WO2014137145A1 - Biocapteur ayant des informations d'identification - Google Patents

Biocapteur ayant des informations d'identification Download PDF

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Publication number
WO2014137145A1
WO2014137145A1 PCT/KR2014/001782 KR2014001782W WO2014137145A1 WO 2014137145 A1 WO2014137145 A1 WO 2014137145A1 KR 2014001782 W KR2014001782 W KR 2014001782W WO 2014137145 A1 WO2014137145 A1 WO 2014137145A1
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WO
WIPO (PCT)
Prior art keywords
biosensor
measuring device
identification information
main body
recognized
Prior art date
Application number
PCT/KR2014/001782
Other languages
English (en)
Korean (ko)
Inventor
이진우
최재규
윤영일
Original Assignee
주식회사 세라젬메디시스
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사 세라젬메디시스 filed Critical 주식회사 세라젬메디시스
Publication of WO2014137145A1 publication Critical patent/WO2014137145A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/14—Devices for taking samples of blood ; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150358—Strips for collecting blood, e.g. absorbent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150763—Details with identification means
    • A61B5/150778—Details with identification means having complementary physical shapes for indexing or registration purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/4875—Details of handling test elements, e.g. dispensing or storage, not specific to a particular test method
    • G01N33/48771—Coding of information, e.g. calibration data, lot number
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/08—Sensors provided with means for identification, e.g. barcodes or memory chips

