JP7458140B2 - Chemical injection device - Google Patents

Description

The present invention relates to a liquid medicine injector that injects liquid medicine into a patient's body by pushing a pusher member.

BACKGROUND ART Liquid drug injectors equipped with hollow needles have been known as medical instruments used to inject liquid drugs into patients in the medical field.

By the way, if the needle tip is removed after injecting a drug solution and left exposed, there is a risk of an accidental puncture in which a doctor, nurse, disposal company, etc. accidentally pricks their finger with the exposed needle tip. If an accidental puncture occurs, there is a risk of infection due to blood adhering to the needle tip, or of inadvertently ingesting the drug solution adhering to the needle tip.

For this reason, as described in, for example, JP 2007-506498 A (Patent Document 1), a drug injection device with a needle tip cover that covers the needle tip after use has been proposed. That is, in the drug injection device described in Patent Document 1, a syringe (injection device 4) equipped with a hollow needle (needle 7) is housed in a device main body (main body 3) equipped with a needle tip cover (protective sleeve 6). Then, by puncturing the skin with the hollow needle and pressing (pushing) the pusher member (plunger), the drug solution contained in the syringe is injected into the patient's body, and by removing the hollow needle from the skin, the needle tip cover protrudes from the device main body toward the tip side, protecting the needle tip of the hollow needle.

However, in the drug injection device described in Patent Document 1, the needle tip cover is only held in place by a spring (spring 26) while protecting the tip of the hollow needle. Therefore, if an external force is applied to the needle tip cover in the direction in which it is housed in the device body, there is a risk that the needle tip may be unintentionally re-exposed.

In addition, as an improvement of the liquid drug injection device described in Patent Document 1, Japanese Patent Publication No. 2011-510731 (Patent Document 2) discloses that a needle tip cover located at a position to protect the tip of a hollow needle is attached to the main body of the device. A fixing means for fixing the needle tip is disclosed, which solves the problem of re-exposure of the needle tip as described above. However, in the chemical liquid injection device described in Patent Document 2, the fixing means for the needle tip cover is provided between the needle tip cover and the device main body, which tends to make the structure of the device main body etc. complicated.

Furthermore, in the liquid drug injection devices described in Patent Documents 1 and 2 above, a syringe is used as an internal reservoir for storing liquid medicine, and by pushing the plunger of the syringe, the liquid medicine in the syringe is poured out from the device. was. Therefore, during use, it is necessary to aspirate the medicinal solution sealed in a vial or the like into a syringe, which is cumbersome to operate.

JP 2007-506498 A Special Publication No. 2011-510731

The present invention was made against the background of the above circumstances, and the problem to be solved by the invention described in claims 1 to 9 is to provide a drug injection device with a new structure that can prevent the hollow needle from being re-exposed.

A first aspect of the present invention is a drug solution injection device in which a pusher member is pushed from the base end into a device main body having a hollow needle at its tip end, causing a drug solution stored in an internal reservoir to be dispensed through the hollow needle, and a needle tip cover that protects the tip of the hollow needle is assembled to the device main body so as to be movable in the axial direction, the device main body having a grippable outer peripheral surface exposed to the outside , a positioning mechanism that positions the pusher member inserted into the device main body at a pushed-in position into the device main body is provided between the pusher member that is directly pushed in and the device main body whose outer peripheral surface is gripped , and the mutual abutment action between the portion of the pusher member positioned to the pushed-in position by the positioning mechanism and the portion of the needle tip cover that is housed in the device main body restricts movement of the needle tip cover toward the base end relative to the device main body to prevent re-exposure of the tip of the hollow needle .

With a drug injection device constructed according to this aspect, re-exposure of the needle tip due to movement of the needle tip cover toward the base end is prevented by the abutting action against the pushed-in pusher member. This avoids the need to complicate the device body in order to restrict movement of the needle tip cover toward the base end. In addition, because the pusher member is directly pushed in, it can be reliably moved to the pushed-in position, and positioning by the positioning mechanism and thus restriction of movement of the needle tip cover toward the base end can be more stably achieved.

Note that the following second or third aspect may be suitably adopted as the internal reservoir for storing the chemical solution.

A second aspect of the present invention is that in the liquid drug injection device according to the first aspect, a vial including a bottle body and a stopper body is employed as the internal reservoir.

A third aspect of the present invention is that, in the liquid drug injection device according to the first aspect, a prefilled syringe is employed as the internal reservoir.

In particular, by employing a vial as the internal reservoir according to the second aspect, the drug solution storage section can be simplified. Further, according to the third aspect, by employing a prefilled syringe as the internal reservoir, complicated operations such as filling a syringe with a medicinal solution each time are unnecessary.

A fourth aspect of the present invention is the liquid injection device according to any one of the first to third aspects, in which, in the positioning mechanism, positioning of the pusher member to the pushing position into the device main body is performed by a release operation means. By having a structure without this, a reuse prevention mechanism is constructed.

According to the chemical liquid injector structured according to this aspect, it is virtually impossible to release the positioning of the pusher member pushed toward the distal end with respect to the main body of the device, which is not expected by the provider of the chemical liquid injector. , intentional or unintentional reuse by the user is prevented.

A fifth aspect of the present invention is that in the liquid drug injection device according to any one of the first to fourth aspects, there is a gap between the pusher member and the device main body, the pusher member being pushed into the device main body. It is equipped with a locking mechanism that makes it impossible to operate.

According to the chemical liquid injector having the structure according to this aspect, the pusher member is prevented from being unintentionally pushed in before use.

A sixth aspect of the present invention is that in the liquid drug injection device according to the fifth aspect, the locking mechanism is released by relatively rotating the pusher member and the device main body in the circumferential direction; The pusher member is allowed to be pushed into the main body of the device.

According to the chemical liquid injector having the structure according to this aspect, the fixation of the pusher member cannot be released unless the pusher member is operated in a rotational direction perpendicular to the pushing direction, which is the normal operating direction. Therefore, unintended pushing operation of the pusher member is prevented.

A seventh aspect of the present invention is the liquid injection device according to any one of the first to sixth aspects, wherein a flexible portion that can be flexibly deformed is provided at a base end portion of the needle tip cover. In this case, the tip of the pusher member, which is directly pushed in, passes over the flexible portion, so that the pusher member reaches the push-in position.

According to the chemical liquid injector having the structure according to the present aspect, since the flexible portion that can be flexibly deformed is provided at the base end of the needle tip cover, the flexible portion is flexibly deformed and pushed. The movement of the distal end of the child member to cross over the proximal end of the needle tip cover can be stably realized.

An eighth aspect of the present invention is the liquid injection device according to any one of the first to seventh aspects, wherein a flexible piece that can be flexibly deformed is provided at the tip of the pusher member; The flexible piece of the pusher member, which is directly pushed in, passes over the base end of the needle tip cover, so that the pusher member reaches the push-in position.

According to the chemical liquid injector having the structure according to this aspect, the flexible piece is flexibly deformed, so that the distal end of the pusher member can stably move over the proximal end of the needle tip cover.

A ninth aspect of the present invention is the liquid injector according to any one of the first to eighth aspects, wherein a mutual interference portion is provided between a distal end portion of the pusher member and a proximal end portion of the needle tip cover. When the needle tip cover moves toward the proximal end with respect to the device main body and the needle tip of the hollow needle is exposed, the mutual interference portions overlap each other, so that the pusher member is While movement toward the distal end with respect to the device main body is allowed, the needle tip cover protrudes from the device main body toward the distal end with the pusher member positioned at the pushing position relative to the device main body. As a result, mutual overlap in the mutual interference portions is eliminated, and movement of the needle tip cover toward the proximal end side is restricted by the mutual axial abutting action of the mutual interference portions.

According to the chemical liquid injector having the structure according to this aspect, mutual movement in one direction due to the overlapping of the needle tip cover and the pusher member is allowed, so that the pushing operation of the pusher member and the tip side of the needle tip cover are allowed. The needle tip cover is allowed to protrude to the needle tip cover, and movement of the protruding needle tip cover toward the proximal end is restricted.

According to the chemical liquid injector having the structure according to the invention described in claims 1 to 9, the proximal end of the needle tip cover protects the needle tip of the hollow needle by contacting the pusher member pushed toward the distal end side. A liquid drug injector with a novel structure can be provided in which re-exposure of the needle tip due to sideward movement is prevented.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a plan view showing a liquid medicine injection device as a first embodiment of the present invention in a state before puncturing. II-II sectional view in FIG. 1. FIG. 2 is an enlarged cross-sectional view showing the III-III cross section in FIG. 1; 2 is a perspective view showing a needle tip cover constituting the liquid injection device shown in FIG. 1 in a separate state prior to being assembled to the device body; FIG. 5 is a perspective view of the needle tip cover shown in FIG. 4 from another direction. FIG. 5 is an enlarged front view of the needle tip cover shown in FIG. 4; 7 is a cross-sectional view taken along line VII-VII in FIG. 6. VIII-VIII cross-sectional view in FIG. 6. 2 is a perspective view showing a pusher member constituting the liquid injector shown in FIG. 1 in a single state; FIG. FIG. 10 is a perspective view of the pusher member shown in FIG. 9 from another direction. FIG. 10 is an enlarged front view of the pusher member shown in FIG. 9 . FIG. 12 is a sectional view taken along line XII-XII in FIG. 11. FIG. 12 is a cross-sectional view taken along line XIII-XIII in FIG. 11. FIG. 2 is a plan view showing the chemical liquid injector shown in FIG. 1 in a state before use. FIG. 2 is a longitudinal cross-sectional view showing a state in which the pusher member is rotated about the central axis relative to the device body to enable a pushing operation in the chemical liquid injector shown in FIG. 1; FIG. 16 is a vertical cross-sectional view showing a state in which the liquid medicine injection device shown in FIG. 15 is pressed against the skin and punctured with a hollow needle. FIG. 17 is a longitudinal cross-sectional view showing a state in the middle of a pushing operation of the pusher member in the chemical liquid injector shown in FIG. 16; FIG. 18 is a longitudinal cross-sectional view showing a state in which the pusher member is further pushed in and reaches the push-in position in the chemical liquid injector shown in FIG. 17; FIG. 19 is a vertical cross-sectional view showing a state in which the liquid drug injection device shown in FIG. 18 is rotated by a predetermined angle around the central axis. FIG. 19 is a plan view showing a state in which the needle tip cover moves toward the distal end side to protect the needle tip of the hollow needle in the chemical liquid injector shown in FIG. 18; XXI-XXI sectional view in FIG. 20. Cross-sectional view taken along the line XXII-XXII in Figure 20 . FIG. 3 is a longitudinal cross-sectional view showing a drug solution injector according to a second embodiment of the present invention in a state before puncturing, and corresponds to FIG. 2 . FIG. 24 is a longitudinal cross-sectional view showing the chemical liquid injector shown in FIG. 23 in a puncturing state, and corresponds to FIG. 16. FIG. 24 is a longitudinal cross-sectional view showing the drug solution injector shown in FIG. 23 in a needle tip protected state, and corresponds to FIG. 22; FIG. 7 is a perspective view showing a liquid medicine injection device as a third embodiment of the present invention in a state before puncturing, and a view showing the main body of the device as seen through. FIG. 27 is a front view of the liquid injector shown in FIG. 26 . FIG. 27 is a perspective view showing the drug solution injector shown in FIG. 26 in a state where the hollow needle is punctured and the pusher member is pushed in; FIG. 27 is a perspective view showing the liquid drug injection device shown in FIG. 26 in a needle tip protected state.

