WO2015048869A1 - Composição para higiene íntima prolongada e para redução de odores, processo de produção e uso - Google Patents
Composição para higiene íntima prolongada e para redução de odores, processo de produção e uso Download PDFInfo
- Publication number
- WO2015048869A1 WO2015048869A1 PCT/BR2014/000311 BR2014000311W WO2015048869A1 WO 2015048869 A1 WO2015048869 A1 WO 2015048869A1 BR 2014000311 W BR2014000311 W BR 2014000311W WO 2015048869 A1 WO2015048869 A1 WO 2015048869A1
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- WIPO (PCT)
- Prior art keywords
- composition
- fragrance
- component
- regulator
- growth
- Prior art date
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- 0 CC(*)C1*2(*C=*(C)COCC(C*C(C)C(C(C)O)[N+]([O-])=O)COC)[C@@]1*C2 Chemical compound CC(*)C1*2(*C=*(C)COCC(C*C(C)C(C(C)O)[N+]([O-])=O)COC)[C@@]1*C2 0.000 description 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/986—Milk; Derivatives thereof, e.g. butter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
Definitions
- the present invention relates to the field of personal care compositions. More particularly, the invention discloses a composition for promoting prolonged intimate personal hygiene which provides for the reduction of the concentration of bad odor forming substances. Its process of obtaining and using it is also described.
- Genital hygiene is of particular importance, either because it is an anatomical region that is difficult to access, lack of knowledge about it, or even because it accumulates different secretions and substances.
- Studies on the behavior of the vaginal ecosystem have brought new insights into the beautiful and perfect interaction between the millions of bacteria that colonize the light of this cavity.
- the vaginal ecosystem is known to be unstable and subject to many variations that depend on diet, sexual activity, hormone production, medication use and also on genital hygiene. Despite this, unfortunately the knowledge is not the same for the vulvar region. It is reasonable to suppose, however, that hygiene in this region plays a much stronger role.
- Female is a great ally in helping to protect women.
- the cleaning of the female intimate region is best done with liquid soap, as most bar soaps have neutral or alkaline pH, and can be shared by others in the same house.
- the products should have mild detergency (high detergency rate may dry the vulvar skin), be hypoallergenic and with physiological pH (slightly acidic and not neutral or alkaline).
- the female external genitalia is formed by numerous skin folds and is located in a region that makes aeration very difficult. Both features
- the skin of the intimate region as well as the rest of the body due to the arrangement of its cells (keratinocytes) and the production of substances (ceramides, fatty acids, triglycerides, free steroids, cholesterol, fat esters, squalene) form a "Skin barrier" that prevents water loss
- This barrier is as much a physical barrier as it is antimicrobial with immunological function, establishes a sensory interface and promotes the maintenance of physiological pH (Cutaneous Acid Cloak).
- the cutaneous acid mantle is one of the main responsible for the balance of the microbiological ecosystem and the perfect functioning of the skin cells. Like other parts of our body, maintaining pH in restricted ranges is critical for biochemical reactions to proceed smoothly. The disruption of the skin barrier and acid mantle may favor tissue damage and compromise the balance of the vulvar ecosystem triggering allergic and infectious processes. There are several factors that can compromise genital and skin homeostasis by activating the production of pro-inflammatory cytokines, cell adhesion molecules, DNA synthesis, among others. Factors such as family history of dry skin, conditions such as eczema and psoriasis, use of dry skin medications, aging, sun exposure, wind and low humidity, inadequate soap and cleanser promote skin dryness and ease skin lesions.
- Genital hygiene is necessary to prevent accumulation of secretions, dead cells and debris. It is natural to assume that poor hygiene can cause foul smell, itching, secretion buildup, and vulvar and vaginal infection.
- the female genital region besides being more sensitive, is subject to more intense bacterial colonization, occlusions and compressions due to dress habits and greater friction by the anatomical location, that is, it is more susceptible to maladjustments of its ecosystem. Prolonged use of occlusive pads and clothing that promotes lack of aeration and excessive compression should be avoided. In the vulvar region, because of the many folds of skin, aggressions tend to be more frequent.
