WO2015115689A1 - Appareil d'imagerie à ondes ultrasonores, et procédé de visualisation de mise au point l'utilisant - Google Patents

Appareil d'imagerie à ondes ultrasonores, et procédé de visualisation de mise au point l'utilisant Download PDF

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WO2015115689A1
WO2015115689A1 PCT/KR2014/000879 KR2014000879W WO2015115689A1 WO 2015115689 A1 WO2015115689 A1 WO 2015115689A1 KR 2014000879 W KR2014000879 W KR 2014000879W WO 2015115689 A1 WO2015115689 A1 WO 2015115689A1
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signal
imaging
image
magnitude
focus
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PCT/KR2014/000879
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English (en)
Korean (ko)
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김대승
김명덕
강국진
손건호
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알피니언메디칼시스템 주식회사
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Priority to PCT/KR2014/000879 priority Critical patent/WO2015115689A1/fr
Publication of WO2015115689A1 publication Critical patent/WO2015115689A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A61B8/0833—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving detecting or locating foreign bodies or organic structures
    • A61B8/085—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving detecting or locating foreign bodies or organic structures for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
    • A61B8/5223—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for extracting a diagnostic or physiological parameter from medical diagnostic data
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
    • G01S7/52—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00
    • G01S7/52017—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00 particularly adapted to short-range imaging
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/5269—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving detection or reduction of artifacts

Definitions

  • the present invention relates to an ultrasound image processing technology, and more particularly, to a technology for improving the resolution of an ultrasound focus image.
  • HIFU High-Intensity Focused Ultrasound
  • biological tissues such as cancer, tumors, lesions, and the like.
  • Treatment using HIFU is a method of necrosis of the subject's tissue through the heat generated by transmitting the HIFU to one of the subject.
  • HIFU treatment can lessen the trauma of the patient and enable non-invasive treatment.
  • Application examples include Liver cancer, Bone sarcoma, Breast cancer, Pancreas cancer, Kidney cancer, Soft tissue tumors and Pelvic tumors ) And so on.
  • an HIFU signal is transmitted to a subject to be treated and a return signal is received to obtain an imaging image from the object.
  • the image quality of the focus position of the imaging image may be degraded by the interference of the scattering signal included in the reflected signal. In this case, it may be difficult to accurately identify the focal position point at which the therapeutic HIFU signal is transmitted.
  • an ultrasound imaging apparatus for visualizing a focus position point by increasing the image quality of an imaging image acquired when a HIFU signal is transmitted, and a focus visualization method using the same.
  • An ultrasound imaging apparatus may include a therapeutic transducer for transmitting high intensity ultrasound to an object having a predetermined output value less than a preset output value for preliminary targeting before transmitting the therapeutic high intensity ultrasound to the object,
  • the imaging transducer is synchronized and receives the high intensity ultrasonic reflected signal from the object, and the high intensity ultrasonic reflected signal is frequency analyzed to decompose the fundamental frequency signal and harmonic signals, and the magnitude of the fundamental frequency signal for each decomposed harmonic signal is measured.
  • an image processor configured to generate a preliminary targeting imaging image in which focus is visualized as the signal is reflected and processed.
  • the image processor may remove the interference of the scattering signal included in the high-intensity ultrasonic reflection signal at a point other than the focus position where the signal intensity is greater than the focus position point in the preliminary targeting imaging image, thereby removing the image resolution of the focus position point.
  • the image processing unit divides the magnitude of each decomposed harmonic signal by the magnitude of the fundamental frequency signal, generates a preliminary targeting imaging image from the combined signal and combines each harmonic signal whose signal magnitude is divided by the magnitude of the signal of the fundamental frequency. can do.
  • the image processing unit calculates the corresponding harmonics by multiplying the intensity of the scattered signal and the strength of the corresponding harmonic signal at each of the decomposed harmonic signals by the focal point and the non-focus point of the pretargeting imaging image.
  • the magnitude of the reflected signal can be calculated, and the magnitude of the reflected signal can be newly calculated by dividing the calculated magnitude of the reflected signal by the magnitude of the fundamental frequency signal at the corresponding point at each of the focal point and the non-focal point. .