Hereinafter, in order to clarify the present invention more specifically, embodiments of the present invention will be described in detail with reference to the drawings.

1 to 3 show a liquid medicine injection device 10 according to a first embodiment of the present invention in a state before puncture, with a cap 114 (see FIG. 14) described later removed. This liquid medicine injection device 10 includes a device body 14 to which a hollow needle 12 is fixed, a needle tip cover 16 provided on the tip side of the device body 14, and a pusher member 18 provided on the base end side of the device body 14. In this embodiment, a vial 20 is attached to the pusher member 18 as an internal reservoir, and the hollow needle 12 is punctured into the skin and the pusher member 18 is pushed in from the base end side to inject the liquid medicine stored in the vial 20 into the body through the hollow needle 12 (poured out of the vial 20), and the hollow needle 12 is removed from the skin, so that the tip side needle tip 22 as the needle tip of the hollow needle 12 after puncture is protected by the needle tip cover 16 protruding from the device body 14 to the tip side. In the following description, the axial direction refers to the left-right direction in FIG. 1, which is the central axial direction of each component of the drug injection device 10. The tip side refers to the left side in FIG. 1, which is the side of the drug injection device 10 that is inserted into the skin, while the base side refers to the right side in FIG. 1, which is the side of the drug injection device 10 where the pushing operation of the plunger member 18 is performed.

More specifically, the hollow needle 12 of this embodiment is a double-ended needle, and has a sharp tip 22 and a proximal needle tip 24 at both ends in the axial direction. A generally cylindrical needle hub 26 is fitted onto the axially intermediate portion of the hollow needle 12, and is fixed thereto with an adhesive or the like, if necessary. A male threaded portion 28 is formed on the outer peripheral surface of the proximal end of the needle hub 26.

A needle hub 26 to which the hollow needle 12 is fixed is assembled to the device main body 14, which has a generally cylindrical shape as a whole. In this embodiment, the device main body 14 has a substantially double-tube structure extending in the axial direction, and includes an inner circumferential wall portion 30 and an outer circumferential wall portion 32 that are positioned inside and outside of each other. Note that both the inner circumferential wall portion 30 and the outer circumferential wall portion 32 extend substantially straight in the axial direction. Further, the outer circumferential wall 32 has a larger axial dimension than the inner circumferential wall 30, and both axial sides of the outer circumferential wall 32 protrude further axially outward than the inner circumferential wall 30.

Further, the inner circumferential wall portion 30 and the outer circumferential wall portion 32 are interconnected at their axially intermediate portions by a connecting plate portion 34 extending in the direction perpendicular to the axis. In this embodiment, four such connecting plate parts 34 are provided at approximately equal intervals in the circumferential direction, and a pair of connecting plate parts 34a, 34a are provided on both sides in one radial direction (both sides in the vertical direction in FIG. 3). In addition, another pair of connecting plate portions 34b, 34b are provided on both sides in the direction orthogonal to the connecting plate portions 34a, 34a (both sides in the left-right direction in FIG. 3). In particular, in this embodiment, the circumferential width dimension of the pair of connecting plate parts 34a, 34a is made larger than the circumferential width dimension of the other pair of connecting plate parts 34b, 34b.

Furthermore, in the inner peripheral wall portion 30, the tip side of the connecting plate portion 34 is a thicker cylindrical mounting tube portion 36 compared to the base end side of the connecting plate portion 34, and a female thread portion 38 is formed on the inner peripheral surface of the mounting tube portion 36. Meanwhile, the base end portion of the inner peripheral wall portion 30 is provided with a fixed tube portion 40 with a reduced inner diameter. The inner diameter of the fixed tube portion 40 is approximately equal to or slightly larger than the outer diameter of the hollow needle 12.

Then, the proximal end portion of the needle hub 26 is inserted into the mounting cylinder portion 36 on the distal end side of the inner circumferential wall portion 30, and the male threaded portion 28 and the female threaded portion 38 are screwed together, so that the hollow needle 12 is attached to the needle. It is indirectly fixed to the device main body 14 via the hub 26. Note that the hollow needle 12 may be directly fixed to the device main body 14 without intervening the needle hub 26. The hollow needle 12 is inserted through the inner circumferential wall 30 , and the tip 22 of the hollow needle 12 protrudes further than the inner circumferential wall 30 and the outer circumferential wall 32 . The proximal needle tip 24 protrudes further toward the proximal end than the inner circumferential wall 30 and protrudes by a length that does not reach the proximal end of the outer circumferential wall 32 . That is, the distal needle tip 22 of the hollow needle 12 projects axially outward from the distal end of the device main body 14, and the proximal needle tip 24 is located inside the device main body 14. Note that the outer circumferential surface of the proximal end portion of the hollow needle 12 may be fixed to the inner circumferential surface of the proximal end portion (fixed cylinder portion 40) of the inner circumferential wall portion 30 with an adhesive or the like.

On the other hand, on the outer circumferential surface of the outer circumferential wall portion 32 of the device main body 14, an annular cap locking portion 42 to which a cap 114, which will be described later, is locked, is continuous over the entire circumferential direction at the tip side end. It is provided. Further, on the inner circumferential surface of the outer circumferential wall portion 32, a distal end claw portion 44 (see FIG. 19) that protrudes inward is provided at the distal end. In this embodiment, four tip-side claw portions 44 are formed at approximately equal intervals in the circumferential direction.

The base end of the outer peripheral wall 32 is provided with a through window 46 that penetrates the outer peripheral wall 32 in the thickness direction, and an elastic piece 48 that can elastically deform in the thickness direction relative to the outer peripheral wall 32. In this embodiment, four of these through windows 46 and elastic pieces 48 are formed at approximately equal intervals (approximately every 90 degrees) in the circumferential direction, and in this embodiment in particular, these through windows 46 and elastic pieces 48 are alternately formed at intervals of 45 degrees in the circumferential direction.

The through window 46 is generally rectangular in shape with an axial dimension larger than the circumferential width dimension. On the other hand, at the position where the elastic piece 48 is formed in the outer peripheral wall 32, a generally rectangular opening window 50 is formed with a circumferential width dimension and an axial dimension that are approximately equal or slightly larger than the circumferential width dimension. The elastic piece 48 protrudes from the inner surface of the tip side of the opening window 50 to the base end side, and the elastic piece 48 is separated on three sides of the inner surface of the opening window 50 excluding the tip side. This allows the elastic piece 48 to be elastically deformable in the thickness direction of the outer peripheral wall 32. A base end claw portion 52 protruding to the inner peripheral side is formed at the protruding tip (axial base end) of the elastic piece 48.

Further, on the inner circumferential surface of the outer circumferential wall portion 32, an overpass protrusion 54 that protrudes toward the inner circumferential side is formed at an axially intermediate portion, specifically, closer to the proximal end than the connecting plate portion 34. In this embodiment, four crossing protrusions 54 are provided on the circumference, and these four crossing protrusions 54 are provided at approximately equal intervals (approximately every 90 degrees) in the circumferential direction. These overpass protrusions 54 are provided at positions on the circumference that substantially correspond to regulating protrusions 70, 70 on the needle tip cover 16, which will be described later. The overpass protrusions 54, 54 face each other at a predetermined distance in the circumferential direction. In addition, the circumferential distance between the circumferentially opposing circumferentially extending protrusions 54 and 54 in one of the left and right directions in FIG. Further, the inner circumferential surface of the riding protrusion 54 is a tapered surface 56 that slopes in a direction in which the protruding dimension of the riding protrusion 54 decreases toward the base end side.

A needle tip cover 16 as shown in Figures 4 to 8 is attached to the tip side of the device body 14 having such a structure so as to be movable in the axial direction. This needle tip cover 16 is generally cylindrical and has a peripheral wall 58 extending in the circumferential direction. The outer diameter of the peripheral wall 58 is approximately equal to or slightly smaller than the inner diameter of the outer peripheral wall portion 32 of the device body 14. At the tip of the peripheral wall 58, a contact protrusion 60 that protrudes outward is formed over approximately the entire circumference in the circumferential direction.

Further, an engagement groove 62 having a predetermined axial dimension is formed on the outer circumferential surface of the distal end portion of the peripheral wall 58 and opens toward the outer circumference. The engagement grooves 62 are formed at positions corresponding to the tip side claws 44 of the device main body 14 on the circumference, and in this embodiment, the four engagement grooves 62 are arranged at approximately equal intervals (approximately) on the circumference. (every 90 degrees). These engagement grooves 62 extend to a substantially axially central portion of the peripheral wall 58. Furthermore, an engagement claw 64 that protrudes toward the outer circumference is provided at the base end of the engagement groove 62 . Note that the proximal side surface of the engaging claw 64 is an inclined surface 66 in which the protruding dimension of the engaging claw 64 gradually decreases toward the proximal end, and the engaging groove 62 including the engaging claw 64 has an inclined surface 66. The base end portion is elastically deformable in the thickness direction of the peripheral wall 58. This makes it easy to assemble the needle tip cover 16 to the device main body 14.

Further, at the base end of the peripheral wall 58, a notch 68 is formed with a predetermined axial dimension and opens toward the base end and penetrates through the peripheral wall 58 in the thickness direction. In this embodiment, it extends from the base end of the peripheral wall 58 to approximately the central portion in the axial direction. Further, in this embodiment, four notches 68 are formed at approximately equal intervals (approximately every 90 degrees) in the circumferential direction, and correspond to the connecting plate portions 34 in the device main body 14 on the circumference. . In particular, in this embodiment, these notches 68 are provided at positions circumferentially apart from the engagement groove 62, and when viewed in the axial direction of the needle tip cover 16, the notches 68 and the engagement groove 62 are separated from each other in the axial direction. They are alternately provided at intervals of approximately 45 degrees in the circumferential direction. That is, a pair of notches 68a, 68a are formed to face each other in the vertical direction in FIG. 3, and another pair of notches 68b, 68b are formed to face each other in the horizontal direction in FIG. has been done. In particular, in this embodiment, the circumferential width dimension of the notch 68b is made larger than the circumferential width dimension of the notch 68a. Specifically, the circumferential width of the notch 68a is approximately equal to or slightly larger than the circumferential width of the connecting plate portion 34a provided at the corresponding position in the device main body 14.

