WO2015150942A3 - Procédé amélioré de préparation de microparticules - Google Patents
Procédé amélioré de préparation de microparticules Download PDFInfo
- Publication number
- WO2015150942A3 WO2015150942A3 PCT/IB2015/051835 IB2015051835W WO2015150942A3 WO 2015150942 A3 WO2015150942 A3 WO 2015150942A3 IB 2015051835 W IB2015051835 W IB 2015051835W WO 2015150942 A3 WO2015150942 A3 WO 2015150942A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- microparticles
- preparing
- improved process
- preparing microparticles
- release
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
L'invention concerne un procédé amélioré de préparation de microparticules. Plus particulièrement, l'invention concerne un procédé permettant de préparer des microparticules possédant un profil de libération choisi pour la libération d'un médicament contenu dans les microparticules. En soumettant l'émulsion à de multiples étapes comprenant la trempe, l'élimination fine par décantation, le lavage et la déshydratation dans une seule cuve, suivie d'une lyophilisation sous la forme d'une étape intermédiaire qui est effectuée pendant la préparation des microparticules, des microparticules de bonne qualité peuvent être préparées. Le procédé de fabrication des microparticules selon l'invention est simple, robuste et nécessite relativement moins de réglages des paramètres de traitement. En outre, les microparticules résultantes possèdent une excellente uniformité de forme, présentant une moindre tendance à l'agglomération après un séchage d'étape intermédiaire et une bonne aptitude à l'écoulement en cas de remplissage de flacons de poudre sèche.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1189/MUM/2014 | 2014-03-29 | ||
IN1190MU2014 | 2014-03-29 | ||
IN1190/MUM/2014 | 2014-03-29 | ||
IN1188/MUM/2014 | 2014-03-29 | ||
IN1189MU2014 IN2014MU01189A (fr) | 2014-03-29 | 2015-03-13 | |
IN1188MU2014 IN2014MU01188A (fr) | 2014-03-29 | 2015-03-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2015150942A2 WO2015150942A2 (fr) | 2015-10-08 |
WO2015150942A3 true WO2015150942A3 (fr) | 2015-11-26 |
Family
ID=54241388
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2015/051835 WO2015150942A2 (fr) | 2014-03-29 | 2015-03-13 | Procédé amélioré de préparation de microparticules |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2015150942A2 (fr) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5650173A (en) * | 1993-11-19 | 1997-07-22 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
US5654008A (en) * | 1993-11-19 | 1997-08-05 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
US20050260272A1 (en) * | 2004-05-05 | 2005-11-24 | Alkermes Controlled Therapeutics, Inc. | Method of forming microparticles that include a bisphosphonate and a polymer |
US20080317865A1 (en) * | 2007-06-20 | 2008-12-25 | Alkermes, Inc. | Quench liquids and washing systems for production of microparticles |
WO2014027253A1 (fr) * | 2012-08-14 | 2014-02-20 | Wockhardt Limited | Compositions microparticulaires pharmaceutiques de polypeptides |
WO2014027254A1 (fr) * | 2012-08-14 | 2014-02-20 | Wockhardt Limited | Compositions microparticulaires pharmaceutiques de polypeptides |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2010115A1 (de) | 1970-03-04 | 1971-09-16 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Mikrogranulaten |
AU5741590A (en) | 1989-05-04 | 1990-11-29 | Southern Research Institute | Improved encapsulation process and products therefrom |
US5945126A (en) | 1997-02-13 | 1999-08-31 | Oakwood Laboratories L.L.C. | Continuous microsphere process |
US6194006B1 (en) | 1998-12-30 | 2001-02-27 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of microparticles having a selected release profile |
US20020114843A1 (en) | 2000-12-27 | 2002-08-22 | Ramstack J. Michael | Preparation of microparticles having improved flowability |
-
2015
- 2015-03-13 WO PCT/IB2015/051835 patent/WO2015150942A2/fr active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5650173A (en) * | 1993-11-19 | 1997-07-22 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
US5654008A (en) * | 1993-11-19 | 1997-08-05 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
US20050260272A1 (en) * | 2004-05-05 | 2005-11-24 | Alkermes Controlled Therapeutics, Inc. | Method of forming microparticles that include a bisphosphonate and a polymer |
US20080317865A1 (en) * | 2007-06-20 | 2008-12-25 | Alkermes, Inc. | Quench liquids and washing systems for production of microparticles |
WO2014027253A1 (fr) * | 2012-08-14 | 2014-02-20 | Wockhardt Limited | Compositions microparticulaires pharmaceutiques de polypeptides |
WO2014027254A1 (fr) * | 2012-08-14 | 2014-02-20 | Wockhardt Limited | Compositions microparticulaires pharmaceutiques de polypeptides |
Also Published As
Publication number | Publication date |
---|---|
WO2015150942A2 (fr) | 2015-10-08 |
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