WO2015127661A1 - Dispositif et procédé de mesure de la vitesse d'écoulement du sang - Google Patents

Dispositif et procédé de mesure de la vitesse d'écoulement du sang Download PDF

Info

Publication number
WO2015127661A1
WO2015127661A1 PCT/CN2014/072733 CN2014072733W WO2015127661A1 WO 2015127661 A1 WO2015127661 A1 WO 2015127661A1 CN 2014072733 W CN2014072733 W CN 2014072733W WO 2015127661 A1 WO2015127661 A1 WO 2015127661A1
Authority
WO
WIPO (PCT)
Prior art keywords
module
light
blood flow
blood
flow rate
Prior art date
Application number
PCT/CN2014/072733
Other languages
English (en)
Chinese (zh)
Inventor
王辉
代祥松
吴蕾
何卫红
Original Assignee
深圳市斯尔顿科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 深圳市斯尔顿科技有限公司 filed Critical 深圳市斯尔顿科技有限公司
Priority to CN201480000036.8A priority Critical patent/CN104168823B/zh
Priority to PCT/CN2014/072733 priority patent/WO2015127661A1/fr
Publication of WO2015127661A1 publication Critical patent/WO2015127661A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0066—Optical coherence imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood

Definitions

  • the present invention relates to the field of optical coherence tomography, and more particularly to a blood flow rate measuring device and method. Background technique
  • OCT Optical Coherence Tomography
  • Doppler OCT can realize the imaging of blood flow rate, which is of great significance in medical research and clinical application.
  • the availability of the OCT allows measurement of the Doppler shift, but this information can only be correlated with blood flow in the scan direction alone, and does not directly reflect blood motion in a direction perpendicular to the scan beam in the Doppler shift. Therefore, in order to measure the exact flow rate of blood, it is also necessary to know the angle between the scanning beam and the direction of blood flow.
  • the OCT signal can obtain the flow velocity component V! along the direction of the probe light by phase analysis, but the entire flow velocity v cannot be obtained due to the angle between the flow velocity and the probe light.
  • the measurement accuracy of OCT is directly limited by factors such as Doppler angle, sampling law and frequency resolution. In practical applications, such as monitoring blood flow in living tissue, it is often impossible to determine the Doppler angle due to the complex geometry of the blood vessel and the deep burial in the highly scattering biological tissue, which often leads to qualitative analysis.
  • v is the true flow rate.
  • the angle ⁇ is the angle between the flow velocity (vessel direction) and the planes of K1 and ⁇ 2. This angle can be obtained by the fundus imaging device.
  • the advantage of this method is that the flow rate of the blood vessels is measured more accurately.
  • the disadvantages are:
  • the optical path is complicated.
  • the use of polarizing devices results in the inability of the OCT system to use fiber-based systems, and the optical path is unstable;
  • Embodiments of the present invention provide a blood flow rate measuring apparatus and method that can accurately and accurately measure blood flow rate without measuring the angle between the scanning beam and the blood flow direction.
  • a blood flow rate measuring device comprising: a light source and a detecting module respectively connected to one end of the beam splitter, a reference arm and a sample arm module respectively connected to the other end of the beam splitter, and a processing module connected to the detecting module, the light output by the light source provides light to the sample arm module and the reference arm through the beam splitter, and the sample arm module includes at least one lens, wherein The sample arm module further includes an optical path rotation reflection module;
  • the optical path rotation reflection module rotates the light beam split by the light source to the sample arm module by the beam splitter to perform a rotation of 0° - 360°, and transmits the rotated light beam to the at least one lens. - - Loss to the object being inspected;
  • the beam splitter receives light scattered by the sample arm module and interferes with light reflected by the reference arm, and the detecting module is configured to detect the interference light;
  • the processing module is configured to obtain at least one blood flow velocity component corresponding to the rotation angle of at least one blood vessel of the detected object according to the interference light, and obtain the quilt according to the at least one blood flow velocity component The absolute blood flow rate of at least one blood vessel of the object is detected.
  • the processing module is configured to obtain an absolute blood flow rate of the at least one blood vessel of the detected object according to the at least one blood flow rate component, specifically:
  • the processing module is configured to obtain an absolute blood flow rate of at least one blood vessel of the detected object based on a maximum flow rate component and a minimum flow velocity component of the at least one blood flow rate component.
  • the optical path rotation reflecting module comprises at least one variable direction light reflecting means and a corresponding driving means.