Here, from the peripheral wall 58 at the proximal opening of the notch 68b, a pair of restricting protrusions 70 as mutual interference parts that protrude inward of the notch 68b are provided to face each other in the circumferential direction. These regulating protrusions 70, 70 are opposed to each other with a predetermined circumferential separation distance without coming into contact with each other, and the circumferential separation distance between the regulating protrusions 70, 70 is at the corresponding position on the device main body 14. It is larger than the circumferential width dimension of the provided connecting plate portion 34b. The inner circumferential surface of each of the regulating protrusions 70 is an inclined surface 72 that is inclined in a direction in which the thickness of the regulating protrusion 70 gradually increases toward the proximal end. The end face is a vertical surface 73 that extends in the direction perpendicular to the axis.

Further, an annular retaining wall portion 74 that protrudes inward is provided on the inner peripheral surface of the axially intermediate portion of the peripheral wall 58, and a proximal end of the retaining wall portion 74 is provided on the inner peripheral edge of the retaining wall portion 74. An insertion cylinder portion 76 that protrudes to the side is provided. In this embodiment, the inner diameter of the holding wall 74 is larger than the outer diameter of the needle hub 26 attached to the distal end of the device main body 14. Further, in this embodiment, reinforcing ribs 78 are provided on the inner peripheral surface of the peripheral wall 58 from the tip of the peripheral wall 58 to the retaining wall portion 74 . In particular, in this embodiment, four reinforcing ribs 78 are provided on the circumference to increase the deformation rigidity of the peripheral wall 58.

On the other hand, a pusher member 18 as shown in FIGS. 9 to 13 is attached to the base end side of the device main body 14 so as to be movable in the axial direction. The pusher member 18 has a substantially bottomed cylindrical shape as a whole, and includes a circumferential wall 80 extending in the circumferential direction and a substantially circular bottom wall portion 81 that closes the proximal opening of the circumferential wall 80. . The outer diameter of the peripheral wall 80 is approximately equal to or slightly smaller than the inner diameter of the outer peripheral wall 32 of the device main body 14. Note that the proximal end surface 81a of the bottom wall portion 81 is a curved surface in which the central portion is located closer to the distal end than the outer circumferential portion, so that a user (for example, a medical worker or a patient himself/herself) can It is said that the operation of placing a finger on 81a and pushing the pusher member 18 toward the distal end side is easy.

A circumferential groove 82 extending in the circumferential direction with a predetermined circumferential dimension is provided on the outer circumferential surface of the tip portion of the circumferential wall 80 and is open to the outer circumferential side, and one circumferential end of the circumferential groove 82 is provided. An axial groove 84 extending toward the proximal end with a predetermined axial dimension is provided to open toward the outer circumferential side. In this embodiment, the circumferential grooves 82 are formed around the peripheral wall 80 with a circumferential dimension of approximately 45 degrees, and the four circumferential grooves 82 are arranged at approximately equal intervals on the circumference (approximately every 90 degrees). It is set in. That is, as will be described later, the proximal claw portion 52 located within the circumferential groove 82 rotates the pusher member 18 by 45 degrees around the central axis with respect to the device main body 14, thereby causing the proximal claw portion 52 located within the circumferential groove 82 to move inside the axial groove 84. It is supposed to move to .

The circumferential groove 82 is provided with an insertion groove 85 extending in the axial direction from the tip of the peripheral wall 80, and when assembling the device main body 14 and the pusher member 18, the device is inserted through the insertion groove 85. The proximal claw portion 52 of the main body 14 can be inserted into the circumferential groove 82. In particular, between the insertion groove 85 and the circumferential groove 82, specifically at the proximal end of the insertion groove 85, a retaining protrusion 85a that protrudes from the groove bottom surface toward the outer circumference is provided. Therefore, the proximal claw portion 52 can move into the circumferential groove 82 by climbing over the retaining protrusion 85a. In this embodiment, the distal end surface of the retaining protrusion 85a is formed into an inclined surface 85b whose protrusion dimension gradually decreases toward the distal end, so that the proximal claw portion 52 can easily move over the retaining protrusion 85a. It is now being realized.

Between the circumferential groove 82 and the axial groove 84, specifically at one circumferential end of the circumferential groove 82, there is provided a locking protrusion 86 that protrudes from the bottom surface of the groove toward the outer periphery. As a result, unless an external force associated with a rotational operation is applied to the pusher member 18, the base end claw portion 52 will not climb over the locking protrusion 86, and the pusher member 18 is prevented from moving toward the tip side (pushing operation) relative to the device body 14.

Further, in the proximal end portion of the axial groove 84, at a position spaced distally by a predetermined axial dimension from the proximal wall of the axial groove 84, the positioning protrusion 88 protrudes outward from the groove bottom surface. ing. As a result, a substantially rectangular positioning recess 90 surrounded by the peripheral wall forming the axial groove 84 and the positioning protrusion 88 is formed at the base end of the axial groove 84. The proximal claw portion 52 that has moved toward the proximal side in the directional groove 84 is configured to overcome the positioning protrusion 88 and enter into the positioning recess 90. That is, the proximal claw portion 52 that has entered the positioning recess 90 is prevented from moving in the axial direction by abutting against the proximal wall portion of the axial groove 84 and the positioning protrusion 88, and the positioning portion 52 is prevented from moving in the axial direction. With the proximal claw portion 52 inserted into the recess 90, unintended relative movement between the device main body 14 and the pusher member 18 is prevented.

Further, at the tip of the peripheral wall 80 of the pusher member 18, an arm portion 92 is provided as a mutual interference portion that protrudes toward the tip side. The arm portions 92 have a generally rectangular curved plate shape when viewed from the front, and are provided in pairs facing each other on both sides in one radial direction (both sides in the left-right direction in FIG. 11). Furthermore, each of these arm portions 92 is made sufficiently thin so as to be able to bend and deform in the radial direction (opposing direction). It has become. That is, in this embodiment, the arm portion 92 constitutes a flexible piece that can be flexibly deformed at the tip of the pusher member 18 . In particular, in this embodiment, the tip portions of these arm portions 92 are provided with inclined portions 94 that slope toward the outer circumferential side, and when an external force is applied to the inclined portions 94 from the tip side, the arm portions 92 Elastic deformation in the radial direction can be easily caused. The maximum separation distance on the outer surface of the arm portions 92, 92 may be approximately equal to or slightly smaller than the inner diameter dimension of the outer circumferential wall portion 32 of the device main body 14, or may be made slightly larger, so that the pusher member The arm portion 92 may be elastically deformed slightly toward the inner circumference when the device body 18 is assembled to the device main body 14. Furthermore, in this embodiment, the end surface of the inclined portion 94 is a vertical surface 95 that extends in the direction perpendicular to the axis.

Furthermore, on the inner peripheral surface of the peripheral wall 80, from the axially intermediate portion of each arm portion 92 to the base end of the peripheral wall 80, reinforcing ribs 96 extending in the axial direction are provided so as to protrude toward the inner peripheral side. That is, these reinforcing ribs 96, 96 are provided to face each other in the radial direction (left-right direction in FIG. 11), which is the direction in which the arm portions 92, 92 oppose each other. On the other hand, from the inner circumferential surface of the peripheral wall 80 including the inner circumferential surfaces of these reinforcing ribs 96, 96, a holding protrusion 98 for holding a vial 20, which will be described later, protrudes inward. In this embodiment, the holding protrusions 98 protrude inward from the inner circumferential surface of each reinforcing rib 96 and are opposed to each other in the radial direction (left-right direction in FIG. 11). , holding protrusions 98 are also provided on both sides in a direction (vertical direction in FIG. 11) perpendicular to the opposing direction of the holding protrusions 98, 98. That is, in this embodiment, the four holding protrusions 98 are provided at approximately equal intervals (approximately every 90 degrees) in the circumferential direction. The distance between the opposing surfaces of these opposing holding protrusions 98, 98 is approximately equal to or slightly larger than the outer diameter dimension of the vial 20, which will be described later, so that the vial 20 can be mounted without substantially tilting with respect to the pusher member 18. It is supposed to be done.

On the other hand, on the outer circumferential surface of the pusher member 18, a positioning piece 100 that protrudes toward the outer circumference is provided at the base end portion of the peripheral wall 80. In this embodiment, the side surface of the distal end of the positioning piece 100 is an inclined surface 102 in which the protruding dimension of the positioning piece 100 gradually decreases toward the distal end, and the positioning piece 100 has a vertical section having a substantially right triangular shape. have. Further, in this embodiment, the four positioning pieces 100 are formed at approximately equal intervals (approximately every 90 degrees) in the circumferential direction, and each positioning piece 100 is located between the axial grooves 84 in the circumferential direction. There is. Therefore, in this embodiment, on the outer peripheral surface of the pusher member 18, the circumferential groove 82 and the insertion groove 85 are located on the distal end side of the positioning piece 100, and the shaft Arm portions 92 are positioned across the distal end side wall portion 101 of the directional groove 84 . That is, a gap 101a that opens toward the outer circumference is formed between the tip side wall portion 101 and the inclined portion 94 that slopes toward the outer circumference at the tip of the arm portion 92 in the axial direction. Furthermore, these positioning pieces 100 are not connected to the peripheral wall 80 or the bottom wall 81 on three sides (the proximal end side and both sides in the circumferential direction), that is, they are connected to the peripheral wall 80 only on the distal end side. Elastic deformation is possible in the thickness direction (radial direction) of 80 mm.

The needle hub 26, device body 14, needle tip cover 16, and plunger member 18 are preferably made of, for example, a hard synthetic resin. The hollow needle 12 is preferably made of, for example, a metal such as stainless steel.

A vial 20 that stores a liquid medicine as an internal reservoir is attached inside the plunger member 18 having the above structure. The vial 20 is configured to include a substantially bottomed cylindrical bottle body 104 that opens at the tip side and a stopper body 106 that closes the tip side opening of the bottle body 104. The material of the bottle body 104 is not limited in any way, and for example, glass or hard synthetic resin can be preferably used. In addition, it is preferable that the stopper body 106 is configured from an elastic body such as rubber. A slit 108 that penetrates in the axial direction is formed in the center of the stopper body 106, and when the stopper body 106 is inserted and attached to the tip side opening of the bottle body 104, the stopper body 106 is compressed from the outer periphery side to close the slit 108, so that the liquid medicine sealed inside the vial 20 does not leak out. Note that the slit 108 is not essential. Furthermore, there are no limitations on the medicinal liquid stored inside the vial 20, and any desired medicinal liquid can be used as appropriate.

