WO2015118978A1

WO2015118978A1 - Polyvinyl alcohol film

Info

Publication number: WO2015118978A1
Application number: PCT/JP2015/052003
Authority: WO
Inventors: 勝啓高藤; 磯▲ざき▼　孝徳
Original assignee: 株式会社クラレ
Priority date: 2014-02-06
Filing date: 2015-01-26
Publication date: 2015-08-13
Also published as: TW201534473A; TWI639510B; JPWO2015118978A1; CN105940050A; KR20160118226A; KR102229234B1; JP6595913B2; CN105940050B

Abstract

[Problem] To provide: a polyvinyl alcohol film which quickly dissolves after being introduced into water and exhibits excellent spreadability for drugs packaged thereby; and a package using the same. [Solution] A polyvinyl alcohol film which comprises a polyvinyl alcohol, surface spreader, and plasticizer, wherein the content of the plasticizer is 10 to 40 parts by mass with respect to 100 parts by mass of the polyvinyl alcohol; and a package which is wrapped with the polyvinyl alcohol film. The content of the surface spreader is preferably 0.1 to 15 parts by mass with respect to 100 parts by mass of the polyvinyl alcohol, the surface spreader is preferably a dialkyl sulfosuccinic acid salt, and at least one of the alkyl groups in the dialkyl sulfosuccinic acid salt is preferably an alkyl group having 6 to 12 carbon atoms.

Description

Polyvinyl alcohol film

The present invention relates to a polyvinyl alcohol film useful for unit packaging of chemicals such as agricultural chemicals and detergents, and a package using the same.

Various chemicals such as agricultural chemicals and detergents are sealed and packaged in unit quantities in water-soluble films (unit packaging), put into the water as it is when used, and dissolved or dispersed in water. There is a way to do it. The advantages of this unit packaging are that it can be used without direct contact with dangerous chemicals, that a certain amount is packaged, so there is no need to measure it at the time of use, and post-treatment such as packaging containers and bags is unnecessary or simple. Etc.

For example, a jumbo agent for paddy fields is an agrochemical active ingredient by dissolving the water-soluble film that wraps it in the paddy field and diffusing it throughout the paddy field by floating the jumbo agent contained in the package. Will spread. At this time, if the water-soluble film does not dissolve quickly or the diffusibility of the pesticidal active ingredient is insufficient, the pesticidal active ingredient cannot be distributed throughout the paddy field.

As a water-soluble film used for unit packaging, a polyvinyl alcohol film (hereinafter, “polyvinyl alcohol” may be abbreviated as “PVA”) is known. Specifically, for example, a specific sulfonic acid group-containing film is used. A film using modified PVA having a unit (see Patent Document 1), a film containing PVA and a water-soluble sulfonate-containing compound (see Patent Document 2), and the like are known.

Japanese Unexamined Patent Publication No. 7-118407 Japanese Patent Laid-Open No. 9-40834

However, conventionally known water-soluble films have room for further improvement in terms of solubility and diffusibility of packaged drugs. Therefore, an object of the present invention is to provide a PVA film that dissolves quickly after being poured into water and has excellent diffusibility of the packaged drug, and a package using the PVA film.

As a result of intensive studies by the present inventors to achieve the above object, when a PVA film containing a specific amount of a plasticizer further contains a water surface spreading agent such as a dialkylsulfosuccinate, it is promptly introduced into water. It was found that the PVA film was excellent in diffusibility of the packaged drug as well as dissolved in the solution, and further studies were made based on the findings to complete the present invention.

