WO2014137145A1

WO2014137145A1 - Biosensor having identification information

Info

Publication number: WO2014137145A1
Application number: PCT/KR2014/001782
Authority: WO
Inventors: 이진우; 최재규; 윤영일
Original assignee: 주식회사 세라젬메디시스
Priority date: 2013-03-05
Filing date: 2014-03-04
Publication date: 2014-09-12
Also published as: KR101425662B1

Abstract

A biosensor is disclosed which has identification information, wherein an identification mark is formed in the biosensor and the identification information of the biosensor is provided to a measuring device. The present invention concerns a biosensor (10) having a reaction substrate (20) for generating a reaction signal upon reacting with a fluid sample that has flowed therein, and having a main body (12) into which the reaction substrate (20) is fitted; being constituted in such a way that the main body (12) is formed so as to have at least one identification mark constituting unevenness in an intake part of the main body (12) which is inserted into a measuring device (1) such that the measuring device (1) can recognise the identification information of the biosensor (10) at the same time as same is inserted into the measuring device (1), thereby making it possible to automatically provide the measuring device with the identification data via the identification mark simply through the act of inserting the biosensor.

Description

Bio sensor with identification

The present invention relates to a biosensor having identification information, and more particularly, to a biosensor having identification information for forming an identification code on the biosensor and allowing the measuring device to recognize it.

Biosensor refers to a means of obtaining information from a substance to be measured by using a biological element or a similar one. Biosensors that use biomaterials such as blood sugar and ketones as detection elements have excellent sensitivity and specificity of reaction, and are used in a wide range of fields such as medical and pharmaceutical fields, process measurement in the bio industry, environmental measurement, and chemical stability evaluation. . For example, biosensors have been used for diagnosis of various self tests and diseases such as blood glucose measurement, pregnancy diagnosis, urine test and the like.

In particular, biosensors operating by electrochemical measuring methods are mainly used for the measurement of blood glucose. When the sample is introduced into the biosensor which operates by the electrochemical measurement method, the target substance in the sample reduces oxygen or an electron transfer medium while oxidizing by the catalytic action of the enzyme. The reduced oxygen or electron transfer medium is oxidized by the voltage of the electrode to induce a change in the electron depending on the concentration of the sample, and to quantify the change in the induced electron to determine the amount of the target material.

Biosensors using the electrochemical measurement method may have a slight variation in the area of the electrode, the amount of electrode material, or the amount, form, or concentration of enzyme immobilized on the electrode. May vary. In order to reduce the deviation as described above, a code is assigned to the biosensor for each production unit, and the measurement device may identify the code and perform correction according to the corresponding code.

Conventionally, in order to input a code assigned to a biosensor into a measuring device, a user must directly input the code into the measuring device or insert a coded chip into the measuring device before use, but this causes inconvenience to the user and inputs incorrectly. There was a problem that caused the malfunctioning code.

In addition, as a method for identifying codes through a measuring device, a technology using bar code recognition, color detection, light transmittance detection, RFID, etc. has been proposed, but these technologies increase the manufacturing cost of biosensors and have limitations in miniaturization of products. However, there is a problem in that power consumption of the measuring device is increased.

(Patent Document 1) Published Patent Publication 10-2007-0040336

An object of the present invention devised in view of the above point is to provide a biosensor having identification information that can provide identification information of the biosensor to the measuring device when the biosensor is inserted into the measuring device.

The biosensor having the identification information for achieving the object of the present invention as described above is a biosensor consisting of a body having a reactor plate for generating a reaction signal in response to the fluid sample, the mounting groove is mounted to the reactor plate In the present invention, at least one identification code forming a convex-concave portion is formed at a lead portion of the main body inserted into the measuring apparatus so that the identification information of the biosensor is recognized by the measuring apparatus.

Further, more preferably, the reactor plate is provided with a working electrode and a reference electrode, a reaction reagent is applied to the working electrode and the reference electrode, and extended to connect the working electrode and the reference electrode to the measuring device. Consisting of each transfer electrode.

Further, more preferably, the reactor plate is mounted in the mounting groove of the main body to form a capillary portion into which the fluid sample flows, and the main body is provided with an exhaust hole for discharging air by communicating with an intermediate region of the capillary portion outside. do.

In addition, more preferably, one side of the main body is provided with a handle portion that the user grips by hand, the front portion of the main body is provided with an inlet portion that is introduced into the measuring device.

In addition, more preferably, the identification code is made of a cutout recessed in at least one side of both ends of the front portion of the lead portion so that it can be recognized by the recognition means formed in the measuring device.

In addition, more preferably, the identification code is made of a recessed groove recessed in at least one side of the side surface portion of the inlet so that it can be recognized by the recognition means formed inside the measuring device.

In addition, more preferably, the identification code is made of a cutout recessed at least one recessed portion in the front portion of the handle to be recognized by the recognition means formed inside the measuring device.

In addition, more preferably, the identification code is formed of irregularities formed on at least one side of the upper surface and the lower surface of the lead-in portion so as to be recognized by the recognition means formed inside the measuring device.

The biosensor having such identification information is easily introduced into the measuring device and at the same time, the measuring device can automatically recognize the identification information of the biosensor.

In addition, the biosensor having the identification information in the present invention is omitted because the separate operation of inputting the identification information of the biosensor to the measuring device is possible to miniaturize the product and the power consumption is reduced.

1 is a perspective view showing a biosensor and a measuring device which is a first embodiment of the present invention;

2 is a plan view showing a reactor plate of a biosensor;

3 is a perspective view of the biosensor shown in FIG. 1;

4 is a state diagram partially showing the state in which the biosensor is drawn in,

5 is a perspective view showing a biosensor as a second preferred embodiment of the present invention;

6 is a perspective view showing a biosensor as a third preferred embodiment of the present invention;

7 is a perspective view showing a biosensor as a fourth preferred embodiment of the present invention;

Hereinafter, a biosensor having identification information which is a preferred embodiment of the present invention will be described in detail with reference to the accompanying drawings.