The bottle body 104 of the vial 20 is held in a state where the portion constituting the proximal side wall portion and the bottom wall portion 81 of the pusher member 18 are in approximate contact, and the portion forming the peripheral wall is held by the pusher member 18. It is held by the protrusion 98 without being substantially tilted in the axial direction.

A needle tip cover 16 is attached to the device main body 14 to which the hollow needle 12 as described above is fixed so as to be movable in the axial direction toward the distal end, and a vial 20 is attached therein so as to be movable in the axial direction toward the proximal end. The pusher member 18 provided is assembled.

That is, the needle tip cover 16 is assembled to the device body 14 by being inserted from the tip side opening 109, and the tip side claw portion 44 of the device body 14 is inserted into the engagement groove 62 provided on the outer circumferential surface of the needle tip cover 16 to position it in the circumferential direction. In addition, in this circumferentially positioned state, the connecting plate portions 34a, 34b of the device body 14 and the notches 68a, 68b of the needle tip cover 16 are aligned with each other in the circumferential direction, so that when the needle tip cover 16 moves toward the base end side relative to the device body 14, the connecting plate portions 34a, 34a can move axially within the notches 68a, 68a, and the connecting plate portions 34b, 34b can move axially within the notches 68b, 68b. When inserting the tip-side claw portion 44 into the engagement groove 62, the base end portion of the engagement groove 62, including the engagement claw 64, is elastically deformable in the radial direction, making it easy to insert the engagement claw 64 into the engagement groove 62.

The distal end claw portion 44 moves axially within the engagement groove 62, allowing the needle tip cover 16 to move without rotating or tilting relative to the device body 14. Such axial movement of the needle tip cover 16 is prevented by the mutual abutment of the distal end of the device body 14 and the abutment protrusion 60 of the needle tip cover 16, and by the mutual abutment of the connecting plate portions 34a, 34b of the device body 14 against the distal inner surfaces of the notches 68a, 68b in the needle tip cover 16, and by the mutual abutment of the distal end claw portion 44 of the device body 14 and the engagement claw 64 of the needle tip cover 16, movement of the needle tip cover 16 toward the distal end is prevented.

In this embodiment, a coil spring 110 as an elastic member is interposed between the device main body 14 and the needle tip cover 16 in the axial direction. Specifically, the tip portion of the coil spring 110 is inserted into the insertion cylinder portion 76 of the needle tip cover 16, abuts against the retaining wall portion 74, and is fixed with an adhesive or the like as necessary. There is. On the other hand, the base end portion of the coil spring 110 is inserted into the mounting cylinder portion 36 of the device main body 14, abuts against the connecting plate portion 34, and is fixed with an adhesive or the like as necessary. Note that in the pre-puncture state shown in FIGS. 1 to 3, the coil spring 110 has a substantially natural length or is placed in a slightly compressed state in the axial direction, so that the device main body 14 is disposed with respect to the needle tip cover 16. A biasing force may be applied in the direction of the distal end. In this pre-puncture state, the distal needle tip 22 of the hollow needle 12 protruding from the device main body 14 is covered and protected by the needle tip cover 16.

On the other hand, the vial 20 pre-filled with a drug solution is inserted from the opening on the distal end side of the pusher member 18 and attached, and the pusher member 18 with the vial 20 attached is attached to the proximal end side of the device main body 14. It is assembled. That is, the proximal claw portion 52 provided at the proximal end portion of the device main body 14 is inserted into the circumferential groove 82 through the insertion groove 85 provided on the outer peripheral surface of the pusher member 18. The child member 18 and the device main body 14 are positioned relative to each other in the circumferential direction. Note that in the state before puncturing shown in FIGS. 1 to 3, the proximal claw portion 52, the retaining protrusion 85a provided at the proximal end of the insertion groove 85, and the proximal side wall portion constituting the circumferential groove 82. 111 prevents axial movement of the pusher member 18 relative to the device main body 14 (for example, pushing operation of the pusher member 18), and also prevents the proximal claw portion 52 and the circumferential groove 82 from moving in the axial direction. Unintended relative rotation between the device main body 14 and the pusher member 18 is prevented by abutting the locking protrusion 86 provided at one end. That is, in this embodiment, the lock fixing mechanism 112 that makes it impossible to push the pusher member 18 into the device main body 14 is located between the proximal claw portion 52 and the circumferential direction between the device main body 14 and the pusher member 18. The groove 82 includes a proximal side wall portion 111 of the groove 82.

In this pre-puncture state, the pusher member 18 is inserted from the proximal opening 113 of the device main body 14, the proximal end portion of the pusher member 18 protrudes from the base end of the device main body 14, and the pusher member 18 The proximal end portion (fixed cylinder portion 40 ) of the inner circumferential wall portion 30 of No. 14 is inserted into the distal end portion of the circumferential wall 80 of the pusher member 18 . In such a state, in this embodiment, the proximal needle tip 24 of the hollow needle 12 is located on the distal side of the stopper 106 in the vial 20; For example, it may be inserted into the plug body 106 and located at an axially intermediate portion of the plug body 106, or it may be inserted through the plug body 106.

A method of using the drug solution injector 10 as described above will be explained with reference to FIGS. 14 to 22 below.

First, FIG. 14 shows the state of the chemical liquid injector 10 before use, that is, the state in which it is sold and can actually be obtained by a user. In this state, the cap 114 is externally attached to the distal end portion of the chemical liquid injection device 10, that is, the distal end portion of the needle tip cover 16 and the device main body 14. Although the specific shape of the cap 114 is not limited in any way, in this embodiment, it has a substantially cylindrical shape with a bottom that opens toward the proximal end.

That is, the cap 114 includes a substantially circular tip wall portion 115a and a cylindrical wall portion 115b protruding toward the proximal end from the outer peripheral end of the tip wall portion 115a. Further, an abutment cylinder part 115c is provided on the inner circumferential side of the cylindrical wall part 115b and protrudes from the distal end wall part 115a toward the proximal end, and is provided with an abutting cylinder part 115c that protrudes from the distal end wall part 115a to the distal end part of the needle tip cover 16 and the main body 14. By attaching the cap 114 externally, the tip end portion of the outer circumferential wall 32 of the needle tip cover 16 and the device main body 14 is inserted between the cylindrical wall 115b and the abutment cylindrical portion 115c in the radial direction, and The outer peripheral side of the tip 22 on the distal end side of the hollow needle 12 is covered with an abutting cylinder portion 115c. In particular, in this embodiment, in such a mounted state, the cap locking part 42 provided at the tip of the outer peripheral wall part 32 contacts the inner peripheral surface of the cylindrical wall part 115b, and the protruding tip of the abutting cylinder part 115c (proximal end in the axial direction) is in contact with the distal end of the needle hub 26, thereby preventing the cap 114 from moving toward the proximal end with respect to the device main body 14.

In this state, the needle tip cover 16 is not in contact with the cap 114 or is in zero contact with the cap 114, so that no external force from the cap 114 is applied to the needle tip cover 16. That is, in the state before use of the liquid drug injection device 10, the needle tip cover 16 is prevented from unintentionally moving toward the proximal end with respect to the device main body 14.

Note that movement of the cap 114 toward the proximal end with respect to the device main body 14 is prevented by the cap locking portion 42 of the outer peripheral wall portion 32 coming into contact with the inner peripheral surface of the cylindrical wall portion 115b of the cap 114, and This may be achieved by either of the protruding tip of the abutting cylinder portion 115c abutting the needle hub 26. That is, for example, in the cap 114, the contact cylinder portion 115c may not be provided. Further, for example, the inner circumferential surface of the cap 114 (the inner circumferential surface of the cylindrical wall portion 115b) may be provided with a convex portion that protrudes inward, and the convex portion is located at the tip of the outer circumferential wall portion 32. By engaging with the provided cap locking portion 42, the cap 114 may be prevented from unintentionally coming off from the liquid drug injection device 10.

Then, by removing the cap 114 from this state, the liquid drug injection device 10 is brought into the state before puncture shown in FIGS. 1 to 3. Further, FIG. 15 shows a state in which the pusher member 18 is rotated by a predetermined angle about the central axis with respect to the device main body 14 from this state. That is, by rotating the pusher member 18 by a predetermined angle around the central axis with respect to the device main body 14, the proximal claw portion 52 of the device main body 14, which was located within the circumferential groove 82, becomes the locking protrusion. 86 and into the axial groove 84. As a result, the pusher member 18, which had been made immovable in the axial direction with respect to the device main body 14 by abutting against the distal side wall portion (removal prevention protrusion 85a) and the proximal side wall portion 111 of the circumferential groove 82, can now be moved. It is movable toward the distal end with respect to the device main body 14. In short, in the state shown in FIGS. 1 to 3, the lock fixing mechanism 112 makes it impossible to push the pusher member 18 into the device main body 14, but the device main body 14 and the pusher member 18 are moved in the circumferential direction ( By relative rotation (about the central axis), the lock by the lock fixing mechanism 112 is released, and the pusher member 18 is allowed to be pushed into the device main body 14.

In this embodiment, by rotating the pusher member 18 by 45 degrees around the central axis with respect to the device main body 14, the proximal claw portion 52 moves from the circumferential groove 82 to the axial groove 84, and the pusher member 18 is rotated 45 degrees around the central axis. The member 18 is axially movable relative to the device body 14. By rotating the pusher member 18 by a predetermined angle (45 degrees in this embodiment) around the central axis with respect to the device main body 14 in this way, the overpass protrusion provided on the outer peripheral wall 32 of the device main body 14 is rotated. The portion 54 and the arm portion 92 provided on the pusher member 18 are aligned with each other in the circumferential direction (that is, the overpass protrusion 54 is located on the tip side of the arm portion 92). Further, in this state, the through window 46 in the device main body 14 and the positioning piece 100 in the pusher member 18 are aligned with each other in the circumferential direction (that is, the through window 46 is located on the tip side of the positioning piece 100). ).

