WO2014195381A3 - Polypeptides with permease activity - Google Patents

Polypeptides with permease activity Download PDF

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Publication number
WO2014195381A3
WO2014195381A3 PCT/EP2014/061640 EP2014061640W WO2014195381A3 WO 2014195381 A3 WO2014195381 A3 WO 2014195381A3 EP 2014061640 W EP2014061640 W EP 2014061640W WO 2014195381 A3 WO2014195381 A3 WO 2014195381A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptides
permease activity
aminoacid
polypeptide
substitution
Prior art date
Application number
PCT/EP2014/061640
Other languages
French (fr)
Other versions
WO2014195381A2 (en
Inventor
Paul Klaassen
Paulus Petrus DE WAAL
René Marcel de Jong
Original Assignee
Dsm Ip Assets B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets B.V. filed Critical Dsm Ip Assets B.V.
Publication of WO2014195381A2 publication Critical patent/WO2014195381A2/en
Publication of WO2014195381A3 publication Critical patent/WO2014195381A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces

Abstract

The invention relates to a polypeptide having one or more substitution at a position corresponding to position 339 or 376 of SEQ ID NO: 59, wherein the polypeptide is a member of the Major Facilitator Superfamily (MFS). In an embodiment, the substitution is at position corresponding to 376 and wherein the aminoacid at that position is replaced by an aminoacid that has a van der Waals volume of 80 to 138Å3 and a side chain hydrophobicity of 10 to 100 ∆tR.
PCT/EP2014/061640 2013-06-05 2014-06-04 Polypeptides with permease activity WO2014195381A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13170648 2013-06-05
EP13170648.3 2013-06-05

Publications (2)

Publication Number Publication Date
WO2014195381A2 WO2014195381A2 (en) 2014-12-11
WO2014195381A3 true WO2014195381A3 (en) 2015-02-05

Family

ID=48537895

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2014/061640 WO2014195381A2 (en) 2013-06-05 2014-06-04 Polypeptides with permease activity

Country Status (2)

Country Link
AR (1) AR096537A1 (en)
WO (1) WO2014195381A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011041426A1 (en) * 2009-09-29 2011-04-07 Butamax(Tm) Advanced Biofuels Llc Improved yeast production host cells
WO2012049173A1 (en) * 2010-10-13 2012-04-19 Dsm Ip Assets B.V. Polypeptides with permease activity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011041426A1 (en) * 2009-09-29 2011-04-07 Butamax(Tm) Advanced Biofuels Llc Improved yeast production host cells
WO2012049173A1 (en) * 2010-10-13 2012-04-19 Dsm Ip Assets B.V. Polypeptides with permease activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NELISSEN BART ET AL: "Classification of all putative permeases and other membrane plurispanners of the major facilitator superfamily encoded by the complete genome of Saccharomyces cerevisiae", 1997, FEMS MICROBIOLOGY REVIEWS, VOL. 21, NR. 2, PAGE(S) 113-134, ISSN: 0168-6445, XP002714218 *

Also Published As

Publication number Publication date
AR096537A1 (en) 2016-01-13
WO2014195381A2 (en) 2014-12-11

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