WO2014160940A3 - Composés de furane, pyrrole et thiophène lipidiques pour le traitement du cancer, de troubles neurologiques et de troubles fibrotiques - Google Patents

Composés de furane, pyrrole et thiophène lipidiques pour le traitement du cancer, de troubles neurologiques et de troubles fibrotiques Download PDF

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Publication number
WO2014160940A3
WO2014160940A3 PCT/US2014/032177 US2014032177W WO2014160940A3 WO 2014160940 A3 WO2014160940 A3 WO 2014160940A3 US 2014032177 W US2014032177 W US 2014032177W WO 2014160940 A3 WO2014160940 A3 WO 2014160940A3
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WO
WIPO (PCT)
Prior art keywords
disorders
cancer
treatment
pyrrole
fibrotic
Prior art date
Application number
PCT/US2014/032177
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English (en)
Other versions
WO2014160940A2 (fr
Inventor
Richard Huber
Original Assignee
Avoscience, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avoscience, Llc filed Critical Avoscience, Llc
Priority to AU2014240950A priority Critical patent/AU2014240950B2/en
Priority to CA2908505A priority patent/CA2908505A1/fr
Priority to EP14772672.3A priority patent/EP2978422A4/fr
Priority to CN201480019528.1A priority patent/CN105209037A/zh
Priority to JP2016505591A priority patent/JP6532860B2/ja
Publication of WO2014160940A2 publication Critical patent/WO2014160940A2/fr
Publication of WO2014160940A3 publication Critical patent/WO2014160940A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/36—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/08—Hydrogen atoms or radicals containing only hydrogen and carbon atoms
    • C07D333/10—Thiophene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des composés, des procédés et des compositions pour le traitement du cancer, de troubles neurologiques et de troubles fibrotiques. De façon spécifique, l'invention comprend l'administration d'une quantité efficace d'un composé de formule I, II ou III, ou d'une composition pharmaceutiquement acceptable, d'un sel pharmaceutiquement acceptable, d'un analogue isotopique pharmaceutiquement acceptable, d'un promédicament pharmaceutiquement acceptable, ou d'une combinaison de ceux-ci, à un sujet souffrant d'un cancer, de trouble neurologique ou de trouble fibrotique.
PCT/US2014/032177 2013-03-29 2014-03-28 Composés de furane, pyrrole et thiophène lipidiques pour le traitement du cancer, de troubles neurologiques et de troubles fibrotiques WO2014160940A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2014240950A AU2014240950B2 (en) 2013-03-29 2014-03-28 Lipidic furan, pyrrole, and thiophene compounds for treatment of cancer, neurological disorders, and fibrotic disorders
CA2908505A CA2908505A1 (fr) 2013-03-29 2014-03-28 Composes de furane, pyrrole et thiophene lipidiques pour le traitement du cancer, de troubles neurologiques et de troubles fibrotiques
EP14772672.3A EP2978422A4 (fr) 2013-03-29 2014-03-28 Composés de furane, pyrrole et thiophène lipidiques pour le traitement du cancer, de troubles neurologiques et de troubles fibrotiques
CN201480019528.1A CN105209037A (zh) 2013-03-29 2014-03-28 用于治疗癌症、神经障碍和纤维化病症的脂类呋喃、吡咯和噻吩化合物
JP2016505591A JP6532860B2 (ja) 2013-03-29 2014-03-28 癌、神経障害及び線維性障害の治療のための、脂質フラン、ピロール及びチオフェン化合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361853163P 2013-03-29 2013-03-29
US61/853,163 2013-03-29

Publications (2)

Publication Number Publication Date
WO2014160940A2 WO2014160940A2 (fr) 2014-10-02
WO2014160940A3 true WO2014160940A3 (fr) 2014-12-31

Family

ID=51625685

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PCT/US2014/032177 WO2014160940A2 (fr) 2013-03-29 2014-03-28 Composés de furane, pyrrole et thiophène lipidiques pour le traitement du cancer, de troubles neurologiques et de troubles fibrotiques

Country Status (7)

Country Link
US (6) US9371302B2 (fr)
EP (1) EP2978422A4 (fr)
JP (1) JP6532860B2 (fr)
CN (2) CN111285841A (fr)
AU (1) AU2014240950B2 (fr)
CA (1) CA2908505A1 (fr)
WO (1) WO2014160940A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014160940A2 (fr) 2013-03-29 2014-10-02 Avoscience, Llc Composés de furane, pyrrole et thiophène lipidiques pour le traitement du cancer, de troubles neurologiques et de troubles fibrotiques
US20170312246A1 (en) 2016-04-27 2017-11-02 Avoscience, Llc Lipidic furan, pyrrole, and thiophene compounds for use in the treatment of atrophic vaginitis
KR102221789B1 (ko) * 2019-06-27 2021-03-02 재단법인대구경북과학기술원 2-펜틸퓨란을 유효성분으로 함유하는 퇴행성 뇌질환 치료용 조성물
CN110859836B (zh) * 2019-11-29 2022-04-15 南京林业大学 灵菌红素在制备淋巴管肌瘤病细胞增殖抑制剂中的应用
CA3207296A1 (fr) * 2021-01-06 2022-07-14 The Penn State Research Foundation Methodes et materiaux de traitement contre la perte de cheveux

