WO2014146598A1

WO2014146598A1 - Freeze dryer

Info

Publication number: WO2014146598A1
Application number: PCT/CN2014/073827
Authority: WO
Inventors: 李兴波; 潘宝峰; 翁宽; 许海兵; 康峰
Original assignee: 楚天科技股份有限公司
Priority date: 2013-03-21
Filing date: 2014-03-21
Publication date: 2014-09-25
Also published as: CN103123206A; CN103900351A; CN103900352B; CN103900352A; CN103900351B; CN203869422U; CN203837417U

Abstract

A freeze dryer, comprising a freeze-drying chamber (1) and a cold trap chamber (5); the freeze-drying chamber (1) is provided with a support plate (2) and multiple freeze-drying plate layers (3) located above the support plate (2); the support plate (2) is connected to a lift drive component (4) for lifting the support plate (2) and the freeze-drying plate layer (3); the freeze-drying chamber (1) is located above the cold trap chamber (5), and communicates with the cold trap chamber (5) via a through hole (9) arranged at the bottom of the freeze-drying chamber (1); and the cold trap chamber (5) or the freeze-drying chamber (1) is provided with a seal for covering the through hole (9) to separate the freeze-drying chamber (1) from the cold trap chamber (5). The freeze dryer has a simple structure, low cost, small footprint, and low pollution risk.

Description

Freeze dryer

[Technical Field]

The invention mainly relates to the field of food and medical packaging machinery, and particularly relates to a lyophilizer.

【Background technique】

In the field of food and pharmaceutical packaging machinery, the freeze-drying box and the cold trap of the traditional freeze-drying machine generally adopt a split structure, and are arranged side by side horizontally, that is, the freeze-drying box and the cold trap are two independent containers, between the two It is connected by a pipe connection and has an independent on-off valve. The lyophilizer has the following disadvantages: 1. The freeze-drying box and the cold trap are connected by a connecting pipe, and the connecting pipe needs to open a large hole in the lyophilizing box and the cold trap, and the large flange is connected and connected, and the connecting pipe is to be connected and connected in the middle. Valves, resulting in complicated structure, high cost, and difficult manufacturing and assembly, the drive cylinder of the on-off valve will also pollute the product; 2. The freeze-drying box and the cold trap are two independent containers arranged horizontally side by side, and the manufacturing cost is high. It takes up a lot of space and is inconvenient to assemble and transport.

[Summary of the Invention]

The technical problem to be solved by the present invention is to provide a lyophilizer with simple structure, low cost, small space occupation and low risk of pollution in view of the deficiencies of the prior art.

In order to solve the above technical problems, the present invention adopts the following technical solutions:

A lyophilizer comprising a lyophilization chamber and a cold trap chamber, wherein the lyophilization chamber is provided with a support plate and a plurality of lyophilized plate layers above the support plate, wherein the support plate is connected to the lyophilization chamber for use a lifting drive member for driving the lifting plate and the lyophilized plate layer, wherein the lyophilization chamber is located above the cold trap chamber, and the lyophilization chamber and the cold trap chamber are communicated through a through hole provided at a bottom of the lyophilization chamber. The cold trap chamber or lyophilization chamber is provided with a seal for covering the through hole to isolate the freeze dry chamber from the cold trap chamber.

As a further improvement of the above technical solution:

The lyophilization chamber and the cold trap chamber are separated by an integral cavity, and the integral cavity is provided with a partition separating the whole cavity into a lyophilization chamber and a cold trap chamber, and the through hole is opened on the partition plate.

The partitions are arranged horizontally.

The lifting drive member is mounted on the lyophilization chamber or the cold trap chamber, the sealing member is a support plate, and the bottom of the support plate is provided with a sealing ring for contacting and engaging with the partition plate.

The bottom of the cold trap chamber is provided with a drain port.

A coil for cooling is provided in the cold trap chamber.

When the lyophilized plate is laminated, the support plate is lowered to the bottom of the lyophilization chamber and covers the through hole to support the lyophilized layer Support.

When the lifting and lowering driving member is disposed on the cold trap cavity, and the supporting plate is lowered to the bottom of the freeze-drying chamber and covers the through hole, the lifting and lowering driving member drives the supporting plate to be pressed against the periphery of the through hole.

The upper limit plate is disposed above the top layer of the lyophilized layer.

The lifting drive member is disposed on the lyophilization chamber, the sealing member is a sealing plate disposed in the cold trap cavity or the freeze-drying chamber, and the cold trap cavity is provided with a sealing driving member for driving the sealing plate. When the sealing plate covers the through hole, the sealing driving member drives the sealing plate to be pressed against the periphery of the through hole.

