WO2015015102A3 - Nouveaux complexes d'agomelatine et d'acides sulfoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents
Nouveaux complexes d'agomelatine et d'acides sulfoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Download PDFInfo
- Publication number
- WO2015015102A3 WO2015015102A3 PCT/FR2014/051944 FR2014051944W WO2015015102A3 WO 2015015102 A3 WO2015015102 A3 WO 2015015102A3 FR 2014051944 W FR2014051944 W FR 2014051944W WO 2015015102 A3 WO2015015102 A3 WO 2015015102A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- agomelatine
- contain
- pharmaceutical compositions
- sulphonic acids
- preparing same
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- YJYPHIXNFHFHND-UHFFFAOYSA-N agomelatine Chemical compound C1=CC=C(CCNC(C)=O)C2=CC(OC)=CC=C21 YJYPHIXNFHFHND-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002629 agomelatine Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/33—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems
- C07C309/34—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems formed by two rings
- C07C309/35—Naphthalene sulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
- C07C303/22—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; from sulfonic halides by reactions not involving the formation of halosulfonyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Priority Applications (25)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14758162.3A EP3027588B1 (fr) | 2013-07-29 | 2014-07-28 | Complexes d'agomélatine et d'acides sulfoniques, procédé de leur préparation et compositions pharmaceutiques qui les contiennent |
DK14758162.3T DK3027588T3 (da) | 2013-07-29 | 2014-07-28 | Komplekser af agomelatin og sulfonsyre, fremgangsmåde til deres fremstilling og lægemiddelsammensætninger som indeholder dem |
SI201431601T SI3027588T1 (sl) | 2013-07-29 | 2014-07-28 | Kompleksi agomelatina in sulfonskih kislin, postopek za pripravo le-teh in farmacevtskih sestavkov, ki jih vsebujejo |
JP2016530580A JP6595990B2 (ja) | 2013-07-29 | 2014-07-28 | アゴメラチンとスルホン酸との新規な複合体、これらの製造方法及びこれらを含有する医薬組成物 |
RS20200720A RS60440B1 (sr) | 2013-07-29 | 2014-07-28 | Kompleksi agomelatina i sulfonskih kiselina, postupak za njihovo dobijanje i farmaceutske kompozicije koje ih sadrže |
KR1020167004732A KR20160035599A (ko) | 2013-07-29 | 2014-07-28 | 아고멜라틴 및 설폰산의 신규한 복합체, 이를 제조하기 위한 방법 및 이를 함유하는 약학적 조성물 |
US14/907,670 US9573891B2 (en) | 2013-07-29 | 2014-07-28 | Complexes of agomelatine and sulphonic acids, a process for their preparation and pharmaceutical compositions containing them |
MX2016001219A MX369303B (es) | 2013-07-29 | 2014-07-28 | Nuevos complejos de agomelatina y de acidos sulfonicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. |
CN201480042633.7A CN105473547B (zh) | 2013-07-29 | 2014-07-28 | 阿戈美拉汀和磺酸的新复合物、其制备方法和包含其的药物组合物 |
AU2014298304A AU2014298304B2 (en) | 2013-07-29 | 2014-07-28 | Novel complexes of agomelatine and sulphonic acids, method for preparing same and the pharmaceutical compositions that contain them |
ES14758162T ES2792248T3 (es) | 2013-07-29 | 2014-07-28 | Complejos de agomelatina y ácidos sulfónicos, procedimiento de su preparación y composiciones farmacéuticas que los contienen |
PL14758162T PL3027588T3 (pl) | 2013-07-29 | 2014-07-28 | Kompleksy agomelatyny i kwasów sulfonowych, sposób ich wytwarzania i kompozycje farmaceutyczne je zawierające |
LTEP14758162.3T LT3027588T (lt) | 2013-07-29 | 2014-07-28 | Agomelatino ir sulfonrūgščių kompleksai, jų gamybos būdas ir juos turinčios farmacinės kompozicijos |
SG11201600006RA SG11201600006RA (en) | 2013-07-29 | 2014-07-28 | Novel complexes of agomelatine and sulphonic acids, method for preparing same and the pharmaceutical compositions that contain them |
EA201600142A EA031237B1 (ru) | 2013-07-29 | 2014-07-28 | Новые комплексы агомелатина и сульфокислот, способ их получения и фармацевтические композиции, которые их содержат |
RU2016106958A RU2673080C2 (ru) | 2013-07-29 | 2014-07-28 | Новые комплексы агомелатина и сульфокислот, способ их получения и фармацевтические композиции, которые их содержат |
CA2919601A CA2919601C (fr) | 2013-07-29 | 2014-07-28 | Nouveaux complexes d'agomelatine et d'acides sulfoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
NZ716151A NZ716151A (en) | 2013-07-29 | 2014-07-28 | Novel complexes of agomelatine and sulphonic acids, method for preparing same and the pharmaceutical compositions that contain them |
