WO2014203855A3 - ２－アミノ－２－ヒドロキシイミノ－ｎ－アルコキシアセトイミドイルシアニドの製造方法およびその製造中間体 - Google Patents

２－アミノ－２－ヒドロキシイミノ－ｎ－アルコキシアセトイミドイルシアニドの製造方法およびその製造中間体 Download PDF

Info

Publication number
WO2014203855A3
WO2014203855A3 PCT/JP2014/065891 JP2014065891W WO2014203855A3 WO 2014203855 A3 WO2014203855 A3 WO 2014203855A3 JP 2014065891 W JP2014065891 W JP 2014065891W WO 2014203855 A3 WO2014203855 A3 WO 2014203855A3
Authority
WO
WIPO (PCT)
Prior art keywords
amino
manufacturing
acetoimidoyl
hydroxyimino
alkoxy
Prior art date
Application number
PCT/JP2014/065891
Other languages
English (en)
French (fr)
Other versions
WO2014203855A2 (ja
Inventor
信吾 安村
裕貴 平野
Original Assignee
イハラケミカル工業株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by イハラケミカル工業株式会社 filed Critical イハラケミカル工業株式会社
Priority to EP14813379.6A priority Critical patent/EP3012247B1/en
Priority to CN201480034948.7A priority patent/CN105377812B/zh
Priority to JP2015522910A priority patent/JP6327754B2/ja
Publication of WO2014203855A2 publication Critical patent/WO2014203855A2/ja
Publication of WO2014203855A3 publication Critical patent/WO2014203855A3/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/63—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C255/64—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

【課題】本発明の目的は、一般式（３）で表わされる２－アミノ－２－ヒドロキシイミノ－Ｎ－アルコキシアセトイミドイルシアニドの工業化に適したかつ経済的に好ましい製造方法を提供することにある。 【解決手段】本発明は、 式（１）：で表わされるマロノニトリルを、プロトン酸の存在下で、亜硝酸のアルカリ金属塩と反応させ、続けて、相間移動触媒の存在下で、Ｃ３～Ｃ６アルキルハライドと反応させた後、得られる新規な一般式（２）：（式中、ＲはＣ３～Ｃ６アルキル基を示す。） で表される化合物すなわち２－アルコキシイミノプロパンジニトリルを、ヒドロキシルアミン化合物と反応させることにより、 一般式（３）：（式中、Ｒは前記と同意義である。） で表わされる化合物すなわち２－アミノ－２－ヒドロキシイミノ－Ｎ－アルコキシアセトイミドイルシアニドを、安全にかつ高収率で製造できることを見出し、完成するに至った。
PCT/JP2014/065891 2013-06-21 2014-06-16 ２－アミノ－２－ヒドロキシイミノ－ｎ－アルコキシアセトイミドイルシアニドの製造方法およびその製造中間体 WO2014203855A2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP14813379.6A EP3012247B1 (en) 2013-06-21 2014-06-16 Manufacturing method for 2-amino-2-hydroxyimino-n-alkoxy acetoimidoyl cyanide, and manufacturing intermediate thereof
CN201480034948.7A CN105377812B (zh) 2013-06-21 2014-06-16 2-氨基-2-肟基-n-烷氧基亚氨代乙酰基氰化物的制备方法及其制备中间体
JP2015522910A JP6327754B2 (ja) 2013-06-21 2014-06-16 ２−アミノ−２−ヒドロキシイミノ−ｎ−アルコキシアセトイミドイルシアニドの製造方法およびその製造中間体

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013-130079 2013-06-21
JP2013130079 2013-06-21

Publications (2)

Publication Number Publication Date
WO2014203855A2 WO2014203855A2 (ja) 2014-12-24
WO2014203855A3 true WO2014203855A3 (ja) 2015-01-29

Family

ID=52105435

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2014/065891 WO2014203855A2 (ja) 2013-06-21 2014-06-16 ２－アミノ－２－ヒドロキシイミノ－ｎ－アルコキシアセトイミドイルシアニドの製造方法およびその製造中間体

Country Status (4)

Country Link
EP (1) EP3012247B1 (ja)
JP (1) JP6327754B2 (ja)
CN (1) CN105377812B (ja)
WO (1) WO2014203855A2 (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114276291B (zh) * 2018-07-13 2023-11-21 沈阳中化农药化工研发有限公司 制备丙二腈肟醚类化合物的方法及中间体化合物
WO2021088756A1 (zh) * 2019-11-04 2021-05-14 沈阳中化农药化工研发有限公司 一种肟醚类化合物及其用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3234266A (en) * 1963-08-13 1966-02-08 Du Pont N-hydrocarbyloxyiminomalononitriles and process for preparing them
JPS57158769A (en) * 1981-03-06 1982-09-30 Fujisawa Pharmaceut Co Ltd Preparation of 2-substituted hydroxyimino-2-(5-amino-1,2,4- thiadiazol-3-yl)acetic acid or its salt, and their intermediate
JPH0477477A (ja) * 1990-07-18 1992-03-11 Takeda Chem Ind Ltd チアジアゾール酢酸誘導体の製造法
JPH04187667A (ja) * 1990-11-20 1992-07-06 Takeda Chem Ind Ltd ２―置換ヒドロキシイミノプロパンジニトリルの製造法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR75487B (ja) 1981-06-22 1984-07-23 Fujisawa Pharmaceutical Co
EP0150609A3 (en) 1983-12-30 1986-04-23 Glaxo Group Limited Cephalosporin antibiotics
CA1293719C (en) 1986-09-22 1991-12-31 Takao Takaya Cephem compounds and processes for preparation thereof
US5202315A (en) 1989-05-11 1993-04-13 Lucky, Ltd. Cephalosporin compounds
EP0517041A1 (en) 1991-06-07 1992-12-09 Fujisawa Pharmaceutical Co., Ltd. New Cephem Compounds
US5392222A (en) 1991-12-30 1995-02-21 Schlumberger Technologies Inc. Locating a field of view in which selected IC conductors are unobscured
DK2559690T3 (en) 2005-05-10 2016-04-25 Incyte Holdings Corp Modulators of indoleamine 2,3-dioxygenase and methods of use thereof
CN1850823A (zh) * 2006-05-19 2006-10-25 中国科学院上海药物研究所 一类含有肟基的喹诺酮类化合物及其制备方法和用途
KR101806187B1 (ko) 2010-06-24 2017-12-07 구미아이 가가쿠 고교 가부시키가이샤 알콕시이미노 유도체 및 유해생물 방제제
EP2792242B1 (en) 2011-11-30 2017-11-15 Kumiai Chemical Industry Co., Ltd. Glyoxime derivative and pest control agent

