WO2014140152A1 - Medicament container carrier and adapter - Google Patents

Medicament container carrier and adapter Download PDF

Info

Publication number
WO2014140152A1
WO2014140152A1 PCT/EP2014/054922 EP2014054922W WO2014140152A1 WO 2014140152 A1 WO2014140152 A1 WO 2014140152A1 EP 2014054922 W EP2014054922 W EP 2014054922W WO 2014140152 A1 WO2014140152 A1 WO 2014140152A1
Authority
WO
WIPO (PCT)
Prior art keywords
medicament container
adapter
medicament
container carrier
carrier
Prior art date
Application number
PCT/EP2014/054922
Other languages
French (fr)
Inventor
Derek Fenlon
Pascal LAUNOIS
Julian MCDONNELL
Martina MOYNE
Conor MULCAHY
Original Assignee
Sanofi-Aventis Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis Deutschland Gmbh filed Critical Sanofi-Aventis Deutschland Gmbh
Priority to DK14709673.9T priority Critical patent/DK2968063T3/en
Priority to CN201480014125.8A priority patent/CN105188636B/en
Priority to JP2015562142A priority patent/JP6487344B2/en
Priority to US14/775,316 priority patent/US11235102B2/en
Priority to EP14709673.9A priority patent/EP2968063B1/en
Publication of WO2014140152A1 publication Critical patent/WO2014140152A1/en
Priority to HK16101479.0A priority patent/HK1213467A1/en
Priority to US17/564,354 priority patent/US20220118183A1/en
Priority to US18/599,791 priority patent/US12036392B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end

