WO2014137249A3 - Procédé de fabrication d'un vaccin contre la fièvre aphteuse - Google Patents

Procédé de fabrication d'un vaccin contre la fièvre aphteuse Download PDF

Info

Publication number
WO2014137249A3
WO2014137249A3 PCT/RU2014/000151 RU2014000151W WO2014137249A3 WO 2014137249 A3 WO2014137249 A3 WO 2014137249A3 RU 2014000151 W RU2014000151 W RU 2014000151W WO 2014137249 A3 WO2014137249 A3 WO 2014137249A3
Authority
WO
WIPO (PCT)
Prior art keywords
virus
dihydrochloride
vaccine against
mouth disease
against foot
Prior art date
Application number
PCT/RU2014/000151
Other languages
English (en)
Russian (ru)
Other versions
WO2014137249A2 (fr
Inventor
Анатолий Яковлевич САМУЙЛЕНКО
Владимир Иванович ЕРЕМЕЦ
Николай Иванович ЗЕНОВ
Ирина Юрьевна ЛИТЕНКОВА
Николай Васильевич МЕЛЬНИК
Сергей Николаевич КРАСУТКИН
Ольга Филипповна СОРОКИНА
Евгений Витальевич МАСЛОВ
Павел Игоревич КАЛИНИН
Original Assignee
Федеральное Казенное Предприятие "Щелковский Биокомбинат"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Федеральное Казенное Предприятие "Щелковский Биокомбинат" filed Critical Федеральное Казенное Предприятие "Щелковский Биокомбинат"
Publication of WO2014137249A2 publication Critical patent/WO2014137249A2/fr
Publication of WO2014137249A3 publication Critical patent/WO2014137249A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne le domaine de la virologie vétérinaire et peut être utilisée dans la fabrication d'un vaccin contre la fièvre aphteuse. Pour améliorer le degré de purification de la suspension virale des impuretés de ballast et augmenter l'immunogénicité du produit cible, le procédé de fabrication d'un vaccin contre la fièvre aphteuse comprend la culture de l'antigène viral dans une culture de suspension des cellules VNK-21 à une température de 36-37ºC, la purification de la suspension virale des impuretés de ballast, l'inactivation de l'antigène obtenu par la concentration de l'antigène du virus de fièvre aphteuse et la combinaison du concentré de l'antigène à un additif, selon l'invention, la purification de la suspension virale des impuretés de ballast se fait par l'ajout de dérivés de polyguanidines dans une concentration finale de 0,005-0,01% ou de mélange de chloroforme et de dérivés de polyguanidines, pris dans un rapport de poids (40-160):1, respectivement, dans une concentration finale 0,4-0,8%, on utilise en tant que dérivés de polyguanidines de dihydrochlorure 1,12-diguanidinohexane, ou de dihydrochlorure bis(3-guanidinopropil)pipérazine, ou de dihydrochlorure 3,6-dioxaoctane-1,8-diguanidine ou de dihydrochlorure 4,9-dioxadodécan-1,2-dibiguanide.
PCT/RU2014/000151 2013-03-06 2014-03-06 Procédé de fabrication d'un vaccin contre la fièvre aphteuse WO2014137249A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2013109994/15A RU2522868C1 (ru) 2013-03-06 2013-03-06 Способ изготовления вакцины против ящура
RU2013109994 2013-03-06

Publications (2)

Publication Number Publication Date
WO2014137249A2 WO2014137249A2 (fr) 2014-09-12
WO2014137249A3 true WO2014137249A3 (fr) 2015-03-05

Family

ID=51217519

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2014/000151 WO2014137249A2 (fr) 2013-03-06 2014-03-06 Procédé de fabrication d'un vaccin contre la fièvre aphteuse

Country Status (2)

Country Link
RU (1) RU2522868C1 (fr)
WO (1) WO2014137249A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2619878C1 (ru) * 2016-10-14 2017-05-18 Федеральное государственное бюджетное учреждение "Федеральный центр охраны здоровья животных" (ФГБУ "ВНИИЗЖ") Способ определения концентрации 146S-компонента вируса ящура в вируссодержащем сырье для вакцины с применением метода обратной транскрипции-полимеразной цепной реакции в режиме реального времени