  • the image processor may assign a weight to a predetermined signal among harmonic signals divided by the magnitude of the fundamental frequency signal.
  • the image processor according to an embodiment may remove noise by filtering the combined signal through a spatial filter.
  • the image processor may generate a focus image from a high intensity ultrasonic reflection signal received by an imaging transducer, and generate a preliminary targeting imaging image by mapping the generated focus image with an imaging image of a previously generated object. have.
  • the imaging transducer transmits imaging ultrasound waves to the object and receives an imaging ultrasound reflection signal returned from the object for generating an imaging image of the object before preliminary targeting, and performs imaging ultrasound transmission of the imaging transducer for preliminary targeting.
  • the high intensity ultrasonic reflection signal transmitted by the therapeutic transducer and returned from the object may be received.
  • the therapeutic transducer outputs a preset output to a focal position point of the object corresponding to the focal position information on the generated focal image when the image processor generates a focal image by signal processing the imaging ultrasonic reflection signal acquired by the imaging transducer. High intensity ultrasonic waves below the value can be transmitted.
  • a focus visualization method using an ultrasound imaging apparatus comprising: transmitting high-intensity ultrasound waves below a preset output value to a subject for preliminary targeting through a therapeutic transducer, and imaging imaging synchronized with the therapeutic transducer; Receiving a signal reflected from the object through the producer, and analyzing the received reflected signal into a frequency analysis and decomposition into a fundamental frequency signal and harmonic signals, and processing the signal by reflecting the magnitude of the fundamental frequency signal for each decomposition signal And generating a preliminary targeting imaging image in which the focus is visualized.
  • high-intensity ultrasound waves below a predetermined output value may be focused on an object, and preliminary targeting may be performed using the reflected signal.
  • the image quality is deteriorated due to the interference of the HIFU scattering signal, thereby making it difficult to identify the focus position point, thereby visualizing the focus position point.
  • FIG. 1 is a block diagram of an ultrasound imaging apparatus according to an embodiment of the present invention.
  • FIG. 2 is a reference diagram illustrating a preliminary targeting imaging image in which a signal processing process for focus visualization is not performed according to an embodiment of the present invention
  • FIG. 3 is a reference diagram illustrating an imaging image of an object and a focus image obtained by signal processing a fundamental frequency signal and a harmonic signal of a HIFU reflection signal according to an embodiment of the present invention
  • 4A and 4B are reference diagrams illustrating a signal processing process for focusing visualization on a fundamental frequency signal and a harmonic signal and a preliminary targeting imaging image generated through the signal processing process according to an embodiment of the present invention
  • FIG. 5 is a reference diagram comparing a preliminary targeting imaging image generated by a signal processing process for focus visualization of the present invention with an original image for a phantom;
  • FIG. 6 is a reference diagram comparing a preliminary targeting imaging image generated by a signal processing process for focus visualization of the present invention with an original image in a tissue of an object;
  • FIG. 7 is a flowchart illustrating a visualization method of a preliminary targeting imaging image of the ultrasound imaging apparatus, according to an exemplary embodiment.
  • FIG. 1 is a block diagram of an ultrasound imaging apparatus 1 according to an exemplary embodiment.
  • the ultrasound imaging apparatus 1 may include an imaging transducer 10, a therapeutic transducer 11, an analog-digital converter 12, an image processor 13, and a display unit 14. ), A user input unit 15 and a storage unit 16.
  • the therapeutic transducer 11 transmits High Intensity Focused Ultrasound (hereinafter referred to as HIFU) having a preset output value for treatment to the object.
  • HIFU High Intensity Focused Ultrasound
  • pre-targeting is performed to confirm that HIFU less than a preset output value is previously transmitted to the treatment site of the subject to confirm that HIFU is well delivered to the treatment site.
  • the output intensity of HIFU for preliminary targeting has a magnitude lower than the preset output value such that the intensity of the HIFU is high but does not damage the object.
  • the imaging transducer 10 receives the HIFU reflection signal returned from the object by the preliminary targeting HIFU signal transmitted through the therapeutic transducer 11.
