WO2015130079A1 - Composition d'obturation dentaire a prise hydraulique de type a pâte unique - Google Patents
Composition d'obturation dentaire a prise hydraulique de type a pâte unique Download PDFInfo
- Publication number
- WO2015130079A1 WO2015130079A1 PCT/KR2015/001822 KR2015001822W WO2015130079A1 WO 2015130079 A1 WO2015130079 A1 WO 2015130079A1 KR 2015001822 W KR2015001822 W KR 2015001822W WO 2015130079 A1 WO2015130079 A1 WO 2015130079A1
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- WO
- WIPO (PCT)
- Prior art keywords
- filler composition
- single paste
- hydraulic
- composition
- cement
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/802—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/50—Preparations specially adapted for dental root treatment
- A61K6/54—Filling; Sealing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
- A61K6/851—Portland cements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
- A61K6/853—Silicates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
- A61K6/856—Pozzolans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
- A61K6/876—Calcium oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
Definitions
- the present invention relates to a single paste-type hydraulic filler composition, more specifically, a single paste-type dental, characterized in that it quickly cures by absorbing moisture from the surrounding liquid or air, including hydraulic cement and non-aqueous liquid It relates to a hydraulic filler composition.
- Endodontics is a specific field of dentistry related to the treatment of dental pulp or pathologic tissue.
- the teeth contain nerves and vascular tissue called pulp inside, covering dentin covering the pulp, and the hardest enamel on the outermost, usually in the root canal treatment.
- Root canal treatment of teeth with pulp tissue where inflammation is progressing or necrosis is generally carried out through the access cavity formed in the crown to access the internal space of the tooth called the pulp chamber. This is done by opening the root canal treatment instrument into the root canal inside the root.
- the root canal is sealed using a root canal filler to prevent secondary infection.
- the ideal dental canal filler is biocompatibility, bactericidal property, sealing property and stability ( It is desirable to have excellent properties such as stability, workability, implanted and distributed properties, and radiopacity.
- Root canal treatment with guttapercha and sealer can be seen as a conservative treatment. It is usually used in two ways, one is lateral pressurization and the other is vertical pressurization.
- Lateral pressurization is a method in which a giant perch cone is placed inside the root canal and pressurized laterally with a mechanism called a spreader to fill the root canal, and the void space between the filled giant perch and the root canal is filled with a sealer.
- Vertical pressurization is a method of filling a root canal by inserting a giant perch into the root canal and pressing it in a vertical direction with a tool called a plugger.
- MTA Mineral Trioxide Aggregate cements
- MTA cements are known as materials with excellent biocompatibility and sealability. It can be used for apical refilling and perforation closure, and can be used for pulp capping, pulpotomy, artificial apical barrier placement, revascularization and apexogenesis procedure. It is established as a representative dental material used in such procedures. Therefore, various efforts have been made to fill the root canal using MTA cement which is hardened by water and has excellent sealing property in a humid environment, and as a part thereof, studies on making MTA cement in paste form have been actively conducted. In this regard, for example, the technique of Korea Patent Publication No. 10-2010-0037979.
- root canals are generally assumed to be a humid environment
- many dentists are accustomed to drying root canals during root canal treatment, so not all root canals are always in a wet condition, and conventional MTA cement products are root canals.
- It is cumbersome to use because it needs to be mixed with the liquid just before it is injected into it, and has the disadvantage of requiring a long time to be placed deep in the root canal due to its relatively poor flow and operability.
- the inventor (s) proposes a single paste-type MTA cement that absorbs ambient moisture even within a dried root canal and reliably cures in an appropriate time.
- the present invention aims to solve all the above-mentioned problems.
- Another object of the present invention is to provide a single paste-type dental filler composition which may be provided in a syringe without requiring a separate mixing process.
- a single paste dental hydraulic filler composition comprising a hydraulic cement, a non-aqueous liquid having hygroscopicity, and a radiopaque material.
- a single paste dental filler composition which can be provided in a syringe without requiring a separate mixing process.
- a single paste-type dental filler composition which is easily cured and is easy to three-dimensionally seal the perforated portion of the root canal or tooth and has excellent biocompatibility.
- a single paste dental filler composition which can be easily cured by absorbing moisture from tissue fluid or air in or around the wet cotton or root canal.
- a safe single paste dental filler composition that does not require heat and pressure.
- the filler composition according to the present invention may include a hygroscopic hydraulic cement having high biocompatibility and sealing property, which is cured by absorbing moisture in or around the root canal.
- Hydraulic cements may comprise calcium oxide or calcium hydroxide as the active ingredient, preferably portland cement or pozzolane cement.
- portland cement that is similar in physical properties and chemical composition to MTA and has good biocompatibility.