Definitions

  • the invention relates to an adapter for a medicament container carrier.
  • a pre-filled medicament container e.g., syringe
  • a carrier which is axially movable to achieve needle penetration in an injection site and, optionally, needle withdrawal.
  • a conventional carrier is typically sized and shaped to retain a medicament container of a predetermined size.
  • a larger carrier would be necessary to accommodate a larger medicament container.
  • a size and shape of the delivery device may not provide space for the larger medicament container. Thus, an entirely different delivery device may be necessary for different dosage amounts.
  • the adapter is adapted to hold a second medicament container having a second predetermined size different from the first predetermined size and capable of containing no more than the first volume of the medicament.
  • the first volume is approximately 2mL.
  • the adapter includes a distal rib adapted to abut a distal end of the second medicament container.
  • the adapter includes at least one opening providing visual access to the second medicament container.
  • the adapter includes at least one resilient arm adapted to engage the second medicament container.
  • the arm includes a first ramp adapted to engage a distal face of a flange to deflect the arm in a first radial direction.
  • the arm includes a first abutment surface adapted to engage the flange to prevent rotation of the second medicament container relative to the adapter and a second abutment surface adapted to engage the flange to prevent axial displacement of the second medicament container relative to the adapter.
  • the arm includes a second ramp adapted to engage an engagement element on the body to deflect the arm in a second radial direction.
  • the arm includes a third abutment surface adapted to abut a proximal stop in the body to prevent axial displacement of the adapter relative to the body, and a fourth abutment surface adapted to engage a restricting surface in the body to prevent rotation of the adapter relative to the body.
  • the proximal stop is formed in an aperture on the body.
  • the first medicament container and the second medicament container are identical to each other.
  • medicament container are each one of a pre-filled syringe and a medicament cartridge.
  • a medicament delivery device comprises a housing, and a medicament container carrier according to the exemplary embodiments described herein.
  • the medicament container carrier may be slidably disposed in the housing.
  • Figure 1 is a schematic perspective exploded view of an exemplary
  • Figure 2 is a schematic perspective view of an exemplary embodiment of a container carrier coupled to a first medicament container according to the present invention
  • Figure 3 is a schematic perspective exploded view of an exemplary
  • Figure 4 is a schematic perspective view of an exemplary embodiment of an adapter according to the present invention.
  • Figure 5 is a schematic perspective view of an exemplary embodiment of a second medicament container coupled to an adapter according to the present invention
  • Figure 6 is a schematic perspective view of an exemplary embodiment of a container carrier coupled to an adapter and a second medicament container according to the present invention
  • Figure 7 is a schematic perspective detail view of an exemplary embodiment of a container carrier coupled to an adapter and a second medicament container according to the present invention.
  • Figure 1 is a schematic perspective exploded view of an exemplary embodiment of a container carrier 1 having a body adapted to hold a first medicament container 2 according to the present invention.
  • the first medicament container 2 which may be a syringe, an ampoule, a cartridge, etc., has a first predetermined size (e.g., length, diameter, etc.) and contains up to a first maximum amount of a medicament.
  • the first medicament container 2 may be a pre-filled syringe containing a 2ml_ dose of a medicament.
  • the first medicament container 2 comprises a
  • medicament container body 2.1 a needle 2.2 mounted to a distal end of the medicament container body 2.1 , a needle 2.2 mounted to a distal end of the medicament container body 2.1 , a needle 2.2 mounted to a distal end of the medicament container body 2.1 , a needle 2.2 mounted to a distal end of the medicament container body 2.1 , a needle 2.2 mounted to a distal end of the medicament container body 2.1 , a needle 2.2 mounted to a distal end of the
  • the needle 2.2 may fixed to the container body 2.1 or may be removably coupled thereto. In the latter exemplary embodiment, the needle 2.2 may be a double-tipped needle and the distal end of the body 2.1 may include a septum which receives a proximal tip of the needle 2.2.
  • Figure 2 is a schematic perspective view of an exemplary embodiment of the container carrier 1 with the first medicament container 2 coupled thereto.
  • the first medicament container 2 may be inserted into a proximal opening of the container carrier 1 and moved distally until it abuts a distal stop.
  • a retention mechanism e.g., snaps, clips, locks, etc.
  • in the container carrier 1 may engage a proximal end (e.g., flange(s)) of the first medicament container 2 to prevent the first medicament container 2 from translating axially relative to the container carrier 1 and/or rotating relative to the container carrier 1 .
  • Figure 3 is a schematic perspective exploded view of an exemplary embodiment of the container carrier 1 , an adapter 4 and a second medicament container 3.