Furthermore, the tip side of the drug solution injection device 10 in this state is pressed against the patient's skin. As a result, as shown in FIG. 16, the needle tip cover 16 is pushed into the inside of the device body 14, i.e., toward the base end, against the biasing force of the coil spring 110, and the tip side needle tip 22 of the hollow needle 12 protruding and exposed from the tip of the needle tip cover 16 pierces the patient's skin. The movement of the needle tip cover 16 toward the base end side relative to the device body 14 is guided by the movement of the connecting plate parts 34a, 34b of the device body 14 within the notches 68a, 68b of the needle tip cover 16. The movement of the needle tip cover 16 toward the base end side relative to the device body 14 can be restricted by the connecting plate parts 34a, 34b abutting against the tip side surfaces on the inner surfaces of the notches 68a, 68b, or by the tip of the device body 14 abutting against the abutment protrusion 60 of the needle tip cover 16. In this manner, when the needle tip cover 16 is fully housed in the device body 14 (when the needle tip cover 16 is restricted from moving any further toward the base end), the restricting protrusion 70 provided at the base end of the needle tip cover 16 and the overhanging protrusion 54 provided on the inner peripheral surface of the axially intermediate portion of the device body 14 are approximately adjacent in the axial direction, and the inclined surface 72, which is the inner peripheral surface of the restricting protrusion 70, and the tapered surface 56, which is the inner peripheral surface of the overhanging protrusion 54, are approximately continuous in the axial direction. In addition, since the coil spring 110 is compressed by the needle tip cover 16 moving toward the base end relative to the device body 14, in this state, a biasing force toward the tip side of the device body 14 is applied to the needle tip cover 16 due to the elastic restoring action of the coil spring 110.

Then, from the state in which the distal needle tip 22 of the hollow needle 12 is punctured into the patient's skin as described above, the pusher member 18 is pushed directly toward the distal side of the device main body 14, as shown in FIG. (For example, by pressing a finger against the proximal end surface 81a of the pusher member 18 and performing a direct pushing operation), both the bottle body 104 and the stopper body 106 move toward the distal end, and the distal end portion of the vial 20 The proximal needle tip 24 of the hollow needle 12 is inserted into and penetrates the slit 108 of the stopper 106 provided in the slit 106 . Thereby, the inside of the vial 20 and the inside of the patient's blood vessel are communicated via the hollow needle 12. In this state, the plug 106 contacts the proximal end portion (fixed cylinder portion 40) of the inner circumferential wall 30 and is unable to move any further toward the distal end. It is positioned in the axial direction with respect to (the device main body 14). Then, by further pushing the pusher member 18 toward the distal end of the device main body 14 from this state, the bottle body 104 moves toward the distal end with respect to the stopper 106. In other words, the inside of the bottle body 104 is As the stopper 106 moves toward the proximal end, the volume within the vial 20 is reduced, and the drug solution stored within the vial 20 is injected into the patient's blood vessel through the hollow needle 12 (poured out of the vial 20). ).

In addition, by pushing the pusher member 18 toward the tip side relative to the device body 14 in this manner, the arm portion 92 provided at the tip of the pusher member 18 comes into contact with the overhanging protrusion 54 provided on the device body 14, and the arm portion 92 is elastically deformed toward the inner circumference in accordance with the guiding action of the tapered surface 56, which is the inner circumference surface of the overhanging protrusion 54. In this embodiment, the arm portion 92 is made sufficiently thin so that such elastic deformation is easily induced.

As shown in FIGS. 18 and 19, when the pusher member 18 is pushed into the device main body 14 to the deepest part (pushing position), the proximal end moves toward the proximal end within the axial groove 84. The claw portion 52 is configured to ride over the positioning protrusion 88 and to be located within the positioning recess 90. In particular, since the proximal claw portion 52 is provided at the protruding tip of the elastic piece 48, the movement of the proximal claw portion 52 to move over the positioning protrusion 88 can be more easily realized. There is. Further, in this state, the positioning piece 100 of the pusher member 18 has entered the through window 46 of the device main body 14. That is, by pushing the pusher member 18 toward the distal side of the device main body 14, the inclined surface 102 of the positioning piece 100 and the peripheral edge of the proximal opening 113 of the device main body 14 come into contact with each other. The positioning piece 100 is elastically deformed inward according to the inclined surface 102, and the positioning piece 100 is elastically deformed by climbing over the peripheral wall (outer peripheral wall portion 32) on the base end side of the through window 46. It is designed to be restored and deformed to enter the through window 46. Therefore, the proximal end of the pusher member 18 relative to the device main body 14 is caused by the mutual contact between the proximal claw portion 52 and the positioning protrusion 88 and the mutual contact between the positioning piece 100 and the proximal inner surface of the through window 46. The pusher member 18 is prevented from moving toward the side (in the direction opposite to the pushing direction), and the pusher member 18 is prevented from moving toward the side (in the direction opposite to the pushing direction), and the pusher member 18 is prevented from moving toward the tip side (in the pushing direction) with respect to the device main body 14. Thereby, the pusher member 18 can be positioned in the axial direction with respect to the device main body 14.

Therefore, in the present embodiment, the positioning mechanism 116 that positions the pusher member 18 at the pushing position into the device main body 14 is arranged between the proximal claw portion 52 and the positioning protrusion between the pusher member 18 and the device main body 14. 88 and fitting of the positioning piece 100 into the through window 46. The engagement between the proximal claw portion 52 and the positioning protrusion 88 and the fitting of the positioning piece 100 into the through window 46 are both realized inside the device main body 14. This positioning mechanism 116 cannot be released from the outside, and has a structure that does not include a release operation means. Therefore, in this embodiment, it is impossible to move the pusher member 18 that has been pushed and positioned to the pushing position again to the proximal end side and reuse it. It is configured to include a prevention mechanism 118. Particularly, in this embodiment, in this pushing position, the base end of the pusher member 18 is located at approximately the same axial position as the base end side opening 113 of the device main body 14 or slightly axially inward. Therefore, it is also impossible to perform an operation such as, for example, grasping the pusher member 18 and forcibly pulling it out toward the proximal end.

In addition, in the process of the pusher member 18 reaching the pushed-in position, the arm 92 of the pusher member 18 climbs over the overhanging protrusion 54 of the device body 14 and the regulating protrusion 70 of the needle tip cover 16 from the inner circumferential side, and after climbing over, the arm 92 elastically restores and deforms to be positioned within the notch 68b of the needle tip cover 16. In other words, when the pusher member 18 is in the pushed-in position, the overhanging protrusion 54 and the regulating protrusion 70 are positioned within the gap 101a on the outer circumferential side of the arm 92. The overhanging action of the overhanging protrusion 54 and the regulating protrusion 70 of the arm 92 can be easily realized because the inner circumferential surfaces of these are the tapered surface 56 and the inclined surface 72, respectively. And the tip of the inclined portion 94 of the arm 92, which has elastically deformed to the outer circumferential side within the notch 68b of the needle tip cover 16, abuts or is slightly separated from the inner circumferential surface of the outer circumferential wall portion 32 of the device body 14. In this state, as shown in FIG. 19, the portion of the peripheral wall 80 of the pusher member 18 other than the position where the arm portion 92 is formed is in approximate contact with the portion of the peripheral wall 58 of the needle tip cover 16 other than the position where the notches 68a, 68b are formed.

In this way, by puncturing the skin with the tip 22 of the hollow needle 12 and pushing the pusher member 18 toward the tip side to the push-in position to inject the drug solution, the hollow needle 12 is removed from the skin, as shown in FIG. 22, the needle tip cover 16 moves so as to protrude from the device main body 14 toward the distal end according to the biasing force of the coil spring 110, and the distal needle tip 22 of the hollow needle 12 is moved by the needle tip cover 16. It is meant to be covered and protected.

That is, when the arm 92 of the pusher member 18 enters the notch 68b of the needle tip cover 16, the needle tip cover 16 moves toward the tip side relative to the device body 14, so that the needle tip cover 16 is positioned toward the tip side of the pusher member 18. In other words, when the regulating protrusion 70 of the needle tip cover 16 is located in the gap 101a on the outer periphery side of the arm 92, the needle tip cover 16 moves toward the tip side, so that the arm 92 is elastically deformed toward the inner periphery along the inclined surface 72 of the regulating protrusion 70, and the regulating protrusion 70 can be released from the gap 101a. Then, after the arm 92 climbs over the regulating protrusion 70, the arm 92 is elastically restored to the outer periphery, so that the tip of the inclined portion 94 of the arm 92 abuts against or is slightly separated from the inner periphery surface of the outer periphery wall portion 32 of the device body 14.

In this state, the regulating protrusion 70 of the needle tip cover 16 is substantially adjacent to the inclined part 94 of the arm part 92 in the axial direction, and the regulating protruding part 70 and the inclined part 94 come into contact with each other. This restricts or prevents the needle tip cover 16 from moving toward the proximal end with respect to the device main body 14. In particular, in this embodiment, the proximal end surface of the regulating protrusion 70 and the distal end surface of the inclined portion 94 are vertical surfaces 73 and 95 that extend in the direction perpendicular to the axis. The effect of preventing movement toward the proximal end side is stably exhibited. On the other hand, movement of the needle tip cover 16 toward the distal end with respect to the device main body 14 is prevented by the mutual contact between the engaging claw 64 of the needle tip cover 16 and the distal end side claw portion 44 of the device main body 14, and The needle tip cover 16 can be prevented from falling off from the needle tip cover 14. In short, in this embodiment, the regulating protrusion 70 of the needle tip cover 16 is moved toward the proximal end when the hollow needle 12 is punctured, and the regulating protrusion 70 of the needle tip cover 16 is moved toward the distal end during the pushing operation and positioned at the pushing position. The arm portions 92 of the child member 18 overlap each other, and the needle tip cover 16 is moved toward the distal end side when the hollow needle 12 is removed, so that the overlapping of the regulating protrusion 70 and the arm portion 92 is eliminated. It looks like this. Then, the regulating protrusion 70 of the needle tip cover 16 and especially the inclined portion 94 of the arm portion 92 of the pusher member 18 positioned at the pushing position come into contact with each other in the axial direction, so that the proximal end of the needle tip cover 16 The movement toward the side is regulated or prevented, and mutual interference portions provided at the distal end portion of the pusher member 18 and the proximal end portion of the needle tip cover 16 interact with the inclined portion 94 of the arm portion 92, respectively. It is constituted by a regulating protrusion 70.

That is, in the liquid drug injector 10 of the present embodiment, the needle tip cover 16 protects the distal needle tip 22 of the hollow needle 12 by coming into contact with the pusher member 18 positioned at the push-in position by the positioning mechanism 116. Since the movement of the needle tip cover 16 toward the proximal end in the state is regulated or prevented, the simple structure prevents unintended movement of the needle tip cover 16 toward the proximal end, that is, the intended movement of the needle tip cover 16 toward the proximal end. Re-exposure of the distal needle tip 22 of the hollow needle 12 that does not occur can be prevented.

