WO2015058942A1 - Composition de désinfection liquide - Google Patents
Composition de désinfection liquide Download PDFInfo
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- WO2015058942A1 WO2015058942A1 PCT/EP2014/071123 EP2014071123W WO2015058942A1 WO 2015058942 A1 WO2015058942 A1 WO 2015058942A1 EP 2014071123 W EP2014071123 W EP 2014071123W WO 2015058942 A1 WO2015058942 A1 WO 2015058942A1
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
- A01N37/04—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof polybasic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
Definitions
- the invention relates to a liquid cleaning and disinfection composition.
- the invention more particularly relates to a composition for disinfection of skin or hard surfaces that provides synergistic antibacterial and antiviral efficacy.
- Liquid compositions for disinfecting and cleaning for personal care and for hard surfaces are known.
- Personal care includes cleansing and care of skin, hair and oral cavity.
- Hard surfaces include floors, walls, windows, doors, furniture, and table tops in various indoor and outdoor locations.
- Toilets and bathrooms are other places where germs proliferate and disinfection and cleaning compositions in liquid form are widely used.
- Other types of hard surfaces that are cleaned by such compositions include utensils and other articles found in households, offices and other public places.
- US6262038B discloses a germicidal composition suitable for cleaning fruits, vegetables, skin and hair, includes a mixture of fruit acids and a surfactant.
- the surfactant may be an anionic surfactant (such as sodium lauryl sulfate), a sophorose lipid biosurfactant, or a combination of the two surfactants.
- the mixture of fruit acids may include citric acid, glycolic acid, lactic acid, malic acid and tartaric acid.
- the fruit acids are preferably present, in an aqueous solution, in a sufficient amount to produce a pH of about 2 to 6, for example 3.8 to 4.2.
- US2006093570 discloses a surface treatment composition, preferably for personal use, comprising at least one surfactant and at least two different organic acids and/or salts or organic acids, and wherein the total concentration of the organic acids and/or salts in the composition is at least 0.5 percent (w/v).
- the invention further extends to a method of treating a surface, preferably hair or skin, to remove dirt and to remove or inhibit microbial growth.
- WO02/080668 A2 Korean Chemical Company LLC (Kimberly Clark Co) discloses that when one or more proton donating agents such as organic or inorganic acids are combined with an alkyl phosphate anionic surfactant comprised at least partially of a mono alkyl phosphate, numerous microorganisms are inactivated. In particular, it discloses antimicrobial action of a combination of acids, citric and malic, together with the mono alkyl phosphate. Also disclosed therein as a reference composition is a composition which has citric and malic, together with sodium lauryl sulphate and the combination has been shown to be effective against S. aureus and S. epidermidis and E.coli.
- the present invention relates to the synergistic interaction between two selective carboxylic acids in the presence of one or more specific anionic surfactant to provide enhanced antibacterial and antiviral action over the above published compositions which can be formulated for hard-surface cleaning or personal care in a liquid composition.
- the invention further relates to providing enhanced antibacterial and antiviral action which is effective over short time frames of less than about 5 minutes.
- the present invention provides for a liquid cleaning and disinfecting composition having a pH from 2 to 5 comprising
- Another aspect of the present invention provides for a method of disinfecting a surface comprising the steps of
- a personal cleaning composition as used herein, is meant to include a composition for cleaning and disinfecting topical areas e.g. skin and/or hair of mammals, especially humans.
- a composition is generally a rinse off composition, and includes any product applied to a human body for also improving appearance, cleansing, odor control or general aesthetics. It is more preferably a rinse off product.
- the composition of the present invention is in the form of a liquid but may be modified to include a lotion, cream, foam or gel, or toner, or applied with an implement or via a face mask, pad or patch.
- skin as used herein is meant to include skin on the face and body (e.g., neck, chest, back, arms, underarms, hands, legs, buttocks and scalp).
