WO2015003233A1 - Composition désinfectante stabilisée, procédé de fabrication d'une composition désinfectante stabilisée, produit désinfectant, utilisation d'une composition et utilisation d'un produit - Google Patents

Composition désinfectante stabilisée, procédé de fabrication d'une composition désinfectante stabilisée, produit désinfectant, utilisation d'une composition et utilisation d'un produit Download PDF

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Publication number
WO2015003233A1
WO2015003233A1 PCT/BR2014/000227 BR2014000227W WO2015003233A1 WO 2015003233 A1 WO2015003233 A1 WO 2015003233A1 BR 2014000227 W BR2014000227 W BR 2014000227W WO 2015003233 A1 WO2015003233 A1 WO 2015003233A1
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WO
WIPO (PCT)
Prior art keywords
hydrogen peroxide
composition
disinfectant
product
acid
Prior art date
Application number
PCT/BR2014/000227
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English (en)
Portuguese (pt)
Inventor
Carlos Henrique CHRISTO
Original Assignee
Thech Desinfecção Ltda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thech Desinfecção Ltda filed Critical Thech Desinfecção Ltda
Publication of WO2015003233A1 publication Critical patent/WO2015003233A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02—Acyclic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds

Definitions

  • the present invention relates to a stabilized disinfectant composition, a process of manufacturing a stabilized disinfectant composition, products comprising the disinfectant composition and use of the composition and products as high level disinfectants.
  • Disinfection is a key procedure in many industrial processes, such as sterilization of hospital equipment and instruments, cleaning of common areas in hospitals and general clinics, as well as cleaning in the pharmaceutical and food industries.
  • the choice of disinfectant product to be used usually meets the following criteria: cleaning capacity; action time; application safety and environmental safety.
  • ANVISA National Health Surveillance Agency
  • Resolution RDC No. 35 of August 16, 2010 aims to define, classify and regulate the conditions for the registration and labeling of antimicrobial products for use in health care for critical and semi-critical articles to be marketed.
  • This regulation, harmonized within Mercosur, introduced a new category of sanitizing products, which are Intermediate level disinfectants; and established distinct microorganisms for the registration of high level disinfectant and Intermediate level disinfectant.
  • the microorganisms for the evaluation of the antimicrobial activity of high level disinfectants are: Staphylococcus aureus / Salmonella choleraesuis / Escherichia coli / Pseudomona aeruginosa / Trichophyton mentagrophytes / Candida albicans / Mycobacterium smegmatis / Mycobacterium bovis / Baccobacterium bovis (BCG) Clostridium sporogenes.
  • ANVISA's RDC No. 31 of July 4, 2011 provides for the indication of use of sterilizers for immersion application and the indication of use of hospital disinfectants for semi-critical articles, which are now classified as high level disinfectants.
  • RDC No. 35/10 One of the requirements of RDC No. 35/10 is that high-level sterilizers and disinfectants are proven to be effective against a variety of microorganisms, including Mycobacterium massiliense. Because some products have not demonstrated efficacy against the latter, the respective records were cleared in accordance with the provisions of Art. 4 of the DRC No. 31/2010. As a result, there was a significant reduction in the supply of high level disinfectant products. It is important to highlight that the situation occurred with aldehyde based products as well as peracetic acid and hydrogen peroxide formulations.
  • disinfectants are particularly toxic and made from carcinogenic compounds, eg glutaraldehyde.
  • Hydrogen peroxide whose chemical formula is H 2 O 2 , is a compound widely used as a disinfectant. It is a clear liquid with characteristic odor and powerful oxidizer. Hydrogen peroxide when in aqueous solution is known commercially as hydrogen peroxide.
  • Hydrogen peroxide acts as a disinfectant and lactic acid as a descaling cleaner.
  • composition of the present invention additionally contains stabilizer (s), defoamer (s) and surfactant (s) which may be present in the following amounts: about 0.5 to 2.5% stabilizer (s) about 0.001 to 0.1% antifoam (s) and about 1 to 5% surfactants.
  • stabilizer s
  • defoamer s
  • surfactant s
  • surfactants ethoxylates, sulfates, phosphates, amphoteres, cationics, anionics and a mixture thereof can be used.
  • a cationic surfactant such as ammonium quaternary, derivatives or mixture thereof is used, particularly dialkyl dimethyl benzyl ammonium chloride and / or didecyldimethyl ammonium chloride is used.
  • the surfactant is known to be a type of molecule that has a nonpolar characteristic part linked to another polar characteristic part.
  • this type of molecule is polar and nonpolar at the same time. Its function in a formulation is to assist in surface cleaning by removing greasy residue.
  • Synergism is due to the biocidal characteristics of the components present in the composition of the present invention, which increase the biocidal action of the composition when combined, ie the action is synergistic compared to the action of each isolated component.
  • the main actions of action on the microorganism are: denaturation and oxidation of proteins, rupture of cell membrane permeability and alteration of osmotic pressure of some microorganisms.
  • V liters of pure water per liter of dilute H2O2;
  • A concentrated H 2 O 2 titer,% by weight
  • the hydrogen peroxide concentration must be equal to or greater than 3.4% (w / w).
  • the hydrogen peroxide concentration can be checked every 30 minutes.
  • the surfactant (s) are preferably added. slowly, while hydrogen peroxide, defoamer (s), and stabilizer (s) are preferably added rapidly.
  • Antimicrobial action occurs through the synergistic action of hydrogen peroxide and peracid formed by donation of active oxygen by peroxide that reacts with lactic acid, as reaction below:
  • the above reaction is a steady-state equilibrium reaction and will decompose if diluted, added with any other component or subjected to a temperature above 56 ° C.
  • the conditions that can cause destabilization are: temperature, catalyst substances, pressure and change in component concentration.
  • catalyst substances can be considered as the main cause in the decomposition of a hydrogen peroxide containing product.
  • the main catalysis that can occur in a hydrogen peroxide solution is associated with photodissociation reactions, as radiation in the ultraviolet region with a wavelength of 310 nm causes excitation in the oxygen-oxygen bond and contributes to formation of a radical oxygen, a species that has two unpaired electrons. The presence of this radical initiates a chain reaction, attacking the oxygen-oxygen bonds to form O2 and water, thus decomposing the solution.
