WO2015028976A3 - Compounds and methods for the treatment of inflammatory diseases - Google Patents

Compounds and methods for the treatment of inflammatory diseases Download PDF

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Publication number
WO2015028976A3
WO2015028976A3 PCT/IB2014/064138 IB2014064138W WO2015028976A3 WO 2015028976 A3 WO2015028976 A3 WO 2015028976A3 IB 2014064138 W IB2014064138 W IB 2014064138W WO 2015028976 A3 WO2015028976 A3 WO 2015028976A3
Authority
WO
WIPO (PCT)
Prior art keywords
formula
compounds
treatment
methods
inflammatory diseases
Prior art date
Application number
PCT/IB2014/064138
Other languages
French (fr)
Other versions
WO2015028976A2 (en
Inventor
Mahesh Kandula
Original Assignee
Mahesh Kandula
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mahesh Kandula filed Critical Mahesh Kandula
Publication of WO2015028976A2 publication Critical patent/WO2015028976A2/en
Publication of WO2015028976A3 publication Critical patent/WO2015028976A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
    • C07C245/06—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings
    • C07C245/08—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings with the two nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings, e.g. azobenzene

Abstract

The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II, and methods for the treatment of inflammatory diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, arthritis and psoriatic arthritis.
PCT/IB2014/064138 2013-08-30 2014-08-29 Compounds and methods for the treatment of inflammatory diseases WO2015028976A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3907CH2013 2013-08-30
IN3907/CHE/2013 2013-08-30

Publications (2)

Publication Number Publication Date
WO2015028976A2 WO2015028976A2 (en) 2015-03-05
WO2015028976A3 true WO2015028976A3 (en) 2015-05-21

Family

ID=52587436

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2014/064138 WO2015028976A2 (en) 2013-08-30 2014-08-29 Compounds and methods for the treatment of inflammatory diseases

Country Status (1)

Country Link
WO (1) WO2015028976A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230107927A1 (en) 2020-02-28 2023-04-06 First Wave Bio, Inc. Methods of treating iatrogenic autoimmune colitis
CN115611760A (en) * 2022-10-13 2023-01-17 天津药明康德新药开发有限公司 Chemical synthesis method suitable for large-scale production of (S) -2-amino-5-alkynyl caproic acid

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003421A1 (en) * 1993-07-19 1995-02-02 Dsm N.V. Process for the enzymatic preparation of optically active n-substituted-3-pyrrolidinol
WO2000012087A1 (en) * 1998-08-31 2000-03-09 Bobrove Arthur M Method for treating hot flashes in humans
WO2009021965A2 (en) * 2007-08-15 2009-02-19 Glaxo Group Limited Substituted quinoline derivatives as h1 receptor antagonists

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003421A1 (en) * 1993-07-19 1995-02-02 Dsm N.V. Process for the enzymatic preparation of optically active n-substituted-3-pyrrolidinol
WO2000012087A1 (en) * 1998-08-31 2000-03-09 Bobrove Arthur M Method for treating hot flashes in humans
WO2009021965A2 (en) * 2007-08-15 2009-02-19 Glaxo Group Limited Substituted quinoline derivatives as h1 receptor antagonists

Also Published As

Publication number Publication date
WO2015028976A2 (en) 2015-03-05

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