  • the rotated light beams are parallel light beams having a set distance.
  • the sample arm reflecting device further comprises a scanning module
  • the rotated light beam is transmitted to the object to be detected via the scanning module and the at least one lens;
  • the scanning module is configured to rotate a set angle, and scan the at least one blood vessel of the detected object with the rotated beam to obtain at least one blood flow rate component of the at least one blood vessel.
  • a method of measuring blood flow rate comprising:
  • An absolute blood flow rate of at least one blood vessel of the detected object is obtained based on the at least one blood flow rate component.
  • the obtaining an absolute blood flow rate of the at least one blood vessel of the detected object according to the at least one blood flow rate component specifically:
  • An absolute blood flow rate of at least one blood vessel of the detected object is obtained based on a maximum flow velocity component and a minimum flow velocity component of the at least one blood flow velocity component.
  • the rotated second light beam is a parallel light beam having a set distance.
  • the transmitting the second light beam after being rotated to the detected object is specifically: transmitting the rotated second light beam to the detected object through a scanning module, and rotating the scanning module
  • the at least one blood vessel of the detected object is scanned with the rotated second light beam to obtain at least one blood flow velocity component of the at least one blood vessel.
  • the sample arm module comprises an optical path rotation reflection module and at least one lens
  • the optical path rotation reflection module comprises at least one variable direction light reflection device and a corresponding driving device.
  • a beam splitting to a sample arm module is rotated by providing an optical path rotating reflection module in a sample arm module, and the rotated beam is rotated. Transmitted to the detected object, and then the beam splitter receives the light scattered by the sample arm module and interferes with the light reflected by the reference arm, the detecting module detects the interference light, and the processing module obtains at least the detected object according to the interference light.
  • At least one blood flow rate component of the blood vessel corresponding to the rotation angle and obtaining an absolute blood flow velocity of the at least one blood vessel of the detected object according to the at least one blood flow velocity component, so that it is not necessary to know the direction between the scanning beam and the blood flow direction In the case of an angle, the flow rate of blood can be accurately measured.
  • Figure 1 is a schematic view of the angle between the blood flow rate and the probe light
  • FIG. 2 is a schematic diagram of measurement of blood flow rate in the prior art
  • FIG. 3 is a schematic diagram of a blood flow rate measuring device according to an embodiment of the present invention
  • FIG. 4 is a schematic diagram of a working principle of an optical path rotating reflecting device
  • - Figure 5 is a schematic diagram of blood flow rate measurement according to an embodiment of the present invention
  • FIG. 6 is a flowchart of a method for measuring blood flow rate according to an embodiment of the present invention. detailed description
  • the measuring device includes a light source 101, a beam splitter 102, a detecting module 105, a processing module 106, a reference arm and a sample arm module, and a light source.
  • the detection module 105 is coupled to one end of the beam splitter 102, the reference arm and sample arm module are coupled to the other end of the beam splitter 102, and the detection module 105 is also coupled to the processing module 106.
  • the processing module 106 can be a computer, the reference arm can include a reference arm optical path lens 103 and a reference arm mirror 104, the beam splitter 102 can be a fiber optic coupler, and the sample arm module includes one or more lenses and an optical path rotating reflective module 108. .
  • the light source 101 is a weak coherent light source, and the output light thereof is supplied to the reference arm and the sample arm module via the beam splitter 102.
  • the reference arm has a known length and reflects light back into the beam splitter 102 by the reference arm mirror 104.
  • the sample arm module supplies light to the eye E of the subject, and the reflected light from the eye E of the subject and the reflected light from the reference arm interfere in the beam splitter 102, and the interference light is detected by the detecting system 105, and then processed.
  • Module 106 processes and finally displays it.
  • the optical path rotation reflection module 108 splits the light beam of the light source 101 through the beam splitter 102 to the sample arm module to perform a rotation of 0° - 360° to obtain a plurality of rotated light beams, and the plurality of rotated light beams are interfering through the lens.
