KR102229234B1 - Polyvinyl alcohol film - Google Patents

Abstract

(Task) To provide a polyvinyl alcohol film that dissolves quickly after being put in water and has excellent diffusibility of the packaged drug, and a package using the same.
(Solving means) a polyvinyl alcohol film containing polyvinyl alcohol, a sleep-promoting agent and a plasticizer, and having a content of the plasticizer of 10 to 40 parts by mass per 100 parts by mass of polyvinyl alcohol; and packaging with the polyvinyl alcohol film Package. The content of the sleep-promoting agent is preferably 0.1 to 15 parts by mass per 100 parts by mass of polyvinyl alcohol, and the sleep-promoting agent is preferably a dialkyl sulfosuccinate, and the alkyl group in the dialkyl sulfosuccinate. At least one of them is preferably an alkyl group having 6 to 12 carbon atoms.

Description

Polyvinyl alcohol film {POLYVINYL ALCOHOL FILM}

The present invention relates to a polyvinyl alcohol film useful for unit packaging of drugs such as agricultural chemicals and detergents, and a package using the same.

There is a method in which various drugs, including pesticides and detergents, are sealed and packaged (unit packaging) in a water-soluble film in units of units, put in water in the form of packaging when used, and the contents are dissolved or dispersed in water. The advantages of this unit packaging are that it can be used without direct contact with dangerous drugs, that it is not necessary to weigh it during use because it is packaged in a certain amount, and that post-treatment such as packaging containers or bags is unnecessary or simple. .

For example, after the jumbo agent for a water faucet is added to a faucet, the water-soluble film that wraps it is dissolved, and the jumbo agent contained in the package floats on the water surface and diffuses throughout the faucet, thereby spreading the active pesticide component widely. At this time, if the water-soluble film does not dissolve quickly or the diffusion property of the pesticide active ingredient is insufficient, the pesticide active ingredient cannot be spread widely throughout the faucet.

As a water-soluble film used for unit packaging, a polyvinyl alcohol film (hereinafter, "polyvinyl alcohol" may be abbreviated as "PVA") is known, and specifically, for example, a specific sulfonic acid group-containing unit is used. A film (refer to Patent Document 1) using the modified PVA having, and a film containing PVA and a water-soluble sulfonate-containing compound (refer to Patent Document 2) are known.

Japanese Laid-Open Patent Publication No. Hei 7-118407 Japanese Patent Application Laid-Open No. Hei 9-40834

However, in the conventionally known water-soluble film, there is room for new improvement in terms of solubility and diffusibility of the packaged drug. Accordingly, an object of the present invention is to provide a PVA film which dissolves quickly after being put in water and has excellent diffusibility of a packaged drug, and a package using the same.

As a result of the inventors' thorough examination in order to achieve the above object, if the PVA film containing a certain amount of plasticizer further contains a sleep-promoting agent such as dialkyl sulfosuccinate, it will be quickly added to the water. While dissolving, it was found that a PVA film excellent in the diffusibility of the packaged drug was found, and further studies were repeated based on the knowledge to complete the present invention.

That is, the present invention,

[1] A PVA film containing PVA, a sleep enhancing agent, and a plasticizer, wherein the content of the plasticizer is 10 to 40 parts by mass per 100 parts by mass of PVA;

[2] The PVA film according to [1], wherein the content of the sleep enhancing agent is 0.1 to 15 parts by mass per 100 parts by mass of PVA;

[3] The PVA film according to [1] or [2], wherein the sleep-promoting agent is dialkyl sulfosuccinate;

[4] The PVA film according to [3], wherein at least one of the alkyl groups in the dialkyl sulfosuccinate is an alkyl group having 6 to 12 carbon atoms;

[5] The PVA film according to [3] or [4], wherein at least one of the alkyl groups in the dialkyl sulfosuccinate is a linear alkyl group;

[6] The PVA film according to any one of [1] to [5], which is a film for pharmaceutical packaging;

[7] The PVA film according to [6], wherein the drug is an agricultural chemical or detergent;

[8] A package formed by packaging the drug with the PVA film according to [6] or [7];

It is about.