  • Figure 4 is a schematic perspective view of an exemplary embodiment of the adapter 4.
  • the adapter 4 is designed to engage a second
  • the adapter 4 may further be designed to engage the container carrier 1 .
  • the second medicament container 3 comprises a medicament container body 3.1 , a needle 3.2 mounted to a distal end of the medicament container body 3.1 and in fluid communication with a cavity defined within the medicament container body 3.1 for containing a medicament, and a stopper (not illustrated) disposed within the cavity near a proximal end of the medicament container body 3.1 , wherein the stopper proximally seals the cavity and can be axially displaced within the cavity for expelling the medicament through the needle 3.2.
  • the needle 3.2 may fixed to the container body 3.1 or may be removably coupled thereto.
  • the needle 3.2 may be a double-tipped needle and the distal end of the body 3.1 may include a septum which receives a proximal tip of the needle 3.2.
  • a flange 3.5 may be arranged at a proximal end of medicament container body 3.1 .
  • the flange 3.5 comprises two arc sections 3.6 connected by two straight sections 3.7.
  • the adapter 4 may be used to allow a medicament delivery device (e.g., a pen injector, an auto-injector, etc.) to accommodate various medicament container sizes.
  • the adapter 4 may allow the usage of a common delivery device for different medicament container sizes. Therefore, a reduction in device costs and consistency in medicament administration may be achieved.
  • the adapter 4 is adapted to retain the second
  • the adapter 4 is also adapted to be retained within the container carrier 1 such that the adapter 4 is axially and rotationally fixed within the container carrier 1 .
  • Preventing rotation of the second medicament container 3 prevents the needle 3.2 from rotating during an injection thus reducing the risk for bending and distorting the needle 3.2 which may otherwise result in pain.
  • Preventing axial movement of the medicament container 3 in a proximal direction P also prevents the second medicament container 3 from being pushed in the proximal direction P relative to the adapter 4 and the container carrier 1 upon contact of the needle 3.2 with an injection site.
  • the adapter 4 may be sized and/or shaped to telescopically engage the container carrier 1 and the second medicament container 3.
  • the adapter 4 may have an outer geometry which
  • a distal rib 4.2 formed on a distal end of the adapter 4 may be adapted to abut the distal end of the container body 3.1 to prevent distal movement of the second medicament container 3 beyond the distal rib 4.2.
  • the adapter 4 may include one or more lateral openings 4.1 for allowing inspection of the contents and state of the second medicament container 3.
  • the adapter 4 may be made from a transparent/translucent material to provide visual access to the contents of the second medicament container 3.
  • the adapter 4 may comprise at least one resilient arm 4.3 extending proximally and adapted to engage a proximal portion (e.g., the flange 3.5) of the container body 3.1 .
  • the adapter 4 includes four resilient arms 4.3.
  • the arm 4.3 may include features to facilitate insertion and retention of the second medicament container 3.
  • a proximal end of the arm 4.3 may include a first ramp 4.9 which is adapted to engage the flange 3.5 (e.g., the straight section 3.7) when the second medicament container 3 is inserted into the adapter 4.
  • a first abutment surface 4.5 may engage the flange 3.5 (e.g., straight section 3.7) and thereby prevent the second medicament container 3 from rotating relative to the adapter 4, and a second abutment surface 4.4 may abut a proximal face of the flange 3.5 and thereby prevent the second medicament container 3 from moving axially relative to the adapter 4.
  • the resilient arm 4.3 may include a second ramp 4.8, a third abutment surface 4.6, and a fourth abutment surface 4.7 which facilitate insertion and retention of the adapter 4 by the container carrier 1 .
  • the second ramp 4.8 may be disposed on a radially outer surface of the arm 4.3.
  • the second ramp 4.8 may engage an element or an aperture 1 .1 on the container carrier 1 , which causes the arm 4.3 to deflect in a second radial direction (opposite the first radial direction) until the second ramp 4.8 bypasses the element.
  • the third abutment surface 4.6 may engage a proximal stop in the container carrier 1 and thereby prevent axial displacement of the adapter 4 relative to the container carrier 1 .
  • the fourth abutment surface 4.7 may engage a surface or element in the container carrier 1 to prevent rotation of the adapter 4 relative to the container carrier 1 .
  • the second medicament container 3 may be assembled with the container carrier 1 as shown in Figures 6 and 7 in at least two ways.
  • the adapter 4 may be inserted into the container carrier 1 and translated distally until it abuts a distal stop 1 .3 and the third abutment surface 4.6 abuts proximal stop.
  • medicament container 3 may then be inserted into the adapter 4 and translated distally until it abuts the distal rib 4.2 and the second abutment surface 4.4 abuts the flange 3.5.
  • the second medicament container 3 may be inserted into the adapter 4, and the adapter 4 may then be inserted into the container carrier 1 .
  • the first medicament container 2 may be adapted to contain greater than approximately 2ml_ of a medicament, and the second medicament container may be adapted to contain less than approximately 2ml_ of a medicament.

