WO2001037659A2 - Compositions biocides - Google Patents

Compositions biocides Download PDF

Info

Publication number
WO2001037659A2
WO2001037659A2 PCT/GB2000/004421 GB0004421W WO0137659A2 WO 2001037659 A2 WO2001037659 A2 WO 2001037659A2 GB 0004421 W GB0004421 W GB 0004421W WO 0137659 A2 WO0137659 A2 WO 0137659A2
Authority
WO
WIPO (PCT)
Prior art keywords
biocide composition
composition according
opa
biocide
edta
Prior art date
Application number
PCT/GB2000/004421
Other languages
English (en)
Other versions
WO2001037659A3 (fr
Inventor
Harley Farmer
Michael Ward Prust
Original Assignee
Tecmark Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tecmark Limited filed Critical Tecmark Limited
Priority to AU15306/01A priority Critical patent/AU1530601A/en
Publication of WO2001037659A2 publication Critical patent/WO2001037659A2/fr
Publication of WO2001037659A3 publication Critical patent/WO2001037659A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
    • A01N35/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals

Definitions

  • the invention relates to biocide compositions, and more particularly, but not exclusively, to biocide compositions with a good cleansing action for use in removing and killing microbes in ail situations.
  • Biocide compositions are well known. Some are based on single chemical components and others are formulations made by combining multiple chemicals. Since many biocides are chemically neutralized and thereby inactivated by organic matter, it is important to thoroughly clean the area to be disinfected before using those biocides. A good example of this is hypochlorous acid or bleach, a good biocide under clean conditions but it has the disadvantage of being less effective in practical situations. Those skilled in biocide technology know that many biocides are inactivated by detergents. This fact becomes critically important in the field of hand washes in hospitals when staff use one hand wash when they simply need to clean their hands or first arrive at work, and a different hand wash when they need to remove bacterial contamination. Anionic components are often used in the cleansing hand washes, and Chlorhexidine is commonly used as the biocidai component in the anti-microbial hand washes, but anionic chemicals inactivate chlorhexidine.
  • EP 0836803 discloses an aqueous disinfecting composition comprising from 1 to 20% aldehydes, especially glutaraldehyde, 3 to 35% salts, especially quaternary ammonium chlorides, 1 to 15% ethoxylated fatty alcohol, and from 0.5 to 15% of an insecticidal agent selected from synthetic pyrethroids. Although this composition has the advantage of a cleaning component, the aldehyde component still produces toxic vapours and the alcohol has the disadvantage of being flammable.
  • biocide composition with both cleaning and disinfecting capacity and which is safe for general and widespread use. It is a further object of this invention to provide a biocide composition which is usable in both the solid and liquid forms.
  • the invention provides a biocide composition comprising at least one of each of the following: (I) a surtace-active chemical (ii) an aldehyde, and (iii) a complexing agent.
  • a biocide composition comprising at least one non-volatile aldehyde.
  • the invention provides for a biocide composition which is provided in a solid form and subsequently dissolved in a solvent including, but not exclusively, water to make a biocidai solution.
  • the contaminated discs When required the contaminated discs were dipped into the test formulation for the required contact time of five minutes, removed and placed into 20 ml of Bacillus growth medium with the dilution ratio being used to terminate the anti-microbial activity. Control contaminated discs were dipped for five minutes in growth medium rather than disinfectant and subsequently treated in the same manner as the test discs. That growth medium containing the discs was incubated for an appropriate number of days, and then a sample was plated onto the appropriate agar and the plates incubated. In the following data, if one or more colonies grew on the agar the formulation was deemed to have failed as a sporicide. If no colonies were seen on the agar, but the control plates had heavy growth, the formulation was deemed to have passed as a sporicide.
  • Formulation Ingredients Bacterial Polio Number Spores Virus
  • Formulation 1 a commercially available disinfectant, failed to kill spores, but with the addition of 0.25% OPA it became sporicidal, whereas with 0.1% added OPA it did not. OPA alone in water at 0.5% failed to kill spores. Therefore the minimal sporicidal level of OPA is greater than 0.5% when tested alone and greater than 0.1% when used in a synergistic mixture with QAC's.
  • Formulation 6 the commercially available product of Formulation 1 with 0.1% OPA and 0.05% EDTA added, was sporicidal.
  • Formulations 7 to 10 followed a similar sequence but with a single QAC. The
  • Formulations 11 to 14 followed the same sequence with a known product based on two QAC's tested against polio virus.
  • Formulations 15 to 18 are based on 2% cetyltrimethyl ammonium bromide, a QAC that is a solid at ambient temperatures. Adding either 0.05% EDTA or 0.25% OPA alone failed to make it sporicidal, but adding 0.05% EDTA and 0.25% OPA together made it sporicidal.
  • Formulation 18 is a biocide solution made by dissolving the solid biocide composition made up of solid QAC, EDTA and OPA in water.
  • the best modes of carrying out the invention relate to the choice of QAC and the decision of whether one or more than one QAC should be used.
  • the QAC group offers a wide variety of features - some are excellent conditioners of skin and fabrics, others have particularly good cleaning properties and others are solids at ambient temperatures which allows for powdered formulations that can additionally be formed into tablets.
  • the QAC's and amine oxide are mixed at room temperature, the EDTA and OPA are dissolved into that mixture and a pH modifier is added slowly until the desired pH is achieved. The appropriate amount of water is then added, depending on whether a concentrate or the use dilution is required. Readers will understand that the formulations and components quoted here are by way of example only and do not represent the limit of the possible choices of surface active agent, compiexing agent or aldehyde, nor the concentrations to be used.
  • OPA was selected as the example aldehyde because it is a solid thereby allowing for the powdered composition that was dissolved in solvent, in this case water, to provide formulation 18.
  • the invention provides biocide compositions suitable for safe and widespread use in the cleaning, sanitising, disinfecting and sterilising fields in all industries and markets.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La présente invention concerne un procédé permettant de produire des compositions biocides, par combinaison d'agents tensio-actifs, d'agents de complexion/de chélation et d'aldéhydes. Des formulations basées sur des composés à base d'ammonium quaternaire, de l'acide éthylène diamine tétra-acétique et de l'orthophthalaldéhyde sont données à titre d'exemple. De telles formulations présentent l'avantage d'être rentables, pour un usage généralisé, et d'être suffisamment sûres, pour un usage domestique, médical, institutionnel, agricole et industriel, sans engendrer d'effets indésirables sur les utilisateurs, les patients, l'équipement ou l'environnement. Dans un mode de réalisation de ces formulations, une composition peut être soit sous forme de poudre, soit sous forme de comprimé.
PCT/GB2000/004421 1999-11-24 2000-11-22 Compositions biocides WO2001037659A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU15306/01A AU1530601A (en) 1999-11-24 2000-11-22 Biocide compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9927614.9 1999-11-24
GBGB9927614.9A GB9927614D0 (en) 1999-11-24 1999-11-24 Sterliant formulation