Advantageous Effects of Invention According to the present invention, there is provided a PVA film which dissolves quickly after being put in water and has excellent diffusibility of the packaged drug, and a package using the same.

The PVA film of the present invention contains PVA, a sleep increasing agent, and a plasticizer. In addition, in the PVA film of the present invention, the content of the plasticizer is 10 to 40 parts by mass per 100 parts by mass of PVA. In the case of containing a plasticizer in the above content, by further containing a sleep-promoting agent, it dissolves quickly after being put in water, and a PVA film having excellent diffusibility of the packaged drug is obtained.

[PVA]

Examples of the PVA include one or two vinyl esters such as vinyl acetate, vinyl formate, vinyl propionate, vinyl butyrate, vinyl pivalate, vinyl basilate, vinyl laurate, vinyl stearate, vinyl benzoate, and isopropenyl acetate. What is obtained by saponifying a polyvinyl ester obtained by polymerizing more than one species can be used. Among the vinyl esters described above, vinyl acetate is preferred from the viewpoints of easiness in production, availability, cost, and the like of PVA.

The polyvinyl ester described above may be obtained using only one or two or more vinyl esters as a monomer, but as long as it is within the range not impairing the effect of the present invention, one or two or more vinyl esters and copolymerization with this It may be a copolymer with other possible monomers.

Other monomers copolymerizable with the above vinyl esters include, for example, α-olefins having 2 to 30 carbon atoms such as ethylene, propylene, 1-butene, and isobutene; (meth)acrylic acid or a salt thereof; methyl (meth)acrylate , Ethyl (meth)acrylate, n-propyl (meth)acrylate, i-propyl (meth)acrylate, n-butyl (meth)acrylate, i-butyl (meth)acrylate, t-butyl (meth)acrylate, (meth) (Meth)acrylic acid esters such as 2-ethylhexyl acrylate, dodecyl (meth)acrylate, and octadecyl (meth)acrylate; (meth)acrylamide, N-methyl (meth)acrylamide, and N-ethyl (meth)acrylamide , N,N-dimethyl (meth)acrylamide, diacetone (meth)acrylamide, (meth)acrylamide propanesulfonic acid or a salt thereof, (meth)acrylamidepropyldimethylamine or a salt thereof, N-methylol (meth) (Meth)acrylamide derivatives such as acrylamide or derivatives thereof; N-vinylamides such as N-vinylformamide, N-vinylacetamide, and N-vinylpyrrolidone; methyl vinyl ether, ethyl vinyl ether, n-propyl Vinyl ethers such as vinyl ether, i-propyl vinyl ether, n-butyl vinyl ether, i-butyl vinyl ether, t-butyl vinyl ether, dodecyl vinyl ether, stearyl vinyl ether; cyanide such as (meth)acrylonitrile Vinyl; vinyl halides such as vinyl chloride, vinylidene chloride, vinyl fluoride, and vinylidene fluoride; allyl compounds such as allyl acetate and allyl chloride; maleic acid or its salt, ester or acid anhydride; itaconic acid or its salt, ester or acid Anhydride; vinyl silyl compounds, such as vinyl trimethoxysilane; Unsaturated sulfonic acid, etc. are mentioned. The polyvinyl ester may have a structural unit derived from one or two or more of the other monomers described above.

The proportion of the structural units derived from the above-described other monomers occupied in the polyvinyl ester is preferably 25 mol% or less, more preferably 15 mol% or less, based on the number of moles of all structural units constituting the polyvinyl ester. And it is more preferable that it is 5 mol% or less.

The PVA described above may be modified with one or two or more graft-copolymerizable monomers as long as it is within a range that does not impair the effects of the present invention. Examples of the graft copolymerizable monomers include unsaturated carboxylic acids or derivatives thereof; unsaturated sulfonic acids or derivatives thereof; α-olefins having 2 to 30 carbon atoms. It is preferable that the ratio of the structural unit (structural unit in the graft-modified portion) derived from a graftable monomer in PVA is 5 mol% or less based on the number of moles of all structural units constituting PVA.