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2498814A (en) * 1943-11-02 1950-02-28 Gen Motors Corp Battery charging system
RU2054039C1 (ru) * 1992-02-07 1996-02-10 Всероссийский научно-исследовательский институт защиты животных Способ очистки и стерилизации культурального вируса ящура
RU2230734C1 (ru) * 2003-06-09 2004-06-20 Общество с ограниченной ответственностью "Международный институт эколого-технологических проблем" Производные полигуанидинов
US7531182B2 (en) * 2000-06-29 2009-05-12 Merial Limited Vaccine against foot-and-mouth disease

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012010357B1 (pt) * 2009-11-02 2022-05-24 Inovio Pharmaceuticals, Inc. Proteínas de consenso de vírus de doença de febre aftosa (fmdv), sequências de codificação para as mesmas e vacinas feitas a partir das mesmas

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2498814A (en) * 1943-11-02 1950-02-28 Gen Motors Corp Battery charging system
RU2054039C1 (ru) * 1992-02-07 1996-02-10 Всероссийский научно-исследовательский институт защиты животных Способ очистки и стерилизации культурального вируса ящура
US7531182B2 (en) * 2000-06-29 2009-05-12 Merial Limited Vaccine against foot-and-mouth disease
RU2230734C1 (ru) * 2003-06-09 2004-06-20 Общество с ограниченной ответственностью "Международный институт эколого-технологических проблем" Производные полигуанидинов

Also Published As

Publication number Publication date
WO2014137249A2 (fr) 2014-09-12
RU2522868C1 (ru) 2014-07-20

Similar Documents

Publication Publication Date Title
PH12017501445A1 (en) Methods for producing virus for vaccine production
PH12018500856A1 (en) Respiratory syncytial virus vaccine
MX2022009429A (es) Composiciones para la inmunizacion contra virus respiratorios.
MX2022006603A (es) Vacuna contra el virus de la influenza de amplio espectro.
EA200801221A1 (ru) Вирусные вакцины, полученные из клеток, с низкими уровнями остаточной клеточной днк
CY1120911T1 (el) Παραγομενες απο mdck κυτταρικες σειρες προσαρμοσμενες σε απαλλαγμενη απο ορο καλλιεργεια και καλλιεργεια εναιωρηματος και μεθοδος για παρασκευη ιου εμβολιου χρησιμοποιωντας τα κυτταρα
UY35141A (es) Derivados de 5-fluoro-n- (piridin-2-il) piridin-2-amina que contienen un grupo sulfoximina
PH12018500855A1 (en) Herpes simplex virus vaccine
WO2017070626A3 (fr) Vaccins contre les virus respiratoires
GT201300293A (es) 4-aril-n-fenil-1,3,5-triazin-2-aminas que contienen un grupo sulfoximina.
MY202109A (en) Viral replication inhibitors
UY35139A (es) 4- (orto) -fluorofenil-5-fluoropirimidin-2-ilaminas que contienen un grupo sulfoximina
BR112019004187A2 (pt) método para produzir um vírus enterovírus c, e, vírus enterovírus c.
DOP2015000117A (es) Derivados de n-(piridin-2-il)pirimidin-4-amina que contienen un grupo sulfoximina
NZ603310A (en) Heterocyclic flaviviridae virus inhibitors
IN2014MN01714A (fr)
MX2014000753A (es) Procedimiento para producir antigeno viral y vacunas.
NZ628515A (en) Antiviral compounds with a dibenzooxaheterocycle moiety
MX354676B (es) Compuestos de benzofurano para el tratamiento de infecciones por el virus de hepatitis c (hcv).
WO2014137249A3 (fr) Procédé de fabrication d'un vaccin contre la fièvre aphteuse
WO2011154976A3 (fr) Vaccin antigrippal amélioré
EA201990780A1 (ru) Твердая форма соединения 4'-тио-2'-фторнуклеозид фосфамида и способ его получения и применения
MY188494A (en) High-growth enterovirus 71 strains and vaccines
BR112015021772A2 (pt) método para a preparação de células embrionárias aviárias, método melhorado para a preparação de células embrionárias aviárias a partir de um embrião, cultura ou composição de células embrionárias aviárias, método para a produção ou amplificação de um vírus, e, composição de vacina
RU2013116505A (ru) Способ получения антирабической вакцины

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 14760565

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 14760565

Country of ref document: EP

Kind code of ref document: A2