When the sealing plate is disposed in the cold trap cavity, the lower end surface of the baffle is provided with a sealing ring that is in contact with the sealing plate; when the sealing plate is disposed in the freeze-drying cavity, the upper end surface of the baffle is provided with a sealing plate Contact mating seals.

When the lyophilized plate is laminated, the support plate is lowered to the bottom of the lyophilization chamber to support the lyophilized layer.

The advantages of the present invention over the prior art are:

1. The lyophilizer of the invention has a lyophilization chamber located above the cold trap chamber, which has a compact structure and a small occupied space;

2. The lyophilizer of the present invention has a lyophilization chamber communicated with the cold trap chamber through the through hole, and can be covered by the support plate to close the lyophilization chamber and the cold trap chamber, so the freeze-dry chamber The switching between the cold trap chamber and the cold trap chamber can be realized by the support plate and the lifting drive member, and it is no longer necessary to provide independent on-off valves and valve cylinders, thereby simplifying the structure, reducing the cost, and avoiding the risk of contamination caused by the valve cylinders, and Optimize the design, manufacture, acceptance, cost control, control procedures, etc. of the freeze dryer;

3. The lyophilizer of the present invention, wherein the lyophilization chamber and the cold trap chamber are separated by a whole cavity, the space can be compressed, the manufacturing material is saved, and the lyophilization chamber and the cold trap chamber can share the inlet and outlet pipes, the safety valve and Drainage port.

4. The lyophilizer according to the present invention, wherein the lifting drive member is disposed on the cold trap cavity, and when the support plate is lowered to the bottom of the freeze-drying chamber and covers the through hole, the lifting drive member applies a downward pulling force to the support plate. The plate is driven to be pressed around the periphery of the through hole to obtain a better sealing and isolation effect, and the pressure rise of the freeze-drying chamber can be measured more accurately, and the lyophilization is accurately determined.

5. The lyophilizer of the present invention, the sealing member is a sealing plate disposed in the cold trap cavity or the freeze-drying cavity, and when the sealing plate covers the through hole, the sealing plate is driven to press the sealing plate against the periphery of the through hole, thereby A better sealing effect can be obtained, which can more accurately measure the pressure rise of the freeze-drying chamber and accurately determine whether the freeze-drying is sufficient.

[Description of the Drawings]

1 is a schematic structural view of a first embodiment of the present invention when a freeze-drying chamber and a cold trap chamber are in a connected state.

2 is a schematic view showing the structure of the lyophilization chamber and the cold trap chamber in an isolated state according to Embodiment 1 of the present invention.

3 is a schematic structural view of the embodiment 2 of the present invention when the freeze-drying chamber and the cold trap chamber are in a connected state.

4 is a schematic view showing the structure of the lyophilization chamber and the cold trap chamber in an isolated state according to Embodiment 2 of the present invention.

FIG. 5 is a schematic structural view of the third embodiment of the present invention when the freeze-drying chamber and the cold trap chamber are in an isolated state. 6 is a schematic view showing the structure of the lyophilization chamber and the cold trap chamber in an isolated state according to Embodiment 3 of the present invention. Legend: 1. Freeze-drying chamber; 2. Support plate; 3. Freeze-dried plate layer; 4. Lifting drive member; 5. Cold trap cavity; 6. Partition; 7. Drainage port; 8. Coil; Through hole; 10, sealing ring; 11, sealing plate; 12, sealing drive member; 13, upper limit plate.

【detailed description】

The invention will be further described in detail below with reference to the drawings and specific embodiments.

Example 1

As shown in Fig. 1, the lyophilizer of the present invention comprises a lyophilization chamber 1 and a cold trap chamber 5, and a coil 8 for cooling is provided in the cold trap chamber 5; a slab 2 is provided in the lyophilization chamber 1 and is located The lyophilized plate layer 3 above the support plate 2 is provided with a lifting drive member 4 for driving the support plate 2 and the lyophilized plate layer 3 to be lifted and lowered. The lifting drive member 4 in the embodiment is a cylinder. . During operation, after the bottle body in the semi-plugged state is lyophilized on the lyophilized layer 3, the support plate 2 and each lyophilized plate layer 3 are lowered by the lifting drive member 4, so that each lyophilized plate The layers 3 are pressed against each other to press the plug on the bottle completely into the mouth of the bottle; the support 2 is lowered to the bottom of the freeze-drying chamber 1 to support the freeze-dried layer 3. The freeze-drying chamber 1 is located above the cold trap chamber 5, and the freeze-drying chamber 1 and the cold trap chamber 5 are connected by a through hole 9 provided at the bottom of the freeze-drying chamber 1; as shown in Fig. 2, when the support plate 2 is driven by the lift When the member 4 is driven down to the bottom of the freeze-drying chamber 1, the through hole 9 can be covered to isolate the freeze-drying chamber 1 from the cold trap chamber 5.