  • the image processor 13 processes the HIFU reflection signal received by the imaging transducer 10 to generate a focus image.
  • the preliminary targeting imaging image is generated by mapping the generated focus image with an imaging image of a previously generated object.
  • the imaging transducer 10 may transmit imaging ultrasound waves to the object and receive an imaging ultrasound reflection signal from the object. Thereafter, the imaging transducer 10 has turned off the imaging ultrasound transmission of the imaging transducer 10 for preliminary targeting, and the HIFU reflection signal transmitted by the therapeutic transducer 11 and returned from the object. Will be received.
  • a point where the intensity is greater than the intensity of the signal strength of the HIFU focus point may occur in a region other than the focus position point.
  • the HIFU focal point is the point at which HIFU is transmitted through the therapeutic transducer 11. This phenomenon is caused by the harmonic signals of the scatter signal included in the HIFU reflection signal.
  • the preliminary targeting image image is severely deformed with respect to the intensity of the reflected signal intensity as shown in FIG. 2, and the distribution of the reflected signal is also uneven, resulting in deterioration of image quality. It becomes difficult to identify correctly.
  • the present invention proposes a technique of visualizing a focal position point by increasing the image resolution of the focal position point by removing interference of the HIFU scattering signal, which causes the signal intensity to be greater in a region other than the focal position point in the preliminary targeting imaging image. do.
  • the present invention decomposes the HIFU reflection signal received by the image processor 13 into a fundamental frequency signal and a harmonic signal. And, by processing the signal by reflecting the fundamental frequency signal to each of the decomposed harmonic signal, an imaging image in which the focal position point is visualized is generated.
  • the imaging transducer 10 includes an array of transducers for the image, and receives the HIFU reflection signal returned from the object by the preliminary targeting HIFU transmitted through the therapeutic transducer 11 at the time of preliminary targeting.
  • the imaging transducer 10 may transmit imaging ultrasound waves to the object and receive a reflection signal reflected from the object before preliminary targeting.
  • the imaging ultrasound refers to ultrasound that the imaging transducer 10 transmits to the object to acquire an image of the object.
  • the imaging transducer 10 converts an electrical analog signal into an ultrasonic wave and transmits the ultrasonic wave to an object, converts a reflected signal from the object into an electrical analog signal, and combines a plurality of transducer elements. It may be in the form.
  • the therapeutic transducer 11 includes a high intensity transducer array.
  • the therapeutic transducer 11 may have a circular shape and may be implemented in a form in which the imaging transducer 10 is formed at the center of the therapeutic transducer 11, but the therapeutic transducer 11 and the imaging transducer ( The structure of 10) is not limited to this.
  • the therapeutic transducer 11 transmits a HIFU corresponding to a preset output value to a subject for treatment.
  • HIFU of less than a preset output value may be transmitted for preliminary targeting.
  • the therapeutic transducer 11 transmits HIFU below a preset output value to a focal position point corresponding to the focal position information.
  • HIFU for preliminary targeting may be transmitted so as to have a duty ratio less than a preset ratio, such as about 5% or less, so as not to damage the subject.
  • the therapeutic transducer 11 may repeatedly transmit HIFU of less than a preset output value to a predetermined number of times to the object.
  • the focal position point of the object to which the therapeutic transducer 11 transmits HIFU of less than a preset output value may be automatically determined. Or it may be input by the user through the user input unit 15. When input by the user, the user first transmits imaging ultrasound to the object through the imaging transducer 10, and the focal position point corresponding to the focal position information of the object through the imaging image generated from the reflected signal returned from the object. Can be determined.
  • the imaging transducer 10 receives the HIFU reflection signal, and as a result, it is possible to detect a point where the pressing of the HIFU below the preset output value or the density of the tissue has changed.
  • HIFU with high amplitude sound pressure is irradiated to the focal point, the medium is momentarily pressed, causing a change in density and sound velocity and being reflected by the acoustic impedance difference.
  • a type of synchronization between the imaging transducer 10 and the therapeutic transducer 11 is required. This synchronization is set according to the distance information between the imaging transducer 10 and the focal position point, the distance information between the therapeutic transducer 11 and the focal position point, the imaging ultrasound and the moving speed information that the HIFU moves within the object's medium. Can be. Due to the synchronization, the therapeutic transducer 11 may transmit a HIFU below a preset output value to the focal position point.