Publications (2)

Publication Number Publication Date
WO2001037659A2 true WO2001037659A2 (fr) 2001-05-31
WO2001037659A3 WO2001037659A3 (fr) 2001-10-18

Family

ID=10864945

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/004421 WO2001037659A2 (fr) 1999-11-24 2000-11-22 Compositions biocides

Country Status (3)

Country Link
AU (1) AU1530601A (fr)
GB (1) GB9927614D0 (fr)
WO (1) WO2001037659A2 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009100879A2 (fr) * 2008-02-12 2009-08-20 Lonza Inc. Composition désinfectante et stérilisante à large spectre
US20110009493A1 (en) * 2008-02-12 2011-01-13 Larry Kent Hall Broad Spectrum Disinfecting and Sterilizing Composition
US20130171264A1 (en) * 2010-06-21 2013-07-04 Mtp Innovations Disinfectant Composition
US8911665B2 (en) * 2001-12-05 2014-12-16 Aseptica, Inc. Antiseptic compositions, methods and systems
CN112931505A (zh) * 2021-01-22 2021-06-11 海韵一剑大卫生科技有限公司 一种邻苯二甲醛消毒剂及其制备方法与应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4661523A (en) * 1984-10-29 1987-04-28 Henkel Kommanditgesellschaft Auf Aktien Disinfectant solutions having improved corrosion properties
US5344838A (en) * 1985-01-18 1994-09-06 Cetylite Industries, Inc. Sterilant composition
FR2718923A1 (fr) * 1994-04-25 1995-10-27 Sogeval Composition désinfectante en solution aqueuse renfermant de l'orthophtalaldéhyde.
FR2743982A1 (fr) * 1996-01-30 1997-08-01 Salkin Andre Utilisation d'aldehydes aromatiques en combinaison avec un agent desinfectant cationique de type ammonium quaternaire et une composition en comportant application
US5891922A (en) * 1997-08-20 1999-04-06 Preserve International, Preserve, Inc. Cleaning and disinfectant biocide composition, and method for cleaning animal husbandry surfaces