In the PVA described above, a part of the hydroxyl group may or may not be crosslinked. In addition, in the PVA described above, a part of the hydroxyl group may react with an aldehyde compound such as acetaldehyde or butylaldehyde to form an acetal structure, and it is not necessary to form an acetal structure without reacting with these compounds.

The degree of polymerization of the PVA is not particularly limited, but it is preferably 300 or more, more preferably 500 or more, even more preferably 800 or more, particularly preferably 1,000 or more, and more preferably 10,000 or less, more preferably 8,000 or less. It is preferable, it is more preferable that it is 5,000 or less, and it is especially preferable that it is 2,000 or less. When the degree of polymerization is 300 or more, the strength of the film is improved and the handleability is excellent. On the other hand, when the degree of polymerization is 10,000 or less, industrial production of the PVA becomes easy. In addition, the polymerization degree of PVA in this specification means the average degree of polymerization measured according to the description of JIS K 6726-1994.

The saponification degree of the PVA is not particularly limited, but it is preferably 80 mol% or more, more preferably 82 mol% or more, and 84 mol% from the viewpoints of strength, elasticity, and bagging properties of the obtained PVA film. It is more preferable that it is above, and it is preferable that it is 99.9 mol% or less, it is more preferable that it is 99 mol% or less, and it is still more preferable that it is 98 mol% or less. When the saponification degree of PVA is 80 mol% or more, sufficient elasticity can be imparted to the film, thereby improving dimensional stability. In addition, when the film is packaged with an alkaline substance or an acidic substance and stored, the decrease in water solubility of the film is further reduced. It can be effectively prevented. On the other hand, when the degree of saponification is 99.9 mol% or less, industrial and stable production of PVA becomes easy. In addition, the degree of saponification of PVA in the present specification refers to the vinyl alcohol unit with respect to the total number of moles of the structural unit (typically a vinyl ester unit) and the vinyl alcohol unit that PVA has and can be converted into a vinyl alcohol unit by saponification. It refers to the ratio (mol%) occupied by moles. The degree of saponification can be measured according to the description of JIS-K 6726-1994.

〔Sleep Enhancement System〕

The type of the sleep-promoting agent is not particularly limited, but dialkyl sulfosuccinate is preferred from the viewpoint of more remarkable effects of the present invention. The dialkyl sulfosuccinate is a compound having a structure corresponding to a structure in which two carboxyl groups in the sulfosuccinate are converted into an alkyl ester, respectively, and may be obtained by any production method as long as it has the structure. Although the alkyl groups in the two alkyl ester moieties of the dialkyl sulfosuccinate may be the same or different, they are preferably the same as each other in consideration of ease of production and the like. Further, the alkyl group in the dialkyl sulfosuccinate salt may be a linear alkyl group in either one or both, and either one or both may be a branched-chain alkyl group. Examples of the alkyl group include methyl group, ethyl group, propyl group, isopropyl group, pentyl group, hexyl group, heptyl group, octyl group, 2-ethylhexyl group, nonyl group, decanyl group, undecanyl group, dodeca Neil group, etc. are mentioned. It is preferable that at least one (preferably both) of the alkyl group in the dialkyl sulfosuccinate is an alkyl group having 6 to 12 carbon atoms, and 7 to carbon atoms from the fact that the packaged drug becomes a PVA film with improved diffusibility. It is more preferable that it is a 10 alkyl group. Further, for the same reason, it is preferable that at least one (preferably both) of the alkyl group in the dialkyl sulfosuccinate is a linear alkyl group.

Examples of the salt in the above dialkyl sulfosuccinate include inorganic salts, sodium salt, potassium salt, and ammonium salt are preferable, and sodium salt is more preferable.