  • Some anions may also cause the breakdown of peroxides such as chlorides, hypochlorites, hypochlorites, bromides, sulfites, thiosulfates, iodides and iodates. These species should be avoided in the formulation, because unlike cations, there is no substance on them as a sequesterer.
  • the present invention also relates to disinfectant products comprising the composition of the present invention.
  • These products are selected from: ready-to-use solutions, concentrated solutions, sprays, gels and wet wipes.
  • the present invention further relates to the use of the composition and products of the invention for high level disinfection, particularly in the area of human and animal health, as a surface disinfectant for institutional use, including for hospitals, featuring broad spectrum of action, acting quickly, particularly within 1 to 30 minutes.
  • the products of the present invention have even longer shelf life (longer shelf life) when compared to products on the market.
  • Hydrogen peroxide was then rapidly added according to the amount obtained in equation 1 above, equivalent to 4.0% (w / w) and at a temperature of about 25 ° C to 30 ° C. It was homogenized and the hydrogen peroxide concentration was checked to 3.5% (w / w).
  • the mixer speed was reduced to 50 rpm and the mixture of dialkyl dimethyl benzyl ammonium chloride and didecyldimethyl ammonium chloride was added slowly.
  • the formulation of the test substance also contained stabilizer and antifoam, but for these tests it is only necessary to state the active principles of the formulation.
  • 35 sterile porcelain cylinders (10 employed in the test, 5 for subculture control and 20 for phenol control) were transferred to 35.0 mL of the bacterial suspension. After 15 minutes of contact, the cylinders were placed on an upright filter paper contained in a Petri dish, then brought to incubation 36 ⁇ 1 ° C for 30 minutes for drying.
  • Microorganisms Mycobacterium massiliense INCQS 00594.
  • test substance was considered satisfactory for its mycobactericidal activity against the tested microorganism, in the condition of cleanliness.
  • the objective of this assay was to evaluate the disinfectant capacity of the test substance against Mycobactenum terrae.
  • This test applies to chemical disinfectants that form a physically stable and homogeneous preparation when diluted in hard water - or in the case of ready-to-use products - with water, so ready-to-use products can be tested at 80% due to dilution. resulting from the addition of inoculum and interfering substance (s).
  • a bacterial suspension in an interfering substance solution is added to a test substance sample at the indicated concentration of use. If in the obligatory condition of the method, the mixture is kept at a temperature of 20 ° C for 60 minutes. At the end of the contact time, an aliquot is taken; Mycobactericidal and / or mycobacteriostatic activity in this portion is immediately neutralized or suppressed by a validated method. Surviving bacteria are counted and the reduction in viable cell numbers is calculated.
  • test substance should be considered satisfactory if it reduces the number of viable cells by 10 4 or more by 60 minutes at 20 ° C under the conditions defined by this method under cleanliness and / or dirt. THE reduction in the number of viable cells of 10 4 or more corresponds to a reduction of 99.99% or more.
  • Neutralizing agent used was a combination of Tween 80, Saponin, L-Histidine, Lecithin and Sodium Thiosulfate;
  • Microorganisms Mycobacterium terrae ATCC 15755.
  • test substance was considered satisfactory for its mycobactericidal activity against the tested microorganism, in the condition of cleanliness.
  • the objective of this assay was to evaluate the disinfectant capacity of the test substance against Mycobacterium avium. This test applies to chemical disinfectants that form a physically stable and homogeneous preparation when diluted in hard water - or in the case of ready-to-use products - with water, so ready-to-use products can be tested at 80% due to dilution. resulting from the addition of inoculum and interfering substance (s).
  • a bacterial suspension in an interfering substance solution is added to a test substance sample at the indicated concentration of use. If in the obligatory condition of the method, the mixture is kept at a temperature of 20 ° C for 60 minutes. At the end of the contact time, an aliquot is taken; Mycobactericidal and / or mycobacteriostatic activity in this portion is immediately neutralized or suppressed by a validated method. Surviving bacteria are counted and the reduction in viable cell numbers is calculated.
  • test substance should be considered satisfactory if it reduces the number of viable cells by 10 or more by 60 minutes at 20 ° C under the conditions defined by this method under cleanliness and / or dirt.
  • the reduction in the number of viable cells of 10 4 or more corresponds to a reduction of 99.99% or more.
  • Neutralizing agent used was a combination of Tween 80, Saponin, L-Histidine, Lecithin and Sodium Thiosulfate;
  • Microorganisms Mycobacterium avium ATCC 15769.
  • A, B and C is greater than or equal to 0.5 x N v0 -
  • test substance was considered satisfactory as to its mycobactericidal activity against the tested microorganism, in the condition of cleanliness.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Toxicology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La présente invention concerne une composition désinfectante stabilisée comprenant du peroxyde d'hydrogène, de l'acide lactique un ou plusieurs stabilisants, un ou plusieurs agents antimousse, un ou plusieurs tensioactifs et de l'eau. La présente invention concerne également un procédé de préparation d'une composition désinfectante stabilisée, comprenant des étapes de mélange des constituants, suivies d'une homogénéisation avec des conditions spécifiques. L'invention concerne également des produits comprenant la composition désinfectante, ainsi que l'utilisation de cette composition et de ces produits en vue d'une désinfection de haut niveau.
PCT/BR2014/000227 2013-07-11 2014-07-10 Composition désinfectante stabilisée, procédé de fabrication d'une composition désinfectante stabilisée, produit désinfectant, utilisation d'une composition et utilisation d'un produit WO2015003233A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BRBR102013017824-1 2013-07-11
BRBR102013017824-1A BR102013017824A2 (pt) 2013-07-11 2013-07-11 Composição desinfetante estabilizada, processo de fabricação de uma composição desinfetante estabilizada, produto desinfetante, uso de uma composição e uso de um produto