That is, the present invention
[1] A PVA film containing PVA, a water surface spreading agent and a plasticizer, wherein the plasticizer content is 10 to 40 parts by mass with respect to 100 parts by mass of PVA;
[2] The PVA film according to [1], wherein the content of the water surface spreading agent is 0.1 to 15 parts by mass with respect to 100 parts by mass of PVA;
[3] The PVA film according to [1] or [2], wherein the water surface spreading agent is a dialkyl sulfosuccinate.
[4] The PVA film according to [3], wherein at least one of the alkyl groups in the dialkylsulfosuccinate is an alkyl group having 6 to 12 carbon atoms;
[5] The PVA film according to [3] or [4], wherein at least one of the alkyl groups in the dialkylsulfosuccinate is a linear alkyl group;
[6] The PVA film according to any one of [1] to [5], which is a film for drug packaging;
[7] The PVA film according to [6], wherein the drug is an agrochemical or a detergent;
[8] A package formed by packaging the drug with the PVA film according to [6] or [7];
About.

According to the present invention, there are provided a PVA film that dissolves rapidly after being poured into water and is excellent in diffusibility of the packaged medicine, and a package using the PVA film.

The PVA film of the present invention contains PVA, a water surface spreading agent and a plasticizer. In the PVA film of the present invention, the plasticizer content is 10 to 40 parts by mass with respect to 100 parts by mass of PVA. In the case where the plasticizer is contained in the above-described content, it further becomes a PVA film that dissolves rapidly after being put into water and is excellent in diffusibility of the packaged medicine by containing the plasticizer.

[PVA]
The PVA is one of vinyl esters such as vinyl acetate, vinyl formate, vinyl propionate, vinyl butyrate, vinyl pivalate, vinyl versatate, vinyl laurate, vinyl stearate, vinyl benzoate, and isopropenyl acetate. Or what is obtained by saponifying the polyvinyl ester obtained by superposing | polymerizing 2 or more types can be used. Among the above vinyl esters, vinyl acetate is preferable from the viewpoints of ease of production of PVA, availability, cost and the like.

The above-mentioned polyvinyl ester may be obtained using only one or two or more kinds of vinyl esters as a monomer. It may be a copolymer of two or more kinds of vinyl esters and other monomers copolymerizable therewith.

Examples of the other monomer copolymerizable with the vinyl ester include α-olefins having 2 to 30 carbon atoms such as ethylene, propylene, 1-butene, and isobutene; (meth) acrylic acid or a salt thereof; (Meth) methyl acrylate, (meth) ethyl acrylate, (meth) acrylate n-propyl, (meth) acrylate i-propyl, (meth) acrylate n-butyl, (meth) acrylate i-butyl, ( (Meth) acrylic acid esters such as t-butyl (meth) acrylate, 2-ethylhexyl (meth) acrylate, dodecyl (meth) acrylate, octadecyl (meth) acrylate; (meth) acrylamide, N-methyl ( (Meth) acrylamide, N-ethyl (meth) acrylamide, N, N-dimethyl (meth) acrylamide, diacetone (meth) acryl (Meth) acrylamide derivatives such as amides, (meth) acrylamide propanesulfonic acid or salts thereof, (meth) acrylamide propyldimethylamine or salts thereof, N-methylol (meth) acrylamide or derivatives thereof; N-vinylformamide, N-vinyl N-vinylamides such as acetamide and N-vinylpyrrolidone; methyl vinyl ether, ethyl vinyl ether, n-propyl vinyl ether, i-propyl vinyl ether, n-butyl vinyl ether, i-butyl vinyl ether, t-butyl vinyl ether, dodecyl vinyl ether, stearyl vinyl ether, etc. Vinyl ether; vinyl cyanide such as (meth) acrylonitrile; vinyl halide such as vinyl chloride, vinylidene chloride, vinyl fluoride, vinylidene fluoride; Allyl compounds such as allyl acetate and allyl chloride; maleic acid or its salts, esters or acid anhydrides; itaconic acid or its salts, esters or acid anhydrides; vinylsilyl compounds such as vinyltrimethoxysilane; unsaturated sulfonic acids be able to. Said polyvinyl ester can have a structural unit derived from 1 type, or 2 or more types of an above described other monomer.