- composition of the invention is also of relevance to applications on any other keratinous substrates of the human body other than skin e.g. hair where products may be formulated with specific aim of providing disinfection and cleaning.
- a hard surface cleaning composition as used herein, is meant to include a composition for cleaning and disinfecting hard surfaces in the homes and other places like offices, restaurants, hotels, and public places like airports, bus stations, railways stations among other places.
- the hard surfaces in such places includes floors, walls, windows, doors, furniture, and table tops in the various indoor and outdoor locations abovementioned. Toilets and bathrooms are other places where such hard surface cleaning and disinfection composition are especially useful.
- Such a composition is generally a rinse off composition, and includes any product applied to such surfaces which may be applied and thereafter either rinsed off or wiped off in a few minutes if not in a few seconds. This is usually used for cleaning and disinfection but is also used for odour control.
- the composition of the present invention is in the form of a liquid but may be modified to include a lotion, cream, foam or gel.
- the present invention relates to a liquid cleaning and disinfecting composition having a pH from 2 to 5.
- the pH is preferably in the range of 2.5 to 3.5.
- the composition comprises 1 to 20% anionic surfactant sodium lauryl ether sulphate (SLES).
- SLES is preferably sodium lauryl ether sulphate(n)EO, (where n is from 1 to 3).
- Sodium laureth sulfate, or sodium lauryl ether sulfate (SLES) is an anionic surfactant . It is added to many personal care products like soaps, shampoos, and toothpaste.
- SLES is an inexpensive and very effective foaming agent. Its chemical formula is
- n CH 3 (CH2)ioCH2(OCH2CH2) n OS0 3 Na.
- the surfactant generally comprises a range of ethoxyl groups, where n denotes the mean.
- General structure of SLES is as follows:
- Sodium Laureth Sulfate (1 EO) with 70% purity has been used which was sourced from Galaxy Surfactants.
- SLES is present in 1 to 20% preferably 2 to 16%, further more preferably 2 to 14% by weight of the composition.
- ethoxylated sodium lauryl sulphate i.e., SLES, provides much enhanced antimicrobial action as compared to its
- composition of the invention comprises 0.05 to 10% of a mixture of two carboxylic acids, the first carboxylic acid is citric acid and the second carboxylic acid is selected from malonic acid, malic acid or glycolic acid.
- the first carboxylic acid is citric acid.
- Citric acid has the structure given below:
- Citric acid is a weak organic acid with the formula C 6 H 8 0 7 .
- Citric acid is a natural preservative. It is used to give a sour taste to foods and soft drinks.
- Citric acid is a commodity chemical and it is also used as a flavouring agent, and as a chelating agent.
- Citric acid is also widely used as a pH adjusting agent in creams and gels of all kinds.
- the second carboxylic acid is one of malonic acid, malic acid or glycolic acid or mixtures thereof. These acids have the structure given below: Malonic acid
- first carboxylic acid is citric acid and the second carboxylic acid is malonic acid.
- the first carboxylic acid citric acid is preferably present in 0.025% to 5% by weight of the composition.
- the second carboxylic acid is preferably present in 0.025% to 5% by weight of the composition.
- the mixture of carboxylic acid is present in 0.05 to 10%, preferably 0.1 to 5% by weight of the composition. It is preferred that the weight ratio of the first carboxylic acid and the second carboxylic acid is in the range of 1 :2 to 5:1.
- the composition comprises 40 to 98%, preferably 65 to 95% by weight water.
- the composition comprising SLES, the mixture of the two carboxylic acid and water is preferably used for personal care compositions for cleaning and disinfection of skin, hair and other topical surfaces of the human body.
- composition of the invention preferably additionally comprises 1 to 20% of another anionic surfactant linear alkyl benzene sulphonate (LAS).
- LAS linear alkyl benzene sulphonate
- Linear alkylbenzene sulfonic acid is the largest-volume synthetic surfactant available and used in various products because of its relatively low cost and good performance. The fact that it can be dried to a stable powder and its biodegradable nature makes it very attractive for use in large volume products.