  • the analog-to-digital converter (ADC) 12 converts the electrical analog signal converted by the transducer provided in the imaging transducer 10 or the therapeutic transducer 11 into an electrical digital signal.
  • ADC analog-to-digital converter
  • the analog-to-digital converter 12 is illustrated as being positioned between the imaging transducer 10 or the therapeutic transducer 11 and the beamformer 132, but is not necessarily limited thereto. It is applicable to being located between different modules in the ultrasonic imaging apparatus 1.
  • the image processor 13 processes the reflection signal corresponding to the imaging ultrasound signal transmitted from the imaging transducer 10 before preliminary targeting to generate an imaging image of the object.
  • the image processor 13 is transmitted through the therapeutic transducer 11 for preliminary targeting, and generates a focus image by processing the HIFU reflection signal received from the object through the imaging transducer 10.
  • the preliminary targeting imaging image is generated by combining the focus image of the generated HIFU reflection signal with the imaging image of the object generated before the preliminary targeting.
  • the image processor 13 may set a region of interest (ROI) on the imaging image by an operation or a command of the user input unit 15.
  • the image processor 13 receives the reflected signal from the imaging transducer rotated at a predetermined angle (0 ° to 360 °) or receives the reflected signal from the imaging transducer 10 configured as a 2D transducer array.
  • the image may be formed into a three-dimensional image based on the received reflection signal.
  • the image processor 13 includes a beamformer 132, a signal processor 134, and a scan converter 136. .
  • the beamformer 132 focuses the reflection signal received by each transducer provided in the imaging transducer 10 to generate frame data, which is raw data.
  • the beamformer 132 forms a receiving focusing signal based on the electrical digital signal converted by the analog-digital converter 12.
  • the beamformer 132 considers the time to reach each transducer of the imaging transducer 10 and the therapeutic transducer 11 from the object, adds an appropriate delay to each electric digital signal, and adds them to form the received focus signal. can do.
  • the beamformer 132 may be used for each transformer in the imaging transducer 10 and the therapeutic transducer 11 when the imaging transducer 10 transmits an imaging ultrasound or the therapeutic transducer 11 transmits HIFU.
  • the driving timing of the producer is adjusted to focus the ultrasound to a focus position point corresponding to the focus position information.
  • the signal processor 134 digitally processes the frame data signal generated by the beamformer 132 to generate an image. That is, the signal processor 134 may operate to form an imaging image of the object from the reflected signal received from the imaging transducer 10, and output the imaging image to the display unit 14. In addition, the signal processor 134 may operate to form a focus image from the HIFU reflection signal received from the imaging transducer 10, and output the focus image to the display unit 14. In addition, the mapped image may be output to the display unit 14 by mapping the imaging image and the focus image.
  • the signal processor 134 analyzes the obtained HIFU reflected signal to decompose it into a fundamental frequency signal and a harmonic signal. Each harmonic signal is divided into fundamental frequency signals, and then each harmonic signal divided by the fundamental frequency signal is combined. In this case, the signal processor 134 may allocate and combine a weight with a predetermined signal among the harmonic signals divided into the fundamental frequency signal. Signal processing examples of the signal processing unit 134 will be described later with reference to FIGS. 3, 4A, and 4B.
  • the signal processor 134 may remove noise by performing data smoothing by filtering a signal generated through the combination through a spatial filter.
  • the spatial filter is a filter that selects only a specific spatial frequency in the target spatial pattern.
  • the signal processor 134 may select the imaging ultrasound reflection signal by passing the signal generated through the coupling to a spatial filter having a frequency band of the imaging ultrasound reflection signal as a bandwidth, rather than the HIFU reflection signal.
  • Data smoothing is an operation that weakens or eliminates these fluctuations or discontinuities and smoothes them when there are minute fluctuations or discontinuities in the data due to noise. For example, processing in the frequency domain removes high frequency components by a low pass filter. can do.
  • the scan converter 136 converts an image into a data format used in the display unit 14 of a predetermined scan line display format.