- EP 2236127 (Rottapharm S.p.A.) describes an intimate hygiene composition comprising one or more active substances in conjunction with xanthan gum, where it is an agent capable of favoring bioadhesion of the active substances to the skin and mucous membranes.
- active substances include, without limitation, lactic acid, which contributes to maintaining the physiological pH of the slightly acidic vulva surface, preventing the development of pathogens, and also pasteurized and atomized whey, which together with lactic acid have buffering action and ensures continued acidity of the vulva surface.
- the present invention differs from said document, among other reasons in that it is directed to other problems rather than adherence of the formulation by the use of xanthan gum.
- xanthan gum is not used in the present invention, being a polysaccharide very distinct from oligosaccharides.
- Polysaccharides are made up of a large amount of monosaccharides, while oligosaccharides are made up of only 2 to 10 monosaccharides.
- the lasting effect of odor reduction over longer periods is provided by the combination of a fragrance with a base composition containing a pH regulator for the mucosal region; a moisturizer; and a component that stimulates the growth of saprophytic flora, a combination that reduces the concentration of substances with unpleasant odors.
- US 6,706,941 discloses an absorbent article and not a liquid hygiene composition.
- microorganisms of a saprophytic flora of the skin or non-pathogenic microorganisms to the skin may proliferate, thereby suppressing the growth of possibly pathogenic microorganisms around the applied area and reducing odor and dermatitis.
- Said document relates to the incorporation into an absorbent article of a compound containing an ⁇ -1-2 backbone such as glycooligosaccharide which may act as a substrate for enzymes present only in certain bacteria.
- Said document differs from the knowledge disclosed by the present invention, among other reasons, in that it does not provide a liquid intimate hygiene composition which contemplates the association of a fragrance with a base composition containing a pH regulator for the mucous region; a moisturizer; and a component that stimulates the growth of saprophytic flora, a combination that reduces the concentration of substances with unpleasant odors.
- WO 2010/004005 describes pharmaceutical and dermatological compositions which comprise a probiotic chosen from oligosaccharides, such as glycooligosaccharides (GOS), fructooligosaccharides (FOS), galactooligosaccharides, and an extract. of plant containing isoflavones selected from soybean extracts (Glycine max) and clover extracts (Trifolium sp.) for use in the treatment of bacterial vaginosis and / or for the treatment of the vaginal mucosa.
- oligosaccharides such as glycooligosaccharides (GOS), fructooligosaccharides (FOS), galactooligosaccharides
- an extract of plant containing isoflavones selected from soybean extracts (Glycine max) and clover extracts (Trifolium sp.) for use in the treatment of bacterial vaginosis and / or for the treatment of the vaginal mucosa.
- the present invention differs from said document, among other reasons, in that it presents in its composition the association of oligosaccharides not with plant extracts (which may present problems of stability and / or compositional variability due to seasonality), but with lactic acid and whey, which act as a moisturizer and tissue recovery ingredient, thus providing some of the desirable effects mentioned above.
- Said document neither discloses or even suggests a liquid intimate hygiene composition which contemplates the association of a fragrance with a base composition containing a pH regulator for the mucous region; a moisturizer; and a component that stimulates growth of saprophytic flora, a combination which reduces the concentration of unpleasantly smelling substances such as the present invention.
- vaginal odor control compositions With regard to vaginal odor control compositions, current known solutions (EP 1886698, EP 1842564, WO 2008/104960, US 2010/324512) are always directed to the use of absorbent articles which are present in the region, and not in liquid compositions of care and cleaning, as is the case of the present invention.
- the systems described in said documents comprise 2 classes of compounds, one having low volatility capable of masking bad odor and a second having high volatility affecting nasal receptors.
- the present invention differs from these documents in that it provides a liquid intimate hygiene composition which contemplates the association of a fragrance with a base composition containing a pH regulator for the mucous region; a moisturizer; and a component that stimulates the growth of saprophytic flora, a combination that provides the surprising effect of reducing the concentration of unpleasant-smelling substances rather than just masking them.
- composition referred to herein as a "base composition”
- base composition comprises: a pH regulator for the mucosal region; a moisturizer; and a component that stimulates the growth of saprophytic flora.
- the present invention differs from said document in that it provides a composition comprising associating a frankness with said "base composition”.