- LAS is an anionic surfactant with molecules characterized by a hydrophobic and a hydrophilic group. LAS is generally a complex mixture of homologues of different alkyl chain lengths (C10 to C13 or C14). It contains an aromatic ring sulfonated at the para position and attached to a linear alkyl chain at any position with the exception of terminal one (1 -phenyl).
- the alkyl carbon chain typically has 10 to 14 carbon atoms and the linearity of the alkyl chains ranges from 87 to 98%. While commercial LAS consists of more than 20 individual components, the ratio of the various homologs and isomers, representing different alkyl chain lengths and aromatic ring positions along the linear alkyl chain, is relatively constant in currently produced products.
- LAS Various LAS are available according to the alkyl chain length, resulting in formulations for various applications.
- the starting material is ro prepare LAS is LAB (linear alkylbenzene).
- LAS is produced by the sulfonation of LAB with oleum in batch reactors.
- Other sulfonation alternative reagents are sulfuric acid, diluted sulfur trioxide, chlorosulfonic acid and sulfamic acid on falling film reactors.
- LAS are then neutralized to the desired salt.
- Surfactants are widely used in the industry needed to improve contact between polar and non-polar media such as between oil and water or between water and minerals.
- Linear alkylbenzene sulfonic acid is mainly used to produce household detergents including laundry powders, laundry liquids, dishwashing liquids and other household cleaners as well as in numerous industrial applications like as a coupling agent and as an emulsifier for agricultural herbicides and in emulsion polymerization.
- LAS is commercially available at 95 - 96% purity from Galaxy Surfactants which has been used in the present invention. LAS is preferably present in 5 to 15% by weight of the composition.
- the total amount of anionic surfactant in the composition is from 1 to 30% by total weight of the composition.
- the composition comprises SLES and LAS it is especially preferred that the composition is useful for hard surface cleaning and disinfection purposes. This is especially so since this combination is found to inhibit growth of bacteria and virus generally present in such surfaces.
- the composition comprises an amphoteric surfactant in addition to the anionic surfactant already present in the composition.
- the amphoteric surfactant is preferably a betaine.
- Cocamidopropyl betaine is an organic compound derived from coconut oil and dimethylaminopropylamine. It is a zwitterion, consisting of both a quaternary ammonium cation and a carboxylate. CAPB is available as viscous pale yellow solution that is used as a surfactant in personal care products. The name reflects that the major part of the molecule, the lauric acid group, is derived from coconut oil.
- Cocamidopropyl betaine is used as a foam booster in shampoos. It is a medium strength surfactant also used in bath products like hand soaps. It is also used in cosmetics as an emulsifying agent and thickener, and to reduce irritation generally caused by purely ionic surfactants. It also serves as an antistatic agent in hair conditioners, which most often does not irritate skin or mucous membranes. It also has antiseptic properties, making it suitable for personal sanitary products. It is compatible with other cationic, anionic, and nonionic surfactants.
- CAPB is obtained as an aqueous solution in concentrations of about 30%. Structure of CAPB is as follows:
- Preferred betaines include alkyl betaines, alkyl amidopropyl betaines, and alkyl sulphobetaines (sultaines), wherein the alkyl and acyl groups have from 8 to 19 carbon atoms.
- Typical amphoteric surfactants for use in compositions of the invention include cocodimethyl sulphopropyl betaine, lauryl betaine, and cocamidopropyl betaine.
- a particularly preferred amphoteric is cocoamidopropyl betaine (CAPB).
- An especially useful combination of surfactants for personal care compositions like body wash and shampoos are a mixture of SLES and CAPB. When present, the amphoteric surfactant is preferably present in 0.1 to 5 wt%.
- composition of the invention is formulated for hard surface cleaning compositions
- the following optional ingredients may be included for providing additional consumer preferred properties to the liquid composition.