  • the interference light wave is detected by the detecting module 105, and the processing module 106 obtains a plurality of blood flow rate components of a certain blood vessel of the human eye E according to the interference light wave obtained by the detecting module 105, and then, the processing module 106 determines the plurality of blood flow rate components according to the plurality of blood flow rate components.
  • the processing module 106 obtains the blood vessel of the human eye E according to the maximum flow velocity component and the minimum flow velocity component of the plurality of blood flow velocity components. Absolute flow rate.
  • variable direction light reflecting devices and corresponding driving devices such as motors and mirrors, motors and total reflection prisms, two-dimensional galvanometers, and micro-electro-mechanical systems (MEMS). Or a piezoelectric ceramic-driven deflection mirror, etc., as shown in the schematic diagram of the optical path rotation reflection module shown in FIG. 4, after the beam splitting to the sample arm module is rotated by the optical path rotation reflection module 108, a plurality of parallel beams are formed. The beam of the distance. When the flow rate of a certain blood vessel of the subject's eye E is measured, the scanning devices 109 and 110 do not move.
  • driving devices such as motors and mirrors, motors and total reflection prisms, two-dimensional galvanometers, and micro-electro-mechanical systems (MEMS).
  • MEMS micro-electro-mechanical systems
  • « is the angle between the scanning beam ⁇ ⁇ ⁇ ⁇ 2 , which is determined by the system design.
  • ⁇ is the angle between the flow velocity (vessel direction) and the plane of Kl ⁇ 2.
  • formula (5) can be derived to solve the actual blood flow velocity V:
  • the sample arm emitting device may further include a scanning device, which may be a two-dimensional optical path scanning device such as the X-direction optical path scanning device 109 and the X-direction optical path scanning device 110 shown in FIG. It can also be a three-dimensional optical path scanning device.
  • a scanning device which may be a two-dimensional optical path scanning device such as the X-direction optical path scanning device 109 and the X-direction optical path scanning device 110 shown in FIG. It can also be a three-dimensional optical path scanning device.
  • the rotated light beam is transmitted to the eye of the subject through the scanning module and one or more lenses, and the scanning module is used to rotate the set angle, and the plurality of blood vessels of the detected object are scanned by the rotated light beam to obtain a plurality of blood vessels. a blood flow rate component.
  • the rotated light beam can be transmitted to the eyelid of the subject through the scanning devices 109 and 110, and the scanning devices 109 and 110 cooperate with the optical path rotation transmitting device 108 to vibrate, and the multi-dimensional scan is performed on the human eye. Can get the total blood flow of the human eye retina, that is, the absolute number of blood vessels in the human eye Blood flow rate.
  • the subject's eye E is scanned by the scanning devices 109 and 110 to realize tomographic imaging. It can be seen from the above that the measuring method does not have to rely on measuring the angle of the fluid, and the flow velocity distribution of the fluid can be measured under the angle of the scanning beam emitted by the sample arm port of the unknown OCT system, that is, the measurement and the incident. Angle has nothing to do.
  • the lens of the sample arm module may include a focus lens 107, a relay lens 111, and an ophthalmoscope 112, wherein the focus lens 107 is connected to the beam splitter 102 and the optical path rotation reflection module 108, respectively, and the relay lens 111 is connected to the ophthalmoscope 112, respectively. And scanning device.
  • the output wavelength of the OCT light source 101 is near-infrared light, and the embodiment of the present invention uses near-infrared light having a wavelength of 800 to 880 nm.
  • a blood flow rate measuring device is configured to rotate a light beam splitted to a sample arm module by providing an optical path rotation reflection module in the sample arm module, and transmit the rotated light beam to the detected object. And then the beam splitter receives the light scattered by the sample arm module and interferes with the light reflected by the reference arm, the detecting module detects the interference light, and the processing module obtains the rotation and rotation of the at least one blood vessel of the detected object according to the interference light.
  • FIG. 6 is a flowchart of a method for measuring blood flow rate according to an embodiment of the present invention. The method includes the following steps:
  • Step S101 splitting the light output by the light source into a first beam and a second beam, the first beam and the second beam being respectively supplied to the reference arm and the sample arm module.
  • the light source in this embodiment is a weakly coherent light source, and the output light is split by the beam splitter and supplied to the reference arm and the sample arm module.
  • the reference arm has a known length and reflects light back into the splitter through the reference arm mirror.