The content of the sleep increasing agent in the PVA film is preferably 0.1 parts by mass or more with respect to 100 parts by mass of PVA from the viewpoint that the effects of the present invention are more remarkable, and high mechanical properties can be maintained and handling properties are improved. And, it is more preferably 1 part by mass or more, still more preferably 3 parts by mass or more, more preferably 15 parts by mass or less, more preferably 14 parts by mass or less, and still more preferably 12 parts by mass or less.

〔Plasticizer〕

Examples of the plasticizer include polyhydric alcohols, and specific examples thereof include ethylene glycol, glycerin, propylene glycol, diethylene glycol, diglycerin, triethylene glycol, tetraethylene glycol, trimethylolpropane, and polyethylene. Glycol and the like. The PVA film may contain one type or two or more types of these plasticizers. Among these, at least one selected from the group consisting of glycerin, diglycerin and polyethylene glycol is preferable. Although there is no restriction|limiting in particular in the number average molecular weight of polyethylene glycol, It is preferable to exist in the range of 100-1,000 from a viewpoint of compatibility with PVA, and also from the viewpoint of preventing a fall in water solubility of a film caused by bleed-out.

The content of the plasticizer in the PVA film is within the range of 10 to 40% by mass per 100 parts by mass of PVA in that it dissolves quickly after being put in water and becomes a PVA film having excellent diffusibility of the packaged drug. It is necessary, and the content is preferably 12 parts by mass or more, more preferably 14 parts by mass or more, and more preferably 38 parts by mass or less, and more preferably 36 parts by mass or less.

[Other ingredients]

For the purpose of controlling the mechanical strength, moisture resistance during handling, the rate of softening by absorption of water when dissolved, and the time required for diffusion in water, the PVA film contains starch and/or other than the PVA. You may further contain a water-soluble polymer.

As starch, for example, natural starches such as corn starch, potato starch, sweet potato starch, wheat starch, rice starch, tapioca starch, sago starch, etc. are processed by etherification, esterification, oxidation processing, etc. Starches and the like, and processed starches are particularly preferred.

The content of the starch in the PVA film is preferably 15 parts by mass or less, and more preferably 10 parts by mass or less with respect to 100 parts by mass of PVA. When the content is 15 parts by mass or less, the impact resistance of the PVA film is improved, and the process passability is improved.

Other water-soluble polymers other than PVA include, for example, dextrin, gelatin, glue, casein, shellac, gum arabic, polyacrylic acid amide, sodium polyacrylate, polyvinyl methyl ether, a copolymer of methyl vinyl ether and maleic anhydride, Copolymers of vinyl acetate and itaconic acid, polyvinylpyrrolidone, cellulose, acetyl cellulose, acetylbutyl cellulose, carboxymethyl cellulose, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, sodium alginate, and the like.

The content of the water-soluble polymer other than PVA in the PVA film is preferably 15 parts by mass or less, and more preferably 10 parts by mass or less with respect to 100 parts by mass of PVA. When the content is 15 parts by mass or less, the water solubility and dispersibility of the PVA film are improved.

In addition to the PVA film, fillers, processing stabilizers such as copper compounds, weather stability stabilizers, colorants, ultraviolet absorbers, light stabilizers, antioxidants, antistatic agents, flame retardants, other thermoplastic resins, lubricants, fragrances, defoaming agents, deodorants, extenders, release agents, Additives, such as a release agent, a reinforcing agent, a crosslinking agent, an anti-mold agent, a preservative, a crystallization rate retarding agent, and a surfactant to be described later, can be appropriately contained as necessary.

In the PVA film, the ratio of the total of PVA, the sleep increasing agent, and the plasticizer is preferably 80% by mass or more, more preferably 90% by mass or more, and 95% by mass, based on the mass of the PVA film. It is more preferable that it is above.

The thickness of the PVA film is not particularly limited, but from the viewpoint of both strength and water solubility, it is preferably 1 µm or more, more preferably 5 µm or more, even more preferably 10 µm or more, and more preferably 100 µm or less, and 75 It is more preferable that it is not more than µm, and even more preferably not more than 60 µm.

