WO2015147357A1 - Dispositif de surveillance à ultrasons pour détecter une cavitation et procédé associé - Google Patents

Dispositif de surveillance à ultrasons pour détecter une cavitation et procédé associé Download PDF

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Publication number
WO2015147357A1
WO2015147357A1 PCT/KR2014/002626 KR2014002626W WO2015147357A1 WO 2015147357 A1 WO2015147357 A1 WO 2015147357A1 KR 2014002626 W KR2014002626 W KR 2014002626W WO 2015147357 A1 WO2015147357 A1 WO 2015147357A1
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WO
WIPO (PCT)
Prior art keywords
signal
intensity
cavitation
noise
ultrasonic monitoring
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PCT/KR2014/002626
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English (en)
Korean (ko)
Inventor
김대승
김명덕
강국진
손건호
Original Assignee
알피니언메디칼시스템 주식회사
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Priority to PCT/KR2014/002626 priority Critical patent/WO2015147357A1/fr
Publication of WO2015147357A1 publication Critical patent/WO2015147357A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B2017/22005—Effects, e.g. on tissue
    • A61B2017/22007—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing

Definitions

  • the present invention relates to ultrasonic signal processing technology, and more particularly, to a medical device using a high-intensity focused ultrasound (HIFU).
  • HIFU high-intensity focused ultrasound
  • HIFU High-Intensity Focused Ultrasound
  • biological tissues such as cancer, tumors and lesions.
  • Treatment using HIFU is a method of necrosis of the subject's tissue through the heat generated by transmitting the HIFU to one of the subject. Compared to general surgery or chemotherapy, HIFU treatment can lessen the trauma of the patient and realize non-invasive treatment.
  • Application examples include Liver cancer, Bone sarcoma, Breast cancer, Pancreas cancer, Kidney cancer, Soft tissue tumors and Pelvic tumors ) And so on.
  • the subject to be treated is irradiated with the HIFU signal and receives an HIFU backscattering signal from the subject to obtain an ultrasound image therefrom.
  • cavitation may occur at the focal region of the subject.
  • the cavitation phenomenon means that small bubbles are formed by the action of sound pressure and positive pressure caused by the pressure change in the object as the ultrasonic waves touch the object, and the cells in the object are destroyed as the bubble expands and bursts to the maximum. .
  • Cavitation promotes an increase in the temperature of the subject's focal region, thereby damaging the lesion corresponding to the focal region and treating the disease.
  • excessive cavitation can distort the ultrasound beam path or cause rapid temperature rise in the focal region, making the lesion difficult to treat. Therefore, detection of cavitation is required when subjects are subject to HIFU irradiation.
  • an ultrasonic monitoring apparatus and method for detecting cavitation generated when a subject is irradiated with HIFU for treatment are provided.
  • an ultrasound monitoring apparatus may include a transducer configured to irradiate an object with high intensity ultrasound and receive a cavitation state generated by the object as a backscatter signal by analyzing the backscattered signal received through the transducer. It includes a signal analyzer for calculating the intensity variation of the noise signal included in the scattering signal.
  • the signal analyzer may include: a converter configured to convert a backscattered signal received through a transducer into a frequency domain signal, a noise separator configured to separate a noise signal from a backscattered signal converted into a frequency domain through the converter; And a derivative for obtaining a cavitation intensity variation by differentiating a noise signal separated through the noise separation unit with respect to time. Further, the signal analyzer may further include a moving average calculator configured to calculate a moving average value for the separated noise signal and provide the calculated moving average value to the derivative unit.
  • the signal analyzer may further include a determiner configured to determine the cavitation state through analysis of the cavitation intensity variation obtained through the derivative, considering that the cavitation noise signal included in the noise signal separated from the backscattering signal is a chaotic signal.
  • the determination unit compares the cavitation intensity variation obtained through the differential unit with the preset cavitation intensity variation, and determines that the cavitation is strong when the cavitation intensity variation obtained through the derivative is greater than or equal to the threshold value of the preset cavitation intensity variation. can do.
  • the transducer according to an embodiment irradiates the high intensity ultrasound to the object while varying the intensity of the high intensity ultrasound without changing the focal position of the object, and the signal analyzer targets the backscattered signal received according to the change in the intensity of the high intensity ultrasound. You can find the amount of variation in cavitation intensity over time.