Definitions

  • the present invention relates to a biosensor having identification information, and more particularly, to a biosensor having identification information for forming an identification code on the biosensor and allowing the measuring device to recognize it.
  • Biosensor refers to a means of obtaining information from a substance to be measured by using a biological element or a similar one.
  • Biosensors that use biomaterials such as blood sugar and ketones as detection elements have excellent sensitivity and specificity of reaction, and are used in a wide range of fields such as medical and pharmaceutical fields, process measurement in the bio industry, environmental measurement, and chemical stability evaluation. .
  • biosensors have been used for diagnosis of various self tests and diseases such as blood glucose measurement, pregnancy diagnosis, urine test and the like.
  • biosensors operating by electrochemical measuring methods are mainly used for the measurement of blood glucose.
  • the target substance in the sample reduces oxygen or an electron transfer medium while oxidizing by the catalytic action of the enzyme.
  • the reduced oxygen or electron transfer medium is oxidized by the voltage of the electrode to induce a change in the electron depending on the concentration of the sample, and to quantify the change in the induced electron to determine the amount of the target material.
  • Biosensors using the electrochemical measurement method may have a slight variation in the area of the electrode, the amount of electrode material, or the amount, form, or concentration of enzyme immobilized on the electrode. May vary.
  • a code is assigned to the biosensor for each production unit, and the measurement device may identify the code and perform correction according to the corresponding code.
  • Patent Document 1 Published Patent Publication 10-2007-0040336
  • An object of the present invention devised in view of the above point is to provide a biosensor having identification information that can provide identification information of the biosensor to the measuring device when the biosensor is inserted into the measuring device.
  • the biosensor having the identification information for achieving the object of the present invention as described above is a biosensor consisting of a body having a reactor plate for generating a reaction signal in response to the fluid sample, the mounting groove is mounted to the reactor plate
  • at least one identification code forming a convex-concave portion is formed at a lead portion of the main body inserted into the measuring apparatus so that the identification information of the biosensor is recognized by the measuring apparatus.
  • the reactor plate is provided with a working electrode and a reference electrode, a reaction reagent is applied to the working electrode and the reference electrode, and extended to connect the working electrode and the reference electrode to the measuring device. Consisting of each transfer electrode.
  • the reactor plate is mounted in the mounting groove of the main body to form a capillary portion into which the fluid sample flows, and the main body is provided with an exhaust hole for discharging air by communicating with an intermediate region of the capillary portion outside. do.
  • one side of the main body is provided with a handle portion that the user grips by hand, the front portion of the main body is provided with an inlet portion that is introduced into the measuring device.
  • the identification code is made of a cutout recessed in at least one side of both ends of the front portion of the lead portion so that it can be recognized by the recognition means formed in the measuring device.
  • the identification code is made of a recessed groove recessed in at least one side of the side surface portion of the inlet so that it can be recognized by the recognition means formed inside the measuring device.
  • the identification code is made of a cutout recessed at least one recessed portion in the front portion of the handle to be recognized by the recognition means formed inside the measuring device.
  • the identification code is formed of irregularities formed on at least one side of the upper surface and the lower surface of the lead-in portion so as to be recognized by the recognition means formed inside the measuring device.
  • the biosensor having such identification information is easily introduced into the measuring device and at the same time, the measuring device can automatically recognize the identification information of the biosensor.
  • the biosensor having the identification information in the present invention is omitted because the separate operation of inputting the identification information of the biosensor to the measuring device is possible to miniaturize the product and the power consumption is reduced.
  • FIG. 1 is a perspective view showing a biosensor and a measuring device which is a first embodiment of the present invention
  • FIG. 2 is a plan view showing a reactor plate of a biosensor
  • FIG. 3 is a perspective view of the biosensor shown in FIG. 1;
  • FIG. 5 is a perspective view showing a biosensor as a second preferred embodiment of the present invention.
  • FIG. 6 is a perspective view showing a biosensor as a third preferred embodiment of the present invention.
  • FIG. 7 is a perspective view showing a biosensor as a fourth preferred embodiment of the present invention.
  • FIG. 1 is a perspective view showing a biosensor and a measuring device as a first preferred embodiment of the present invention
  • Figure 2 is a plan view showing a reactor plate of the biosensor
  • Figure 3 is a perspective view showing the biosensor shown in Figure 1 4 is a state diagram partially illustrating a state in which the biosensor is drawn in.
  • the present invention includes a biosensor 10 having identification information and a measuring device 1 for measuring the concentration of analyte through the biosensor 10.
  • the biosensor 10 which is a first preferred embodiment of the present invention, has a structure that is inserted into the measuring device 1.
  • the biosensor 10 may generate a reaction signal in response to the injected sample, and the measuring device 1 may measure the concentration of the analyte based on the reaction signal generated by the biosensor 10.
  • the biosensor 10 includes identification information for identifying itself, and the measurement device 1 may recognize or identify the corresponding identification information of the biosensor 10.
  • the measuring device 1 is provided with a display unit, it is possible to measure the reaction signal generated by the biosensor 10, and display the content according to the measurement results.
  • the measuring device 1 is formed with a connection port connected to a separate device such as a printer can print the measurement results.
  • the biosensor 10 includes a reactor plate 20 for generating a reaction signal in response to the introduced fluid sample, a main body 12 on which the reactor plate 20 is mounted, and a main body. Protruding to one side of the side portion (12) is composed of a handle portion 11 which the user grips by hand, and an inlet portion 13 formed in the front portion of the main body 12 to be introduced into the measuring device (1).
  • the lead portion 13 introduced into the measuring device 1 may extend to one side of the handle portion 11.
  • the main body 12 is provided with an exhaust hole 16 for communicating the intermediate region of the gap forming the capillary portion 15 with the outside.
  • the exhaust hole 16 is used as a passage through which the air filled in when the fluid is introduced along the capillary portion 15 is discharged.
  • the working electrode 21 and the reference electrode 22 are formed on the first surface of the reactor plate 20.
  • the reference electrode 22 as shown in FIG. 2 may be formed to surround the working electrode 21, but is not limited thereto.
  • a reaction reagent is applied on the working electrode 21 and the reference electrode 22 to react with the fluid sample.
  • Each of the transfer electrodes 23 and 24 is formed on the second surface opposite to the first surface of the reactor plate 20 to be exposed to the outside.
  • the exposed transfer electrodes 23 and 24 may be electrically connected to the measuring unit 2 formed in the measuring device 1 to transmit a reaction signal to the measuring device 1.
  • Each of the transfer electrodes 23 and 24 formed on the second surface of the reactor plate 20 may have a working electrode 21 and a reference electrode 22 formed on the first surface of the reactor plate 20 through the gas passage 25, respectively. Is electrically connected).
  • An identification code is formed in the lead portion 13 of the main body 12.
  • the identification code has the meaning of a mark that can identify the biosensor 10.
  • the identification code may have a variety of shapes and makes it possible to identify the biosensor 10 through its positional or shape characteristics.
  • an identification code is formed at at least one end of both ends of the front part of the inlet part 13, and the identification code is the measuring device 1. It is recognized by the recognition means 3 formed in the inside of the, and the recognized information is transmitted to the measuring device 1.
  • the recognition means 3 preferably uses electrical recognition means such as a micro switch or a socket as shown.