  • the scan converter 136 converts the image into a data form displayed on the actual display unit 14.
  • the user input unit 15 receives an instruction by a user's manipulation or input.
  • the user command may be a control command for controlling the ultrasound imaging apparatus 1.
  • the user input unit 15 receives the focus position information on the imaging image of the object. That is, the user input unit 15 receives the focal position information of the two-dimensional coordinate values (x, z) when the imaging image of the object is a two-dimensional image, and the three-dimensional coordinate values (x, y, z) focus position information is received.
  • the user input unit 15 may set the ROI on the imaging image of the object by a user's manipulation or command.
  • the display unit 14 outputs an image received by the image processor 13 as a B-mode or C-mode image.
  • the storage unit 16 stores various data required for driving the ultrasound imaging apparatus 1. In addition, the storage unit 16 may store the received signal using the imaging transducer 10.
  • FIG. 2 is a reference diagram illustrating a preliminary targeting imaging image in which a signal processing process for focus visualization is not performed according to an embodiment of the present invention.
  • FIG. 3 is a reference diagram illustrating an imaging image of an object and a focus image obtained by signal processing a fundamental frequency signal and a harmonic signal of a HIFU reflection signal according to an embodiment of the present invention.
  • x denotes a HIFU focus position point in a focus image having each frequency signal.
  • reflected signal distributions for a fundamental frequency signal, a second harmonic signal, and a third harmonic signal are different from each other. That is, the HIFU focus position point and the position point corresponding to the reflected signal having the largest signal strength are different from each other. Therefore, the present invention aims to minimize the influence of the intensity of the scattering signals distributed in the medium of the object.
  • the magnitude of the harmonic signal is a signal whose frequency is proportional to the square of the magnitude of the fundamental frequency signal.
  • the second harmonic signal is a frequency signal whose magnitude is the square of the fundamental frequency signal.
  • 4A and 4B are reference diagrams illustrating a signal processing process for focusing visualization of a fundamental frequency signal and a harmonic signal and a preliminary targeting imaging image generated by the signal processing process according to an embodiment of the present invention.
  • the ultrasound imaging apparatus divides each harmonic signal into the fundamental frequency signal. For example, as shown in 4a, the amplitude of the second harmonic signal is divided by the fundamental frequency signal, and the third harmonic signal is divided by the fundamental frequency signal. Then, after combining each harmonic signal whose signal magnitude is divided by the fundamental frequency signal magnitude, a preliminary targeting imaging image is generated therefrom. For example, as shown in FIG. 4A, after combining the signal obtained by dividing the magnitude of the second harmonic signal by the fundamental frequency signal size and the signal obtained by dividing the third harmonic signal size by the fundamental frequency signal size, a preliminary targeting imaging image is generated and focused. Visualize
  • the ultrasound imaging apparatus assigns a weight to a predetermined signal among harmonic signals divided into a fundamental frequency signal, and combines the weights. For example, as shown in FIG. 4A, a weight is assigned to a signal obtained by dividing a third harmonic signal size by a fundamental frequency signal size.
  • FIG. 4B shows a focus image generated from a signal obtained by dividing a magnitude of a second harmonic signal by a fundamental frequency signal size, and a focus image generated from a signal assigned weights to a signal obtained by dividing a third harmonic signal size by a fundamental frequency signal size.
  • preliminary targeting imaging images combining these images, respectively. In the preliminary targeting imaging image, it may be confirmed that the HIFU focal position point coincides with the position point corresponding to the reflected signal having the largest signal intensity.
  • the point where the size of the preliminary targeting imaging image has the largest magnitude at the fundamental frequency is the HIFU focal point. Since the magnitude of the harmonic signal is proportional to the square of the magnitude of the fundamental frequency signal, the point where the magnitude of the harmonic signal is the largest in the space should also be the HIFU focal point. However, in the preliminary targeting imaging image actually generated, the magnitude of the scattering signal distributed in the space is stronger than the HIFU focusing point, not the HIFU focusing point.
  • the intensity of the scattering signal at the focus position is 1 and the intensity of the scattering signal at the points other than the focus position is 100.