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Publication Number Publication Date
WO2015003233A1 true WO2015003233A1 (fr) 2015-01-15

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PCT/BR2014/000227 WO2015003233A1 (fr) 2013-07-11 2014-07-10 Composition désinfectante stabilisée, procédé de fabrication d'une composition désinfectante stabilisée, produit désinfectant, utilisation d'une composition et utilisation d'un produit

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2624845C1 (ru) * 2016-08-23 2017-07-07 федеральное государственное бюджетное научное учреждение "Федеральный центр токсикологической, радиационной и биологической безопасности" (ФГБНУ "ФЦТРБ-ВНИВИ") Дезинфицирующее средство с моющим эффектом

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0423922A1 (fr) * 1989-10-17 1991-04-24 Ecolab Inc. Composition antimicrobienne non contaminante
EP1027827A1 (fr) * 1998-05-28 2000-08-16 Mandalay Inversiones, S.L. Composition desinfectante
US6908628B2 (en) * 2001-06-15 2005-06-21 Oftrai, S.L. Disinfectant and antiseptic composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0423922A1 (fr) * 1989-10-17 1991-04-24 Ecolab Inc. Composition antimicrobienne non contaminante
EP1027827A1 (fr) * 1998-05-28 2000-08-16 Mandalay Inversiones, S.L. Composition desinfectante
US6908628B2 (en) * 2001-06-15 2005-06-21 Oftrai, S.L. Disinfectant and antiseptic composition

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2624845C1 (ru) * 2016-08-23 2017-07-07 федеральное государственное бюджетное научное учреждение "Федеральный центр токсикологической, радиационной и биологической безопасности" (ФГБНУ "ФЦТРБ-ВНИВИ") Дезинфицирующее средство с моющим эффектом

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