The proportion of structural units derived from the other monomers described above in the polyvinyl ester is preferably 25 mol% or less based on the number of moles of all structural units constituting the polyvinyl ester, and is 15 mol%. More preferably, it is more preferably 5 mol% or less.

The above PVA may be modified with one or two or more types of graft copolymerizable monomers as long as the effects of the present invention are not impaired. Examples of the graft copolymerizable monomer include unsaturated carboxylic acids or derivatives thereof; unsaturated sulfonic acids or derivatives thereof; α-olefins having 2 to 30 carbon atoms, and the like. The proportion of structural units derived from the graft copolymerizable monomer in PVA (structural units in the graft modified portion) is preferably 5 mol% or less based on the number of moles of all structural units constituting PVA. .

The PVA described above may be partially or not crosslinked in the hydroxyl group. Moreover, said PVA may react with aldehyde compounds, such as acetaldehyde and a butyraldehyde, etc. to form an acetal structure, and the said PVA does not react with these compounds and does not form an acetal structure. May be.

The degree of polymerization of the PVA is not particularly limited, but is preferably 300 or more, more preferably 500 or more, further preferably 800 or more, particularly preferably 1,000 or more, It is preferably 10,000 or less, more preferably 8,000 or less, further preferably 5,000 or less, and particularly preferably 2,000 or less. By the said polymerization degree being 300 or more, the intensity | strength of a film improves and it is excellent in handleability. On the other hand, when the degree of polymerization is 10,000 or less, industrial production of the PVA becomes easy. In this specification, the degree of polymerization of PVA means the average degree of polymerization measured according to the description of JIS K6726-1994.

The degree of saponification of the above PVA is not particularly limited, but is preferably 80 mol% or more, more preferably 82 mol% or more, and 84 mol% from the viewpoint of strength, waist and bag-making property of the obtained PVA film. % Or more, more preferably 99.9 mol% or less, more preferably 99 mol% or less, and even more preferably 98 mol% or less. When the degree of saponification of PVA is 80 mol% or more, sufficient elasticity can be imparted to the film, and the form stability is improved. In addition, when an alkaline substance or acidic substance is packaged and stored in the film Moreover, the water-soluble fall of a film can be prevented more effectively. On the other hand, when the degree of saponification is 99.9 mol% or less, industrial and stable production of PVA becomes easy. In this specification, the degree of saponification of PVA refers to the total number of moles of structural units (typically vinyl ester units) that can be converted into vinyl alcohol units by saponification and the vinyl alcohol units of PVA. The proportion (mol%) occupied by the number of moles of vinyl alcohol units. The degree of saponification can be measured according to the description of JIS-K6726-1994.

[Water surface spreading agent]
The type of the water surface spreading agent is not particularly limited, but dialkylsulfosuccinate is preferable because the effects of the present invention are more remarkably exhibited. The dialkylsulfosuccinate is a compound having a structure corresponding to a structure in which two carboxyl groups in the sulfosuccinate are each converted to an alkyl ester, and is obtained by any production method as long as it has the structure. There may be. The alkyl groups in the two alkyl ester moieties of the dialkyl sulfosuccinate may be the same or different from each other, but are preferably the same from the viewpoint of ease of production. . Further, either one or both of the alkyl groups in the dialkyl sulfosuccinate may be a linear alkyl group, or one or both may be a branched alkyl group. Examples of the alkyl group include methyl group, ethyl group, propyl group, isopropyl group, pentyl group, hexyl group, heptyl group, octyl group, 2-ethylhexyl group, nonyl group, decanyl group, undecanyl group, and dodecanyl group. Can be mentioned. In order to obtain a PVA film in which the diffusibility of the packaged drug is further improved, at least one (preferably both) of the alkyl groups in the dialkylsulfosuccinate is preferably an alkyl group having 6 to 12 carbon atoms. An alkyl group of 7 to 10 is more preferable. For the same reason, at least one (preferably both) of the alkyl groups in the dialkylsulfosuccinate is preferably a linear alkyl group.