- the present invention provides a novel approach to the development of products in the form of stable intimate liquid composition.
- the composition of the invention further provides (iv) the reduction of the concentration of substances with unpleasant odors.
- the present invention provides an extended intimate hygiene composition comprising the combination of:
- a base composition comprising: pH regulator for the mucosal region; moisturizing component; and a selective component for saprophytic flora growth.
- This combination provides, with prolonged action, the concentration of substances with unpleasant odors, besides maintaining a balanced pH in the region of the mucosa where it is applied, regulating the skin acidity; prevents / minimizes proliferation of undesirable microbial / bacterial flora; and provides hydration.
- the composition comprises: from 0.2% to 0.7% by weight of fragrance; and a base composition comprising: from 0.1% to 10% by weight of selective component for saprophytic flora growth, from 0.1% to 20%; by weight of moisturizing component; from 0.1% to 20% by weight of pH regulator.
- the growth stimulating component of saprophyte flora is alpha-glucan oligosaccharide.
- the process of the invention comprises the steps of mixing (i) a base comprising: pH regulator for the mucosal region; moisturizing component; and a selective component for the growth of saprophytic flora; and (ii) fragrance, to one or more cosmetically acceptable vehicles until the pH is in the range of 4.2 to 4.8.
- Figure 1 shows a butyric acid SPME chromatogram obtained from (A) the composition of the invention which provides for the reduction of the concentration of unpleasant-smelling substances; and (B) a composition that does not provide for reducing the concentration of unpleasant smelling substances (i.e., which does not use the base composition / fragrance combination of the present invention).
- the present invention provides a prolonged intimate hygiene liquid composition which provides for the reduction of the concentration of unpleasant smelling substances, said composition comprising the combination of:
- a base composition comprising: pH regulator for the mucosal region; moisturizing component; and a selective component for saprophytic flora growth.
- This combination provides a prolonged action, reduces the concentration of substances with unpleasant odors and maintains a balanced pH in the region of the mucosa where it is applied, regulating the skin acidity; avoiding / minimizing proliferation of undesirable microbial / bacterial flora. It also provides tissue hydration, aiding in their recovery.
- Body cleansing habits are essential to ensure the health of the whole body against external stimuli such as the proliferation of unwanted and disease causing microorganisms.
- the set of body cleansing habits characterizes an individual's personal hygiene.
- Personal hygiene is fundamental in the face of inability to perceive the onslaught of pathogens, which gives hygiene a fundamental role for body well-being.
- intimate hygiene is defined as the use of products that do not harm an individual's external genital regions.
- composition of the present invention provides for the elimination or reduction of the concentration of unpleasant odor generating substances, in addition to inhibiting the growth of non-saprophytic flora, stimulating beneficial flora and preventing opportunistic colonization, thus being a cosmetic as well as a personal hygiene composition. functional.
- Fragrance is commonly considered an accessory component in cosmetic formulations, as it does not impact the effect produced by the composition.
- the combination of the fragrance with the base composition provides the effect of reducing the presence of unpleasant odor generating substance. Such effect however does not occur with any fragrance.
- a specific combination of base composition and fragrance must be used, resulting in a composition that meets the criteria in Table 1:
- the quantification of odor reduction can be performed by an experiment that monitors the concentration of a bad odor causing molecule.
- An example of a suitable molecule is butyric acid.
- One trial was designed and conducted to compare two compositions, where the difference between them is the ability to reduce concentration and odor generating substances and the other without this ability.
- the efficiency of The composition of the present invention is proven when the calculated area for the peak of the odor-causing molecule is smaller than the area calculated when using another composition that does not use the combination of the invention.
- the composition of the invention when analyzed by chromatography, should generate a chromatogram that meets the following criteria:
- the composition comprises from 0.2% to 0.7% by weight of fragrance. '
- the selective component for growth of saprophyte flora is an oligosaccharide.
- Oligosaccharides useful for the purposes of the present invention include, but are not limited to, saccharides of up to 10 monomers, obtained from natural and / or synthetic sugars such as by enzymatic synthesis involving the transferase enzyme.
