WO2015128882A3 - Formes cristallines de n-(2,4-di-tert-butyl -5-hydroxyphényl)-1,4-dihydro -4-oxoquinoléine-3-carboxamide et procédé de préparation de celles-ci - Google Patents

Formes cristallines de n-(2,4-di-tert-butyl -5-hydroxyphényl)-1,4-dihydro -4-oxoquinoléine-3-carboxamide et procédé de préparation de celles-ci Download PDF

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Publication number
WO2015128882A3
WO2015128882A3 PCT/IN2015/000112 IN2015000112W WO2015128882A3 WO 2015128882 A3 WO2015128882 A3 WO 2015128882A3 IN 2015000112 W IN2015000112 W IN 2015000112W WO 2015128882 A3 WO2015128882 A3 WO 2015128882A3
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WO
WIPO (PCT)
Prior art keywords
oxoquinoline
hydroxyphenyl
dihydro
tert
butyl
Prior art date
Application number
PCT/IN2015/000112
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English (en)
Other versions
WO2015128882A2 (fr
Inventor
Srinivasan Thirumalai Rajan
Chakilam Nagaraju
Achampeta Kodanda Ramprasad
Original Assignee
Msn Laboratories Private Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msn Laboratories Private Limited filed Critical Msn Laboratories Private Limited
Publication of WO2015128882A2 publication Critical patent/WO2015128882A2/fr
Publication of WO2015128882A3 publication Critical patent/WO2015128882A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des formes cristallines d'un composé de N-(2,4-di-tert-butyl-5-hydroxyphényl)-1,4-dihydro-4-oxoquinoléine-3-carboxamide de formule-1 et également un procédé de préparation de ce composé de formule-1 qui est représenté par la formule de structure suivante : formule-1.
PCT/IN2015/000112 2014-02-27 2015-02-27 Formes cristallines de n-(2,4-di-tert-butyl -5-hydroxyphényl)-1,4-dihydro -4-oxoquinoléine-3-carboxamide et procédé de préparation de celles-ci WO2015128882A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1006/CHE/2014 2014-02-27
IN1006CH2014 2014-02-27

Publications (2)

Publication Number Publication Date
WO2015128882A2 WO2015128882A2 (fr) 2015-09-03
WO2015128882A3 true WO2015128882A3 (fr) 2016-02-11

Family

ID=54009735

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2015/000112 WO2015128882A2 (fr) 2014-02-27 2015-02-27 Formes cristallines de n-(2,4-di-tert-butyl -5-hydroxyphényl)-1,4-dihydro -4-oxoquinoléine-3-carboxamide et procédé de préparation de celles-ci

Country Status (1)

Country Link
WO (1) WO2015128882A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE049976T2 (hu) 2005-12-28 2020-11-30 Vertex Pharma N-[2,4-bisz(1,1-dimetil-etil)-5-hidroxi-fenil]-1,4-dihidro-4-oxo-kinolin-3-karboxamid amorf alakjának gyógyászati kompozíciói
CN107250113B (zh) * 2014-10-07 2019-03-29 弗特克斯药品有限公司 囊性纤维化跨膜传导调节蛋白的调节剂的共晶
ES2839299T3 (es) 2015-09-02 2021-07-05 Laurus Labs Ltd Procedimientos para la preparación de ivacaftor
US11384054B2 (en) 2020-10-22 2022-07-12 Scinopharm Taiwan, Ltd. Crystalline form of ivacaftor and a process for preparing the same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7495103B2 (en) * 2004-06-24 2009-02-24 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US8410274B2 (en) * 2005-12-28 2013-04-02 Vertex Pharmaceuticals Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US8623894B2 (en) * 2007-09-14 2014-01-07 Vertex Pharmaceuticals Incorporated Solid forms of N-[2,4-Bis(1,1-dimethyethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquioline-3-carboxamide

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7495103B2 (en) * 2004-06-24 2009-02-24 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US8410274B2 (en) * 2005-12-28 2013-04-02 Vertex Pharmaceuticals Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US8623894B2 (en) * 2007-09-14 2014-01-07 Vertex Pharmaceuticals Incorporated Solid forms of N-[2,4-Bis(1,1-dimethyethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquioline-3-carboxamide

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Publication number Publication date
WO2015128882A2 (fr) 2015-09-03

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