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Described is a medicament container carrier (1) adapted to hold a first medicament container (2) having a first predetermined size and capable of containing more than a first volume of a medicament. The container carrier (1) comprises a body, and an adapter (4) coupled to the body. The adapter (4) is adapted to hold a second medicament container (3) having a second predetermined size different from the first predetermined size and capable of containing no more than the first volume of the medicament.

Description

Medicament container carrier and adapter Technical Field
The invention relates to an adapter for a medicament container carrier. Background of the Invention
In a conventional medicament delivery device (e.g., an autoinjector), a pre-filled medicament container (e.g., syringe) is housed in a carrier which is axially movable to achieve needle penetration in an injection site and, optionally, needle withdrawal. A conventional carrier is typically sized and shaped to retain a medicament container of a predetermined size. In order to increase a dose that can be administered by the delivery device, a larger carrier would be necessary to accommodate a larger medicament container. However, a size and shape of the delivery device may not provide space for the larger medicament container. Thus, an entirely different delivery device may be necessary for different dosage amounts.
Accordingly, there is a need for a carrier and an adapter that allows the carrier to accommodate medicament containers of various sizes.
Summary of the Invention
It is an object of the present invention to provide a medicament container carrier and an adapter for the medicament container carrier.
In an exemplary embodiment, a medicament container carrier adapted to hold a first medicament container having a first predetermined size and capable of containing more than a first volume of a medicament according to the present invention comprises a body, and an adapter coupled to the body. The adapter is adapted to hold a second medicament container having a second predetermined size different from the first predetermined size and capable of containing no more than the first volume of the medicament.
In an exemplary embodiment, the first volume is approximately 2mL. In an exemplary embodiment, the adapter includes a distal rib adapted to abut a distal end of the second medicament container.
In an exemplary embodiment, the adapter includes at least one opening providing visual access to the second medicament container.
In an exemplary embodiment, the adapter includes at least one resilient arm adapted to engage the second medicament container. The arm includes a first ramp adapted to engage a distal face of a flange to deflect the arm in a first radial direction. The arm includes a first abutment surface adapted to engage the flange to prevent rotation of the second medicament container relative to the adapter and a second abutment surface adapted to engage the flange to prevent axial displacement of the second medicament container relative to the adapter. The arm includes a second ramp adapted to engage an engagement element on the body to deflect the arm in a second radial direction. The arm includes a third abutment surface adapted to abut a proximal stop in the body to prevent axial displacement of the adapter relative to the body, and a fourth abutment surface adapted to engage a restricting surface in the body to prevent rotation of the adapter relative to the body. The proximal stop is formed in an aperture on the body.
In an exemplary embodiment, the first medicament container and the second
medicament container are each one of a pre-filled syringe and a medicament cartridge.
In an exemplary embodiment, a medicament delivery device according to the present invention comprises a housing, and a medicament container carrier according to the exemplary embodiments described herein. The medicament container carrier may be slidably disposed in the housing.
Further scope of applicability of the present invention will become apparent from the detailed description given hereinafter. However, it should be understood that the detailed description and specific examples, while indicating preferred embodiments of the invention, are given by way of illustration only, since various changes and modifications within the spirit and scope of the invention will become apparent to those skilled in the art from this detailed description. Brief Description of the Drawings
The present invention will become more fully understood from the detailed description given hereinbelow and the accompanying drawings which are given by way of illustration only, and thus, are not limitive of the present invention, and wherein:
Figure 1 is a schematic perspective exploded view of an exemplary
embodiment of a container carrier and a first medicament container according to the present invention, Figure 2 is a schematic perspective view of an exemplary embodiment of a container carrier coupled to a first medicament container according to the present invention,