Examples of the salt in the dialkylsulfosuccinate include inorganic salts, preferably sodium salt, potassium salt, and ammonium salt, and more preferably sodium salt.

The content of the water surface broadening agent in the PVA film is such that the effects of the present invention are more remarkably achieved, and the high mechanical properties can be maintained and the handleability is improved. It is preferably 1 part by mass or more, more preferably 1 part by mass or more, further preferably 3 parts by mass or more, and preferably 15 parts by mass or less, and 14 parts by mass or less. More preferably, the amount is 12 parts by mass or less.

[Plasticizer]
Examples of the plasticizer include polyhydric alcohols, and specific examples thereof include ethylene glycol, glycerin, propylene glycol, diethylene glycol, diglycerin, triethylene glycol, tetraethylene glycol, trimethylolpropane, and polyethylene glycol. Can be mentioned. The PVA film can contain one or more of these plasticizers. Among these, at least one selected from the group consisting of glycerin, diglycerin and polyethylene glycol is preferable. The number average molecular weight of polyethylene glycol is not particularly limited, but may be in the range of 100 to 1,000 from the viewpoint of compatibility with PVA and prevention of reduction in water solubility of the film due to bleeding out. preferable.

The content of the plasticizer in the PVA film dissolves quickly after being poured into water, and becomes a PVA film excellent in the diffusibility of the packaged medicine. Therefore, the content of the plasticizer is within the range of 10 to 40% by mass with respect to 100 parts by mass of PVA. The content is preferably 12 parts by mass or more, more preferably 14 parts by mass or more, and preferably 38 parts by mass or less, and 36 parts by mass or less. More preferably.

[Other ingredients]
For the purpose of adjusting mechanical strength, moisture resistance during handling, speed of softening due to absorption of water when dissolving, time required for diffusion in water, etc., PVA films include starch and / or other than PVA. Another water-soluble polymer may be further contained.

Examples of the starch include natural starches such as corn starch, potato starch, sweet potato starch, wheat starch, rice starch, tapioca starch, and sago starch; processed starches subjected to etherification, esterification, oxidation, etc. In particular, modified starches are preferred.

The starch content in the PVA film is preferably 15 parts by mass or less and more preferably 10 parts by mass or less with respect to 100 parts by mass of PVA. When the content is 15 parts by mass or less, the impact resistance of the PVA film is improved and the process passability is improved.

Other water-soluble polymers other than PVA include, for example, dextrin, gelatin, glue, casein, shellac, gum arabic, polyacrylic acid amide, sodium polyacrylate, polyvinyl methyl ether, methyl vinyl ether and maleic anhydride. Examples thereof include a polymer, a copolymer of vinyl acetate and itaconic acid, polyvinyl pyrrolidone, cellulose, acetyl cellulose, acetyl butyl cellulose, carboxymethyl cellulose, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, and sodium alginate.

The content of the water-soluble polymer other than PVA in the PVA film is preferably 15 parts by mass or less and more preferably 10 parts by mass or less with respect to 100 parts by mass of PVA. When the content is 15 parts by mass or less, the water solubility and dispersibility of the PVA film are improved.

The PVA film further includes a filler, a processing stabilizer such as a copper compound, a weather resistance stabilizer, a colorant, an ultraviolet absorber, a light stabilizer, an antioxidant, an antistatic agent, a flame retardant, and other thermoplastic resins. , Lubricants, fragrances, antifoaming agents, deodorants, extenders, release agents, mold release agents, reinforcing agents, crosslinking agents, fungicides, preservatives, crystallization rate retarders, surfactants described later, etc. Additives can be appropriately contained as necessary.

In the PVA film, the proportion of the total of the PVA, the water surface spreading agent and the plasticizer is preferably 80% by mass or more, more preferably 90% by mass or more based on the mass of the PVA film. And more preferably 95% by mass or more.