  • the output wavelength of the light source is near-infrared light, and the embodiment of the present invention uses near-infrared light having a wavelength of 800 to 880 nm.
  • the sample arm module includes an optical path rotation reflection module and one or more lenses, the optical path rotation reflection module including one or more variable direction light reflecting devices and corresponding driving devices, such as motors and mirrors, motors, and Reflective prisms, two-dimensional galvanometers, MEMS or piezoelectric ceramic-driven deflection mirrors, etc.
  • Step S102 performing rotation of the second light beam by 0° - 360°, and rotating the second - - Two beams are transmitted to the detected object.
  • the light beam split from the light source to the sample arm module by the beam splitter is rotated by 0° - 360° to obtain a plurality of rotated light beams, and the plurality of rotated light beams are transmitted to the object to be inspected.
  • a plurality of parallel beams having a certain distance are formed.
  • Step S103 Receive light scattered by the sample arm module, interfere with light reflected by the reference arm, and detect the interference light. The wave is detected by the detection module.
  • Step S104 Obtain at least one blood flow rate component corresponding to the rotation angle of the at least one blood vessel of the detected object according to the detected interference light.
  • the interference light wave obtained by the detecting module a plurality of blood flow velocity components of a certain blood vessel of the object to be inspected are obtained.
  • Step S105 Obtain an absolute blood flow rate of at least one blood vessel of the detected object according to the at least one blood flow rate component.
  • the absolute flow rate of the blood vessel of the object to be examined is obtained based on the obtained plurality of blood flow rate components.
  • the processing module obtains an absolute flow rate of the blood vessel of the object to be inspected based on the maximum flow rate component and the minimum flow rate component of the plurality of blood flow rate components.
  • « is the angle between the scanning beam ⁇ ⁇ ⁇ ⁇ 2 , which is determined by the system design.
  • ⁇ is the angle between the flow velocity (vessel direction) and the plane of Kl ⁇ 2.
  • formula (5) can be derived to solve the actual blood flow velocity V:
  • the blood flow velocity V is independent of the beta angle. It can be seen from the above that the measurement method does not have to rely on the measurement of the angle of the fluid, and the flow velocity distribution of the fluid can be measured at the angle between the scanning beam emitted by the sample arm port of the unknown OCT system and the blood flow velocity, that is, the measurement and the incident. Angle has nothing to do.
  • the measurement method may further comprise the steps of:
  • the rotated beam can be transmitted to the eye of the subject through a two-dimensional or three-dimensional scanning device, and the scanning device cooperates with the optical rotation device to vibrate, and the multi-dimensional scanning is performed on the human eye to obtain the human retina.
  • the human eye E is scanned by a two-dimensional or three-dimensional scanning device to perform tomographic imaging.
  • a method for measuring blood flow rate by rotating a beam split to a sample arm module, and transmitting the rotated beam to an object to be detected, and then receiving light scattered by the sample arm module, And interfering with the light reflected by the reference arm, detecting the interference light, and obtaining at least one blood flow velocity component corresponding to the rotation angle of the at least one blood vessel of the detected object according to the detected interference light, and according to at least one blood
  • the flow rate component obtains an absolute blood flow rate of at least one blood vessel of the object to be detected, so that the flow rate of the blood can be accurately measured without knowing the angle between the scanning beam and the blood flow direction.
  • Computer readable media includes both computer storage media and communication media including any medium that facilitates transfer of a computer program from one location to another.
  • a storage medium may be any available media that can be accessed by a computer.
  • the computer readable medium may include a random access memory (RAM), a read-only memory (ROM), and an electrically erasable programmable read-only memory (Electrically Erasable Programmable).
  • RAM random access memory
  • ROM read-only memory
  • EEPROM Electrically erasable programmable read-only memory
  • CD-ROM Compact Disc Read-Only Memory
  • Any connection may suitably be a computer readable medium.
  • a disk and a disc include a compact disc (CD), a laser disc, a disc, a digital versatile disc (DVD), a floppy disk, and a Blu-ray disc, wherein the disc is usually magnetically copied, and the disc is The laser is used to optically replicate the data. Combinations of the above should also be included within the scope of the computer readable media.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physiology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Eye Examination Apparatus (AREA)