The shape of the PVA film is not particularly limited, and may include a shape such as a square (e.g., rectangle, square, etc.), circle, triangle, etc., and it can be appropriately set according to the usage form of the PVA film of the present invention. It is preferable that it is a long film from the point that it can manufacture and can easily store and transport in a rolled state. The length of the long PVA film is not particularly limited, but it is preferably 1 m or more, more preferably 100 m or more, and even more preferably 1,000 m or more from the viewpoint of productivity at the time of processing. The upper limit of the length is, for example, 10,000 m. On the other hand, the width of the long PVA film is also not particularly limited, but it is preferably 50 cm or more, more preferably 80 cm or more, and even more preferably 100 cm or more from the viewpoint of productivity at the time of processing. As the upper limit of the said width, 5 m is mentioned, for example. When using the said PVA film, it can cut into a desired size, and can be used.

The manufacturing method of the PVA film of the present invention is not particularly limited, and a manufacturing method in which the thickness and width of the PVA film after film formation are more uniform can be preferably employed, for example, the aforementioned PVA constituting the PVA film, water surface In addition, one or two or more of the above-described starch, other water-soluble polymers and additives are dissolved in a liquid medium, or PVA, a sleep-retaining agent, a plasticizer, and additionally as necessary. It can be produced using a film-forming stock solution containing one or two or more of starch, other water-soluble polymers, additives, and liquid media, and in which PVA is melted. When the said film forming stock solution contains at least 1 type of starch, another water-soluble polymer, and an additive, it is preferable that these components are uniformly mixed.

Examples of the liquid medium used in the preparation of the stock solution for film formation include water, dimethyl sulfoxide, dimethylformamide, dimethylacetamide, N-methylpyrrolidone, ethylene glycol, glycerin, propylene glycol, diethylene glycol, Triethylene glycol, tetraethylene glycol, trimethylolpropane, ethylenediamine, diethylenetriamine, and the like, and one or two or more of them can be used. Among them, water is preferred from the viewpoint of load on the environment and recoverability.

The volatile fraction of the film-forming stock solution (the content ratio in the film-forming stock solution of a volatile component such as a liquid medium that is removed by volatilization or evaporation at the time of film-forming) is also different depending on the film-forming method and film-forming conditions, but is generally 50 to It is preferably in the range of 95 mass%, more preferably in the range of 55 to 90 mass%, and even more preferably in the range of 60 to 85 mass%. When the volatile fraction of the film-forming stock solution is 50% by mass or more, the viscosity of the film-forming stock solution is not too high, so that filtration and defoaming at the time of preparing the film-forming stock solution are smoothly performed, and the production of a PVA film with few foreign matters and defects becomes easy. On the other hand, when the volatile fraction of the film-forming stock solution is 95% by mass or less, the concentration of the film-forming stock solution is not too low, and the production of an industrial PVA film becomes easy.

It is preferable that the film forming stock solution contains a surfactant. By containing a surfactant, the film-forming properties are improved, the occurrence of nonuniformity in the thickness of the PVA film is suppressed, and peeling of the PVA film from the metal roll or belt used for film-forming becomes easy. When a PVA film is produced from a film-forming stock solution containing a surfactant, a surfactant may be contained in the PVA film. Although the kind of surfactant is not particularly limited, anionic surfactants or nonionic surfactants are preferable from the viewpoint of peelability from metal rolls or belts.

Examples of anionic surfactants include carboxylic acid types such as potassium laurate; sulfuric acid ester types such as polyoxyethylene lauryl ether sulfate and octyl sulfate; and sulfonic acid types such as dodecylbenzenesulfonate. Do.