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US6960594B2 (en) * 1998-06-29 2005-11-01 Shire Biochem Inc. Thiophene and furan 2,5-dicarboxamides useful in the treatment of cancer
WO2007032591A1 (fr) * 2005-09-13 2007-03-22 Industry-Academic Cooperation Foundation, Yeungnam University Composition comprenant 1-furan-2-yl-3-pyridine-2-yl-propenone presentant une activite anti-angiogenique et une activite inhibitrice du cancer
US7375105B2 (en) * 2001-09-05 2008-05-20 Smithkline Beecham P.L.C. Pyridine substituted furan derivatives as Raf kinase inhibitors
WO2008080986A1 (fr) * 2006-12-28 2008-07-10 Neuropharma, S.A. Dérivés du furane, leur procédé de synthèse et leurs utilisations

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CA1339784C (fr) 1988-06-23 1998-03-31 Shinya Inoue Derives de l'acide pyrrolecarboxylique
FR2678614A1 (fr) * 1991-07-03 1993-01-08 Pharmascience Lab Compose presentant une activite en tant qu'inhibiteur de la collagenase et medicament le contenant.
US5514709A (en) 1993-10-25 1996-05-07 Conkle & Olsten Lipidic furans and retinol palmitate compositions useful for skin therapeutics
US5468490A (en) * 1993-10-25 1995-11-21 Conkle & Olesten Lipidic furans useful for skin therapeutics
US6166003A (en) * 1999-02-17 2000-12-26 Lkt Laboratories, Inc. Heterocyclic compounds for cancer chemoprevention
FR2798667B1 (fr) 1999-09-22 2001-12-21 Pharmascience Lab Procede d'extraction des composes furaniques et alcools gras polyhydroxyles de l'avocat, composition a base de et utilisation de ces composes en therapeutique, cosmetique et alimentaire
US6734207B2 (en) * 2001-04-20 2004-05-11 Parker Hughes Institute Cytotoxic compounds
WO2004016106A1 (fr) 2002-07-29 2004-02-26 Laboratoires Expanscience Procede d'obtention d'un insaponifiable d'avocat riche en lipides furaniques
US20060018937A1 (en) 2002-10-25 2006-01-26 Foamix Ltd. Steroid kit and foamable composition and uses thereof
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FR2870742B1 (fr) 2004-05-28 2008-03-14 Expanscience Laboratoires Sa Utilisation d'alkyle furannes pour la preparation d'un medicament destine au traitement du diabete, de l'obesite et pour le traitement cosmetique de la cellulite et de la surcharge ponderale
WO2006004759A2 (fr) 2004-06-29 2006-01-12 Mcclellan Stephanie N Compositions topiques anti-age et leurs methodes d'utilisation
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WO2014160940A2 (fr) 2013-03-29 2014-10-02 Avoscience, Llc Composés de furane, pyrrole et thiophène lipidiques pour le traitement du cancer, de troubles neurologiques et de troubles fibrotiques
US20170312246A1 (en) 2016-04-27 2017-11-02 Avoscience, Llc Lipidic furan, pyrrole, and thiophene compounds for use in the treatment of atrophic vaginitis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4427693A (en) * 1981-08-05 1984-01-24 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-α,α-bis (polyhalomethyl)-2-thiophenemethanamines
US6960594B2 (en) * 1998-06-29 2005-11-01 Shire Biochem Inc. Thiophene and furan 2,5-dicarboxamides useful in the treatment of cancer
US7375105B2 (en) * 2001-09-05 2008-05-20 Smithkline Beecham P.L.C. Pyridine substituted furan derivatives as Raf kinase inhibitors
WO2007032591A1 (fr) * 2005-09-13 2007-03-22 Industry-Academic Cooperation Foundation, Yeungnam University Composition comprenant 1-furan-2-yl-3-pyridine-2-yl-propenone presentant une activite anti-angiogenique et une activite inhibitrice du cancer
WO2008080986A1 (fr) * 2006-12-28 2008-07-10 Neuropharma, S.A. Dérivés du furane, leur procédé de synthèse et leurs utilisations

Non-Patent Citations (2)

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Title
"Toxicology and carcinogenesis studies of furan (CAS No. 110-00-9) in F344/N RATS and B6C3F1 mice (gavage studies).", NATIONAL TOXICOLOGY PROGRAM TECHNICAL REPORT SERIES NO. 402, January 1993 (1993-01-01), XP055289079, Retrieved from the Internet <URL:http://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr402.pdf> [retrieved on 20141015] *
DATABASE PUBCHEM [online] 16 September 2004 (2004-09-16), "FURAN", XP055290826, accession no. NCBI Database accession no. CID 8029 *

Also Published As

Publication number Publication date
EP2978422A4 (fr) 2017-04-05
CN105209037A (zh) 2015-12-30
CN111285841A (zh) 2020-06-16
JP6532860B2 (ja) 2019-06-19
US10525031B2 (en) 2020-01-07
JP2016515585A (ja) 2016-05-30
US20200237709A1 (en) 2020-07-30
US20140309274A1 (en) 2014-10-16
AU2014240950B2 (en) 2018-11-01
US20180050013A1 (en) 2018-02-22
CA2908505A1 (fr) 2014-10-02
AU2014240950A1 (en) 2015-10-22
EP2978422A2 (fr) 2016-02-03
US9814694B2 (en) 2017-11-14
US20210137876A1 (en) 2021-05-13
US11058663B2 (en) 2021-07-13
WO2014160940A2 (fr) 2014-10-02
US11833129B2 (en) 2023-12-05
US10085962B2 (en) 2018-10-02
US20160263080A1 (en) 2016-09-15
US9371302B2 (en) 2016-06-21
US20180360798A1 (en) 2018-12-20

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