Abstract

L'invention concerne un dispositif de mesure de la vitesse d'écoulement du sang qui comprend une source de lumière (101) et un module de détection (105) respectivement raccordés à une extrémité d'un séparateur de faisceau (102), un module de bras de référence et un module de bras d'échantillon respectivement raccordés à l'autre extrémité du séparateur de faisceau (102), et un module de traitement (106) raccordé au module de détection (105). La lumière émise par la source de lumière (101) est fournie au module de bras d'échantillon et au module de bras de référence par l'intermédiaire du séparateur de faisceau (102). Le module de bras d'échantillon comprend au moins un objectif et comprend également un module de rotation et de réflexion de trajectoire optique (108). Le module de rotation et de réflexion de trajectoire optique (108) fait pivoter le faisceau lumineux séparé vers le module de bras d'échantillon de 0 à 360 degrés et transmet le faisceau lumineux ayant pivoté à un objet devant être détecté par l'intermédiaire d'au moins un objectif. Le séparateur de faisceau (102) reçoit la lumière diffusée par le module de bras d'échantillon et interfère avec la lumière réfléchie par le module de bras de référence. Le module de détection (105) est utilisé pour détecter une lumière d'interférence. Le module de traitement (106) est destiné à obtenir au moins une composante de vitesse d'écoulement du sang, qui correspond à l'angle de rotation, d'au moins un vaisseau sanguin de l'objet devant être détecté conformément à la lumière d'interférence, et à obtenir une vitesse d'écoulement de sang absolue d'au moins un vaisseau sanguin de l'objet devant être détecté conformément au ou aux composantes de vitesse d'écoulement du sang. Le dispositif peut mesurer avec précision la vitesse d'écoulement du sang d'une manière simple et pratique sans connaître l'angle inclus entre un faisceau de lumière de balayage et la direction d'écoulement du sang.
PCT/CN2014/072733 2014-02-28 2014-02-28 Dispositif et procédé de mesure de la vitesse d'écoulement du sang WO2015127661A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201480000036.8A CN104168823B (zh) 2014-02-28 2014-02-28 一种血液流速的测量装置及方法
PCT/CN2014/072733 WO2015127661A1 (fr) 2014-02-28 2014-02-28 Dispositif et procédé de mesure de la vitesse d'écoulement du sang

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2014/072733 WO2015127661A1 (fr) 2014-02-28 2014-02-28 Dispositif et procédé de mesure de la vitesse d'écoulement du sang

Publications (1)

Publication Number Publication Date
WO2015127661A1 true WO2015127661A1 (fr) 2015-09-03

Family

ID=51912323

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2014/072733 WO2015127661A1 (fr) 2014-02-28 2014-02-28 Dispositif et procédé de mesure de la vitesse d'écoulement du sang

Country Status (2)

Country Link
CN (1) CN104168823B (fr)
WO (1) WO2015127661A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015172581A1 (fr) * 2014-05-14 2015-11-19 深圳市斯尔顿科技有限公司 Appareil et procédé de mesure de flux sanguin
CN104159505B (zh) * 2014-05-14 2016-03-09 深圳市斯尔顿科技有限公司 血液流量测量装置及方法
CN104523233B (zh) * 2014-12-29 2017-02-22 浙江大学 基于复数互相关的微血管光学造影及抖动补偿方法
WO2016117106A1 (fr) * 2015-01-23 2016-07-28 オリンパス株式会社 Dispositif de traitement chirurgical
CN104825148B (zh) * 2015-05-27 2017-11-14 深圳市斯尔顿科技有限公司 一种测量血管血液流量的设备及方法
CN105286779B (zh) * 2015-10-30 2017-06-30 温州医科大学 一种在体视网膜血流动力学的成像与绝对流速测量方法
CN105167766B (zh) * 2015-11-03 2018-06-08 深圳市斯尔顿科技有限公司 血液流量测量设备及血液流量测量方法
EP3919919A4 (fr) * 2019-01-31 2022-09-07 Air Water Biodesign Inc. Dispositif de spécification de débit
CN112022085B (zh) * 2020-09-16 2022-04-15 中山大学 一种视网膜内的血管流量的计算方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1135043A (zh) * 1994-10-19 1996-11-06 卡尔蔡斯公司 短相干长度多普勒速度测量系统
WO2010131531A1 (fr) * 2009-05-11 2010-11-18 Canon Kabushiki Kaisha Appareil de traitement d'information dans un systeme de tomographie en coherence optique
CN102356322A (zh) * 2009-03-16 2012-02-15 医疗数据有限公司 用于测量流体速度的方法及相关设备
US20120265039A1 (en) * 2011-02-25 2012-10-18 Cercacor Laboratories, Inc. Patient monitor for monitoring microcirculation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5683946B2 (ja) * 2007-04-10 2015-03-11 ユニヴァーシティー オブ サザン カリフォルニア ドップラー光コヒーレンス・トモグラフィを用いた血流測定のための方法とシステム
JP5627321B2 (ja) * 2010-07-09 2014-11-19 キヤノン株式会社 光断層画像撮像装置及びその撮像方法
JP5900950B2 (ja) * 2012-01-05 2016-04-06 国立大学法人 筑波大学 波長走査型光干渉断層計及びその位相安定化プログラム
CN202537487U (zh) * 2012-05-11 2012-11-21 浙江大学 基于oct的大动态范围流速的高灵敏度测量系统