Figure 3 is a schematic perspective exploded view of an exemplary
embodiment of a container carrier, an adapter and a second medicament container according to the present invention,
Figure 4 is a schematic perspective view of an exemplary embodiment of an adapter according to the present invention,
Figure 5 is a schematic perspective view of an exemplary embodiment of a second medicament container coupled to an adapter according to the present invention, Figure 6 is a schematic perspective view of an exemplary embodiment of a container carrier coupled to an adapter and a second medicament container according to the present invention, and Figure 7 is a schematic perspective detail view of an exemplary embodiment of a container carrier coupled to an adapter and a second medicament container according to the present invention. Corresponding parts are marked with the same reference symbols in all figures. Detailed Description
Figure 1 is a schematic perspective exploded view of an exemplary embodiment of a container carrier 1 having a body adapted to hold a first medicament container 2 according to the present invention. The first medicament container 2, which may be a syringe, an ampoule, a cartridge, etc., has a first predetermined size (e.g., length, diameter, etc.) and contains up to a first maximum amount of a medicament. For example, the first medicament container 2 may be a pre-filled syringe containing a 2ml_ dose of a medicament.
In an exemplary embodiment, the first medicament container 2 comprises a
medicament container body 2.1 , a needle 2.2 mounted to a distal end of the
medicament container body 2.1 and in fluid communication with a cavity defined within the medicament container body 2.1 for containing a medicament, and a stopper (not illustrated) disposed within the cavity near a proximal end of the medicament container body 2.1 , wherein the stopper proximally seals the cavity and can be axially displaced within the cavity for expelling the medicament through the needle 2.2. The needle 2.2 may fixed to the container body 2.1 or may be removably coupled thereto. In the latter exemplary embodiment, the needle 2.2 may be a double-tipped needle and the distal end of the body 2.1 may include a septum which receives a proximal tip of the needle 2.2.
Figure 2 is a schematic perspective view of an exemplary embodiment of the container carrier 1 with the first medicament container 2 coupled thereto. The first medicament container 2 may be inserted into a proximal opening of the container carrier 1 and moved distally until it abuts a distal stop. A retention mechanism (e.g., snaps, clips, locks, etc.) in the container carrier 1 may engage a proximal end (e.g., flange(s)) of the first medicament container 2 to prevent the first medicament container 2 from translating axially relative to the container carrier 1 and/or rotating relative to the container carrier 1 .
Figure 3 is a schematic perspective exploded view of an exemplary embodiment of the container carrier 1 , an adapter 4 and a second medicament container 3. Figure 4 is a schematic perspective view of an exemplary embodiment of the adapter 4.
In an exemplary embodiment, the adapter 4 is designed to engage a second
medicament container 3 having a second predetermined size smaller than the first predetermined size of the first medicament container 2. The adapter 4 may further be designed to engage the container carrier 1 . The second medicament container 3 comprises a medicament container body 3.1 , a needle 3.2 mounted to a distal end of the medicament container body 3.1 and in fluid communication with a cavity defined within the medicament container body 3.1 for containing a medicament, and a stopper (not illustrated) disposed within the cavity near a proximal end of the medicament container body 3.1 , wherein the stopper proximally seals the cavity and can be axially displaced within the cavity for expelling the medicament through the needle 3.2. The needle 3.2 may fixed to the container body 3.1 or may be removably coupled thereto. In the latter exemplary embodiment, the needle 3.2 may be a double-tipped needle and the distal end of the body 3.1 may include a septum which receives a proximal tip of the needle 3.2. A flange 3.5 may be arranged at a proximal end of medicament container body 3.1 . In an exemplary embodiment, the flange 3.5 comprises two arc sections 3.6 connected by two straight sections 3.7. In an exemplary embodiment, the adapter 4 may be used to allow a medicament delivery device (e.g., a pen injector, an auto-injector, etc.) to accommodate various medicament container sizes. The adapter 4 may allow the usage of a common delivery device for different medicament container sizes. Therefore, a reduction in device costs and consistency in medicament administration may be achieved.
In an exemplary embodiment, the adapter 4 is adapted to retain the second