The thickness of the PVA film is not particularly limited, but it is preferably 1 μm or more, more preferably 5 μm or more, further preferably 10 μm or more, and 100 μm or less from the viewpoint of both strength and water solubility. Preferably, it is 75 μm or less, and more preferably 60 μm or less.

The shape of the PVA film is not particularly limited, and examples thereof include a quadrangle (for example, a rectangle, a square, etc.), a circle, a triangle, and the like, and can be appropriately set according to the usage form of the PVA film of the present invention. A long film is preferable because it can be continuously produced and can be easily stored and transported in a rolled state. The length of the long PVA film is not particularly limited, but is preferably 1 m or more, more preferably 100 m or more, and more preferably 1,000 m or more from the viewpoint of productivity during processing. preferable. The upper limit of the length is, for example, 10,000 m. On the other hand, the width of the long PVA film is not particularly limited, but is preferably 50 cm or more, more preferably 80 cm or more, and further preferably 100 cm or more from the viewpoint of productivity during processing. . An example of the upper limit of the width is 5 m. The PVA film can be used by cutting into a desired size when used.

The production method of the PVA film of the present invention is not particularly limited, and a production method in which the thickness and width of the PVA film after film formation are more uniform can be preferably adopted. For example, the above-described PVA constituting the PVA film, A film-forming stock solution in which one or two or more of the above-mentioned starch, other water-soluble polymer and additives are dissolved in a liquid medium, PVA, A film-forming stock solution containing one or more of a water surface spreading agent, a plasticizer and, if necessary, starch, other water-soluble polymers, additives, and a liquid medium, in which PVA is melted Can be used. When the film-forming stock solution contains at least one of starch, other water-soluble polymers and additives, it is preferable that these components are uniformly mixed.

Examples of the liquid medium used for the preparation of the membrane forming stock solution include water, dimethyl sulfoxide, dimethylformamide, dimethylacetamide, N-methylpyrrolidone, ethylene glycol, glycerin, propylene glycol, diethylene glycol, triethylene glycol, and tetraethylene glycol. , Trimethylolpropane, ethylenediamine, diethylenetriamine and the like, and one or more of them can be used. Among these, water is preferable from the viewpoint of environmental load and recoverability.

The volatile fraction of the film-forming stock solution (content ratio in the film-forming stock solution of volatile components such as liquid media removed by volatilization or evaporation during film formation) varies depending on the film-forming method, film-forming conditions, etc. Specifically, it is preferably in the range of 50 to 95% by mass, more preferably in the range of 55 to 90% by mass, and still more preferably in the range of 60 to 85% by mass. When the volatile fraction of the film-forming stock solution is 50% by mass or more, the viscosity of the film-forming stock solution does not become too high, and filtration and defoaming are smoothly performed during preparation of the film-forming stock solution, and there are few foreign matters and defects. Film production is facilitated. On the other hand, when the volatile fraction of the film-forming stock solution is 95% by mass or less, the concentration of the film-forming stock solution does not become too low, and the production of an industrial PVA film becomes easy.

The film forming stock solution preferably contains a surfactant. By including the surfactant, the film-forming property is improved and the occurrence of uneven thickness of the PVA film is suppressed, and the PVA film is easily peeled off from the metal roll or belt used for film formation. When a PVA film is produced from a film-forming stock solution containing a surfactant, the PVA film may contain a surfactant. Although the kind of said surfactant is not specifically limited, From a viewpoint of the peelability from a metal roll or a belt, an anionic surfactant or a nonionic surfactant is preferable.

As the anionic surfactant, for example, a carboxylic acid type such as potassium laurate; a sulfuric acid ester type such as polyoxyethylene lauryl ether sulfate and octyl sulfate; and a sulfonic acid type such as dodecylbenzene sulfonate are suitable.