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1135043A (zh) * 1994-10-19 1996-11-06 卡尔蔡斯公司 短相干长度多普勒速度测量系统
CN102356322A (zh) * 2009-03-16 2012-02-15 医疗数据有限公司 用于测量流体速度的方法及相关设备
WO2010131531A1 (fr) * 2009-05-11 2010-11-18 Canon Kabushiki Kaisha Appareil de traitement d'information dans un systeme de tomographie en coherence optique
US20120265039A1 (en) * 2011-02-25 2012-10-18 Cercacor Laboratories, Inc. Patient monitor for monitoring microcirculation

Also Published As

Publication number Publication date
CN104168823B (zh) 2017-01-18
CN104168823A (zh) 2014-11-26

Similar Documents

Publication Publication Date Title
WO2015127661A1 (fr) Dispositif et procédé de mesure de la vitesse d'écoulement du sang
US20180085095A1 (en) Apparatus and Method of Image Registration
US11473896B2 (en) Coherence range imaging using common path interference
Dai et al. Absolute retinal blood flow measurement with a dual-beam Doppler optical coherence tomography
EP1931238B1 (fr) Tomographie par coherence optique destinee a la mesure de la longueur de l'oeil
US8594757B2 (en) Apparatus for biomedical imaging
US8059274B2 (en) Low-loss polarized light diversion
Trasischker et al. In vitro and in vivo three-dimensional velocity vector measurement by three-beam spectral-domain Doppler optical coherence tomography
WO2016188178A1 (fr) Appareil et procédé permettant de mesurer le débit sanguin dans un vaisseau sanguin
WO2015172322A1 (fr) Dispositif et procédé de détection de la quantité d'écoulement sanguin
US20130107274A1 (en) Optical imaging and mapping using propagation modes of light
WO2009033064A2 (fr) Systèmes, procédés et support accessible par ordinateur destinés à fournir une microscopie de phase à cohérence optique dans le domaine spectral pour une imagerie de cellule et de tissu profond
US20140180075A1 (en) System and method for imaging subsurface of specimen
RU184084U1 (ru) Устройство эндоскопического зонда для оптической когерентной томографии
JP2013522619A (ja) シングルモード光ファイバベースの角度分解低コヒーレンス干渉計測（ＬＣＩ）（ａ／ＬＣＩ）および不干渉計測システムならびに方法
Blatter et al. Angle independent flow assessment with bidirectional Doppler optical coherence tomography
KR101503272B1 (ko) 관절염 진단을 위한 다중 모드 광 영상장치
JP2015099078A (ja) 光断層画像撮影装置
CN109363627A (zh) 一种血液流速的测量装置及方法
CN110192852B (zh) 双扫描线光学相干层析的流速横向分量测量系统及方法
KR20100099025A (ko) 광학적 도플러 단층 촬영 장치 및 그의 도플러 주파수 검출방법
CN106872407B (zh) 一种提高扫频光学相干层析成像分辨率方法
Ke et al. Determination of birefringence of biological tissues using modified PS-OCT based on the quaternion approach
RU179037U1 (ru) Устройство эндоскопической оптической когерентной томографии
WO2022231877A1 (fr) Scanner de tomographie par cohérence optique intrabuccale avec adaptateur de fibre optique

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 14884088

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 14884088

Country of ref document: EP

Kind code of ref document: A1