medicament container 3 such that the second medicament container 3 is axially and rotationally fixed within the adapter 4. The adapter 4 is also adapted to be retained within the container carrier 1 such that the adapter 4 is axially and rotationally fixed within the container carrier 1 . Preventing rotation of the second medicament container 3 prevents the needle 3.2 from rotating during an injection thus reducing the risk for bending and distorting the needle 3.2 which may otherwise result in pain. Preventing axial movement of the medicament container 3 in a proximal direction P also prevents the second medicament container 3 from being pushed in the proximal direction P relative to the adapter 4 and the container carrier 1 upon contact of the needle 3.2 with an injection site.
In an exemplary embodiment as shown in Figure 4, the adapter 4 may be sized and/or shaped to telescopically engage the container carrier 1 and the second medicament container 3. For example, the adapter 4 may have an outer geometry which
corresponds to an inner shape of the container carrier 1 and an inner geometry which corresponds to the second predetermined size/shape of the second medicament container 3. A distal rib 4.2 formed on a distal end of the adapter 4 may be adapted to abut the distal end of the container body 3.1 to prevent distal movement of the second medicament container 3 beyond the distal rib 4.2.
In an exemplary embodiment, the adapter 4 may include one or more lateral openings 4.1 for allowing inspection of the contents and state of the second medicament container 3. In another exemplary embodiment, the adapter 4 may be made from a transparent/translucent material to provide visual access to the contents of the second medicament container 3.
In an exemplary embodiment, the adapter 4 may comprise at least one resilient arm 4.3 extending proximally and adapted to engage a proximal portion (e.g., the flange 3.5) of the container body 3.1 . In the exemplary embodiment shown in Figure 4, the adapter 4 includes four resilient arms 4.3. The arm 4.3 may include features to facilitate insertion and retention of the second medicament container 3. For example, a proximal end of the arm 4.3 may include a first ramp 4.9 which is adapted to engage the flange 3.5 (e.g., the straight section 3.7) when the second medicament container 3 is inserted into the adapter 4. As the flange 3.5 engages the first ramp 4.9, the arm 4.3 is deflected in a first radial direction until the flange 3.5 bypasses the ramped face 4.9. As shown in Figure 5, when the arm 4.3 returns to a non-deflected position, a first abutment surface 4.5 may engage the flange 3.5 (e.g., straight section 3.7) and thereby prevent the second medicament container 3 from rotating relative to the adapter 4, and a second abutment surface 4.4 may abut a proximal face of the flange 3.5 and thereby prevent the second medicament container 3 from moving axially relative to the adapter 4. Referring back to the exemplary embodiment shown in Figure 4, the resilient arm 4.3 may include a second ramp 4.8, a third abutment surface 4.6, and a fourth abutment surface 4.7 which facilitate insertion and retention of the adapter 4 by the container carrier 1 . For example, the second ramp 4.8 may be disposed on a radially outer surface of the arm 4.3. When the adapter 4 is inserted into the container carrier 1 , the second ramp 4.8 may engage an element or an aperture 1 .1 on the container carrier 1 , which causes the arm 4.3 to deflect in a second radial direction (opposite the first radial direction) until the second ramp 4.8 bypasses the element. When the arm 4.3 returns to the non-deflected position, the third abutment surface 4.6 may engage a proximal stop in the container carrier 1 and thereby prevent axial displacement of the adapter 4 relative to the container carrier 1 . The fourth abutment surface 4.7 may engage a surface or element in the container carrier 1 to prevent rotation of the adapter 4 relative to the container carrier 1 .
The second medicament container 3 may be assembled with the container carrier 1 as shown in Figures 6 and 7 in at least two ways. In a first exemplary process, the adapter 4 may be inserted into the container carrier 1 and translated distally until it abuts a distal stop 1 .3 and the third abutment surface 4.6 abuts proximal stop. The second
medicament container 3 may then be inserted into the adapter 4 and translated distally until it abuts the distal rib 4.2 and the second abutment surface 4.4 abuts the flange 3.5. In a second exemplary process, the second medicament container 3 may be inserted into the adapter 4, and the adapter 4 may then be inserted into the container carrier 1 .
In an exemplary embodiment, the first medicament container 2 may be adapted to contain greater than approximately 2ml_ of a medicament, and the second medicament container may be adapted to contain less than approximately 2ml_ of a medicament.
Those of skill in the art will understand that modifications (additions and/or removals) of various components of the apparatuses, methods and/or systems and
embodiments described herein may be made without departing from the full scope and spirit of the present invention, which encompass such modifications and any and all equivalents thereof.