  • the transducer according to another embodiment may irradiate the subject with high-intensity ultrasound while varying the focus position of the object, and the signal analyzer may obtain a variation in cavitation intensity with respect to time based on the received backscattered signal according to the focus position variation. .
  • an ultrasound monitoring apparatus presets irradiation conditions of high-intensity ultrasound waves to be irradiated to an object, irradiates high-intensity ultrasound waves through a transducer under preset irradiation conditions, and determines the high-intensity ultrasound according to a result analyzed by the signal analyzer. It further includes a control unit for changing the irradiation conditions or stop the operation.
  • an ultrasound monitoring method includes irradiating high intensity ultrasound to an object through a transducer, receiving a cavitation state generated in the object by high intensity ultrasound as a backscattering signal, and analyzing the received backscattering signal. Calculating an intensity variation of the noise signal included in the backscattered signal.
  • the backscattered signal generated by the cavitation at the focal position exhibits a chaotic pattern, thereby obtaining a variation in time of the noise signal included in the backscattered signal. This allows you to indirectly monitor whether cavitation has occurred and how strong it is.
  • FIG. 1 is a reference diagram showing the shape of a noise signal (a) without cavitation and a noise signal (b) with cavitation for a noise signal separated from the HIFU backscattering signal according to an embodiment of the present invention
  • FIG. 2 is a reference diagram illustrating various forms of a noise signal obtained according to a change in HIFU intensity irradiated to an object according to an embodiment of the present disclosure
  • FIG. 3 is a reference diagram illustrating a noise signal obtained according to a change in a focal position of an object to which HIFU is irradiated according to an embodiment of the present invention
  • FIG. 4 is a block diagram of an ultrasonic monitoring apparatus for cavitation detection according to an embodiment of the present invention.
  • FIG. 5 is a detailed configuration diagram of the signal analyzer of FIG. 4 according to an embodiment of the present disclosure
  • FIG. 6 is a reference diagram illustrating various forms of cavitation intensity variation for a noise signal acquired according to a change in HIFU intensity irradiated to an object according to an embodiment of the present disclosure
  • FIG. 7 is a reference diagram illustrating various forms of cavitation intensity variation for a noise signal acquired according to a change in focal position of an object to which HIFU is irradiated according to an embodiment of the present disclosure
  • FIG. 8 is a flowchart illustrating an ultrasonic monitoring method for cavitation detection according to an embodiment of the present invention.
  • the ultrasound monitoring apparatus irradiates a HIFU signal to a subject to be treated using a transducer and receives a HIFU backscattering signal.
  • cavitation may occur at the focal region of the subject. Cavitation refers to the formation of small bubbles due to the action of negative pressure and positive pressure caused by the pressure change in the object as the ultrasonic waves touch the object, and the cells in the object are destroyed as the bubble expands and bursts to the maximum.
  • the backscattered signal generated by the cavitation has a chaos signal shape as shown in FIG. 1 (b).
  • the present invention focuses on the fact that the cavitation signal is in the form of a chaotic signal, calculates the intensity variation over time of the noise signal included in the HIFU backscattering signal, and estimates the degree of chaos occurrence from the intensity variation. Through the above-described estimation method, it is possible to indirectly monitor whether cavitation has occurred and its strength.
  • FIG. 2 is a reference diagram illustrating various forms of a noise signal acquired according to a change in HIFU intensity irradiated to an object according to an exemplary embodiment.
  • FIG. 2 shows a noise signal separated from a backscatter signal when the HIFU intensity is 0 W, (b) is 50 W, (c) is 100 W, and (d) is 100 W. It is shown.
  • the embodiment of FIG. 2 is only an embodiment for better understanding of the present invention, and a noise signal form obtainable according to HIFU intensity change is not limited thereto.
  • the source noise refers to noise generated by the transducer for irradiating HIFU.
  • the noise signal obtained includes source noise and noise signal generated by cavitation.
  • cavitation can occur even if the intensity level falls below the intensity level of the source noise due to cavitation. This is because the noise signal generated by the cavitation shows the form of the chaotic signal having a large deviation as described above with reference to FIG.