- compositions may contain other ingredients which aid in their cleaning
- the composition may contain detergent builders such as nitrilotriacetates, polycarboxylates, water-soluble phosphates (especially ortho-, pyro-or poly-phosphates or mixtures thereof), zeolites and mixtures thereof in an amount up to 25%. If present, the builder preferably will form at least 0.1 % of the composition.
- Metal ion sequestrants such as ethylenediaminetetraacetates, polyphosphonates (DEQUESTTM-range) and the (ortho, pyro, poly) phosphoric acids/phosphates
- compositions according to the invention are usefully between 0.05 and 5% by weight of the composition, preferably 0. 1 -1 %.
- a further optional ingredient for compositions according to the invention is a suds regulating material, which can be employed in compositions which have a tendency to produce excessive suds in use.
- a suds regulating material is soap.
- Soaps are salts of fatty acids and include alkali metal soaps such as the sodium, potassium and ammonium salts of fatty acids containing from about 8 to about 24 carbon atoms, and preferably from about 10 to about 20 carbon atoms. Particularly useful are the sodium and potassium and mono-, di-and triethanolamine salts of the mixtures of fatty acids derived from coconut oil and ground nut oil. When employed, the amount of soap can form at least 0.005 wt%, preferably at least 0.1 % by weight of the composition.
- a further example of a suds regulating material is a silicone oil. Where a hydrocarbon co-solvent is present at a sufficiently high level this may itself provide some or all of the desired antifoaming activity.
- Compositions according to the invention can also contain, in addition to the ingredients already mentioned, various other optional ingredients such as colorants, whiteners, optical brighteners, soil suspending agents, detersive enzymes, gel- control agents, freeze-thaw stabilisers, preservatives (for example 1 , 2-benzisothiazolin-3-one), and hydrotropes.
- composition of the invention When the composition of the invention is formulated for personal care applications the following optional ingredients may be included.
- compositions may comprise a skin lightening agent.
- the skin lightening agent is preferably chosen from a vitamin B3 compound or its derivative e.g. niacin, nicotinic acid, niacinamide or any other well known skin lightening agent. Most preferred skin lightening agent is niacinamide. Niacinamide, when used, is preferably present in an amount in the range of 0.1 to 10%, more preferably 0.2 to 5 wt% of the composition.
- the personal care composition may preferably additionally comprise one or more UV sunscreens.
- the UV sunscreens may be inorganic or organic.
- organic sunscreen agents are suitable for use in combination with the essential ingredients of this invention. Most suitable organic sunscreen are 2-ethylhexyl-p- methoxycinnamate (as a UVB sunscreen agent) and/ or
- butylmethoxydibenzoylmethane (as a UVA sunscreen agent).
- a safe and effective amount of sunscreen may be used in the compositions of the present invention.
- the composition preferably comprises from about 0.1 % to about 10%, more preferably from about 0.1 % to about 5% w/w of a sunscreen agent.
- Useful inorganic sun-blocks are also preferably used in the present invention. These include, for example, zinc oxide iron oxide, silica, such as fumed silica, and titanium dioxide. Ultrafine titanium dioxide is preferably included. Ultrafine titanium dioxide are particles having an average particle size of less than 100 nm, preferably 70 nm or less, more preferably from 10 to 40 nm and most preferably from 15 to 25 nm. The total amount of sun block that is preferably incorporated in the composition according to the invention is from 0.1 to 5 wt% of the composition.
- composition according to the invention may also comprise other diluents.
- the diluents act as a dispersant or carrier for other materials present in the composition, so as to facilitate their distribution when the composition is applied to the skin.
- Diluents other than water can include liquid or solid emollients, solvents, humectants, thickeners and powders.
- compositions of the present invention may include a wide range of other optional components.
