WO2014195520A3 - Polypeptides with permease activity - Google Patents

Polypeptides with permease activity Download PDF

Info

Publication number
WO2014195520A3
WO2014195520A3 PCT/EP2014/063068 EP2014063068W WO2014195520A3 WO 2014195520 A3 WO2014195520 A3 WO 2014195520A3 EP 2014063068 W EP2014063068 W EP 2014063068W WO 2014195520 A3 WO2014195520 A3 WO 2014195520A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptides
permease activity
polypeptide
permease
activity
Prior art date
Application number
PCT/EP2014/063068
Other languages
French (fr)
Other versions
WO2014195520A2 (en
Inventor
Paul Klaassen
Paulus Petrus DE WAAL
René Marcel de Jong
Arnold Jacob Mattieu Driessen
Jeroen Gerben Nijland
Hyun Yong Shin
Original Assignee
Dsm Ip Assets B.V.
Rijksuniversiteit Groningen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets B.V., Rijksuniversiteit Groningen filed Critical Dsm Ip Assets B.V.
Publication of WO2014195520A2 publication Critical patent/WO2014195520A2/en
Publication of WO2014195520A3 publication Critical patent/WO2014195520A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The invention relates to a polypeptide having one or more substitution corresponding to F85T/A/C/H/M/N, T89H/D/C/A/N, V187T/C/D/E/F/G/H/K/M/Q/R/S/W/Y, A191N/G/P/ C/D/F/H/I/K/Q/V/W/Y, Y214V/Q/G/L/M/N/P/R/S, Q215L/M/I/A/C/D/F/S, I218K/N/A/C/D/E/H/L, T219G/F/D/N, I222D/C/H/E/G/P/S/V/Y, Y226D/M/R/C/G/H/I/L/P/Q/T/W, Q338C/E/F/D/G/I/P/R/S/T/V/W/Y, M339N/V/D/E/H/K/P/Q/R/Y, Q341T/M/N/S/Y, Q342Y/S/C/A/D/F/G/H/I/K/L/N/P/R/T/V/W, L343K/R/P/C/D/E/G/H/I/M/N/Q/S/T/Y, N346W/Y/F/G/H/K/L/M/R/T, N347A/I/E/H/L, Y350R/L/T/D/K/M/N/V, G373L/E/N /F/K/M/R/V/W/Y, N376I/T/M/A/C/E/F/H/K/L/P/Q/R/V/W/Y, T380M/F/H/N/P/Q/R/S/V, S383Q/T/C/D/E/F/I/K/L/M/R/V/W/Y, F444Y/D/E/H/K/N/P/Q/R/W, F446Q/L/H/D/E/I/M/N, T448M/H/D/E/F/K/R/W/Y, T449F/M/N/S/D/E/G/H/I/K/L/P/Q/R/V/W/Y, T451I/E/C/D/F/H/K/L/M/N/Q/R/S/T/V/W/Y, W455T/N/A/C/E/L/P/Q/T, N478P/F/V/G/I/K/R/W, or W479T/S/Q/D/E/F/G/H/I/M/N/P/R/V/Y of SEQ ID NO:59, wherein the polypeptide is a member of the Major Facilitator Superfamily (MFS).
PCT/EP2014/063068 2013-12-18 2014-06-20 Polypeptides with permease activity WO2014195520A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP13197988.2 2013-12-18
EP13197988 2013-12-18
EP14160772.1 2014-03-19
EP14160772 2014-03-19
EP14164270.2 2014-04-10
EP14164270 2014-04-10

Publications (2)

Publication Number Publication Date
WO2014195520A2 WO2014195520A2 (en) 2014-12-11
WO2014195520A3 true WO2014195520A3 (en) 2015-02-26