  • the intensity of the fundamental frequency is 10 at the point of focus position and 1 at the point other than the focus position
  • the intensity of the reflected signal with respect to the fundamental frequency is the product of the intensity of the scattered signal at the corresponding point and the intensity of the fundamental frequency. , 10 (1 ⁇ 10) at the focal position, and 100 (100 ⁇ 1) outside the focal position.
  • the intensity of the second harmonic signal is proportional to the square of the intensity of the fundamental frequency signal, it is 100 (10 2 ) at the focus position and 1 (1 2 ) at the point other than the focus position, and the intensity of the scattering signal
  • the intensity of the reflected signal with respect to the second harmonic signal becomes 100 (100 ⁇ 1) at the focus position, and 100 (1 ⁇ 100) at the points other than the focus position. Therefore, when the preliminary targeting imaging image is displayed from the second harmonic signal, there is no difference in image resolution between the focal position point and the non-focus position.
  • the strength of the second harmonic signal at each point is divided by the strength of the fundamental frequency signal, the strength of the reflected signal with respect to the second harmonic signal is 10 (100/10) at the focus position. ) And 1 (100/100) at points other than the focusing position. Therefore, since the resolution of the focus position point in the preliminary targeting imaging image is higher than the resolution of the point other than the focus position, the resolution of the focus position point is improved.
  • the third harmonic signal is also divided by the strength of the fundamental frequency signal at each point, the third harmonic signal has the same effect as the second harmonic signal, and the same also applies to harmonic signals having higher orders.
  • FIG. 5 is a reference diagram comparing a preliminary targeting imaging image generated by a signal processing process for focus visualization of the present invention with an original image for a phantom.
  • the pre-targeting imaging image of the phantom having a weight of 1 and the interference of the HIFU scattering signal is removed by the signal processing process of the present invention corresponds to the HIFU focal point and the signal intensity having the largest signal intensity. You can see that the points match.
  • FIG. 6 is a reference diagram comparing a preliminary targeting imaging image generated by a signal processing process for focus visualization according to the present invention with a tissue image of a subject.
  • the pre-targeting imaging image of the tissue having a weight of 3 and the interference of the HIFU scattering signal is removed by the signal processing process of the present invention corresponds to the HIFU focal point and the reflected signal having the largest signal intensity. You can see that the points match.
  • FIG. 7 is a flowchart illustrating a visualization method of a preliminary targeting imaging image of the ultrasound imaging apparatus, according to an exemplary embodiment.
  • the ultrasound imaging apparatus transmits the high-intensity ultrasound wave below the preset output value to the object for preliminary targeting through the therapeutic transducer (700).
  • the ultrasound imaging apparatus Before transmitting the high intensity ultrasound to the object 700, the ultrasound imaging apparatus according to an embodiment generates an imaging image of the object by transmitting the imaging ultrasound to the object through an imaging transducer and obtaining a received signal reflected from the object. do.
  • a focal position point of the high intensity ultrasound to be transmitted by the therapeutic transducer may be determined from the imaging image of the object.
  • the ultrasound imaging apparatus receives the HIFU reflection signal returned from the object by the HIFU signal transmitted by the therapeutic transducer (710).
  • the ultrasonic imaging apparatus analyzes the received HIFU reflection signal into frequency and decomposes the fundamental frequency signal and harmonic signals, and processes the signal by reflecting the fundamental frequency signal on the decomposed harmonic signals and combines to generate a focus image.
  • the preliminary targeting imaging image is generated by combining with the imaging image of the object generated before the preliminary targeting.
  • a preliminary targeting imaging image is generated, and the ultrasound imaging apparatus according to an embodiment divides the magnitude of each decomposed harmonic signal by the magnitude of the fundamental frequency signal based on the obtained high-intensity ultrasound reflection signal.
  • the ultrasound imaging apparatus In the step of dividing the magnitude of each decomposed harmonic signal by the magnitude of the fundamental frequency signal, the ultrasound imaging apparatus according to an embodiment targets each of the decomposed harmonic signals and points other than the focal position and the focal position of the preliminary targeting imaging image.