In this embodiment, the freeze-drying chamber 1 and the cold trap chamber 5 are separated by a whole cavity, and the whole chamber is provided with a partition 6 separating the whole cavity into the freeze-drying chamber 1 and the cold trap chamber 5, and the partition plate 6 is laterally It is arranged such that the lyophilization chamber 1 and the cold trap chamber 5 are arranged one above the other, and the through hole 9 is opened on the partition plate 6. When the coil 8 is defrosted, the freeze-drying chamber 1 needs to be separated from the cold trap chamber 5. At this time, the support plate 2 can be driven by the lifting and lowering drive member 4 to descend to the bottom of the freeze-drying chamber 1 to be in contact with the partition plate 6. The hole 9 is covered. Therefore, the support plate 2 can be used for supporting the freeze-dried plate layer 3 during the plugging, and can also serve as a valve for the freeze-drying chamber 1 to open and close with the cold trap chamber 5; the lifting and lowering drive member 4 can be used for driving when the plug is pressed. The power can also be driven as a valve for the lyophilization chamber 1 and the cold trap chamber 5 to open and close.

In the present embodiment, the partitions 6 are horizontally arranged to facilitate better contact engagement with the partitions 6 when the support 2 is lowered to the bottom of the freeze-drying chamber 1.

In this embodiment, the bottom of the support plate 2 is provided with a sealing ring 10 for contact engagement with the partition plate 6 to ensure the reliability of the isolation and to provide proper cushioning when the support plate 2 is in contact with the partition plate 6.

In the present embodiment, the bottom of the cold trap chamber 5 is provided with a drain port 7; during operation, the condensed water generated by the freeze-drying chamber 1 and the cold trap chamber 5 is discharged from the drain port 7.

Example 2:

As shown in FIG. 3 and FIG. 4, this embodiment is basically the same as Embodiment 1, except that the seal is in this embodiment. For the sealing plate 11 provided in the cold trap chamber 5, a lower portion of the cold trap chamber 5 is provided with a sealing driving member 12 for driving the sealing plate 11, and when the sealing plate 11 covers the through hole 9, the sealing driving member 12 applies the sealing plate 11 The upward lifting force drives the sealing plate 11 to be pressed against the periphery of the through hole 9, thereby obtaining a better sealing isolation effect, and can more accurately measure the pressure rise of the freeze-drying chamber 1, and accurately determine whether the lyophilization is sufficient (freeze dryer) Mainly to evaporate the water in the mixture in the bottle, seal the freeze-drying chamber 1 before the plugging, and measure the pressure rise of the freeze-drying chamber 1. If the pressure in the freeze-drying chamber 1 is obviously rising, the mixture in the bottle is indicated. The water in the water still evaporates continuously, so that it needs to be further lyophilized. On the contrary, it means that the water in the mixture in the bottle has been fully evaporated, and it can enter the plugging action to complete the sealing of the bottle body). In addition, the lower end surface of the partition plate 6 is provided with a sealing ring 10 which is in contact with the sealing plate 11 to further improve the sealing effect. In other embodiments, when the sealing plate 11 is disposed in the freeze-drying chamber 1, the upper end surface of the partition plate 6 is provided with a sealing ring 10 that is in contact with the sealing plate 11. When the lyophilized ply 3 is plugged, the support 2 is lowered onto the partition 6 at the bottom of the freeze-drying chamber 1 to support the lyophilized ply 3, and the lyophilized ply 3 is pressed against the stopper.

Example 3:

As shown in FIG. 5 and FIG. 6, this embodiment is basically the same as the first embodiment except that: in this embodiment, the lifting drive member 4 is disposed at the bottom of the cold trap cavity 5, and when the support plate 2 is lowered to the freeze-drying chamber 1 When the bottom portion covers the through hole 9, the lifting driving member 4 applies a downward pulling force to the supporting plate 2 to drive the supporting plate 2 to be pressed around the periphery of the through hole 9, thereby obtaining a better sealing isolation effect, which can be more accurately measured. The pressure rise of the freeze-drying chamber 1 accurately determines whether the lyophilization is sufficient. In addition, an upper limit plate 13 is disposed above the top lyophilized layer 3, and when the lifting drive 4 drives the support 2 to move upward until the uppermost bottle moves to the upper limit by the upper limit plate 13, all The tampon of the bottle. The lifting and lowering drive member 4 is a hydraulic push rod, and the cylinder portion of the hydraulic push rod is located in the cold trap chamber 5, so that the telescopic length of the push rod can be shortened, and the smoothing action of the plugging operation can be ensured. In other embodiments, The cylinder of the hydraulic push rod is disposed outside the cold trap chamber 5, so that the occupation of the volume of the cold trap chamber 5 by the hydraulic push rod can be reduced, so that the cold trap chamber 5 can be appropriately reduced, and the space occupied by the whole machine can be reduced.