In particular, in this embodiment, the positioning mechanism 116 that positions the pusher member 18 at the push-in position is configured to engage the proximal claw portion 52 with the positioning protrusion 88 and fit the positioning piece 100 into the through window 46. Since the positioning mechanism 116 is configured to include the above, the positioning mechanism 116 is provided inside the chemical liquid injection device 10. Therefore, for example, it is virtually impossible to release the positioning between the pusher member 18 and the device main body 14, and the positioning state of the pusher member 18 and the device main body 14, as well as the hollow space created by the needle tip cover 16. The protected state of the distal needle tip 22 of the needle 12 can be stably maintained.

Further, in this embodiment, when both the needle tip cover 16 and the pusher member 18 are housed in the device main body 14, the mutual interference portions (especially the inclined portions 94 of the regulating protrusion 70 and the arm portion 92) of the needle tip cover 16 and the pusher member 18 are Since they are made to overlap with each other, it is possible to avoid an increase in the axial dimension of the device main body 14 and, by extension, the chemical liquid injection device 10. In particular, in this embodiment, since the arm portion 92 is elastically deformable, the movement of the arm portion 92 to move over the regulating protrusion 70 can be stably realized.

Furthermore, in this embodiment, since the vial 20 is employed as the internal reservoir for storing the drug solution, the internal reservoir can be provided in the drug solution injection device 10 simply by attaching the vial 20 to the pusher member 18. In addition, leakage of the chemical solution can be effectively avoided, and the ease of assembling the internal reservoir to the drug solution injection device 10 and the manufacturing efficiency of the drug solution injection device 10 can be improved. Furthermore, by preparing a plurality of vials 20 in which different types of medicinal solutions are stored, it is possible to easily manufacture a plurality of drug solution injection devices 10 that can inject different drug solutions.

23 shows a liquid medicine injection device 120 according to a second embodiment of the present invention in a state before the hollow needle 122 is inserted. FIG. 24 shows the liquid medicine injection device 120 in a state in which the hollow needle 122 is inserted, and FIG. 25 shows the state after the hollow needle 122 is inserted. In the liquid medicine injection device 120 of this embodiment, a pre-filled syringe 124 is used as an internal reservoir. In the following description, the same reference numerals as those in the first embodiment are used in the drawings to designate the substantially same members and parts as those in the first embodiment, and detailed description thereof will be omitted.

That is, the prefilled syringe 124 of this embodiment is configured to include a syringe barrel 126 in which a medical solution is substantially stored, and a plunger 128 inserted from the proximal opening of the syringe barrel 126. A needle hub 130 to which the hollow needle 122 is fixed is integrally formed at the distal end portion of the syringe barrel 126, and the proximal end portion of the hollow needle 122 having only the distal needle tip 22 is fixed to the needle hub 130. has been done. The syringe barrel 126 is inserted and fixed into the inner circumferential wall 30 of the device main body 14, and the tip 22 of the hollow needle 122 protrudes toward the distal end from the distal end of the device main body 14.

On the other hand, the plunger 128 constituting the prefilled syringe 124 is integrally formed with the pusher member 132. That is, the pusher member 132 of this embodiment has a double cylinder-like shape with the plunger 128 on the inner peripheral side of the peripheral wall 80, and the proximal opening of the peripheral wall 80 is a substantially annular bottom wall. 81, and a substantially cylindrical plunger 128 extends from the inner peripheral edge of the bottom wall portion 81 toward the distal end side. Note that a rubber stopper 134 is fixed to the tip of the plunger 128, and when the rubber stopper 134 is inserted from the proximal opening of the syringe barrel 126, the rubber stopper 134 is compressed in the radial direction and the syringe is closed. It comes into close contact with the peripheral wall of the barrel 126. Of course, the rubber plug 134 may not be fixed to the plunger 128, and in the state before puncture shown in FIG. 23, the rubber plug 134 and the tip of the plunger 128 are spaced apart from each other in the axial direction. Good too.

A syringe barrel 126 equipped with such a hollow needle 122 is inserted into and positioned in the inner circumferential wall 30 of the device main body 14, and a pusher member 132 integrally equipped with a plunger 128 is axially extended toward the proximal end side of the device main body 14. The medical fluid injector 120 of the present embodiment is configured in a movable manner. In this embodiment, in the pre-puncture state shown in FIG. is fluid-tightly closed.

Note that the method of storing the drug solution in the prefilled syringe 124 is not limited in any way; The drug solution can be stored in the prefilled syringe 124 by puncturing the rubber stopper of the vial containing the drug solution and pulling out the plunger 128 from this state. Then, the prefilled syringe 124 containing the drug solution and the pusher member 132 are inserted through the proximal opening 113 of the device main body 14, and the syringe barrel 126 is inserted into the inner peripheral wall 30 of the device main body 14, and the pusher member 132 is pushed. By assembling the child member 132 to the device main body 14, the liquid drug injection device 120 of this embodiment can be manufactured.

The liquid drug injection device 120 having such a structure is also used in the same manner as in the first embodiment, and from the pre-puncture state shown in FIG. By rotating the pusher member 132 by a predetermined angle (45 degrees in this embodiment) around the axis, the pushing operation of the pusher member 132 into the device main body 14 is permitted. By pressing the liquid drug injection device 120 in this state against the skin, the hollow needle 122 punctures the skin as shown in FIG. 24, and by further pushing the pusher member 132 against the device main body 14, the prefilled syringe The medical solution contained within 124 is injected into the patient's blood vessel.

Then, when the pusher member 132 is pushed to the deepest position, the pusher member 132 is positioned at the push-in position by the positioning mechanism 116, and substantially all of the liquid medicine in the prefilled syringe 124 is injected into the blood vessel. By removing the hollow needle 122 from the skin after injecting the drug solution, the needle tip cover 16 is moved toward the distal end side of the device main body 14 by the elastic restoring action of the coil spring 110, as shown in FIG. Thus, the distal needle tip 22 of the hollow needle 122 can be protected by the needle tip cover 16.

Also in the liquid drug injector 120 of this embodiment having the above-described structure, movement of the needle tip cover 16 toward the proximal end side is prevented by coming into contact with the pusher member 132 positioned at the push-in position. , the same effects as the first embodiment can be achieved.

Next, FIGS. 26 and 27 show a liquid drug injection device 140 as a third embodiment of the present invention. That is, the shapes of the needle tip cover and the pusher member are not limited to those described in the above embodiments, but may be shaped like the needle tip cover 142 and the pusher member 144 that constitute the liquid drug injection device 140 of this embodiment. It may be a shape. Note that in this embodiment, illustration of the device main body (14) is omitted. Further, in this embodiment, a vial (20) is installed as an internal reservoir inside the pusher member 144, as in the first embodiment, but as in the second embodiment, the vial (20) is installed as an internal reservoir. A prefilled syringe (124) may also be attached as a prefilled syringe.

That is, the peripheral wall 58 of the needle tip cover 142 is provided with a plurality (four in this embodiment) of support arms 146 on the circumference that protrude toward the proximal end, and a protruding tip portion of each support arm 146 is provided on the circumference. A pair of elastic pieces 148, 148 protrude toward the base end from both ends in the circumferential direction (base end portion in the axial direction) and face each other in the circumferential direction. These elastic pieces 148 have sufficiently small circumferential dimensions to enable elastic deformation in the circumferential direction.

Further, at the protruding tips of these elastic pieces 148, regulating protrusions 150 are provided as mutual interference parts that protrude in a direction in which the elastic pieces 148 approach each other. That is, the circumferential separation distance between the elastic pieces 148, 148 is made small at the proximal end portion of the elastic piece 148, which is the formation position of the regulating protrusion 150, and the distance between the supporting arm 146, the elastic pieces 148, 148, and the regulating protrusion is reduced. A region surrounded by the portions 150, 150 is a storage region 152 extending in the axial direction. In particular, the circumferential separation distance between the regulating protrusions 150, 150 is made smaller than the width dimension of the positioning protrusion 158 on the vertical surface 160, which will be described later. In the present embodiment, the end surface of the regulating protrusion 150 on the distal end side is an inclined surface 154 that slopes in a direction in which the protrusion dimension gradually decreases toward the distal end side.

Further, the peripheral wall 80 of the pusher member 144 is provided with a plurality of arm portions 156 (four in this embodiment) on the circumference that protrude toward the distal end side, and on the outer peripheral surface of the distal end of each arm portion 156, A positioning protrusion 158 is provided as a mutual interference part that protrudes toward the outer circumference. In particular, the positioning protrusion 158 of this embodiment has a substantially triangular shape, and the distal end surface of the positioning protrusion 158 is a vertical surface 160 that extends in the direction perpendicular to the axis, and the proximal end thereof is the regulating protrusion 150, The inclined surfaces 162, 162 are inclined in the direction corresponding to the inclined surfaces 154, 154 of 150.

In the liquid drug injector 140 of this embodiment, in the state before puncturing, the positioning protrusion 158 of the pusher member 144 is inserted into the accommodation area 152 of the needle tip cover 142, as shown in FIGS. 26 and 27. . Specifically, the positioning protrusion 158 is located at the base end of the accommodation area 152, and the inclined surfaces 154, 154 of the regulating protrusion 150, which are mutually interfering parts, and the inclined surfaces 162, 162 of the positioning protrusion 158 are arranged at the circumference. They are in contact and overlap in the direction. Of course, these inclined surfaces 154, 162 may be spaced apart from each other. By pressing the tip of the chemical liquid injector 140 in this state against the patient's skin, the needle tip cover 142 moves toward the proximal end with respect to the device body (14), and the pusher further moves as shown in FIG. By pushing the member 144 toward the distal end of the device body (14), the hollow needle 12 punctures the patient's skin and the medicinal solution is injected into the patient's blood vessel. At that time (i.e., when the needle tip cover 142 moves toward the proximal end and the pusher member 144 moves toward the distal end), the positioning protrusion 158 of the pusher member 144 moves toward the distal end within the storage area 152. Then, as shown in FIG. 28, it is moved to the distal end of the storage area 152. At this position, the pusher member 144 is positioned relative to the device main body (14). In this embodiment, although a positioning mechanism for positioning the pusher member 144 and the device main body (14) is not shown, for example, a positioning mechanism (116) similar to that of the previous embodiment may be employed.

