WO2014184723A3 - Compositions and methods for the treatment of cardiovascular diseases and lipid disorders - Google Patents

Compositions and methods for the treatment of cardiovascular diseases and lipid disorders Download PDF

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Publication number
WO2014184723A3
WO2014184723A3 PCT/IB2014/061366 IB2014061366W WO2014184723A3 WO 2014184723 A3 WO2014184723 A3 WO 2014184723A3 IB 2014061366 W IB2014061366 W IB 2014061366W WO 2014184723 A3 WO2014184723 A3 WO 2014184723A3
Authority
WO
WIPO (PCT)
Prior art keywords
formula
treatment
compositions
methods
cardiovascular diseases
Prior art date
Application number
PCT/IB2014/061366
Other languages
French (fr)
Other versions
WO2014184723A2 (en
Inventor
Mahesh Kandula
Original Assignee
Mahesh Kandula
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mahesh Kandula filed Critical Mahesh Kandula
Publication of WO2014184723A2 publication Critical patent/WO2014184723A2/en
Publication of WO2014184723A3 publication Critical patent/WO2014184723A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
    • C07C59/19—Pyruvic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/03—Monocarboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II, and methods for the treatment of cardiovascular diseases and lipid disorders may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of hypertriglyceridemia, arthritis, chronic aneurysm, angina, atherosclerosis, cerebrovascular accident (stroke), cerebrovascular disease, congestive heart failure, coronary artery disease, myocardial infarction.
PCT/IB2014/061366 2013-05-12 2014-05-11 Compositions and methods for the treatment of cardiovascular diseases and lipid disorders WO2014184723A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2106CH2013 2013-05-12
IN2106/CHE/2013 2013-05-12

Publications (2)

Publication Number Publication Date
WO2014184723A2 WO2014184723A2 (en) 2014-11-20
WO2014184723A3 true WO2014184723A3 (en) 2015-04-02

Family

ID=51898934

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2014/061366 WO2014184723A2 (en) 2013-05-12 2014-05-11 Compositions and methods for the treatment of cardiovascular diseases and lipid disorders

Country Status (1)

Country Link
WO (1) WO2014184723A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080200725A1 (en) * 2007-02-20 2008-08-21 Macdougall Joseph Preparation of amino acid-fatty acid anhydrides
WO2011106688A1 (en) * 2010-02-26 2011-09-01 Catabasis Pharmaceuticals, Inc. Bis-fatty acid conjugates and their uses
WO2012154554A1 (en) * 2011-05-06 2012-11-15 Catabasis Pharmaceuticals, Inc. Fatty acid triterpene derivatives and their uses
US20130059801A1 (en) * 2011-08-31 2013-03-07 Catabasis Pharmaceuticals, Inc. Fatty acid amides, compositions and methods of use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080200725A1 (en) * 2007-02-20 2008-08-21 Macdougall Joseph Preparation of amino acid-fatty acid anhydrides
WO2011106688A1 (en) * 2010-02-26 2011-09-01 Catabasis Pharmaceuticals, Inc. Bis-fatty acid conjugates and their uses
WO2012154554A1 (en) * 2011-05-06 2012-11-15 Catabasis Pharmaceuticals, Inc. Fatty acid triterpene derivatives and their uses
US20130059801A1 (en) * 2011-08-31 2013-03-07 Catabasis Pharmaceuticals, Inc. Fatty acid amides, compositions and methods of use

Also Published As

Publication number Publication date
WO2014184723A2 (en) 2014-11-20

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