- Alpha-glucan is a preferred oligosaccharide of the present invention having the following formula:
- Said oligosaccharide is in the form of a powder with a white appearance and a mild and characteristic odor. It is soluble in water, polyethylene glycol and glycerol, insoluble in ethanol 50 ° GL and not miscible with oils. vegetables and / or minerals. Your CAS number is 27707-45-5.
- the preferred oligosaccharide of the present invention is a component that selectively stimulates the growth of an individual's (resident and beneficial) saprophyte flora over a pathogenic flora.
- the alpha1-6 and alpha1-2 bonds of their polymeric structure provide more difficult hydrolysis leading to bioselectivity as this substrate restricts the growth of a pathogenic flora.
- Alpha-glucan is an oligosaccharide that protects the skin's ecosystem by keeping the ecosystem constant or balancing it in such a way as to revert it to its previous or natural state. It acts selectively, eliminating the use of antibiotics to prevent the emergence of unwanted flora.
- the composition comprises from 0.1% to 10% by weight of selective component for saprophytic flora growth.
- the moisturizing component of the present invention is a component capable of acting by increasing hydration of the application region. It can act both by preventing the water present from evaporating and by the hydroscopic capacity.
- Moisturizers useful for use in the present invention include, without limitation, moisturizers commonly used in the art of cosmetic products.
- the moisturizing component is whey.
- Whey whey or lactose
- Whey is the product derived from the hydromineral fraction of milk. Its main function in composition is to maintain the effect of lactic acid for a longer time as well as hydrate and maintain the skin's electrolyte balance, acting as a tissue recovery factor.
- the whey used in the present invention is atomized (whey) whey.
- the composition comprises from 0.1% to 20%; by weight of moisturizing component.
- PH regulator is a component that ensures skin acidity, hindering microbial proliferation, as well as maintaining the pH of the skin surface on which the intimate hygiene product will be applied
- PH regulators useful in the present invention include, without limitation lactic acid, citric acid, phosphoric acid, maleic acid, succinic acid, and other acids commonly used in the prior art.
- the pH regulator used in the present invention is lactic acid (or 2-hydroxypropanoic acid).
- the composition comprises from 0.1% to 20% by weight of pH regulator.
- Table 2 illustrates a preferred embodiment of composition of the invention.
- Figure 1 illustrates the comparison of detection of deodor generating substances in two compositions, one containing the base + fragrance combination and the other containing only the base composition. It can be seen that the composition of the invention, which results from the combination base composition + fragrance (indicated by the letter A), provides a reduction in the concentration of odor-forming substances, while composition B, which does not have the combination of the invention, does not. has satisfactory performance.
- the composition of the invention further provides other advantages, such as: maintaining a balanced pH in the mucosal region where it is applied by regulating the skin acidity; prevents / minimizes proliferation of undesirable microbial / bacterial flora; and provides hydration.
- alpha glucan oligosaccharide When used in the composition, alpha glucan oligosaccharide favors the growth of saprophytic flora over pathogenic, as glycosidic bonds (a1-6) and (a1-2) are more difficult to hydrolyze by pathogenic flora.
- a comparison was made of the use of alpha glucan oligosaccharide and glucose as a carbon source. The results are in the tables below. Table 3: Classification used for the scores.
- Table 4 Results of the use of alpha glucan oligosaccharide and glucose by saprophyte flora as carbon source.
- Table 5 Results of the use of alpha glucan oligosaccharide and glucose by pathogenic flora as carbon source.
- alpha glucan oligosaccharide is a carbon source for most saprophytic microorganisms tested, and not for the pathogenic microorganisms tested.
- alpha glucan oligosaccharide provides a selective carbon source for desirable plant growth, indirectly acting as a growth inhibitor of these undesirable bacteria.
- Table 7 Growth of Staphylococcus aureus and Micrococcus kristinae.
- Micrococcus kristinae and Corynebacterium xerosis were inoculated at a concentration of 10 5 cells / ml.
- Table 8 Development-related bacterial inoculation time. Inoculation of 10 5 cells / ml.
- alpha glucan oligosaccharide preferentially promotes the growth of Micrococcus kristinae over Corynebacterium xerosis. This competitive inhibition occurs due to a bioselective assimilation of alpha glucan oligosaccharide by Micrococcus kristinae. Therefore, there is a faster and more beneficial metabolism of alpha glucan oligosaccharide by saprophytic flora, favoring its growth over pathogens, inhibiting opportunistic colonization.