Claims

Claims
1 . A medicament container carrier (1 ) adapted to hold a first medicament container (2) having a first predetermined size and capable of containing more than a first volume of a medicament, the container carrier (1 ) comprising:
a body; and
an adapter (4) coupled to the body, the adapter (4) adapted to hold a second medicament container (3) having a second predetermined size different from the first predetermined size and capable of containing no more than the first volume of the medicament.
2. The medicament container carrier (1 ) according to claim 1 , wherein the first volume is approximately 2mL.
3. The medicament container carrier (1 ) according to any one of the preceding claims, wherein the adapter (4) includes a distal rib (4.2) adapted to abut a distal end of the second medicament container (3).
4. The medicament container carrier (1 ) according to any one of the preceding claims, wherein the adapter (4) includes at least one opening (4.1 ) providing visual access to the second medicament container (3).
5. The medicament container carrier (1 ) according to any one of the preceding claims, wherein the adapter (4) includes at least one resilient arm (4.3) adapted to engage the second medicament container (3).
6. The medicament container carrier (1 ) according to claim 5, wherein the arm (4.3) includes a first ramp (4.9) adapted to engage a distal face of a flange (3.5) to deflect the arm (4.3) in a first radial direction.
7. The medicament container carrier (1 ) according to claim 5 or 6, wherein the arm (4.3) includes a first abutment surface (4.5) adapted to engage the flange (3.5) to prevent rotation of the second medicament container (3) relative to the adapter (4) and a second abutment surface (4.4) adapted to engage the flange (3.5) to prevent axial displacement of the second medicament container (3) relative to the adapter (4).
8. The medicament container carrier (1 ) according to claim 5, 6 or 7, wherein the arm (4.3) includes a second ramp (4.8) adapted to engage an engagement element on the body to deflect the arm (4.3) in a second radial direction.
9. The medicament container carrier (1 ) according to claim 5, 6, 7, or 8 wherein the arm (4.3) includes a third abutment surface (4.6) adapted to abut a proximal stop in the body to prevent axial displacement of the adapter (4) relative to the body, and a fourth abutment surface (4.7) adapted to engage a restricting surface in the body to prevent rotation of the adapter (4) relative to the body.
10. The medicament container carrier (1 ) according to claim 9, wherein the proximal stop is formed in an aperture (1 .1 ) on the body.
1 1 . The medicament container carrier (1 ) according to any one of the preceding claims, wherein the first medicament container (2) and the second medicament container (3) are each one of a pre-filled syringe and a medicament cartridge.
12. A medicament delivery device comprising:
a housing; and
a medicament container carrier (1 ) according to any one of the preceding claims disposed in the housing.
13. The medicament delivery device according to claim 12, wherein the medicament container carrier (1 ) is slidably disposed in the housing.
PCT/EP2014/054922 2013-03-14 2014-03-13 Medicament container carrier and adapter WO2014140152A1 (en)

Priority Applications (8)

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DK14709673.9T DK2968063T3 (en) 2013-03-14 2014-03-13 HOLDER AND ADAPTER TO MEDICINAL CONTAINER
CN201480014125.8A CN105188636B (en) 2013-03-14 2014-03-13 medicament container carrier and adapter
JP2015562142A JP6487344B2 (en) 2013-03-14 2014-03-13 Drug container carrier and adapter
US14/775,316 US11235102B2 (en) 2013-03-14 2014-03-13 Medicament container carrier and adapter
EP14709673.9A EP2968063B1 (en) 2013-03-14 2014-03-13 Medicament container carrier and adapter
HK16101479.0A HK1213467A1 (en) 2013-03-14 2016-02-11 Medicament container carrier and adapter
US17/564,354 US20220118183A1 (en) 2013-03-14 2021-12-29 Medicament Container Carrier and Adapter
US18/599,791 US12036392B1 (en) 2013-03-14 2024-03-08 Medicament container carrier and adapter

Applications Claiming Priority (2)

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EP13159253.7 2013-03-14
EP20130159253 EP2777684A1 (en) 2013-03-14 2013-03-14 Medicament container carrier and adapter

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US17/564,354 Continuation US20220118183A1 (en) 2013-03-14 2021-12-29 Medicament Container Carrier and Adapter

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EP (2) EP2777684A1 (en)
JP (1) JP6487344B2 (en)
CN (1) CN105188636B (en)
DK (1) DK2968063T3 (en)
HK (1) HK1213467A1 (en)
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US11235102B2 (en) 2013-03-14 2022-02-01 Sanofi-Aventis Deutschland Gmbh Medicament container carrier and adapter
US12036392B1 (en) 2013-03-14 2024-07-16 Sanofi-Aventis Deutschland Gmbh Medicament container carrier and adapter
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US11077021B2 (en) 2016-02-09 2021-08-03 Sanofi-Aventis Deutschland Gmbh Two-chamber carpule

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CN105188636B (en) 2018-05-18
US12036392B1 (en) 2024-07-16
EP2777684A1 (en) 2014-09-17
US20220118183A1 (en) 2022-04-21
US20240207517A1 (en) 2024-06-27
US11235102B2 (en) 2022-02-01
DK2968063T3 (en) 2017-11-13
CN105188636A (en) 2015-12-23
EP2968063B1 (en) 2017-08-02
JP6487344B2 (en) 2019-03-20
HK1213467A1 (en) 2016-07-08
JP2016513509A (en) 2016-05-16
EP2968063A1 (en) 2016-01-20
US20160022907A1 (en) 2016-01-28

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