- compositions examples include: antioxidants, binders, biological additives, buffering agents, colorants, thickeners, polymers, astringents, fragrance, humectants, opacifying agents, conditioners, exfoliating agents, pH adjusters, preservatives, natural extracts, essential oils, skin sensates, skin soothing agents, and skin healing agents.
- a preferred embodiment of the composition has less than 1 % halogenated biocide e.g., chlorinated biocide. Further preferably it is less than 0.1 wt%.
- a method of disinfecting a surface comprising the steps of (i) applying a composition of the invention on to a surface; and (ii) rinsing the surface with a solvent or wiping the surface with a wipe.
- the solvent for rinsing the surface is preferably water but could also be a mixture of water and alcohol.
- the word rinsing herein includes the act of wiping the surface with a suitable wipe.
- the surface e.g hand, face, body, oral cavity or any hard surface e.g. a utensil is first contacted with the composition of the invention. It is then rinsed preferably with sufficient amounts of water after a pre-determined period of time to remove any visible or sensory reside of the composition.
- an alcohol wipe or a water/alcohol impregnated wipe may be used to wipe the surface to be visibly free of the anti-microbial composition.
- the step of rinsing the substrate is preferably carried out less than five minutes, preferably less than two minutes, further more preferably less than a minute and in many cases less than fifteen seconds after the step of applying the composition on the substrate.
- Yet another aspect of the present invention provides for use of the composition of the invention for enhanced antibacterial efficacy.
- Yet another aspect of the present invention provides for use of the composition of the invention for enhanced antiviral efficacy.
- compositions as shown in Table-1 were prepared. The compositions were tested for antibacterial efficacy using the standard European Suspension Test protocol EN:1276 which is briefly described below.
- BSA bovine serum albumin
- the number of bacteria in each sample was determined by plating on TSA agar. The plates were incubated at 37 ° C for 48 hours. The plates with colonies >15 and ⁇ 300 were counted. The cell numbers were converted to log counts. Reduction in viable count was calculated. The sample (at a particular concentration) was deemed to have passed the European Suspension test if there was a ⁇ 5 log reduction in the viable count demonstrated under the required test conditions.
- compositions in these set of experiments were tested for antibacterial efficacy against a Gram negative bacteria (P. aeruginosa ATCC 15442) by maintaining a contact time of five minutes of the composition with the bacteria under dirty (high soil) condition for the anti-bacterial efficacy.
- the log reduction of bacteria for each of the compositions from a starting value of 7.3 log bacteria is shown in Table 1.
- compositions control as well as preferred
- acid(s) and the surfactant content has been shown in the table.
- Each composition had 80 wt% water and the compositions had other minor ingredients adding up to 100wt%.
- the pH of each composition was in the range of 2.5 to 3.5.
- compositions as per the invention demonstrate high antibacterial efficacy and synergistic interaction over the individual components (Examples A to D).
- Example E to H and 4 to 6 Experiments conducted with the compositions of Table -1 but with Gram +ve bacteria.
- compositions as in Table 1 were tested under similar conditions and analysed for residual bacteria using the same protocol but with a Gram positive bacteria (S. aureus ATCC 6538). The data is presented in Table 2.
- Table 2 Table 2
- compositions as shown in Table 3 were prepared. The efficacy was evaluated using the test method ASTM 2783-1 1 . The compositions were tested for efficacy against Gram negative bacteria (£. coli ATCC 10536) where the compositions were tested at 50% (1 :1 dilution in water) for a contact time of 10 seconds with the bacteria. The residual bacterial count was measured and the data is summarized in Table 3.
- compositions as shown in Table 4 were prepared and the efficacy was tested using the standard European Suspension Test protocol EN:1276 against Gram -ve bacteria (P. aeruginosa ATCC 15442) under clean (low soil condition) when the compositions were diluted 1 :10 with water and the contact time was 1 minute.