Examples of the nonionic surfactant include alkyl ether types such as polyoxyethylene oleyl ether; alkylphenyl ether types such as polyoxyethylene octylphenyl ether; alkyl ester types such as polyoxyethylene laurate; polyoxy Alkylamine types such as ethylene laurylamino ether; Alkylamide types such as polyoxyethylene lauric acid amide; Polypropylene glycol ether types such as polyoxyethylene polyoxypropylene ether; Diethanolamide laurate, diethanolamide oleic acid, etc. Alkanolamide type; Allyl phenyl ether types, such as polyoxyalkylene allyl phenyl ether, etc. are preferable.

These surfactants may be used alone or in combination of two or more.

When the film-forming stock solution contains a surfactant, the content thereof is preferably in the range of 0.01 to 5 parts by mass, more preferably in the range of 0.02 to 4 parts by mass, and more preferably in the range of 0.02 to 4 parts by mass, based on 100 parts by mass of PVA contained in the film-forming stock solution. It is particularly preferably in the range of 3 parts by mass. When the content is 0.01 parts by mass or more, film forming properties and peelability are further improved. On the other hand, when the content is 5 parts by mass or less, it is possible to suppress that the surfactant bleeds out to the surface of the PVA film, resulting in blocking and deterioration in handling properties.

As a film-forming method when forming a PVA film using the above-described film-forming stock solution, for example, a cast film-forming method, an extrusion film-forming method, a wet film-forming method, and a gel film-forming method may be mentioned. These film forming methods may be employed alone or in combination of two or more. Among these film forming methods, a cast film forming method and an extrusion film forming method are preferable from the viewpoint of obtaining a PVA film having a uniform thickness and width and good physical properties. Drying or heat treatment can be performed on the PVA film formed into a film as needed.

As an example of a specific manufacturing method of a PVA film, for example, using a T-type slit die, a hopper plate, an I-die, a lip coater die, etc., the film forming stock solution is rotated to be located on the uppermost side. Evaporate and dry volatile components from one side of the film, uniformly discharged or softened on the circumferential surface of the roll (or belt), and discharged or cast on the circumferential surface of this first roll (or belt), and then Industrially, a method of additionally drying on the circumferential surface of one or more rotating heated rolls arranged on the downstream side, or further drying by passing through a hot air drying device, and then winding up by a winding device is industrially used. It can be preferably employed. Drying by a heated roll and drying by a hot air drying device may be combined suitably and may be implemented.

For the purpose of improving the slip property of the surface of the PVA film, it is preferable that the surface is subjected to a mat treatment. Examples of the mat treatment method include an online mat treatment method in which the surface of a mat on a roll or belt is transferred to a film at the time of film formation, and a method of performing an emboss treatment after the film-formed film is once wound up on a roll. It is preferable that it is 0.5 micrometers or more, and, as for the arithmetic mean height (Ra) of the surface on which the mat treatment was performed, it is more preferable that it is 1 micrometers or more. The upper limit of the arithmetic mean height Ra is, for example, 10 µm from the viewpoint of pinhole resistance. If the arithmetic mean height (Ra) is less than 0.5 µm, it is difficult to obtain sufficient slip properties. Moreover, it is preferable that it is 1 micrometer or more in a maximum height (Rz), and it is more preferable that it is 3 micrometers or more. The upper limit of the maximum height Rz is, for example, 20 µm from the viewpoint of pinhole resistance. If the maximum height Rz is less than 0.5 µm, it is difficult to obtain sufficient slip properties. In addition, in this specification, the arithmetic mean height (Ra) and maximum height (Rz) are defined by JIS B 0601: 2001.

It is preferable to use the PVA film of the present invention as a film for drug packaging because it dissolves quickly after being put in water and has excellent diffusibility of the packaged drug. Examples of the drug to be packaged include pesticides, detergents (including bleach), and the like, and pesticides are preferable. Although there is no particular limitation on the specific kind of the pesticide, it is preferable that it is a jumbo agent in that the effect of this invention appears more remarkably, and it is especially preferable that it is a floating type jumbo agent which floats on the water surface after dispersion. The physical properties of the drug packaged with the PVA film of the present invention are not particularly limited, and may be acidic, neutral, or alkaline. Examples of the form of the drug include a powder, a bulk, a gel, a liquid, and the like, but a powder or a bulk is preferable from the viewpoint of excellent diffusion properties of the drug. There is no particular limitation on the form of packaging, but a form of unit packaging in which the drug is packaged in unit amount (preferably sealed packaging) is preferred. By using the PVA film of the present invention as a film for drug packaging to package drugs, the packaged body of the present invention is obtained.