  • the magnitude of the reflected signal having the corresponding harmonics is calculated by multiplying the intensity of the scattered signal by the strength of the corresponding harmonic signal.
  • the magnitude of the reflected signal is newly calculated by dividing the calculated magnitude of the reflected signal by the magnitude of the fundamental frequency signal at the corresponding point at the focal point and the point other than the focal point.
  • a preliminary targeting imaging image is generated from the combined signal.
  • a weight may be assigned to a predetermined signal among the harmonic signals divided by the fundamental frequency signal signal size.
  • the combined signal may be filtered through a spatial filter to remove noise.

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Abstract

L'invention concerne un appareil d'imagerie à ondes ultrasonores et un procédé de visualisation de mise au point l'utilisant. L'appareil d'imagerie à ondes ultrasonores selon un premier mode de réalisation de la présente invention comprend : un transducteur pour le traitement, qui transmet une onde ultrasonore à haute intensité pour le pré-ciblage, qui a une valeur inférieure à une valeur de sortie prédéterminée, d'un objet avant de transmettre une onde ultrasonore à haute intensité pour le traitement de l'objet ; un transducteur d'imagerie, qui est synchronisé avec le transducteur pour le traitement et reçoit un signal de réflexion d'onde ultrasonore à haute intensité revenant de l'objet ; et une unité de traitement d'image pour séparer le signal de réflexion d'onde ultrasonore à haute intensité en signaux de fréquence de base et signaux harmoniques par analyse de la fréquence du signal de réflexion d'onde ultrasonore à haute intensité, puis réalisation d'un traitement de signal sur chacun des signaux harmoniques séparés, en tenant compte de la dimension des signaux de fréquence de base, en générant ainsi une image d'imagerie de pré-ciblage ayant une mise au point visualisée.
PCT/KR2014/000879 2014-01-29 2014-01-29 Appareil d'imagerie à ondes ultrasonores, et procédé de visualisation de mise au point l'utilisant WO2015115689A1 (fr)

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PCT/KR2014/000879 WO2015115689A1 (fr) 2014-01-29 2014-01-29 Appareil d'imagerie à ondes ultrasonores, et procédé de visualisation de mise au point l'utilisant

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PCT/KR2014/000879 WO2015115689A1 (fr) 2014-01-29 2014-01-29 Appareil d'imagerie à ondes ultrasonores, et procédé de visualisation de mise au point l'utilisant

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080177180A1 (en) * 2004-08-17 2008-07-24 Technion Research & Development Ultrasonic Image-Guided Tissue-Damaging Procedure
KR20080095328A (ko) * 2007-04-24 2008-10-29 주식회사 메디슨 초음파 영상 시스템 및 방법
JP2010259806A (ja) * 2009-05-04 2010-11-18 Siemens Medical Solutions Usa Inc 医用超音波イメージングにおける高密度焦点式超音波に対するフィードバックを行う方法、システムおよびコンピュータ読み出し可能記録媒体
JP2011235139A (ja) * 2004-07-23 2011-11-24 Bjorn A J Angelsen 超音波イメージング
KR20130034987A (ko) * 2011-09-29 2013-04-08 서강대학교산학협력단 하이푸 초점 영상을 얻기 위한 초음파 영상 시스템 및 이를 이용한 초음파 영상 생성 방법

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011235139A (ja) * 2004-07-23 2011-11-24 Bjorn A J Angelsen 超音波イメージング
US20080177180A1 (en) * 2004-08-17 2008-07-24 Technion Research & Development Ultrasonic Image-Guided Tissue-Damaging Procedure
KR20080095328A (ko) * 2007-04-24 2008-10-29 주식회사 메디슨 초음파 영상 시스템 및 방법
JP2010259806A (ja) * 2009-05-04 2010-11-18 Siemens Medical Solutions Usa Inc 医用超音波イメージングにおける高密度焦点式超音波に対するフィードバックを行う方法、システムおよびコンピュータ読み出し可能記録媒体
KR20130034987A (ko) * 2011-09-29 2013-04-08 서강대학교산학협력단 하이푸 초점 영상을 얻기 위한 초음파 영상 시스템 및 이를 이용한 초음파 영상 생성 방법

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