  • FIG. 3 is a reference diagram illustrating a noise signal acquired according to a change in a focal position of an object to which HIFU is irradiated according to an exemplary embodiment.
  • FIG. 3 illustrates a noise signal acquired when the HIFU is irradiated while the focal position is changed while the intensity of the HIFU irradiated to the object is kept constant.
  • the change in the intensity level of the noise signal is severe according to the focal position to which the ultrasound is irradiated.
  • the embodiment of FIG. 3 is only an embodiment for better understanding of the present invention, and a noise signal form obtainable according to a change in focus position is not limited thereto.
  • FIG. 4 is a block diagram of the ultrasonic monitoring device 1 for cavitation detection according to an embodiment of the present invention.
  • the ultrasonic monitoring apparatus 1 includes a transducer 10 and a signal analyzer 12, and includes a display 14, a storage 16, and a controller 17. It may further include.
  • the transducer 10 irradiates the subject with HIFU and receives the cavitation state generated in the subject by the HIFU as a backscattering signal.
  • the signal analyzer 12 analyzes the backscattered signal received through the transducer 10 and calculates an intensity variation of the noise signal included in the backscattered signal. A detailed configuration of the signal analyzer 12 will be described in detail with reference to FIG. 5 to be described later.
  • the display unit 14 outputs the result calculated by the signal analyzer 12 to the screen.
  • the storage unit 16 stores information necessary for signal analysis of the signal analyzer 12 or stores information analyzed by the signal analyzer 12.
  • the information necessary for signal analysis may include noise signal strength variation information which is set in advance in order to be compared with an intensity variation of the noise signal obtained through the signal analysis unit 12.
  • the controller 17 sets the irradiation condition of the HIFU irradiated to the object and irradiates the HIFU through the transducer 10 under the set irradiation condition.
  • the irradiation conditions of HIFU may be the strength, power, pressure, etc. of HIFU.
  • the controller 17 changes the HIFU irradiation condition or stops the operation of the device according to the analysis result of the signal analyzer 12. For example, if the cavitation state determination result of the signal analysis unit 12 is outside the preset allowable range, the irradiation condition of HIFU may be changed.
  • the cavitation intensity fluctuation obtained by differentiating is greater than the threshold value of the preset cavitation intensity fluctuation, it is determined that it is out of the allowable range and the irradiation conditions such as the intensity, power, pressure, etc. of HIFU can be adjusted low or the device operation can be stopped.
  • FIG. 5 is a detailed block diagram of the signal analyzer 12 of FIG. 4 according to an exemplary embodiment.
  • the signal analyzer 12 may include a converter 120, a noise separator 122, a moving average calculator 124, a derivative 126, and a determiner. (128).
  • the converter 120 converts the backscattered signal received through the transducer 10 into a frequency domain signal.
  • the transform unit 120 performs a fast Fourier transform (FFT) on the backscattered signal, and multiplies the result of the Fourier transform by a modulation transfer function (MMF).
  • FFT fast Fourier transform
  • MMF modulation transfer function
  • the noise separator 122 separates the noise signal from the backscattered signal converted into the frequency domain through the converter 120.
  • the noise separator 122 separates and adds the remaining signals except for the fundamental frequency signal and the harmonic signals from the backscattered signal converted into the frequency domain, and adds them to the noise summing signal. Can be extracted.
  • the noise separator 122 displays the separated noise signal based on the time axis.
  • the moving average calculator 124 calculates a moving average value for the noise signal separated by the noise separator 122. At this time, the number of taking the moving average is made within the limit that the loss of cavitation information can be minimized.
  • the derivative unit 126 obtains the cavitation intensity variation by differentiating the noise signal in which the moving average is reflected with respect to the time t through the moving average calculation unit 124. By differentiating the noise signal with respect to time, the degree of variation in the cavitation intensity corresponding to the slope can be obtained.
  • the determiner 128 determines the cavitation state by analyzing the intensity variation of the noise signal separated from the backscattered signal.
  • the determination result may be provided to the display unit 14.
  • the noise signal separated from the backscattered signal includes a source noise signal and a noise signal generated by cavitation.
