3A EP3137083A2 (fr) 2014-04-28 2015-04-21 Nouvelles formes polymorphes de la vortioxétine et de ses sels pharmaceutiquement acceptables
CA2940097A CA2940097A1 (fr) 2014-04-28 2015-04-21 Nouvelles formes polymorphes de la vortioxetine et de ses sels pharmaceutiquement acceptables
AU2015254949A AU2015254949A1 (en) 2014-04-28 2015-04-21 Novel polymorphic forms of Vortioxetine and its pharmaceutically acceptable salts
US15/304,929 US10071092B2 (en) 2014-04-28 2015-04-21 Polymorphic forms of vortioxetine and its pharmaceutically acceptable salts

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN1476/MUM/2014 2014-04-28
IN1476MU2014 2014-04-28
IN3288/MUM/2014 2014-10-14
IN3288MU2014 2014-10-14

Publications (2)

Publication Number Publication Date
WO2015166379A2 WO2015166379A2 (fr) 2015-11-05
WO2015166379A3 true WO2015166379A3 (fr) 2016-03-03

Family

ID=54359441

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2015/052904 WO2015166379A2 (fr) 2014-04-28 2015-04-21 Nouvelles formes polymorphes de la vortioxétine et de ses sels pharmaceutiquement acceptables

Country Status (5)

Country Link
US (1) US10071092B2 (fr)
EP (1) EP3137083A2 (fr)
AU (1) AU2015254949A1 (fr)
CA (1) CA2940097A1 (fr)
WO (1) WO2015166379A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105209036B (zh) 2013-04-09 2018-10-26 莱克斯特生物技术公司 氧杂双环庚烷和氧杂双环庚烯的配制品
US9687484B2 (en) 2014-07-18 2017-06-27 Dipharma Francis S.R.L. Crystalline forms of an antidepressant compound
EP3209297A1 (fr) * 2014-10-24 2017-08-30 Hexal Aktiengesellschaft Bromhydrate de vortioxétine amorphe
WO2016079751A2 (fr) * 2014-11-17 2016-05-26 Megafine Pharma (P) Ltd. Procédé de préparation de vortioxétine et de polymorphes de cette substance
CZ201531A3 (cs) * 2015-01-21 2016-08-03 Zentiva, K.S. Polymerem stabilizované amorfní formy vortioxetinu
CN105622546B (zh) * 2016-01-07 2020-08-28 万全万特制药（厦门）有限公司 沃替西汀的一种制备方法
WO2017154016A1 (fr) * 2016-03-07 2017-09-14 Msn Laboratories Private Limited Nouveaux polymorphes cristallins de bromhydrate de 1-[2-(2,4-diméthyl-phénylsulfanyl)- phényl]-pipérazine et leur procédé de préparation
US10519121B2 (en) * 2016-12-30 2019-12-31 Apicore Us Llc Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts
US11020390B2 (en) * 2017-02-17 2021-06-01 Unichem Laboratories Ltd Bioequivalent pharmaceutical composition of vortioxetine hydrobromide
EP3412661A1 (fr) 2017-06-08 2018-12-12 Enantia, S.L. Co-cristaux de bromhydrate vortioxetine et du résorcinol
KR102026337B1 (ko) 2017-07-07 2019-09-27 영진약품 주식회사 1-[2-(2,4-디메틸페닐설파닐)페닐]피페라진의 신규염 및 이의 제조방법
CN109928941A (zh) * 2017-12-19 2019-06-25 成都弘达药业有限公司 一种氢溴酸沃替西汀的结晶化合物及其制备方法
CN108912069A (zh) * 2018-08-22 2018-11-30 梧州学院 一种沃替西汀与c2-c4二羧酸新盐型及其制备方法与应用
CN111320592A (zh) * 2018-12-17 2020-06-23 天津理工大学 一种1-[2-(2,4-二甲基苯硫基)-苯基]哌嗪的制备方法
TR202001040A2 (tr) * 2020-01-23 2021-07-26 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Vorti̇okseti̇n hi̇drobromi̇di̇n kri̇stali̇n c formu
CN115160258B (zh) * 2022-06-24 2023-11-17 辰欣药业股份有限公司 一种氢溴酸沃替西汀γ晶型的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2885266A1 (fr) * 2012-09-19 2014-03-27 Sandoz Ag Nouvelle forme cristalline de bromhydrate de vortioxetine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4590013B2 (ja) * 2006-06-16 2010-12-01 ハー・ルンドベック・アクチエゼルスカベット 認識機能障害（ｃｏｇｎｉｔｉｖｅｉｍｐａｉｒｍｅｎｔ）を治療するための、組み合わされたセロトニン再取り込み、５−ＨＴ３および５−ＨＴ１Ａ活性を有する化合物としての１−［２−（２，４−ジメチルフェニルスルファニル）−フェニル］ピペラジン
AU2013273868A1 (en) * 2012-06-13 2015-02-05 Apotex Inc. Forms of Vilazodone and processes for the preparation thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2885266A1 (fr) * 2012-09-19 2014-03-27 Sandoz Ag Nouvelle forme cristalline de bromhydrate de vortioxetine

Also Published As

Publication number Publication date
CA2940097A1 (fr) 2015-11-05
WO2015166379A2 (fr) 2015-11-05
AU2015254949A1 (en) 2016-10-06
US20170189394A1 (en) 2017-07-06
US10071092B2 (en) 2018-09-11
EP3137083A2 (fr) 2017-03-08

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