Example

Hereinafter, the present invention will be described in more detail by examples, but the present invention is not limited at all by these examples. In addition, the evaluation method employed in the following Examples and Comparative Examples is shown below.

Model testing of pharmaceutical packaging

The PVA film produced in the following Examples or Comparative Examples was humidified at 20°C and 65%RH for 24 hours. Subsequently, 2.5 g of polyethylene pellets of 3 to 4 mmφ were sealed and packaged with a humidified PVA film. Specifically, three sides were heat-sealed to produce a bag so that the shape of the portion into which the polyethylene pellets were placed was a square of 30 mm×30 mm, and then the polyethylene pellets were put into the bag, and the other side was heat-sealed to package it. Next, water at 15°C was put in an 18 cm×25 cm bat to a depth of 2 cm, and the above-described bag packed with polyethylene pellets was floated on the water surface at the center of the bat. After the bag is floated on the water surface, the time until the PVA film dissolves and the polyethylene pellets in the bag begin to diffuse onto the water surface is the bagging time, and when the bagging time is 80 seconds or less, the solubility is judged as ``○'' (good). In the case of exceeding 80 seconds, the solubility was determined as "x" (defective). In addition, 180 seconds after the bag is floated on the water surface is photographed with a camera from the top, and when the polyethylene pellets are diffused by 80% or more with respect to the area of the bat (450 cm2), the diffusivity is "○" (good). It was determined, and the case where the diffusion was 60% or more and less than 80% was judged as "Δ" (slightly good), and the case where the diffusion was less than 60% was judged as "x" (defective). In addition, in the determination of diffusion, 25 equal divisions (one area is 3.6 cm × 5 cm) in the bat, and if even one polyethylene pellet is present in the divided area, the area was determined to have diffused.

[Example 1]

100 parts by mass of PVA (saponified product of vinyl acetate homopolymer) having a degree of polymerization of 1,700 and a saponification degree of 88 mol%, 20 parts by mass of glycerin, 0.1 parts by mass of sodium polyoxyethylene lauryl ether sulfate, An aqueous solution containing 5 parts by mass of sodium octylsulfosuccinate and having a PVA content of 10% by mass was prepared. This aqueous solution was dried on a metal roll at 80° C., peeled off, and then subjected to heat treatment at 100° C. for 1 minute to prepare a PVA film having a thickness of 40 μm.

Using the obtained PVA film, a model test of drug packaging was performed by the method described above. The obtained results are shown in Table 1.

[Example 2]

A PVA film having a thickness of 40 µm was prepared in the same manner as in Example 1, except that the amount of sodium dioctyl sulfosuccinate was changed to 1 part by mass.

Using the obtained PVA film, a model test of drug packaging was performed by the method described above. The obtained results are shown in Table 1.

[Example 3]

A PVA film having a thickness of 40 µm was prepared in the same manner as in Example 1, except that the amount of sodium dioctyl sulfosuccinate was changed to 10 parts by mass.

Using the obtained PVA film, a model test of drug packaging was performed by the method described above. The obtained results are shown in Table 1.

[Example 4]

A PVA film having a thickness of 40 µm was prepared in the same manner as in Example 1, except that 5 parts by mass of sodium di(2-ethylhexyl) sulfosuccinate were used instead of 5 parts by mass of sodium dioctyl sulfosuccinate as a sleep-promoting agent.

Using the obtained PVA film, a model test of drug packaging was performed by the method described above. The obtained results are shown in Table 1.

[Example 5]

A PVA film having a thickness of 40 µm was prepared in the same manner as in Example 3 except that the amount of glycerin used was changed to 35 parts by mass.