Nonionic surfactants include, for example, alkyl ether types such as polyoxyethylene oleyl ether; alkylphenyl ether types such as polyoxyethylene octylphenyl ether; alkyl ester types such as polyoxyethylene laurate; polyoxyethylene laurylamino Alkylamine type such as ether; alkylamide type such as polyoxyethylene lauric acid amide; polypropylene glycol ether type such as polyoxyethylene polyoxypropylene ether; alkanolamide type such as lauric acid diethanolamide and oleic acid diethanolamide; polyoxy An allyl phenyl ether type such as alkylene allyl phenyl ether is preferred.

These surfactants can be used alone or in combination of two or more.

When the film-forming stock solution contains a surfactant, the content thereof is preferably in the range of 0.01 to 5 parts by mass with respect to 100 parts by mass of PVA contained in the film-forming stock solution, and 0.02 to 4 It is more preferably in the range of parts by mass, and particularly preferably in the range of 0.05 to 3 parts by mass. When the content is 0.01 parts by mass or more, the film forming property and the peelability are further improved. On the other hand, when the content is 5 parts by mass or less, it can be suppressed that the surfactant bleeds out to the surface of the PVA film to cause blocking and lower the handleability.

Examples of the film forming method for forming a PVA film using the above-described film forming stock solution include a cast film forming method, an extrusion film forming method, a wet film forming method, and a gel film forming method. These film forming methods may be used alone or in combination of two or more. Among these film forming methods, the cast film forming method and the extrusion film forming method are preferable because a PVA film having uniform thickness and width and good physical properties can be obtained. The formed PVA film can be dried or heat-treated as necessary.

As an example of a specific method for producing a PVA film, for example, a T-type slit die, a hopper plate, an I-die, a lip coater die or the like is used to rotate the above film forming stock solution on the most upstream side. The volatile component is uniformly discharged or cast on the peripheral surface of the first roll (or belt) and the volatile component is discharged from one surface of the film discharged or cast on the peripheral surface of the first roll (or belt). Evaporate to dry, then further dry on the circumference of one or more rotating heated rolls located downstream, or pass through a hot air dryer and further dry, The method of winding with a winding device can be preferably employed industrially. Drying with a heated roll and drying with a hot air dryer may be performed in an appropriate combination.

The surface of the PVA film is preferably matted for the purpose of improving the slip property of the surface. Examples of the mat treatment method include an on-line mat treatment method in which the surface of a mat on a roll or belt is transferred to a film during film formation, and a method in which an emboss treatment is performed after the formed film is once wound on a roll. The arithmetic average height (Ra) of the mat-treated surface is preferably 0.5 μm or more, and more preferably 1 μm or more. The upper limit of the arithmetic average height (Ra) is, for example, 10 μm from the viewpoint of pinhole resistance. When the arithmetic average height (Ra) is less than 0.5 μm, it is difficult to obtain sufficient slip properties. Further, the maximum height (Rz) is preferably 1 μm or more, and more preferably 3 μm or more. The upper limit of the maximum height (Rz) is, for example, 20 μm from the viewpoint of pinhole resistance. When the maximum height (Rz) is less than 0.5 μm, it is difficult to obtain sufficient slip properties. In this specification, the arithmetic average height (Ra) and the maximum height (Rz) are defined by JIS B 0601: 2001.

The PVA film of the present invention is preferably used as a drug packaging film because it dissolves quickly after being poured into water and has excellent diffusibility of the packaged drug. Examples of the medicine to be packaged include agricultural chemicals and detergents (including bleaching agents), and agricultural chemicals are preferable. There are no particular restrictions on the specific type of pesticide, but it is preferably a jumbo agent because the effects of the present invention are more prominent. In particular, it should be a floating type jumbo agent that floats on the water surface after spraying. preferable. There is no restriction | limiting in particular in the physical property of the chemical | medical agent packaged with the PVA film of this invention, It may be acidic, neutral, or alkaline. Examples of the form of the drug include powder, lump, gel, liquid and the like. From the viewpoint of excellent drug diffusibility, it is preferably powder or lump. Although there is no restriction | limiting in particular in a packaging form, The form of the unit packaging which packages a chemical | medical agent unit by unit quantity (preferably sealed packaging) is preferable. By packaging the drug using the PVA film of the present invention as a film for drug packaging, the package of the present invention is obtained.

Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples. The evaluation methods employed in the following examples and comparative examples are shown below.

Model test for drug packaging The PVA film produced in the following examples or comparative examples was conditioned at 20 ° C. and 65% RH for 24 hours. Subsequently, 2.5 g of 3-4 mmφ polyethylene pellets were hermetically packaged with a conditioned PVA film. Specifically, a bag is prepared by heat-sealing three sides so that the shape of the part containing the polyethylene pellets is a 30 mm × 30 mm square, and then the polyethylene pellets are put into this, and the remaining one is heat-sealed. And packaged. Next, 15 ° C. water was introduced to a depth of 2 cm in an 18 cm × 25 cm bat, and the above-mentioned bag in which polyethylene pellets were packaged was floated on the water surface at the center of the bat. The time from when the bag floats on the surface of the water until the PVA film dissolves and the polyethylene pellets in the bag begin to diffuse into the surface of the water is defined as the bag breakage time. (Good) and the case where it exceeded 80 second was determined as solubility "x" (poor). In addition, the state of 180 seconds after the bag was floated on the surface of the water was photographed with a camera from above, and when the polyethylene pellet was diffused by 80% or more with respect to the area of the bat (450 cm ² ), the diffusivity was “◯”. (Good), when the diffusion was 60% or more and less than 80%, the diffusivity was determined as “△” (slightly good), and when the diffusion was less than 60%, the diffusivity was “x” (bad) ). In the determination of diffusion, the bat is divided into 25 equal parts (one area is 3.6 cm × 5 cm), and if there is at least one polyethylene pellet in the equally divided area, the area is diffused. It was done by judging.

[Example 1]
100 parts by mass of PVA (saponified product of vinyl acetate homopolymer) having a polymerization degree of 1,700 and a saponification degree of 88 mol%, 20 parts by mass of glycerin, 0.1 parts by mass of sodium polyoxyethylene lauryl ether sulfate, and Then, an aqueous solution containing 5 parts by mass of sodium dioctyl sulfosuccinate as a water surface spreading agent and having a PVA content of 10% by mass was prepared. This aqueous solution was dried and peeled off on a metal roll at 80 ° C. and then heat treated at 100 ° C. for 1 minute to produce a PVA film having a thickness of 40 μm.
Using the obtained PVA film, a drug packaging model test was carried out by the method described above. The obtained results are shown in Table 1.

[Example 2]
A PVA film having a thickness of 40 μm was produced in the same manner as in Example 1 except that the amount of sodium dioctylsulfosuccinate was changed to 1 part by mass.
Using the obtained PVA film, a drug packaging model test was carried out by the method described above. The obtained results are shown in Table 1.

[Example 3]
A PVA film having a thickness of 40 μm was produced in the same manner as in Example 1 except that the amount of sodium dioctylsulfosuccinate was changed to 10 parts by mass.
Using the obtained PVA film, a drug packaging model test was carried out by the method described above. The obtained results are shown in Table 1.

[Example 4]
A PVA film having a thickness of 40 μm was prepared in the same manner as in Example 1 except that 5 parts by mass of sodium di (2-ethylhexyl) sulfosuccinate was used as the water surface spreading agent in place of 5 parts by mass of sodium dioctyl sulfosuccinate. Manufactured.
Using the obtained PVA film, a drug packaging model test was carried out by the method described above. The obtained results are shown in Table 1.

[Example 5]
A PVA film having a thickness of 40 μm was produced in the same manner as in Example 3 except that the amount of glycerin used was changed to 35 parts by mass.
Using the obtained PVA film, a drug packaging model test was carried out by the method described above. The obtained results are shown in Table 1.