Family

ID=50979778

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/EP2014/063068 WO2014195520A2 (en) 2013-12-18 2014-06-20 Polypeptides with permease activity
PCT/EP2014/063070 WO2014195522A2 (en) 2013-12-18 2014-06-20 Polypeptides with permease activity
PCT/EP2014/063069 WO2014195521A2 (en) 2013-12-18 2014-06-20 Polypeptides with permease activity

Family Applications After (2)

Application Number Title Priority Date Filing Date
PCT/EP2014/063070 WO2014195522A2 (en) 2013-12-18 2014-06-20 Polypeptides with permease activity
PCT/EP2014/063069 WO2014195521A2 (en) 2013-12-18 2014-06-20 Polypeptides with permease activity

Country Status (1)

Country Link
WO (3) WO2014195520A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019096718A1 (en) * 2017-11-14 2019-05-23 Dsm Ip Assets B.V. Polypeptides with improved arabinose transport specificity
CA3130763A1 (en) 2019-02-25 2020-09-03 Ginkgo Bioworks, Inc. Biosynthesis of cannabinoids and cannabinoid precursors
US20230037234A1 (en) * 2019-11-27 2023-02-02 Genomatica, Inc. ENGINEERED CELLS FOR PRODUCTION OF CANNABINOIDS AND OTHER MALONYL-CoA-DERIVED PRODUCTS

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012049173A1 (en) * 2010-10-13 2012-04-19 Dsm Ip Assets B.V. Polypeptides with permease activity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012006939A2 (en) * 2009-09-29 2015-09-08 Butamax Tm Advanced Biofuels Recombinant yeast production host cell and method for producing a product selected from the group consisting of 2,3-butanediol, isobutanol, 2-butanol, 1-butanol, 2-butanone, valine, leucine, lactic acid, malic acid , alcohol, isoampyl and isoprenoids

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012049173A1 (en) * 2010-10-13 2012-04-19 Dsm Ip Assets B.V. Polypeptides with permease activity

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DATABASE Protein [online] 1 May 2013 (2013-05-01), XP002714348, Database accession no. P40886 *
DATABASE UniProt [online] 3 April 2013 (2013-04-03), XP002714345, Database accession no. G0W6D0 *
DATABASE UniProt [online] 3 April 2013 (2013-04-03), XP002714346, Database accession no. G0VKG3 *
JONATHAN L GORDON ET AL: "Evolutionary erosion of yeast sex chromosomes by mating-type switching accidents", 13 December 2011, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, PAGE(S) 20024 - 20029, ISSN: 0027-8424, XP002714344 *
KASAHARA MICHIHIRO ET AL: "Amino acid residues responsible for galactose recognition in yeast Gal2 transporter", 1997, JOURNAL OF BIOLOGICAL CHEMISTRY, VOL. 272, NR. 27, PAGE(S) 16721-16724, ISSN: 0021-9258, XP002727810 *
KASAHARA: "Three aromatic amino acid residues critical for galactose transport in yeast Gal2 transporter.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 6, 1 February 2000 (2000-02-01), pages 4422 - 4428, XP055017377, ISSN: 0021-9258 *
MICHELINE VANDENBOL ET AL: "X. Yeast sequencing reports. Sequence analysis of a 40.2 kb DNA fragment located near the left telomere of yeast chromosome X", 1 December 1994, YEAST, JOHN WILEY & SONS LTD, GB, PAGE(S) 1657 - 1662, ISSN: 0749-503X, XP002714347 *
NELISSEN BART ET AL: "Classification of all putative permeases and other membrane plurispanners of the major facilitator superfamily encoded by the complete genome of Saccharomyces cerevisiae", 1997, FEMS MICROBIOLOGY REVIEWS, VOL. 21, NR. 2, PAGE(S) 113-134, ISSN: 0168-6445, XP002714218 *

Also Published As

Publication number Publication date
WO2014195521A2 (en) 2014-12-11
WO2014195520A2 (en) 2014-12-11
WO2014195521A3 (en) 2015-02-19
WO2014195522A3 (en) 2015-03-05
WO2014195522A2 (en) 2014-12-11

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