- D50 average particle size of the hydraulic cement
- calcium chloride having hygroscopicity and degradability may be further added to the hydraulic cement in order to improve the hygroscopicity of the paste to enable fast and reliable curing, while maintaining biocompatibility and improving hermeticity.
- pozzolane cement which includes active silica material in portland cement and uses water as the crystallized water in the hydration process as in the following formula (About the construction of such pozzolane cement)
- the composition intended in the present invention can be achieved without the addition of calcium chloride with the help of the crystal water produced by the above formula.
- composition according to the invention may comprise a non-aqueous liquid having hygroscopicity in order to paste the hydraulic cement.
- non-aqueous liquids may contain substantially minimal water that does not substantially cause or harden water that reacts with the hydraulic cement to cause hydration.
- it may be desirable to include up to about 3% by weight of water relative to the non-aqueous liquids.
- biocompatibility, storage stability, hygroscopicity, surface activity, easily mixed with water, and quickly absorbed into the human body may be required.
- Non-aqueous liquids with the above characteristics include N-methyl-2-pyrrolidone (ie, "NMP"), polyoxyethylene sorbitan monolaurate, dimethyl iso Group consisting of dimethyl isosorbide, diethylene glycol dimethyl ether (diglyme) (or diethylene glycol monoethyl ether (Carbitol Cellosolve)) and butylene glycol It may include at least one selected from, and may preferably include NMP.
- NMP N-methyl-2-pyrrolidone
- polyoxyethylene sorbitan monolaurate dimethyl iso Group consisting of dimethyl isosorbide
- diethylene glycol dimethyl ether diglyme
- diethylene glycol monoethyl ether Carbitol Cellosolve
- butylene glycol It may include at least one selected from, and may preferably include NMP.
- Such non-aqueous liquid may preferably be included in an amount of 15 to 35% by weight based on the total composition. If the content is less than 15% by weight, it is difficult to secure proper flowability. If the content is more than 35% by weight, the flowability is too large and the hydration reaction may be hindered.
- composition according to the present invention comprises at least one material selected from the group consisting of radiopaque materials such as barium sulfate, zirconium oxide, bismuth oxide, tantalum oxide and calcium tungstate for ease of reading. It may be included, preferably it is preferable to use bismuth oxide or zirconium oxide for a high level of radiopacity and biocompatibility.
- radiopaque materials such as barium sulfate, zirconium oxide, bismuth oxide, tantalum oxide and calcium tungstate for ease of reading. It may be included, preferably it is preferable to use bismuth oxide or zirconium oxide for a high level of radiopacity and biocompatibility.
- radiopaque material in an amount of 20 to 55% by weight based on the total composition.
- hygroscopic cement and hygroscopic non-aqueous liquid as described above may be slightly insufficient to ensure the hardening process even in severely dry root canals, so that higher hygroscopicity and other requirements for root canal fillers, such as sufficient flow It may be desirable to further include hygroscopic clay to satisfy sex, operability, ultrasonic delivery, and the like (although such hygroscopic clay may not necessarily be included).
- the hygroscopic clay material may include at least one selected from the group consisting of bentonite, smectite, and swellable synthetic clay minerals, and may preferably include bentonite.
- Bentonite is composed of a large number of natural clays to ensure viscosity stability and tissue formation over a wide range of temperatures, improves resistance to sagging and peeling, and acts as a retardant to improve open time for Portland cement. It is also resistant to bacteria and enzymes, so it can also act as an antibacterial agent.
- Such hygroscopic clay may be included in an amount of 1 to 10% by weight based on the total composition.
- composition according to the present invention at least one selected from the group consisting of hydroxyethyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose, polyvinyl alcohol and polyvinylpyrrolidone to impart a suitable viscosity to the non-aqueous liquid It may further comprise a hygroscopic thickener.
- thickeners prevent the paste from separating, conserve moisture, increase operability, increase cohesion, and act as surfactants to help penetrate deep into the root canal filling material and help to maintain the smoothness of the paste surface Can give In addition, it has excellent resistance to bacterial fungi and excellent storage stability.
- thickeners in an amount of 0.1 to 1 weight percent based on the total composition.
- a powder was prepared by mixing 100 parts by weight of Portland cement, 20 parts by weight of bentonite, 10 parts by weight of calcium chloride and 100 parts by weight of zirconium oxide, NMP with 2% by weight of methyl cellulose, NMP and poly with 7% by weight of polyvinyl alcohol.
- a single paste-type dental hydraulic filler composition was prepared by mixing with NMP to which 7% by weight of vinylpyrrolidone was added.
- Each paste was stored in a syringe, blocked from air, and when used, when exposed outside the syringe, all absorbed moisture in the atmosphere at 50% humidity and cured within two days.