[Example 6]
Instead of 100 parts by mass of PVA (saponified vinyl acetate homopolymer) having a polymerization degree of 1,700 and a saponification degree of 88 mol%, a polymerization degree of 1,700, a saponification degree of 88 mol%, 2-acrylamido-2-methyl Example 1 except that 100 parts by mass of PVA (saponified copolymer of vinyl acetate and sodium 2-acrylamido-2-methylpropanesulfonate) having a sodium propanesulfonate unit content of 2 mol% was used. Similarly, a PVA film having a thickness of 40 μm was produced.
Using the obtained PVA film, a drug packaging model test was carried out by the method described above. The obtained results are shown in Table 1.

[Example 7]
A PVA film having a thickness of 40 μm was produced in the same manner as in Example 6 except that 10 parts by mass of glycerin and 10 parts by mass of diglycerin were used instead of 20 parts by mass of glycerin.
Using the obtained PVA film, a drug packaging model test was carried out by the method described above. The obtained results are shown in Table 1.

[Example 8]
A PVA film having a thickness of 40 μm was obtained in the same manner as in Example 6 except that 10 parts by mass of glycerin, 10 parts by mass of diglycerin and 5 parts by mass of polyethylene glycol having a number average molecular weight of 400 were used instead of 20 parts by mass of glycerin. Manufactured.
Using the obtained PVA film, a drug packaging model test was carried out by the method described above. The obtained results are shown in Table 1.

[Comparative Example 1]
A PVA film having a thickness of 40 μm was produced in the same manner as in Example 1 except that sodium dioctyl sulfosuccinate was not used.
Using the obtained PVA film, a drug packaging model test was carried out by the method described above. The obtained results are shown in Table 1.

[Comparative Example 2]
A PVA film having a thickness of 40 μm was produced in the same manner as in Example 1 except that 10 parts by mass of sodium allyl sulfonate was used instead of 5 parts by mass of sodium dioctyl sulfosuccinate.
Using the obtained PVA film, a drug packaging model test was carried out by the method described above. The obtained results are shown in Table 1.

[Comparative Example 3]
A PVA film having a thickness of 40 μm was produced in the same manner as in Example 1 except that the amount of glycerin used was changed to 5 parts by mass.
Using the obtained PVA film, a drug packaging model test was carried out by the method described above. The obtained results are shown in Table 1.

[Comparative Example 4]
A PVA film having a thickness of 40 μm was produced in the same manner as in Comparative Example 3 except that dioctyl sodium sulfosuccinate was not used.
Using the obtained PVA film, a drug packaging model test was carried out by the method described above. The obtained results are shown in Table 1.

As is clear from the above results, the PVA films of Examples 1 to 8 that satisfy the provisions of the present invention were excellent in water solubility and diffusibility.

Claims

A polyvinyl alcohol film containing polyvinyl alcohol, a water surface spreading agent and a plasticizer, wherein the plasticizer content is 10 to 40 parts by mass with respect to 100 parts by mass of polyvinyl alcohol.
The polyvinyl alcohol film according to claim 1, wherein the content of the water surface spreading agent is 0.1 to 15 parts by mass with respect to 100 parts by mass of polyvinyl alcohol.
The polyvinyl alcohol film according to claim 1 or 2, wherein the water surface spreading agent is a dialkylsulfosuccinate.
The polyvinyl alcohol film according to claim 3, wherein at least one of the alkyl groups in the dialkylsulfosuccinate is an alkyl group having 6 to 12 carbon atoms.
The polyvinyl alcohol film according to claim 3 or 4, wherein at least one of the alkyl groups in the dialkyl sulfosuccinate is a linear alkyl group.
The polyvinyl alcohol film according to any one of claims 1 to 5, which is a drug packaging film.
The polyvinyl alcohol film according to claim 6, wherein the drug is an agrochemical or a detergent.
A package formed by packaging the drug with the polyvinyl alcohol film according to claim 6 or 7.