  • the determination unit 128 may determine the cavitation state by analyzing an intensity variation of the noise signal in consideration of the cavitation noise signal as a chaotic signal. For example, if it is analyzed that the intensity variation with respect to the noise signal is large, it can be seen that cavitation noise showing a chaotic signal shape is included and the cavitation intensity is determined to be strong.
  • the determination unit 128 compares the cavitation intensity variation previously determined with the cavitation intensity variation obtained through the derivative unit 126. Then, if the cavitation intensity variation obtained through the derivative unit 126 is equal to or greater than the threshold value of the preset cavitation intensity variation, it is determined that the cavitation is in a strong state.
  • the transducer 10 irradiates the subject with high-intensity ultrasound while varying the intensity of HIFU without changing the focal position of the object. Then, the signal analyzer 12 obtains a variation in cavitation intensity with respect to time based on the received backscattered signal according to the variation in the HIFU intensity.
  • the transducer 10 according to another embodiment irradiates HIFU to the subject while changing the focal position of the subject. Then, the signal analyzer 12 obtains a variation in cavitation intensity with respect to time based on the received backscattered signal according to the focal position variation.
  • FIG. 6 is a reference diagram illustrating various forms of cavitation intensity variation for a noise signal acquired according to a change in HIFU intensity irradiated to an object according to an exemplary embodiment of the present disclosure.
  • FIG. 6A illustrates noise signals separated from backscatter signals when HIFU intensity is 0W, (B) is 50W, (c) is 100W, and (d) is 100W.
  • FIG. 7 is a reference diagram illustrating various forms of cavitation intensity variation for a noise signal acquired according to a change in a focal position of an object to which HIFU is irradiated according to an embodiment of the present disclosure.
  • FIG. 7 illustrates various forms of cavitation intensity fluctuations when the HIFU is irradiated while changing the focal position while the intensity of the HIFU irradiated to the object is kept constant.
  • the shape of the noise signal of FIG. 7A and the noise signal of FIG. 7C obtained for each focal position of the same object are different from each other because the media characteristics of the object may change with each HIFU irradiation.
  • the intensity level of the noise signal changes according to the change in the focus position, and whether or not the cavitation is generated or not may be determined according to the degree of the intensity variation for the noise signal.
  • FIG. 8 is a flowchart illustrating an ultrasonic monitoring method for cavitation detection according to an embodiment of the present invention.
  • an ultrasound monitoring apparatus irradiates HIFU to a subject through a transducer and receives a cavitation state generated in the subject by the HIFU as a backscattering signal (810). Subsequently, the ultrasound monitoring apparatus calculates and analyzes an intensity variation of the noise signal included in the backscattered signal (820). In this case, the ultrasonic monitoring apparatus according to an embodiment converts the backscattered signal received through the transducer into a frequency domain signal. In addition, the noise signal is separated from the converted frequency domain signal, and the separated noise signal is differentiated with respect to time to obtain a variation in cavitation intensity.
  • the cavitation state may be determined by analyzing the intensity variation of the noise signal.
  • the ultrasound monitoring apparatus may output an analysis result.
  • the ultrasound monitoring apparatus sets the irradiation condition of HIFU irradiated to the object through the transducer (800).
  • the irradiation conditions of HIFU may be the strength, power, pressure, etc. of HIFU.
  • the HIFU is irradiated under the set HIFU irradiation condition, and the cavitation state generated in the subject by the HIFU is received as a backscattering signal (810).
  • the ultrasound monitoring apparatus may calculate and analyze an intensity variation of the noise signal included in the backscattered signal (820) and output an analysis result (830).
  • the ultrasonic monitoring apparatus determines whether the analysis result is abnormal (840), and if there is an abnormality, changes the irradiation condition of HIFU (850).
  • the irradiation condition of HIFU can be changed if the cavitation state is out of the preset allowable range. For example, if the cavitation intensity fluctuation obtained by differentiating is larger than the threshold value of the preset cavitation intensity fluctuation, it is determined that it is out of the allowable range, and the irradiation conditions such as HIFU intensity, power and pressure can be adjusted low.
  • the ultrasound monitoring apparatus may determine whether the analysis result is abnormal (840), and stop the operation of the apparatus if there is an error.