Then, by removing the hollow needle 12 from the skin after injecting the drug solution, the elastic restoring action of the coil spring 110 moves the needle tip cover 142 toward the distal end with respect to the device body (14), and the hollow needle 12 is removed from the skin. The distal needle tip 22 of the needle 12 may be protected by a needle tip cover 142. In addition, in the protected state by the needle tip cover 142, the needle tip cover 142 is positioned on the distal end side of the pusher member 144, and the pusher member 144 is positioned against the regulating protrusions 150, 150 of the needle tip cover 142. By abutting the positioning protrusion 158 from the proximal end side, movement of the needle tip cover 142 toward the proximal end side is prevented.

That is, in this embodiment, after the needle is removed, the needle tip cover 142 moves toward the distal end side with respect to the pusher member 144 due to the elastic restoring action of the coil spring 110. In short, the positioning protrusion 158 located at the distal end of the accommodation area 152 is moved within the accommodation area 152 toward the proximal end. At this time, the repulsive force of the coil spring 110 causes the needle tip cover 142 to move further toward the distal end than in the pre-puncture state shown in FIGS. By coming into contact with the regulating protrusions 150, 150 provided in the side openings, the regulating protrusions 150, 150 (elastic pieces 148, 148) are elastically deformed outward in the circumferential direction, that is, in a direction in which they are separated from each other. As a result, the positioning protrusion 158 can pass between the expanded regulation protrusions 150, 150, and the regulation protrusions 150, 150 can pass over the positioning protrusion 158, as shown in FIG. 150, 150 (elastic pieces 148, 148) are elastically restored to their initial positions, and the proximal end surface of the regulating protrusion 150 comes into contact with the vertical surface 160 of the positioning protrusion 158. In particular, in this embodiment, since the distal end surface of the regulating protrusion 150 and the proximal side surface of the positioning protrusion 158 that abuts the distal end surface are the inclined surface 154 and the inclined surface 162, respectively, the regulating protrusion Elastic deformation of the elastic pieces 150, 150 (elastic pieces 148, 148) outward in the circumferential direction can be facilitated.

In the liquid medicine injection device 140 of this embodiment, which has the above-described structure, the pusher member 144 positioned at the pushed-in position abuts against the needle tip cover 142 from the base end side, preventing the needle tip cover 142 in the needle tip protection state from moving toward the base end side, thereby achieving the same effect as in the first embodiment.

Although the embodiments of the present invention have been described above, the present invention is not to be construed as being limited by the specific descriptions in such embodiments, and various changes, modifications, improvements, etc. can be made based on the knowledge of those skilled in the art. It can be implemented in a manner in which the following is added.

For example, in the embodiment described above, the positioning mechanism 116 was configured to include the engagement between the proximal claw portion 52 and the positioning protrusion 88, and the fitting of the positioning piece 100 into the through window 46. It may be one or the other. Of course, the specific structure of the positioning mechanism for positioning the pusher member with respect to the device main body is not limited in any way; for example, the uneven shape as described above may be provided oppositely to the device main body and the pusher member. Good too. Furthermore, in the embodiment described above, the portion into which the positioning piece 100 is fitted is the through window 46 that penetrates the outer peripheral wall 32 of the device main body 14 in the thickness direction. The bottom hole shape may make it more difficult to release the positioning of the device main body 14 and pusher member 18 by the positioning mechanism 116 from the outside.

Further, in the embodiment, the proximal claw portion 52, the positioning protrusion 88, the positioning piece 100, and the through window 46, which constitute the positioning mechanism 116, are all provided at the proximal end portion of the device main body 14 and the pusher member 18. The positioning mechanism 116 was provided at the proximal end portion of the liquid drug injector 10, 120, 140 when the pusher member 18 was in the pushed-in position. In this state, it may be provided at an axially intermediate portion or a distal end portion of the chemical liquid injector. Furthermore, as in the embodiment, the positioning mechanism 116 is configured to include engagement between the proximal claw portion 52 and the positioning protrusion 88, and fitting the positioning piece 100 into the through window 46. , their axial positions may be different from each other; for example, one of them may be located between the distal end or axially intermediate portion of the device body and the distal end or axially intermediate portion of the pusher member. may be provided.

In addition, in the embodiment, when the pusher member 18 is in the pushed-in position, the base end of the pusher member 18 is at approximately the same axial position as the base opening 113 of the device main body 14 or slightly axially. Although the proximal end of the pusher member is located inward in the axial direction, the base end of the pusher member may be located outward in the axial direction from the proximal opening of the device main body. Furthermore, in a state where the pusher member is in the pushed-in position, the pusher member may be movable in the axial direction (for example, toward the proximal end) by a predetermined distance. That is, by moving the pusher member toward the proximal end (i.e., in the opposite direction to the pushing direction), the needle tip cover can also move toward the proximal end, but the amount of movement is such that the needle tip of the hollow needle is not exposed. If there is, the state of protection of the needle tip by the needle tip cover can be maintained.

Further, in the present invention, the lock fixing mechanism 112 that makes it impossible to push the pusher member 18 into the device main body 14 in a state before the pusher member 18 is punctured is not essential. Moreover, even if a lock fixing mechanism is provided, the circumferential groove 82 is not essential, and only an axial groove may be provided. In such a case, a locking protrusion that disables the pushing operation of the pusher member is provided in the axially intermediate portion of the axial groove, and the proximal claw portion moves over the locking protrusion to close the pusher member. A pushing operation of the member may be permitted. In the embodiment described above, the lock by the lock fixing mechanism 112 is released by rotating the pusher member 18 by 45 degrees in the circumferential direction with respect to the device main body 14. The rotation angle is not limited in any way.

In addition, in the above embodiment, a coil spring 110 is used as an elastic member that exerts a biasing force on the needle tip cover 16 toward the tip side, but it may be a cylindrical member made of a rubber elastic body, or a biasing force may be exerted on the needle tip cover using magnetic force or the like. However, such an elastic member is not essential, and the needle tip cover that moves toward the base end when the hollow needle is inserted may be manually moved toward the tip side when the hollow needle is removed.

Furthermore, in the embodiment, the tip portions (arm portions 92, 156) of the pusher members 18, 132, 144 positioned at the push-in position directly contact the proximal portions of the needle tip covers 16, 142, so that the needle tip Although the covers 16 and 142 are prevented from moving toward the proximal end, an intermediate member may be provided between the needle tip cover and the pusher member, and the The needle tip cover and the pusher member may come into contact with each other to prevent the needle tip cover from moving toward the proximal end side.

Further, in the first embodiment, the vial 20 is mounted inside the pusher member 18, but the pusher member may be constituted by the vial itself. Specifically, the pusher member may be configured by the bottle that constitutes the vial. A positioning mechanism may be provided to position the child member (bottle body) at the pushed-in position.

Further, in the second embodiment, the plunger 128 is integrally formed inside the pusher member 132, but the pusher member and the plunger may be separate bodies. That is, the syringe barrel may be assembled to the device body and the plunger may be assembled to the pusher member, and the device body and the pusher member may be assembled to each other. In such a case, a commercially available syringe may be used. be. In addition, when the internal reservoir is of the syringe type in this way, it is not limited to the embodiment in which a prefilled syringe containing a drug solution is assembled in advance as in the second embodiment, but the method is not limited to the embodiment in which the drug solution injection device is manufactured. After that, the drug solution may be contained in the syringe barrel through the tip of the hollow needle. Specifically, the chemical injection device is manufactured in a state in which it is advanced to a position immediately before the pusher member is positioned relative to the main body of the device, and in this state, the needle tip of the hollow needle is immersed in the drug solution, and the pusher member is moved forward. By moving the member toward the proximal end, a medicinal solution can be accommodated within the syringe barrel. In addition, in the second embodiment, the syringe barrel 126 is not essential, and it is also possible to configure an internal reservoir by the inner circumferential wall.

Furthermore, in the present invention, it is essential that the needle tip cover, which is positioned to protect the needle tip of the hollow needle, is prevented from moving toward the proximal end by coming into contact with the pusher member positioned at the pushing position. It's not a thing. That is, the needle tip cover as in the embodiment described above is not essential; for example, a mechanism for protecting the tip of the hollow needle after use may be provided separately, and the needle tip of the hollow needle may not necessarily be protected after use. It doesn't have to be done.

In addition, in the first embodiment, the stopper 106 is pushed into the bottle body 104 of the vial 20 to the deepest part (until the stopper 106 comes into contact with the bottom wall on the proximal side of the bottle 104). Although the position has been described as the pushing position of the pusher member 18 with respect to the device main body 14, it is not limited to this embodiment. That is, for example, the position where the stopper is pushed into the axially intermediate portion of the bottle body may be defined as the pushed-in position, and the position may be determined by the positioning mechanism. Similarly, in the second embodiment, the pushed-in position may be, for example, the position where the plunger is pushed into the axially intermediate portion of the syringe barrel.

In the first and second embodiments, the arm 92 is elastically deformed inward relative to the restricting protrusion 70, so that the arm 92 overcomes the restricting protrusion 70. However, the restricting protrusion, which is capable of bending or elastic deformation, may be elastically deformed outward relative to the arm, so that the arm overcomes the restricting protrusion. In such a case, the flexible portion that is capable of bending at the base end of the needle tip cover may be constituted by the restricting protrusion.