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3234266A (en) * 1963-08-13 1966-02-08 Du Pont N-hydrocarbyloxyiminomalononitriles and process for preparing them
JPS57158769A (en) * 1981-03-06 1982-09-30 Fujisawa Pharmaceut Co Ltd Preparation of 2-substituted hydroxyimino-2-(5-amino-1,2,4- thiadiazol-3-yl)acetic acid or its salt, and their intermediate
JPH0477477A (ja) * 1990-07-18 1992-03-11 Takeda Chem Ind Ltd チアジアゾール酢酸誘導体の製造法
JPH04187667A (ja) * 1990-11-20 1992-07-06 Takeda Chem Ind Ltd ２―置換ヒドロキシイミノプロパンジニトリルの製造法

Also Published As

Publication number Publication date
JPWO2014203855A1 (ja) 2017-02-23
JP6327754B2 (ja) 2018-05-23
EP3012247B1 (en) 2018-01-10
CN105377812A (zh) 2016-03-02
WO2014203855A2 (ja) 2014-12-24
EP3012247A2 (en) 2016-04-27
CN105377812B (zh) 2018-09-18
EP3012247A4 (en) 2017-01-25

Similar Documents

Publication Publication Date Title
WO2012150155A9 (de) Verfahren zur herstellung eines kristallinen l-mgda-trialkalimetallsalzes
PH12016502334B1 (en) Method for producing fused heterocyclic compound
MX2014006992A (es) Disales de acido malonico y metodo para preparar dihaluros de malonilo.
IN2014DN09746A (ja)
NZ718009A (en) Process for producing diazabicyclooctane derivative and intermediate thereof
WO2012099734A3 (en) Improved process for preparation of low molecular weight molybdenum succinimide complexes
WO2012138147A3 (en) 1-(3-cyano-1-isopropyl-indol-5-yl)pyrazole-4-carboxylic acid crystalline form and the producing method thereof
MX336483B (es) Procedimiento para preparar soluciones acuosas de sales trialcalinometalicas de acido metilglicin - n, n - diacetico.
MX2015015844A (es) Proceso para preparar compuestos n-sustituidos de acido 1h-pirazol-5-carboxilico y sus derivados.
MX2014014138A (es) Procedimiento nuevo para la preparacion de acido 2-ciclopentil-6-metoxi-isonicotinico.
UA111868C2 (uk) Спосіб одержання естерів (5-фтор-2-метил-3-хінолін-2-ілметиліндол-1-іл)-оцтової кислоти
WO2012099736A3 (en) Improved process for preparation of high molecular weight molybdenum succinimide complexes
WO2016038628A3 (en) A process for preparing olodaterol and intermediates thereof
MX354498B (es) Cristal de hidrato 5-hidroxi-1h-imidazol-4-carboxamida-3/4, metodo para producir el mismo y cristal de hidrato de 5-hidroxi-1h-imidazol-4-carboxamida.
WO2014203855A3 (ja) ２－アミノ－２－ヒドロキシイミノ－ｎ－アルコキシアセトイミドイルシアニドの製造方法およびその製造中間体
MY194792A (en) Method for producing optically active 2-(2-fluorobiphenyl-4-yl) propanoic acid
MX2020006837A (es) Metodo para producir un compuesto de sal de tiocarboxamidina.
GB201104203D0 (en) Chemical process
WO2011007136A3 (en) Process for the preparation of o-desmethyl venlafaxine and intermediate for use therein
WO2015022702A3 (en) Process for preparation of 4,5-dimethoxybenzene derivatives and use in the synthesis of ivabradine and salts thereof
FR2976940B1 (fr) Procede de preparation d'acide alpha- et beta-aminophosphores et leurs derives
MX2013004193A (es) Procedimiento para la preparacion de derivados de acido 3-(6-amino-piridin-3-il)-2-acrilico.
WO2014136047A3 (en) A process for the preparation of 2-amino-1,3-propane diol compounds and salts thereof
MX351176B (es) Método para producir y purificar sales del ácido acrilamido-2- metilpropan sulfónico.
WO2011110198A8 (en) A process for making voriconazole

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 14813379

Country of ref document: EP

Kind code of ref document: A2

ENP Entry into the national phase

Ref document number: 2015522910

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2014813379

Country of ref document: EP