WO2014199397A3 - Process for the preparation of liraglutide - Google Patents
Process for the preparation of liraglutide Download PDFInfo
- Publication number
- WO2014199397A3 WO2014199397A3 PCT/IN2014/000384 IN2014000384W WO2014199397A3 WO 2014199397 A3 WO2014199397 A3 WO 2014199397A3 IN 2014000384 W IN2014000384 W IN 2014000384W WO 2014199397 A3 WO2014199397 A3 WO 2014199397A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- liraglutide
- preparation
- iiraglutide
- fragments
- synthesized
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
Abstract
The present invention relates to an improved process for the synthesis of Iiraglutide or pharmaceutically acceptable salts by hybrid approach. The fragments are synthesized by solid phase synthesis approach and the Iiraglutide is synthesized by making use of the fragments in solution phase.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2536CH2013 | 2013-06-11 | ||
IN2536/CHE/2013 | 2013-06-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2014199397A2 WO2014199397A2 (en) | 2014-12-18 |
WO2014199397A3 true WO2014199397A3 (en) | 2015-01-29 |
Family
ID=51417545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2014/000384 WO2014199397A2 (en) | 2013-06-11 | 2014-06-09 | Process for the preparation of liraglutide |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2014199397A2 (en) |
Cited By (2)
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---|---|---|---|---|
CN107286234A (en) * | 2016-03-31 | 2017-10-24 | 深圳翰宇药业股份有限公司 | A kind of method for reducing and/or removing default peptide in Solid-phase synthesis peptides |
CN107903318A (en) * | 2017-12-29 | 2018-04-13 | 江苏诺泰澳赛诺生物制药股份有限公司 | A kind of method for purifying Liraglutide |
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WO2017127007A1 (en) | 2016-01-20 | 2017-07-27 | Poypeptide Laboratories Holding (Ppl) Ab | METHOD FOR PREPARATION OF PEPTIDES WITH psWANG LINKER |
EP3205660A1 (en) * | 2016-02-10 | 2017-08-16 | Polypeptide Laboratories Holding (PPL) AB | Method for preparation of peptides with pswang linker |
EP3205664A1 (en) * | 2016-02-11 | 2017-08-16 | Polypeptide Laboratories Holding (PPL) AB | Method for preparation of liraglutide using bal linker |
US11117946B2 (en) * | 2016-03-23 | 2021-09-14 | Bachem Holding Ag | Method for preparing glucagon-like peptides |
CA3018627A1 (en) | 2016-03-23 | 2017-09-28 | Bachem Holding Ag | Purification of glucagon-like peptide 1 analogs |
WO2018032521A1 (en) * | 2016-08-19 | 2018-02-22 | 深圳市健元医药科技有限公司 | Method for synthesizing liraglutide |
MX2019006711A (en) * | 2016-12-10 | 2019-10-30 | Biocon Ltd | Synthesis of liraglutide. |
CN107022021A (en) * | 2017-03-24 | 2017-08-08 | 吉尔生化(上海)有限公司 | A kind of solid-phase synthesis of Liraglutide |
WO2019069274A1 (en) * | 2017-10-04 | 2019-04-11 | Chemical & Biopharmaceutical Laboratories Of Patras S.A. | A process for preparing a glucagon-like peptide |
CN111757891A (en) | 2018-03-09 | 2020-10-09 | 恩细贝普有限公司 | Chemical-enzymatic synthesis of somaglutide, liraglutide and GLP-1 |
CN111819191A (en) | 2018-03-09 | 2020-10-23 | 恩细贝普有限公司 | Chemoenzymatic synthesis of liraglutide, somaglutide and GLP-1 |
CN110894227A (en) * | 2018-09-13 | 2020-03-20 | 南京华威医药科技集团有限公司 | Solid-phase synthesis method of liraglutide |
EP3894387A4 (en) * | 2018-12-12 | 2023-07-19 | Levim Biotech LLP | Acylation process for preparation of n-substituted peptide |
EP3897570A1 (en) | 2018-12-19 | 2021-10-27 | KRKA, d.d., Novo mesto | Pharmaceutical composition comprising glp-1 analogue |
WO2020161664A2 (en) * | 2019-02-06 | 2020-08-13 | Enzene Biosciences Limited | Glucagon-like peptide-1 (glp-1) agonist analog, process of preparation and uses thereof |
JP2022526115A (en) | 2019-03-19 | 2022-05-23 | エンゼン・バイオサイエンシズ・リミテッド | Glucagon-like peptide-1 (GLP-1) receptor agonist and its analog manufacturing process |
WO2020202182A1 (en) * | 2019-03-29 | 2020-10-08 | Mylan Laboratories Limited | Process for the preparation of abaloparatide |
CN111944038B (en) * | 2019-04-30 | 2023-06-13 | 深圳市健元医药科技有限公司 | Synthetic method of somalupeptide |
CN112010961B (en) * | 2019-05-31 | 2023-05-16 | 深圳市健元医药科技有限公司 | Solid-liquid synthesis method of somalupeptide |
WO2021123228A1 (en) | 2019-12-18 | 2021-06-24 | Krka, D.D., Novo Mesto | Pharmaceutical composition comprising glp-1 analogue |
US20230044268A1 (en) * | 2019-12-23 | 2023-02-09 | Shilpa Medicare Ltd | An improved process for preparation of liraglutide |
CN113135989B (en) * | 2020-01-20 | 2023-10-03 | 深圳市健元医药科技有限公司 | Method for preparing liraglutide |
CN113278054B (en) * | 2021-06-24 | 2023-03-24 | 安徽大学 | Cyclic peptide combined with new coronavirus RBD site as well as preparation method and application thereof |
CN113480633B (en) * | 2021-08-04 | 2023-08-25 | 成都诺和晟泰生物科技有限公司 | Preparation method of tidulcin |
CN113861273B (en) * | 2021-12-06 | 2022-03-25 | 浙江湃肽生物有限公司深圳分公司 | Synthesis method of myristoyl pentapeptide-4 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6268343B1 (en) * | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
WO2012062803A1 (en) * | 2010-11-09 | 2012-05-18 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
WO2013037266A1 (en) * | 2011-09-14 | 2013-03-21 | 深圳翰宇药业股份有限公司 | Method for solid phase synthesis of liraglutide |
-
2014
- 2014-06-09 WO PCT/IN2014/000384 patent/WO2014199397A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6268343B1 (en) * | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
WO2012062803A1 (en) * | 2010-11-09 | 2012-05-18 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
WO2013037266A1 (en) * | 2011-09-14 | 2013-03-21 | 深圳翰宇药业股份有限公司 | Method for solid phase synthesis of liraglutide |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107286234A (en) * | 2016-03-31 | 2017-10-24 | 深圳翰宇药业股份有限公司 | A kind of method for reducing and/or removing default peptide in Solid-phase synthesis peptides |
CN107286234B (en) * | 2016-03-31 | 2021-06-08 | 深圳翰宇药业股份有限公司 | Method for reducing and/or removing default peptide in polypeptide solid phase synthesis |
CN107903318A (en) * | 2017-12-29 | 2018-04-13 | 江苏诺泰澳赛诺生物制药股份有限公司 | A kind of method for purifying Liraglutide |
Also Published As
Publication number | Publication date |
---|---|
WO2014199397A2 (en) | 2014-12-18 |
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