Furthermore, in the first and second embodiments, the vial 20 or the prefilled syringe 124 was used as the internal reservoir, but the internal reservoir may be sealed with a stopper or the like on the distal end and proximal end, and A cartridge in which a chemical solution is stored may be used. In this case, for example, the proximal needle tip of a double-ended hollow needle can be inserted into the distal stopper, and the proximal stopper can be inserted into the cartridge as the pusher member is pushed. The inside of the tube can be moved toward the distal end. In addition, when such a cartridge is adopted, in order to prevent the medicinal solution inside the cartridge from leaking from the hollow needle, the proximal needle tip of the hollow needle is inserted into the stopper on the distal end to communicate the inside and outside of the cartridge. This operation is performed when the cartridge is pushed toward the distal end of the device main body due to the pushing operation of the pusher member, when a pusher member to which a cartridge is fixed in advance is attached to the device main body, or when the pusher member is inserted into the device body. The configuration may be such that this is achieved when the cartridge is installed in the apparatus main body before being installed in the main body. In a liquid drug injection device having such a structure, for example, the cartridge is moved to the distal end side by a pushing operation of the pusher member, and the proximal needle tip of the hollow needle is pierced into the stopper at the distal end, and the cartridge is removed from this state. When the pusher member is further pushed in, the stopper on the proximal end side moves inside the cartridge toward the distal end, so that the medicinal solution inside the cartridge is administered to the patient.
Further, the present invention originally includes the inventions described below, and additional notes will be made regarding their configurations and effects.
(i) By pushing the pusher member from the proximal side into the main body of the device, which is equipped with a hollow needle at the distal end, the medicinal solution stored in the internal reservoir is poured out through the hollow needle, and the hollow needle is In a chemical liquid injection device in which a needle tip cover that protects a needle tip is assembled so as to be movable in the axial direction with respect to the device main body, a positioning mechanism that positions the pusher member to a pushing position into the device main body is directly pushed. The needle tip cover is provided between the pusher member and the main body of the device, and the needle tip cover is moved toward the proximal end side by the abutting action on the pusher member that has been positioned to the push-in position by the positioning mechanism. A liquid drug injection device characterized in that movement is regulated;
(ii) The liquid drug injection device according to (i), wherein a vial including a bottle body and a stopper is employed as the internal reservoir;
(iii) the liquid drug injection device according to (i), wherein a prefilled syringe is employed as the internal reservoir;
(iv) In the positioning mechanism, a reuse prevention mechanism is configured by having a structure that does not include a release operation means for positioning the pusher member to the pushing position into the device main body. (i) (iii) The liquid drug injection device according to any one of the above,
(v) Any one of (i) to (iv), wherein a locking mechanism is provided between the pusher member and the device main body, which makes it impossible to push the pusher member into the device main body. The liquid drug injection device according to item 1,
(vi) By relatively rotating the pusher member and the device main body in the circumferential direction, the fixation by the lock fixing mechanism is released, and the pushing operation of the pusher member with respect to the device main body is permitted. The liquid drug injection device according to (v),
(vii) A flexible portion that is capable of bending and deforming is provided at the base end of the needle tip cover, and the tip of the pusher member that is directly pressed passes over the flexible portion to The chemical liquid injector according to any one of (i) to (vi), wherein the pusher member reaches the push-in position;
(viii) A flexible piece that can be flexibly deformed is provided at the distal end of the pusher member, and the flexible piece of the pusher member that is directly pushed in touches the proximal end of the needle tip cover. The chemical liquid injector according to any one of (i) to (vii), wherein the pusher member reaches the pushing position by climbing over the
(ix) A mutual interference portion is provided between the distal end portion of the pusher member and the proximal end portion of the needle tip cover, and the needle tip cover moves toward the proximal end with respect to the device main body. With the needle tip of the hollow needle exposed, the mutual interference portions overlap each other, allowing the pusher member to move toward the distal end with respect to the device main body, while the pusher member When the needle tip cover is positioned at the push-in position, the needle tip cover protrudes from the main body of the device toward the distal end side, thereby eliminating the mutual overlap in the mutual interference part and aligning the mutual axes of the mutual interference part. The liquid drug injection device according to any one of (i) to (viii), wherein movement of the needle tip cover toward the proximal end is regulated by the abutting action in the direction;
(x) A drug solution injection device in which the drug solution stored in the internal reservoir is poured out through the hollow needle by pushing a pusher member from the proximal end side into the device main body equipped with a hollow needle at the distal end side; A vial having a bottle body and a stopper is adopted as the internal reservoir, and the stopper is positioned with respect to the main body of the device, and the bottle moves toward the distal end side as the pusher member is pushed. a drug solution injection device, characterized in that the drug solution in the vial is injected through the hollow needle pierced by the stopper;
(xi) It is assembled so as to be movable in the axial direction from the proximal end of a device body having a hollow needle on the distal end side, and is pushed into the device body to transfer the medicinal solution stored in the internal reservoir into the hollow needle. A pusher member for a drug injector for dispensing liquid through a needle, which is equipped with a vial constituting the internal reservoir, and is adapted to hold the vial body and move it toward the distal end with respect to the device body. a pusher member, characterized in that the vial body is moved relative to the stopper body of the vial positioned by the device main body;
Including inventions related to.
The problem to be solved by the invention described in (x) and (xi) above is to provide a chemical liquid injection device with a novel structure that does not require injection of chemical liquid during use and is easy to operate.
According to the chemical liquid injector having the structure according to the aspect described in (i) above, the re-exposure of the needle tip due to the movement of the needle tip cover toward the proximal end is caused by the contact action against the pusher member that is pushed. is prevented. Therefore, complication of the main body of the device for restricting movement of the needle tip cover toward the proximal end side is avoided. In addition, since the pusher member is pushed directly, it can be reliably moved to the push-in position, and the positioning mechanism can more stably position the needle tip cover, thereby regulating the needle tip cover's movement toward the proximal end. becomes.
Note that the above embodiment (ii) or (iii) can be suitably adopted as the internal reservoir for storing the chemical solution.
By employing a vial as the internal reservoir according to the aspect described in (ii) above, the drug solution storage section can be simplified. Furthermore, by employing a prefilled syringe as the internal reservoir according to the aspect described in (iii) above, complicated operations such as filling a syringe with a medicinal solution each time are unnecessary.
According to the chemical liquid injector having the structure according to the aspect described in (iv) above, it is virtually impossible to release the positioning of the pusher member pushed toward the distal end side with respect to the main body of the device. Intentional or unintentional reuse by the user that is not anticipated by the provider of the product is prevented.
According to the chemical liquid injector having the structure according to the aspect described in (v) above, the pusher member is prevented from being unintentionally pushed in before use.
According to the chemical liquid injector having the structure according to the aspect described in (vi) above, if the pusher member is not operated in the rotational direction perpendicular to the pushing direction, which is the normal operating direction, the pusher member must be operated. Since the fixation of the pusher member is not released, unintended pushing operation of the pusher member is prevented.
According to the chemical liquid injector having the structure according to the aspect described in (vii) above, since the flexible portion that can be bent and deformed is provided at the base end of the needle tip cover, the flexible portion is By bending and deforming, the movement of the distal end of the pusher member to move over the proximal end of the needle tip cover can be stably realized.
According to the chemical liquid injector having the structure according to the aspect described in (viii) above, the bending and deformation of the flexible piece allows the distal end of the pusher member to stably move over the proximal end of the needle tip cover. It can be realized.
According to the chemical liquid injector having the structure according to the aspect described in (ix) above, the needle tip cover and the pusher member are allowed to mutually move in one direction due to their overlapping, so that the pushing operation of the pusher member can be easily performed. The operation of protruding the needle tip cover toward the distal end is allowed, and the movement of the protruding needle tip cover toward the proximal end is restricted.
According to the liquid drug injection device having the structure according to the aspect described in (x) above, it is possible to attach a vial containing a liquid drug, and the operability is significantly improved compared to, for example, when using a syringe with a conventional structure. can be improved.
According to the drug solution injection device having the structure according to the aspect described in (xi) above, since a vial containing the drug solution is attached, by assembling and using the pusher member in the device main body, it is possible to inject the drug solution. There will be no need for accommodation work. Furthermore, it is also possible to prepare a plurality of vials containing different types of medicinal solutions, or to prepare a plurality of types of pusher members to which various vials are attached in advance, and provide them to the user as appropriate.
That is, according to the liquid drug injection device having the structure according to the invention described in (x) and (xi) above, by employing a vial as the internal reservoir, the liquid medicine can be delivered more easily than when using a conventional syringe, for example. It is possible to improve the operability when using the injection device from storing the medicinal solution to dispensing it.

10, 120, 140: Liquid injection device, 12, 122: Hollow needle, 14: Device main body, 16, 142: Needle tip cover, 18, 132, 144: Pusher member, 20: Vial (internal reservoir), 22: Tip side needle tip (needle tip), 70: Regulating protrusion (mutual interference part), 92: Arm part (mutual interference part, flexible piece), 94: Inclined part (mutual interference part), 104: Bottle body, 106 : Plug body, 112: Lock fixing mechanism, 116: Positioning mechanism, 118: Reuse prevention mechanism, 124: Prefilled syringe (internal reservoir), 150: Regulation protrusion (mutual interference part), 158: Positioning protrusion (mutual interference part) )

Claims (9)

By pushing the pusher member from the proximal side into the main body of the device, which is equipped with a hollow needle at the distal end, the medicinal solution stored in the internal reservoir is poured out through the hollow needle, and the needle tip of the hollow needle is In a chemical liquid injection device in which a protecting needle tip cover is assembled so as to be movable in the axial direction with respect to the main body of the device,
The device main body has a grippable outer peripheral surface exposed to the outside,
A positioning mechanism that positions the pusher member inserted into the device main body to a pushing position into the device main body is provided between the pusher member to be directly pushed and the device main body whose outer peripheral surface is gripped. It is provided,
The needle tip of the hollow needle is moved by the mutual contact between the housing portion of the pusher member positioned in the push-in position by the positioning mechanism and the housing portion of the needle tip cover in the device body. A chemical liquid injector characterized in that movement of the needle tip cover toward a proximal end with respect to a device main body is restricted to prevent re-exposure of the needle tip cover . The liquid drug injection device according to claim 1, wherein the internal reservoir is a vial including a bottle body and a stopper body. The liquid drug injection device according to claim 1, wherein a prefilled syringe is employed as the internal reservoir. The drug injection device according to any one of claims 1 to 3, wherein the positioning mechanism is structured so that the positioning of the pusher member to the pushed-in position in the device body is not provided with a release operation means, thereby forming a reuse prevention mechanism. 5. A locking mechanism according to claim 1, further comprising a locking mechanism disposed between the pusher member and the apparatus main body to prevent the pusher member from being pushed into the apparatus main body. Chemical injection device. The fixing by the lock fixing mechanism is released by relative rotation of the pusher member and the device main body in the circumferential direction, and the pushing operation of the pusher member with respect to the device main body is permitted. Item 5. The liquid drug injection device according to item 5. A flexible portion that can be flexibly deformed is provided at the base end of the needle tip cover, and the tip of the pusher member that is directly pressed passes over the flexible portion, thereby deforming the pusher member. The chemical liquid injector according to any one of claims 1 to 6, wherein the liquid injector is configured to reach the pushed-in position. The drug solution injection device according to any one of claims 1 to 7, wherein the tip of the pusher member is provided with a flexible piece that can be flexibly deformed, and when the pusher member is directly pushed in, the flexible piece of the pusher member overcomes the base end of the needle tip cover, causing the pusher member to reach the pushed-in position. A mutual interference portion is provided between a distal end portion of the pusher member and a proximal end portion of the needle tip cover,
When the needle tip cover moves toward the proximal end with respect to the device main body and the needle tip of the hollow needle is exposed, the mutual interference portions overlap each other, so that the tip of the pusher member relative to the device main body is exposed. While lateral movement is allowed,
With the pusher member positioned at the push-in position with respect to the device main body, the needle tip cover protrudes from the device main body toward the distal end side, thereby eliminating mutual overlap in the mutual interference portion, The liquid drug injection device according to any one of claims 1 to 8, wherein movement of the needle tip cover toward the proximal end is regulated by the mutual axial abutting action of the mutual interference portions.

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