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Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2016004062A MX2016004062A (es) | 2013-10-04 | 2014-09-05 | Composicion para higiene intima prolongada y para reduccion de olores, proceso de produccion y uso. |
CR20160159A CR20160159A (es) | 2013-10-04 | 2016-04-04 | Composición para higiene íntima prolongada y para reducción de olores, proceso de producción y uso |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRBR102013025773-7A BR102013025773A2 (pt) | 2013-10-04 | 2013-10-04 | Composição para higiene íntima prolongada e para redução de odores, processo de produção e uso |
BRBR102013025773-7 | 2013-10-04 |
Publications (1)
Publication Number | Publication Date |
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WO2015048869A1 true WO2015048869A1 (pt) | 2015-04-09 |
Family
ID=52778244
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/BR2014/000311 WO2015048869A1 (pt) | 2013-10-04 | 2014-09-05 | Composição para higiene íntima prolongada e para redução de odores, processo de produção e uso |
Country Status (7)
Country | Link |
---|---|
AR (1) | AR097929A1 (pt) |
BR (1) | BR102013025773A2 (pt) |
CL (1) | CL2016000764A1 (pt) |
CR (1) | CR20160159A (pt) |
MX (1) | MX2016004062A (pt) |
PE (1) | PE20160650A1 (pt) |
WO (1) | WO2015048869A1 (pt) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2236127A1 (en) * | 2009-04-03 | 2010-10-06 | Rottapharm S.p.A. | A composition for intimate hygiene |
-
2013
- 2013-10-04 BR BRBR102013025773-7A patent/BR102013025773A2/pt not_active Application Discontinuation
-
2014
- 2014-09-05 WO PCT/BR2014/000311 patent/WO2015048869A1/pt active Application Filing
- 2014-09-05 PE PE2016000428A patent/PE20160650A1/es unknown
- 2014-09-05 MX MX2016004062A patent/MX2016004062A/es unknown
- 2014-10-03 AR ARP140103710A patent/AR097929A1/es unknown
-
2016
- 2016-04-01 CL CL2016000764A patent/CL2016000764A1/es unknown
- 2016-04-04 CR CR20160159A patent/CR20160159A/es unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2236127A1 (en) * | 2009-04-03 | 2010-10-06 | Rottapharm S.p.A. | A composition for intimate hygiene |
Non-Patent Citations (4)
Title |
---|
"Especificaciones do Biocolia ®", 25 July 2002 (2002-07-25), Retrieved from the Internet <URL:http://www.lipocol.com/applications/lipocolombia/archivos/17_ESPECIFICACIONES.pdfrecoveredfrom:<URL:http://www.lipocol.com/index.php?option=com_wrapper&view=wrapper&Itemid=220> [retrieved on 20141119] * |
"Informacion Tecnica do BioEcolia®", 1 February 2012 (2012-02-01), Retrieved from the Internet <URL:http://www.lipocol:com/applications/lipocolombia/archivos/18_INFORMACIONTECNICA.pdfrecoveredfrom<URL:http://www.lipocol.com/index.php?option=comwrapper&view=wrapper&Itemid=220> [retrieved on 20141119] * |
"Propriedades da página", Retrieved from the Internet <URL:http://www.lipocol.com/applications/lipocolombia/archivos/18INFORMACIONTECNICA.pdf> [retrieved on 20141209] * |
"Sabonete Íntimo Liz Mulher da Hinode Cosmesticos", 8 November 2008 (2008-11-08), Retrieved from the Internet <URL:http://redehinode.wordpress.com/2008/11/08/sabonete-intimo-liz-mulher> [retrieved on 20141119] * |
Also Published As
Publication number | Publication date |
---|---|
PE20160650A1 (es) | 2016-07-22 |
BR102013025773A2 (pt) | 2015-08-25 |
AR097929A1 (es) | 2016-04-20 |
CL2016000764A1 (es) | 2016-12-02 |
CR20160159A (es) | 2016-07-27 |
MX2016004062A (es) | 2016-06-06 |
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