- EN:1276 against Gram -ve bacteria P. aeruginosa ATCC 15442
- clean low soil condition
- compositions as shown in Table 5 were prepared and the efficacy tested using the standard European Suspension Test protocol EN:1276 against Gram negative bacteria (P. aeruginosa) under dirty (high soil) condition when the compositions were diluted 1 :20 with water and the contact time was five minutes.
- EN:1276 against Gram negative bacteria P. aeruginosa
- LAS in the table refers to sodium alkyl benzene sulphonate.
- the data on log reduction of the bacteria is shown in Table 5.
- compositions as per the present invention provides vastly improved antibacterial efficacy as compared to that disclosed in the past viz.
- Example P as in US2006093570 (Reckitt).
- Examples Q, R and 15 to 17 Various other compositions
- compositions as shown in Table 6 were prepared and the efficacy tested using the standard European Suspension Test protocol EN:1276 against Gram +ve bacteria (S. aureus ATCC 6538) under dirty (high soil) condition when the compositions were diluted 1 :30 with water and the contact time was one minute.
- EN:1276 against Gram +ve bacteria S. aureus ATCC 6538
- dirty (high soil) condition when the compositions were diluted 1 :30 with water and the contact time was one minute.
- the data on log reduction of the bacteria is shown in Table 6.
- fruit acid is a mixture of 4 parts citric acid, 15 parts glycolic acid, 30 parts lactic acid, 1 part malic acid and 1 part tartaric acid.
- Example 6 indicates that compositions as per the present invention (Examples 15 to 17) provides vastly improved antibacterial efficacy as compared to compositions outside the invention (Examples Q and R).
- Example Q indicates that combination of SLS with citric and malic acid [and also some more fruit acids] does not provide antimicrobial effect anywhere comparable to that obtained with combination of SLS with citric and malic acid or citric and malonic acid.
- compositions as shown in Table 7 were prepared and the efficacy tested using the standard European Suspension Test protocol EN:1276 against Gram +ve bacteria (S. aureus ATCC 6538) under dirty condition when the compositions were diluted 1 :60 with water and the contact time was five minute.
- EN:1276 against Gram +ve bacteria S. aureus ATCC 6538
- Table 7 The data on log reduction of the bacteria is shown in Table -7.
- composition as per the invention gives vastly superior antibacterial efficacy as compared to a combination of citric acid and lactic acid with surfactant SLES (Example T) which has been used in the past and is outside the scope of the present invention.
- Example U,V and Example 19 Experiments conducted with the compositions of Table 7 but with Gram -ve bacteria (P. aeruginosa ATCC 15442)
- compositions as in Table- 7 were tested under similar conditions and analysed for residual bacteria using the same protocol but with a Gram negative bacteria (P.
- Example 19 provides much enhanced antibacterial efficacy as compared to those outside the invention (Examples U and V).
- Example W and 20 Antiviral efficacy of the compostion as per the invention
- compositions as in Table 9 were prepared and tested for anti-viral efficacy (against Feline calcivirus used at 4.5 log) after a dilution of the composition of 1 :10 with water.
- the procedure for measuring the anti-viral efficacy is given below:
- bovine albumin fraction V was dissolved in 100 ml of water and sterilized by passing the solution through a 0.2 ⁇ filter).
- test mixture 100 ⁇ of interfering substance (hard water or clean water or dirty water) was pipette into a suitable container, followed by addition of 100 ⁇ of test virus suspension. To this, 800 ⁇ of product test solution was added. At the end of chosen contact time period, 100 ⁇ of the test mixture was added to resin column, centrifuged in a microspin column (735 xg, 2 minutes) and the elutant was diluted upto 10 "6 in ice cold virus growth medium. The infectivity of each dilution was measured by TCID50 using the Karber formula. The effect of clean conditions, on virus was also determined by infectivity.
- interfering substance hard water or clean water or dirty water
- Monolayers of cells were grown in 96-well tissue-culture plates (Costar) at 37 °C in an atmosphere of 95% air and 5% carbon dioxide (C0 2 ).
- Tenfold dilutions of virus suspension were prepared in virus growth medium.
- One hundred microlitres of each dilution was added to five replicate wells in 96-well tissue-culture plates.
- Cell controls were included on each plate. Plates were incubated at 37 °C in an atmosphere of 95% air/ 5% C0 2 . Cultures were observed daily for viral cytopathic effect for a period of seven days after which they were discarded.
- the virus titre was calculated by TCID50 (Tissue culture infective dose ) using the Karber formula.
- Negative logarithm of the 50 % end point Negative logarithm of the highest virus concentration used - [(Sum of % affected at each dilution / 100 - 0.5) x (log of dilutions)]
- the log reduction of the virus for the compositions is summarized in Table -9.
- Table 9 indicates that a composition as per the invention (Example 20) provides for vastly improved anti-viral efficacy as compared to a conventional clean composition.
Abstract
L'invention porte sur une composition liquide de nettoyage et désinfection. Plus particulièrement, l'invention concerne une composition pour la désinfection de la peau ou de surfaces dures, qui a une efficacité synergique antibactérienne et antivirale. A cet effet, un tensioactif anionique SLES ainsi que deux acides carboxyliques sont ajoutés, le premier étant l'acide citrique et le second étant choisi entre l'acide malonique, l'acide malique ou l'acide glycolique.
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EP3288520A4 (fr) * | 2015-05-01 | 2018-12-12 | L'oreal | Utilisation d'agents actifs pendant des traitements chimiques |
US10441518B2 (en) | 2015-11-24 | 2019-10-15 | L'oreal | Compositions for treating the hair |
WO2020165566A1 (fr) | 2019-02-11 | 2020-08-20 | Reckitt Benckiser Health Limited | Compositions désinfectantes à usage topique |
US11083675B2 (en) | 2015-11-24 | 2021-08-10 | L'oreal | Compositions for altering the color of hair |
US11090249B2 (en) | 2018-10-31 | 2021-08-17 | L'oreal | Hair treatment compositions, methods, and kits for treating hair |
US11135150B2 (en) | 2016-11-21 | 2021-10-05 | L'oreal | Compositions and methods for improving the quality of chemically treated hair |
US11213470B2 (en) | 2015-11-24 | 2022-01-04 | L'oreal | Compositions for treating the hair |
WO2022101235A1 (fr) * | 2020-11-13 | 2022-05-19 | Unilever Ip Holdings B.V. | Composition de nettoyage à activité antimicrobienne |
WO2022112764A1 (fr) | 2020-11-30 | 2022-06-02 | Reckitt Benckiser Health Limited | Compositions de soins personnels |
US11419809B2 (en) | 2019-06-27 | 2022-08-23 | L'oreal | Hair treatment compositions and methods for treating hair |
US11433011B2 (en) | 2017-05-24 | 2022-09-06 | L'oreal | Methods for treating chemically relaxed hair |
US11596588B2 (en) | 2017-12-29 | 2023-03-07 | L'oreal | Compositions for altering the color of hair |
WO2023070503A1 (fr) * | 2021-10-29 | 2023-05-04 | The Procter & Gamble Company | Méthode non thérapeutique d'assistance au maintien de la capacité naturelle de défense de la peau humaine contre les bactéries |
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JP7421903B2 (ja) | 2019-10-25 | 2024-01-25 | 花王株式会社 | ウイルス不活性化剤組成物 |
JP7421902B2 (ja) | 2019-10-25 | 2024-01-25 | 花王株式会社 | ウイルス不活性化剤組成物 |
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WO2020165566A1 (fr) | 2019-02-11 | 2020-08-20 | Reckitt Benckiser Health Limited | Compositions désinfectantes à usage topique |
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WO2022101235A1 (fr) * | 2020-11-13 | 2022-05-19 | Unilever Ip Holdings B.V. | Composition de nettoyage à activité antimicrobienne |
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