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Abstract

L'invention concerne un dispositif de surveillance à ultrasons destiné à détecter une cavitation et un procédé associé. Le dispositif de surveillance par ultrasons, selon un mode de réalisation de la présente invention, comprend : un transducteur pour irradier un objet avec des ultrasons de haute intensité et recevoir, en tant que signal de rétrodiffusion, un état de cavitation généré à partir de l'objet par les ultrasons de haute intensité ; et une unité d'analyse de signal pour analyser le signal de rétrodiffusion reçu dans le transducteur de façon à calculer un changement dans l'intensité d'un signal de bruit contenu dans le signal de rétrodiffusion.
PCT/KR2014/002626 2014-03-27 2014-03-27 Dispositif de surveillance à ultrasons pour détecter une cavitation et procédé associé WO2015147357A1 (fr)

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PCT/KR2014/002626 WO2015147357A1 (fr) 2014-03-27 2014-03-27 Dispositif de surveillance à ultrasons pour détecter une cavitation et procédé associé

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113117265A (zh) * 2019-12-30 2021-07-16 重庆融海超声医学工程研究中心有限公司 检测装置
CN113117261A (zh) * 2019-12-30 2021-07-16 重庆融海超声医学工程研究中心有限公司 用于检测空化效应的方法及装置、超声治疗设备
CN113221986A (zh) * 2021-04-30 2021-08-06 西安理工大学 一种贯流式水轮机振动信号分离方法
CN113332620A (zh) * 2021-07-12 2021-09-03 重庆融海超声医学工程研究中心有限公司 一种超声医疗设备
WO2021258645A1 (fr) * 2020-06-22 2021-12-30 飞依诺科技(苏州)有限公司 Procédé et appareil d'ajustement pour onde ultrasonore thérapeutique, et dispositif informatique et support d'enregistrement

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113117265A (zh) * 2019-12-30 2021-07-16 重庆融海超声医学工程研究中心有限公司 检测装置
CN113117261A (zh) * 2019-12-30 2021-07-16 重庆融海超声医学工程研究中心有限公司 用于检测空化效应的方法及装置、超声治疗设备
CN113117265B (zh) * 2019-12-30 2023-03-28 重庆融海超声医学工程研究中心有限公司 检测装置
CN113117261B (zh) * 2019-12-30 2023-06-02 重庆融海超声医学工程研究中心有限公司 用于检测空化效应的装置及超声治疗设备
WO2021258645A1 (fr) * 2020-06-22 2021-12-30 飞依诺科技(苏州)有限公司 Procédé et appareil d'ajustement pour onde ultrasonore thérapeutique, et dispositif informatique et support d'enregistrement
CN113221986A (zh) * 2021-04-30 2021-08-06 西安理工大学 一种贯流式水轮机振动信号分离方法
CN113332620A (zh) * 2021-07-12 2021-09-03 重庆融海超声医学工程研究中心有限公司 一种超声医疗设备
CN113332620B (zh) * 2021-07-12 2023-03-14 重庆融海超声医学工程研究中心有限公司 一种超声医疗设备

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