  • the recognition means 3 may also use optical recognition means comprising a light emitting portion and a light receiving portion.
  • the identification code is composed of cutout grooves 31a and 31b recessed in at least one side of both ends of the front portion of the inlet 13. That is, as shown in (a) of FIG. 3, a structure in which no incision grooves are formed at either side of both ends of the front part, and as shown in (b), a incision groove at one end of both ends of the front part. And a structure in which a cutout 31b is formed at the other end of the both ends of the front portion as shown in (c). In addition, although not shown, it may be included in a structure in which the cutting grooves 31a and 31b are formed at both ends of both ends of the front part.
  • the identification code may generate an on / off signal to the recognition means 3 of the measuring device 1, and the measuring device 1 may calculate the identification information through at least one on / off signal generated by the identification code. Can be.
  • the measuring device 12 may calculate a binary code through an on / off signal, and utilize the calculated binary code as identification information of the biosensor 10.
  • the right signal is not recognized by the incision groove 31a in the recognition means 3 formed inside the measuring device, and is read as 0, and the left side.
  • the signal is recognized by the recognizing means 3 and the end is read as 1, combined with 01, and classified into a code 1 matching it.
  • the right side signal is recognized as 1 at the end portion of the recognition means 3 formed inside the measuring device, and the left signal is read out at the recognition means 3. It is not recognized due to the incision groove 31b, and is read as 0, which is combined with 10, and classified into 2 codes that match.
  • the incision groove is not formed as shown in (a)
  • the right end signal is read as 1 by the recognition means 3 formed in the measuring device and the left signal is read as 1 by the end signal. Combination of 11 and matching with code 3 matching.
  • an identification code is formed on at least one side of both side portions of the inlet 13, and the identification code is located inside the measuring device 1. Recognized through the recognition means 3 is formed and is transmitted to the measuring device (1).
  • the identification code is composed of recessed grooves 32a and 32b recessed in at least one side portion of both side portions of the lead portion 13. That is, as shown in (a) of FIG. 5, a structure in which the recessed grooves 32a are formed in one side surface portion of both side portions, and as shown in (b), the recessed grooves 32b are formed in the other side surface portions of both side portions. As shown in (c), the concave convex groove 32a is formed in one side surface portion of both side portions, and the concave concave groove 32b is formed in the other side surface portion.
  • the on / off signal is generated by the recognition means 3 according to the presence or absence of the recessed grooves 32a and 32b formed in the side portions of the inlet portion 31, and the measuring device 12 is turned on as in the first embodiment described above.
  • the binary code can be calculated through the on / off signal, and the calculated binary code is used as identification information of the biosensor 10. Through the on / off signal, (a) is code 1, (b) code 2 and (c) code 3 is classified.
  • an identification code is formed at the front side of the handle part 11, and the identification part is handled to be recognized by the recognition means 2. It consists of incision grooves 33a, 33b, 33c recessed in at least one front part of (11). At this time, the front portion of the handle portion 11 is configured to be introduced into the measuring device, the recognition means 3 inside the measuring device 1 is formed at a position capable of recognizing the identification code formed on the handle portion (11). . This identification code is recognized by the recognition means 3 formed inside the measuring device 1 and transmitted to the measuring device 1.
  • the identification code is composed of incision grooves 33a, 33b, 33c recessed in at least one front portion of the handle portion 11. That is, as shown in (a) of FIG. 6, one cut groove 33a is formed in the front portion of the handle portion 11, and as shown in (b) two cut grooves 33a and 33b. ) Is formed in parallel with the structure, and as shown in (c) three cut grooves (33a, 33b, 33c) is formed.
  • the on / off signal is generated by the recognition means 3 according to the presence or absence of the cutting grooves 33a, 33b, 33c formed in the front portion of the handle portion 11, and the measuring device is turned on as in the first embodiment described above.
  • the binary code can be calculated through the on / off signal, and the calculated binary code is used as identification information of the biosensor 10. Through the on / off signal, (a) is code 1, (b) code 2 and (c) code 3 is classified.
  • an identification code is formed on at least one side of the upper and lower surfaces of the inlet 13, and the identification code is formed inside the measuring device 1. Recognized through the recognition means (3) formed in the transfer to the measuring device.
  • the identification code is composed of irregularities 34a, 34b, 34c formed on at least one side of the upper and lower surfaces of the lead portion 13. That is, as shown in (a) of FIG. 7, one unevenness 34a is formed at each of both sides of the upper surface of the inlet 13, and as shown in (b) of the inlet 13.
  • One concave and convex portion 34a is formed at one side of the upper surface both sides, and two concave and convex portions 34b are formed at the other side, and as shown in (c), one side of both sides of the upper surface of the inlet portion 13 is shown. It is composed of a structure in which three unevenness 34c is formed.
  • the number of the unevennesses 34a, 34b, and 34b formed on the upper surface of the inlet portion 31 may be changed according to a worker's request, and the recognition means (according to the presence or absence of the unevennesses 34a, 34b, and 34c) 3) generates an on / off signal, and as in the first embodiment described above, the measuring device 12 can calculate a binary code through the on / off signal, and the calculated binary code of the biosensor 10 It is used as identification information. Through the on / off signal, (a) is code 1, (b) code 2 and (c) code 3 is classified.
  • the unevenness of one side of the inlet part 13 indicates that the unevenness is a biosensor for measuring blood sugar if one unevenness is used. It may indicate that the purpose, and the other side irregularities may be used to distinguish the calibration code of the biosensor.
  • identification codes of different shapes For example, one side of the inlet 13 may be provided with the recessed grooves as shown in FIG. 5, and the other side may be provided with the irregularities as shown in FIG. 7.
  • the biosensor is mounted on the measuring device, and the measuring device can be used in any measuring system for identifying the type or characteristic of the biosensor by the identification shape formed by the identifier.
  • a reaction unit or a reaction zone may be provided instead of the reactor plate.
  • a reaction indicator means for directly indicating the reaction result may be further included.
  • Such a biosensor according to the present invention provides a technology for providing a measuring device with identification information for identifying a biosensor through an identification code determined by an identifier.
  • the biosensor having identification information according to the present invention can be manufactured in a small size, and the power consumption of the measuring device can be reduced.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
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  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne un biocapteur qui a des informations d'identification, une marque d'identification étant formée dans le biocapteur et les informations d'identification du biocapteur étant fournies à un dispositif de mesure. La présente invention concerne un biocapteur (10) ayant un substrat de réaction (20) pour générer un signal de réaction lorsqu'on met à réagir avec un échantillon de fluide qui s'est écoulé à l'intérieur, et ayant un corps principal (12) dans lequel le substrat de réaction (20) est ajusté ; constitué d'une telle façon que le corps principal (12) est formé afin d'avoir au moins une marque d'identification de façon inégale dans une partie de capture du corps principal (12) qui est insérée dans un dispositif de mesure (1), de telle sorte que le dispositif de mesure (1) puisse reconnaître les informations d'identification du biocapteur (10) en même temps qu'il est inséré dans le dispositif de mesure (1), rendant ainsi possible de fournir automatiquement les données d'identification au dispositif de mesure par l'intermédiaire de la marque d'identification simplement par l'action d'insertion du biocapteur.
PCT/KR2014/001782 2013-03-05 2014-03-04 Biocapteur ayant des informations d'identification WO2014137145A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2013-0023251 2013-03-05
KR1020130023251A KR101425662B1 (ko) 2013-03-05 2013-03-05 식별정보를 갖는 바이오 센서