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4661523A (en) * 1984-10-29 1987-04-28 Henkel Kommanditgesellschaft Auf Aktien Disinfectant solutions having improved corrosion properties
US5344838A (en) * 1985-01-18 1994-09-06 Cetylite Industries, Inc. Sterilant composition
FR2718923A1 (fr) * 1994-04-25 1995-10-27 Sogeval Composition désinfectante en solution aqueuse renfermant de l'orthophtalaldéhyde.
FR2743982A1 (fr) * 1996-01-30 1997-08-01 Salkin Andre Utilisation d'aldehydes aromatiques en combinaison avec un agent desinfectant cationique de type ammonium quaternaire et une composition en comportant application
US5891922A (en) * 1997-08-20 1999-04-06 Preserve International, Preserve, Inc. Cleaning and disinfectant biocide composition, and method for cleaning animal husbandry surfaces

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8911665B2 (en) * 2001-12-05 2014-12-16 Aseptica, Inc. Antiseptic compositions, methods and systems
WO2009100879A2 (fr) * 2008-02-12 2009-08-20 Lonza Inc. Composition désinfectante et stérilisante à large spectre
WO2009100879A3 (fr) * 2008-02-12 2010-06-24 Lonza Inc. Composition désinfectante et stérilisante à large spectre
US20110009493A1 (en) * 2008-02-12 2011-01-13 Larry Kent Hall Broad Spectrum Disinfecting and Sterilizing Composition
US20130171264A1 (en) * 2010-06-21 2013-07-04 Mtp Innovations Disinfectant Composition
US10827752B2 (en) * 2010-06-21 2020-11-10 Peter Finan Disinfectant composition
CN112931505A (zh) * 2021-01-22 2021-06-11 海韵一剑大卫生科技有限公司 一种邻苯二甲醛消毒剂及其制备方法与应用

Also Published As

Publication number Publication date
WO2001037659A3 (fr) 2001-10-18
AU1530601A (en) 2001-06-04
GB9927614D0 (en) 2000-01-19

Similar Documents

Publication Publication Date Title
AU2003302067B2 (en) Hydrogen peroxide disinfectant containing an acid and/or an alcohol
CN109169653B (zh) 一种阳离子复合消毒液及其应用
US9233180B2 (en) Hydrogen peroxide disinfectant containing a cyclic carboxylic acid and/or aromatic alcohol
KR101302457B1 (ko) 4차 암모늄 화합물을 사용한 고수준 소독을 위한 방법 및조성물
CN101969768A (zh) 杀病毒组合物
US9433643B2 (en) Microbicidal composition comprising hydrogen peroxide and aminocarboxylic acids
IE921537A1 (en) Methods of using a cleaner, sanitizer, disinfectant,¹fungicide, sporicide, chemical sterilizer
CA2699684A1 (fr) Procede de desinfection a large spectre, generant peu de residus et faisant appel a un aerosol a base de peroxyde d'hydrogene en petites gouttelettes
US6530384B1 (en) Potentiated disinfectant cleaning solutions and methods of use
EP0844827B1 (fr) Compositions desinfectantes synergiques tuberculocides et procedes de desinfection
EP0609106B1 (fr) Une composition de glutaraldehyde
WO2010035008A2 (fr) Composition
WO2001037659A2 (fr) Compositions biocides
JP2004002229A (ja) 殺菌方法
EP3405218B1 (fr) Composition désinfectante
US20070286907A1 (en) Germicide composition
JP4228175B2 (ja) 殺菌剤組成液及び殺菌方法
JP2002161011A (ja) 殺菌剤組成物
US5674829A (en) Stable aqueous glutaraldehyde solutions containing sodium acetate and a nonionic detergent
WO2008122773A2 (fr) Composition biocide
US20220394979A1 (en) Multipurpose disinfection solutions

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase