WO2015057016A3 - 양이온성 아미노산과 소수성 아미노산을 포함하는 펩타이드 분자 및 이의 용도 - Google Patents

양이온성 아미노산과 소수성 아미노산을 포함하는 펩타이드 분자 및 이의 용도 Download PDF

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Publication number
WO2015057016A3
WO2015057016A3 PCT/KR2014/009793 KR2014009793W WO2015057016A3 WO 2015057016 A3 WO2015057016 A3 WO 2015057016A3 KR 2014009793 W KR2014009793 W KR 2014009793W WO 2015057016 A3 WO2015057016 A3 WO 2015057016A3
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WO
WIPO (PCT)
Prior art keywords
amino acid
peptide molecule
anionic
hydrophobic amino
hydrophobic
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Application number
PCT/KR2014/009793
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English (en)
French (fr)
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WO2015057016A2 (ko
Inventor
채수영
최은정
이정민
김민우
김수진
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삼성전자 주식회사
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Publication of WO2015057016A2 publication Critical patent/WO2015057016A2/ko
Publication of WO2015057016A3 publication Critical patent/WO2015057016A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/85—Fusion polypeptide containing an RNA binding domain
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

양이온성 아미노산과 소수성 아미노산을 포함하는 펩타이드 분자, 상기 펩타이드 분자를 포함하는 핵산 전달용 조성물, 및 상기 펩타이드 분자와 핵산을 포함하는 핵산-펩타이드 분자 복합체가 제공된다.
PCT/KR2014/009793 2013-10-18 2014-10-17 양이온성 아미노산과 소수성 아미노산을 포함하는 펩타이드 분자 및 이의 용도 WO2015057016A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2013-0124811 2013-10-18
KR20130124811A KR20150045559A (ko) 2013-10-18 2013-10-18 양이온성 아미노산과 소수성 아미노산을 포함하는 펩타이드 분자 및 이의 용도

Publications (2)

Publication Number Publication Date
WO2015057016A2 WO2015057016A2 (ko) 2015-04-23
WO2015057016A3 true WO2015057016A3 (ko) 2015-06-18

Family

ID=52828821

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2014/009793 WO2015057016A2 (ko) 2013-10-18 2014-10-17 양이온성 아미노산과 소수성 아미노산을 포함하는 펩타이드 분자 및 이의 용도

Country Status (2)

Country Link
KR (1) KR20150045559A (ko)
WO (1) WO2015057016A2 (ko)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030065053A (ko) * 2002-01-29 2003-08-06 주식회사 웰진 Ｄｎａ의 세포 또는 조직 내 전달 효율을 높이는 펩타이드
JP2008520209A (ja) * 2004-11-17 2008-06-19 ユニヴァーシティ・オブ・メリーランド，バルチモア ｓｉＲＮＡの有効なキャリアとしての高度に枝分かれしたＨＫペプチド
KR20080109751A (ko) * 2008-09-05 2008-12-17 학교법인 포항공과대학교 신규한 세포 내 물질 전달용 펩타이드
KR20110002794A (ko) * 2009-07-02 2011-01-10 한양대학교 산학협력단 아르기닌―기제 양친성 펩티드 마이셀
US20130115700A1 (en) * 2010-07-10 2013-05-09 Kitakyushu Foundation For The Advancement Of Industry Science And Technology Method for transfecting nucleic acid to cell and nucleic acid complex

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030065053A (ko) * 2002-01-29 2003-08-06 주식회사 웰진 Ｄｎａ의 세포 또는 조직 내 전달 효율을 높이는 펩타이드
JP2008520209A (ja) * 2004-11-17 2008-06-19 ユニヴァーシティ・オブ・メリーランド，バルチモア ｓｉＲＮＡの有効なキャリアとしての高度に枝分かれしたＨＫペプチド
KR20080109751A (ko) * 2008-09-05 2008-12-17 학교법인 포항공과대학교 신규한 세포 내 물질 전달용 펩타이드
KR20110002794A (ko) * 2009-07-02 2011-01-10 한양대학교 산학협력단 아르기닌―기제 양친성 펩티드 마이셀
US20130115700A1 (en) * 2010-07-10 2013-05-09 Kitakyushu Foundation For The Advancement Of Industry Science And Technology Method for transfecting nucleic acid to cell and nucleic acid complex

Also Published As

Publication number Publication date
KR20150045559A (ko) 2015-04-29
WO2015057016A2 (ko) 2015-04-23

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