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WO2014137145A1 true WO2014137145A1 (fr) 2014-09-12

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3293519A1 (fr) * 2016-09-13 2018-03-14 Bionime Corporation Module de mesure de paramètres physiologiques
EP3017760B1 (fr) * 2014-11-10 2019-06-19 ndd Medizintechnik AG Tube respiratoire destiné à être utilisé dans des systèmes de débitmètre à ultra-sons

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101793074B1 (ko) * 2016-05-17 2017-11-02 (주)플렉센스 바이오센서 및 이를 이용한 시료 분석방법

Citations (3)

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Publication number Priority date Publication date Assignee Title
KR101062356B1 (ko) * 2010-03-12 2011-09-05 에스디 바이오센서 주식회사 혈액 내의 단백 측정을 위한 센서스트립 장치
KR20120019940A (ko) * 2010-08-27 2012-03-07 주식회사 인포피아 바이오센서 측정기기
KR20120133029A (ko) * 2011-05-30 2012-12-10 주식회사 세라젬메디시스 바이오센서

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101062356B1 (ko) * 2010-03-12 2011-09-05 에스디 바이오센서 주식회사 혈액 내의 단백 측정을 위한 센서스트립 장치
KR20120019940A (ko) * 2010-08-27 2012-03-07 주식회사 인포피아 바이오센서 측정기기
KR20120133029A (ko) * 2011-05-30 2012-12-10 주식회사 세라젬메디시스 바이오센서

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3017760B1 (fr) * 2014-11-10 2019-06-19 ndd Medizintechnik AG Tube respiratoire destiné à être utilisé dans des systèmes de débitmètre à ultra-sons
US10786178B2 (en) 2014-11-10 2020-09-29 Ndd Medizintechnik Ag Breathing tube for use in ultrasonic flow measurement systems
EP3293519A1 (fr) * 2016-09-13 2018-03-14 Bionime Corporation Module de mesure de paramètres physiologiques

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