Using the obtained PVA film, a model test of drug packaging was performed by the method described above. The obtained results are shown in Table 1.

[Example 6]

In place of 100 parts by mass of PVA (saponified product of vinyl acetate homopolymer) having a degree of polymerization of 1,700 and a degree of saponification of 88 mol%, a degree of polymerization of 1,700, a degree of saponification of 88 mol%, and a content rate 2 of sodium 2-acrylamide-2-methylpropanesulfonate unit A PVA film having a thickness of 40 μm was prepared in the same manner as in Example 1 except that 100 parts by mass of PVA (saponified product of a copolymer of vinyl acetate and sodium 2-acrylamide-2-methylpropanesulfonate) was used. .

Using the obtained PVA film, a model test of drug packaging was performed by the method described above. The obtained results are shown in Table 1.

[Example 7]

A PVA film having a thickness of 40 µm was prepared in the same manner as in Example 6, except that it was changed to 20 parts by mass of glycerin and 10 parts by mass of glycerin and 10 parts by mass of diglycerin were used.

Using the obtained PVA film, a model test of drug packaging was performed by the method described above. The obtained results are shown in Table 1.

[Example 8]

It was changed to 20 parts by mass of glycerin, and 10 parts by mass of glycerin, 10 parts by mass of diglycerin, and 5 parts by mass of polyethylene glycol having a number average molecular weight of 400 were used in the same manner as in Example 6 to prepare a PVA film having a thickness of 40 µm.

Using the obtained PVA film, a model test of drug packaging was performed by the method described above. The obtained results are shown in Table 1.

[Comparative Example 1]

A PVA film having a thickness of 40 µm was prepared in the same manner as in Example 1 except that sodium dioctyl sulfosuccinate was not used.

Using the obtained PVA film, a model test of drug packaging was performed by the method described above. The obtained results are shown in Table 1.

[Comparative Example 2]

A PVA film having a thickness of 40 µm was prepared in the same manner as in Example 1, except that 10 parts by mass of sodium allylsulfonate was used instead of 5 parts by mass of sodium dioctylsulfosuccinate.

Using the obtained PVA film, a model test of drug packaging was performed by the method described above. The obtained results are shown in Table 1.

[Comparative Example 3]

A PVA film having a thickness of 40 µm was prepared in the same manner as in Example 1 except that the amount of glycerin was changed to 5 parts by mass.

Using the obtained PVA film, a model test of drug packaging was performed by the method described above. The obtained results are shown in Table 1.

[Comparative Example 4]

A PVA film having a thickness of 40 µm was prepared in the same manner as in Comparative Example 3 except that sodium dioctyl sulfosuccinate was not used.

Using the obtained PVA film, a model test of drug packaging was performed by the method described above. The obtained results are shown in Table 1.

As is clear from the above results, the PVA films of Examples 1 to 8 satisfying the provisions of the present invention were excellent in water solubility and diffusivity.

Claims (8)

It contains polyvinyl alcohol, a sleep-improving agent, a plasticizer, and a surfactant, and the content of the plasticizer is 10 to 40 parts by mass per 100 parts by mass of polyvinyl alcohol, and the content of the sleep-improving agent is 3 per 100 parts by mass of polyvinyl alcohol. A polyvinyl alcohol film having an excess of 15 parts by mass or less and wherein the sleep-promoting agent is dialkyl sulfosuccinate. The method of claim 1,
A polyvinyl alcohol film in which at least one of the alkyl groups in the dialkyl sulfosuccinate is an alkyl group having 6 to 12 carbon atoms. The method according to claim 1 or 2,
A polyvinyl alcohol film in which at least one of the alkyl groups in the dialkyl sulfosuccinate is a linear alkyl group. The method of claim 1,
Polyvinyl alcohol film, a film for pharmaceutical packaging. The method of claim 4,
Polyvinyl alcohol film where the drug is a pesticide or detergent. A package obtained by packaging a drug with the polyvinyl alcohol film according to claim 4 or 5. delete delete