WO2011095989A3 - An improved process for the preparation of enfuvirtide - Google Patents

An improved process for the preparation of enfuvirtide Download PDF

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Publication number
WO2011095989A3
WO2011095989A3 PCT/IN2011/000074 IN2011000074W WO2011095989A3 WO 2011095989 A3 WO2011095989 A3 WO 2011095989A3 IN 2011000074 W IN2011000074 W IN 2011000074W WO 2011095989 A3 WO2011095989 A3 WO 2011095989A3
Authority
WO
WIPO (PCT)
Prior art keywords
enfuvirtide
preparation
improved process
fragments
synthesized
Prior art date
Application number
PCT/IN2011/000074
Other languages
French (fr)
Other versions
WO2011095989A2 (en
Inventor
Ananda Kuppanna
Maria Bhaskar Reddy Komma Reddy
Debashish Datta
Original Assignee
Matrix Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Laboratories Ltd filed Critical Matrix Laboratories Ltd
Publication of WO2011095989A2 publication Critical patent/WO2011095989A2/en
Publication of WO2011095989A3 publication Critical patent/WO2011095989A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to a novel process for the synthesis of Enfuvirtide or pharmaceutically acceptable salts by using a hybrid approach. The fragments are synthesized by solid phase synthesis approach and the Enfuvirtide is synthesized by making use of the fragments in solution phase.
PCT/IN2011/000074 2010-02-04 2011-02-02 An improved process for the preparation of enfuvirtide WO2011095989A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN283/CHE/2010 2010-02-04
IN283CH2010 2010-02-04

Publications (2)

Publication Number Publication Date
WO2011095989A2 WO2011095989A2 (en) 2011-08-11
WO2011095989A3 true WO2011095989A3 (en) 2012-01-12

Family

ID=44355890

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2011/000074 WO2011095989A2 (en) 2010-02-04 2011-02-02 An improved process for the preparation of enfuvirtide

Country Status (1)

Country Link
WO (1) WO2011095989A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111825742B (en) * 2019-04-18 2024-01-30 陈铭 Polypeptide solid phase synthesis of CTPA as special coupling agent for amino acid ionic liquid

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464933A (en) * 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission
WO1999048513A1 (en) * 1998-03-23 1999-09-30 Trimeris, Inc. Methods and compositions for peptide synthesis
WO2005089796A1 (en) * 2004-03-15 2005-09-29 Trimeris, Inc. Site-specific chemical modification of hiv gp41-derived peptides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464933A (en) * 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission
WO1999048513A1 (en) * 1998-03-23 1999-09-30 Trimeris, Inc. Methods and compositions for peptide synthesis
WO2005089796A1 (en) * 2004-03-15 2005-09-29 Trimeris, Inc. Site-specific chemical modification of hiv gp41-derived peptides

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BRAY B L: "LARGE-SCALE MANUFACTURE OF PEPTIDE THERAPEUTICS BY CHEMICAL SYNTHESIS", NATURE REVIEWS. DRUG DISCOVERY, NATURE PUBLISHING GROUP, GB, vol. 2, no. 7, 1 July 2003 (2003-07-01), pages 587 - 593, XP009046605, ISSN: 1474-1784, DOI: 10.1038/NRD1133 *
LAWLESS M K ET AL: "HIV-1 MEMBRANE FUSION MECHANISM: STRUCTURAL STUDIES OF THE INTERACTIONS BETWEEN BIOLOGICALLY-ACTIVE PEPTIDES FROM GP41", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 35, no. 42, 22 October 1996 (1996-10-22), pages 13697 - 13708, XP002059093, ISSN: 0006-2960, DOI: 10.1021/BI9606962 *
LEE ET AL: "Application of AM SURE(TM) resin to solid-phase peptide synthesis", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 46, no. 42, 17 October 2005 (2005-10-17), pages 7135 - 7138, XP005077503, ISSN: 0040-4039, DOI: 10.1016/J.TETLET.2005.08.093 *
NAKAMURA M ET AL: "DESIGN AND SYNTHESIS OF HIGHLY ACTIVE ANTI-HIV PEPTIDE BASED ON GP41-C34 PEPTIDE", PEPTIDE SCIENCE, PROTEIN RESEARCH FOUNDATION, MINOO, JP, 3 October 2001 (2001-10-03), pages 73 - 76, XP008018872, ISSN: 1344-7661 *

Also Published As

Publication number Publication date
WO2011095989A2 (en) 2011-08-11

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