- composition which concerns on this invention hardens in a humid environment.
- a powder was prepared by mixing 200 parts by weight of EndocemZR (a product in which zirconium oxide was mixed in one-to-one) with 20 parts by weight of bentonite, NMP with 2% by weight of methyl cellulose, NMP with 7% by weight of polyvinyl alcohol, and A single paste-type dental hydraulic filler composition was prepared by mixing with NMP to which 7% by weight of polyvinylpyrrolidone was added, respectively.
- EndocemZR a product in which zirconium oxide was mixed in one-to-one
- Each paste was stored in a syringe, blocked from air, and when used, when exposed outside the syringe, all absorbed moisture in the atmosphere at 50% humidity and cured within two days.
- composition which concerns on this invention hardens in a humid environment.
- solubility of the filler composition according to the invention was measured in the following manner according to the test method of ISO 6876: 2012 (E) 5.6.
- the size change of the filler composition according to the present invention was measured according to the test method of ISO 6876: 2001 (E) 7.6 as follows.
- the coating degree of the filler composition according to the present invention was measured according to the test method of ISO 6876: 2012 (E) 5.5 in the following manner.
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- Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Ceramic Engineering (AREA)
- Dental Preparations (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15755391.8A EP3111913B1 (fr) | 2014-02-25 | 2015-02-25 | Composition d'obturation dentaire a prise hydraulique de type a pâte unique |
CN201580010591.3A CN106163488A (zh) | 2014-02-25 | 2015-02-25 | 单糊剂型水硬牙科充填组合物 |
JP2016553854A JP6542247B2 (ja) | 2014-02-25 | 2015-02-25 | 単一のペースト型の歯科用水硬性充填材組成物 |
US15/246,836 US10154945B2 (en) | 2014-02-25 | 2016-08-25 | Single paste type hydraulic dental filling composition |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20140021907 | 2014-02-25 | ||
KR10-2014-0021907 | 2014-02-25 | ||
KR10-2014-0032686 | 2014-03-20 | ||
KR1020140032686A KR101615622B1 (ko) | 2014-02-25 | 2014-03-20 | 단일 페이스트형 치과용 수경성 충전재 조성물 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US15/246,836 Continuation US10154945B2 (en) | 2014-02-25 | 2016-08-25 | Single paste type hydraulic dental filling composition |
Publications (1)
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WO2015130079A1 true WO2015130079A1 (fr) | 2015-09-03 |
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PCT/KR2015/001822 WO2015130079A1 (fr) | 2014-02-25 | 2015-02-25 | Composition d'obturation dentaire a prise hydraulique de type a pâte unique |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017137286A (ja) * | 2016-02-03 | 2017-08-10 | 太平洋セメント株式会社 | 粉末状歯科用セメント組成物 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000351958A (ja) * | 1999-04-11 | 2000-12-19 | Orochemie Duerr & Pflug Gmbh & Co | 硬組織および硬組織補てつ物の処理のための懸濁液 |
US20070009858A1 (en) * | 2005-06-23 | 2007-01-11 | Hatton John F | Dental repair material |
KR20090125141A (ko) * | 2007-03-02 | 2009-12-03 | 신세스 게엠바하 | 적합한 기계적 특성을 가지는 골 시멘트 |
US20120035296A1 (en) * | 2009-02-25 | 2012-02-09 | Takashi Nakamura | Bone cement composition, bone cement composition kit and forming method of bone cement hardened material |
US20130023601A1 (en) * | 2010-01-25 | 2013-01-24 | Ogliari Fabricio Aulo | Dental Composition Comprising A Calcium Source |
-
2015
- 2015-02-25 WO PCT/KR2015/001822 patent/WO2015130079A1/fr active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000351958A (ja) * | 1999-04-11 | 2000-12-19 | Orochemie Duerr & Pflug Gmbh & Co | 硬組織および硬組織補てつ物の処理のための懸濁液 |
US20070009858A1 (en) * | 2005-06-23 | 2007-01-11 | Hatton John F | Dental repair material |
KR20090125141A (ko) * | 2007-03-02 | 2009-12-03 | 신세스 게엠바하 | 적합한 기계적 특성을 가지는 골 시멘트 |
US20120035296A1 (en) * | 2009-02-25 | 2012-02-09 | Takashi Nakamura | Bone cement composition, bone cement composition kit and forming method of bone cement hardened material |
US20130023601A1 (en) * | 2010-01-25 | 2013-01-24 | Ogliari Fabricio Aulo | Dental Composition Comprising A Calcium Source |
Non-Patent Citations (1)
Title |
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See also references of EP3111913A4 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017137286A (ja) * | 2016-02-03 | 2017-08-10 | 太平洋セメント株式会社 | 粉末状歯科用セメント組成物 |
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