The above is only a preferred embodiment of the present invention, and the scope of protection of the present invention is not limited to the above embodiments, and all the technical solutions falling under the inventive concept belong to the protection scope of the present invention. It should be noted that a number of modifications and adaptations of the present invention are considered to be within the scope of the present invention without departing from the principles of the invention.

Claims

Rights request

1. A freeze-drying machine, including a freeze-drying chamber (1) and a cold trap chamber (5). The freeze-drying chamber (1) is provided with a support plate (2) and a plurality of blocks located above the support plate (2). Freeze-drying plate (3), the support plate (2) is connected with a lifting driver (4) for driving the support plate (2) and the freeze-drying plate (3) to rise and fall, which is characterized by: the freeze-drying chamber (1) Located above the cold trap chamber (5), the freeze-drying chamber (1) and the cold trap chamber (5) are connected through the through hole (9) provided at the bottom of the freeze-drying chamber (1), The cold trap chamber (5) or freeze-drying chamber (1) is provided with a seal for covering the through hole (9) to isolate the freeze-drying chamber (1) from the cold trap chamber (5).

2. The freeze-drying machine according to claim 1, characterized in that: the freeze-drying chamber (1) and the cold trap chamber (5) are separated by an integral chamber, and the integral chamber is provided with an integral chamber. A partition (6) is divided into a freeze-drying chamber (1) and a cold trap chamber (5), and the through hole (9) is opened on the partition (6).

3. The freeze-drying machine according to claim 2, characterized in that: the partition (6) is arranged horizontally.

4. The freeze-drying machine according to claim 3, characterized in that: the lifting driving member (4) is installed on the freeze-drying chamber (1) or the cold trap chamber (5), and the sealing member is a support plate (2), the bottom of the support plate (2) is equipped with a sealing ring (10) for contact and matching with the partition plate (6).

5. The freeze-drying machine according to any one of claims 1 to 4, characterized in that: a drainage port (7) is provided at the bottom of the cold trap chamber (5).

6. The freeze-drying machine according to any one of claims 1 to 4, characterized in that: the cold trap cavity (5) is provided with a coil (8) for refrigeration.

7. The freeze-drying machine according to any one of claims 1 to 4, characterized in that: when the freeze-drying plate layer (3) is pressed, the support plate (2) drops to the freeze-drying chamber (1 ) and cover the through hole (9) to support the freeze-dried layer (3).

8. The freeze-drying machine according to claim 4, characterized in that: the lifting driving member (4) is provided on the cold trap chamber (5), and the support plate (2) is lowered to the freeze-drying chamber (1). ) and covers the through hole (9), the lifting driving member (4) drives the support plate (2) to press the periphery of the through hole (9).

9. The freeze-drying machine according to claim 8, characterized in that: an upper limit plate (13) is provided above the top freeze-drying plate layer (3).

10. The freeze-drying machine according to any one of claims 1 to 3, characterized in that: the lifting driving member (4) is installed on the freeze-drying chamber (1), and the sealing member is installed on the cooling chamber (1). The cold trap cavity (5) or the sealing plate (11) in the freeze-drying chamber (1) is provided with a sealing driving part (12) for driving the sealing plate (11). The sealing plate (11) When covering the through hole (9), the seal driver (12) drives the sealing plate (11) to press against the periphery of the through hole (9).

11. The freeze-drying machine according to claim 10, characterized in that: when the sealing plate (11) is located in the cold trap chamber (5), the lower end surface of the partition (6) is provided with the sealing plate (11). ) a sealing ring (10) that contacts and matches; when the sealing plate (11) is located in the freeze-drying chamber (1), the upper end surface of the partition plate (6) is provided with a sealing ring (10) that contacts and matches the sealing plate (11) 10).

12. The freeze-drying machine according to claim 10, characterized in that: when the freeze-drying plate layer (3) is pressed, the support plate (2) drops to the bottom of the freeze-drying chamber (1) to seal the freeze-drying chamber (1). Dry ply (3) for support.