MEP-2020-125A ME03741B (fr) | 2013-07-29 | 2014-07-28 | Nouveaux complexes d'agomelatine et d'acides sulfoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
UAA201601715A UA116811C2 (uk) | 2013-07-29 | 2014-07-28 | Комплекси агомелатину та сульфонових кислот, спосіб їх одержання та фармацевтичні композиції, що їх містять |
ZA2016/00448A ZA201600448B (en) | 2013-07-29 | 2016-01-20 | Novel complexes of agomelatine and sulphonic acids, method for preparing same and the pharmaceutical compositions that contain them |
HK16106760.7A HK1218745A1 (zh) | 2013-07-29 | 2016-06-13 | 阿戈美拉汀和磺酸的新複合物、其製備方法和包含其的藥物組合物 |
HK16111309.5A HK1223088A1 (zh) | 2013-07-29 | 2016-09-27 | 阿戈美拉汀和磺酸的新複合物、其製備方法和包含其的藥物組合物 |
HRP20200927TT HRP20200927T1 (hr) | 2013-07-29 | 2020-06-10 | Kompleksi agomelatina i sulfonskih kiselina, postupak njihove proizvodnje i proizvodnje farmaceutskih pripravaka koji ih sadržavaju |
CY20201100565T CY1123214T1 (el) | 2013-07-29 | 2020-06-19 | Συμπλοκα αγομελατινης και σουλφονικα οξεα, μεθοδος παρασκευης αυτων και φαρμακευτικες συνθεσεις που περιεχουν αυτα |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2013/080337 WO2015013865A1 (fr) | 2013-07-29 | 2013-07-29 | Complexes d'acides sulfoniques et d'agomélatine et leur préparation |
CNPCT/CN2013/080337 | 2013-07-29 | ||
FR1360124 | 2013-10-17 | ||
FR1360124A FR3012142B1 (fr) | 2013-10-17 | 2013-10-17 | Nouveaux complexes d'agomelatine et d'acides sulfoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2015015102A2 WO2015015102A2 (fr) | 2015-02-05 |
WO2015015102A3 true WO2015015102A3 (fr) | 2015-12-03 |
Family
ID=51453772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2014/051944 WO2015015102A2 (fr) | 2013-07-29 | 2014-07-28 | Nouveaux complexes d'agomelatine et d'acides sulfoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Country Status (26)
Country | Link |
---|---|
US (1) | US9573891B2 (fr) |
EP (1) | EP3027588B1 (fr) |
JP (1) | JP6595990B2 (fr) |
CN (1) | CN105473547B (fr) |
AU (1) | AU2014298304B2 (fr) |
CA (1) | CA2919601C (fr) |
CY (1) | CY1123214T1 (fr) |
DK (1) | DK3027588T3 (fr) |
EA (1) | EA031237B1 (fr) |
ES (1) | ES2792248T3 (fr) |
HK (2) | HK1218745A1 (fr) |
HR (1) | HRP20200927T1 (fr) |
HU (1) | HUE049928T2 (fr) |
LT (1) | LT3027588T (fr) |
ME (1) | ME03741B (fr) |
MX (1) | MX369303B (fr) |
NZ (1) | NZ716151A (fr) |
PL (1) | PL3027588T3 (fr) |
PT (1) | PT3027588T (fr) |
RS (1) | RS60440B1 (fr) |
RU (1) | RU2673080C2 (fr) |
SG (1) | SG11201600006RA (fr) |
SI (1) | SI3027588T1 (fr) |
UA (1) | UA116811C2 (fr) |
WO (1) | WO2015015102A2 (fr) |
ZA (1) | ZA201600448B (fr) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2517700A1 (fr) * | 2011-04-28 | 2012-10-31 | Zentiva, k.s. | Cocristaux pharmaceutiquement acceptables de la N-[2-(7-méthoxy-1-naphthyl)éthyl]acetamide et méthodes de leur préparation |
WO2013170738A1 (fr) * | 2012-05-14 | 2013-11-21 | 上海右手医药科技开发有限公司 | Composite à base de radical acide d'agomélatine et procédé de préparation et application associés |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0706044D0 (en) * | 2007-03-28 | 2007-05-09 | Syngenta Ltd | C0-Crystals |
WO2009140466A2 (fr) * | 2008-05-14 | 2009-11-19 | Dr. Reddy's Laboratories Ltd. | Co-cristaux de linézolide |
CN101481321B (zh) * | 2009-02-27 | 2012-04-18 | 上海医药工业研究院 | 阿戈美拉汀卤化氢复合物及其制备方法 |
CN102690210A (zh) * | 2011-03-23 | 2012-09-26 | 上海医药工业研究院 | 阿戈美拉汀的新晶型ⅶ、其制备方法、应用和包含其的药物组合物 |
CN102690209A (zh) * | 2011-03-23 | 2012-09-26 | 上海医药工业研究院 | 阿戈美拉汀的混晶(形式-ⅷ)、其制备方法、应用和包含其的药物组合物 |
PH12012000132A1 (en) * | 2011-06-09 | 2014-10-20 | Servier Lab | New co-crystals of agomelatine, a process for their preparation and pharmaceutical compositions containing them |
CN102718675B (zh) * | 2012-06-07 | 2015-03-25 | 上海右手医药科技开发有限公司 | 阿戈美拉汀甲磺酸复合物及其制备方法 |
CN102702041B (zh) * | 2012-05-14 | 2013-08-14 | 上海右手医药科技开发有限公司 | 阿戈美拉汀苯磺酸类复合物及其制备方法 |
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Patent Citations (2)
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EP2517700A1 (fr) * | 2011-04-28 | 2012-10-31 | Zentiva, k.s. | Cocristaux pharmaceutiquement acceptables de la N-[2-(7-méthoxy-1-naphthyl)éthyl]acetamide et méthodes de leur préparation |
WO2013170738A1 (fr) * | 2012-05-14 | 2013-11-21 | 上海右手医药科技开发有限公司 | Composite à base de radical acide d'agomélatine et procédé de préparation et application associés |
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