1 is a perspective view showing a biosensor and a measuring device as a first preferred embodiment of the present invention, Figure 2 is a plan view showing a reactor plate of the biosensor, Figure 3 is a perspective view showing the biosensor shown in Figure 1 4 is a state diagram partially illustrating a state in which the biosensor is drawn in.

As shown in FIG. 1 to FIG. 4, the present invention includes a biosensor 10 having identification information and a measuring device 1 for measuring the concentration of analyte through the biosensor 10. The biosensor 10, which is a first preferred embodiment of the present invention, has a structure that is inserted into the measuring device 1. The biosensor 10 may generate a reaction signal in response to the injected sample, and the measuring device 1 may measure the concentration of the analyte based on the reaction signal generated by the biosensor 10. The biosensor 10 includes identification information for identifying itself, and the measurement device 1 may recognize or identify the corresponding identification information of the biosensor 10. In addition, the measuring device 1 is provided with a display unit, it is possible to measure the reaction signal generated by the biosensor 10, and display the content according to the measurement results. In addition, the measuring device 1 is formed with a connection port connected to a separate device such as a printer can print the measurement results.

As illustrated in FIGS. 1 to 4, the biosensor 10 includes a reactor plate 20 for generating a reaction signal in response to the introduced fluid sample, a main body 12 on which the reactor plate 20 is mounted, and a main body. Protruding to one side of the side portion (12) is composed of a handle portion 11 which the user grips by hand, and an inlet portion 13 formed in the front portion of the main body 12 to be introduced into the measuring device (1). The lead portion 13 introduced into the measuring device 1 may extend to one side of the handle portion 11.

When the reactor plate 20 is mounted in a mounting area 14 such as a mounting groove, a gap is maintained between the reactor plate 20 and the bottom surface of the mounting area 14 so as to form a fine gap, and the gap is capillary portion. (15) To play a role. The main body 12 is provided with an exhaust hole 16 for communicating the intermediate region of the gap forming the capillary portion 15 with the outside. The exhaust hole 16 is used as a passage through which the air filled in when the fluid is introduced along the capillary portion 15 is discharged.

The reactor plate 20 generates a reaction signal in response to the incoming fluid sample (= sample). It is preferable that the reactor plate 20 has a plate shape drawn into the mounting region 14. The working electrode 21 and the reference electrode 22 are formed on the first surface of the reactor plate 20. The reference electrode 22 as shown in FIG. 2 may be formed to surround the working electrode 21, but is not limited thereto. A reaction reagent is applied on the working electrode 21 and the reference electrode 22 to react with the fluid sample.

Each of the

transfer electrodes

23 and 24 is formed on the second surface opposite to the first surface of the reactor plate 20 to be exposed to the outside. The exposed

transfer electrodes

23 and 24 may be electrically connected to the measuring unit 2 formed in the measuring device 1 to transmit a reaction signal to the measuring device 1. Each of the

transfer electrodes

23 and 24 formed on the second surface of the reactor plate 20 may have a working electrode 21 and a reference electrode 22 formed on the first surface of the reactor plate 20 through the gas passage 25, respectively. Is electrically connected).

An identification code is formed in the lead portion 13 of the main body 12. The identification code has the meaning of a mark that can identify the biosensor 10. The identification code may have a variety of shapes and makes it possible to identify the biosensor 10 through its positional or shape characteristics.

As shown in FIG. 3, in the biosensor according to the first embodiment of the present invention, an identification code is formed at at least one end of both ends of the front part of the inlet part 13, and the identification code is the measuring device 1. It is recognized by the recognition means 3 formed in the inside of the, and the recognized information is transmitted to the measuring device 1. The recognition means 3 preferably uses electrical recognition means such as a micro switch or a socket as shown. The recognition means 3 may also use optical recognition means comprising a light emitting portion and a light receiving portion.

The identification code is composed of

cutout grooves

31a and 31b recessed in at least one side of both ends of the front portion of the inlet 13. That is, as shown in (a) of FIG. 3, a structure in which no incision grooves are formed at either side of both ends of the front part, and as shown in (b), a incision groove at one end of both ends of the front part. And a structure in which a cutout 31b is formed at the other end of the both ends of the front portion as shown in (c). In addition, although not shown, it may be included in a structure in which the cutting

grooves

31a and 31b are formed at both ends of both ends of the front part.

Code division of the biosensor 10 configured as described above is as follows.

The identification code may generate an on / off signal to the recognition means 3 of the measuring device 1, and the measuring device 1 may calculate the identification information through at least one on / off signal generated by the identification code. Can be.

For example, the measuring device 12 may calculate a binary code through an on / off signal, and utilize the calculated binary code as identification information of the biosensor 10.

That is, as shown in (b), when the incision groove 31a is formed at one side, the right signal is not recognized by the incision groove 31a in the recognition means 3 formed inside the measuring device, and is read as 0, and the left side. The signal is recognized by the recognizing means 3 and the end is read as 1, combined with 01, and classified into a code 1 matching it. As shown in (c), when the incision groove 31b is formed at the other side, the right side signal is recognized as 1 at the end portion of the recognition means 3 formed inside the measuring device, and the left signal is read out at the recognition means 3. It is not recognized due to the incision groove 31b, and is read as 0, which is combined with 10, and classified into 2 codes that match. When the incision groove is not formed as shown in (a), the right end signal is read as 1 by the recognition means 3 formed in the measuring device and the left signal is read as 1 by the end signal. Combination of 11 and matching with code 3 matching.

Likewise, in the biosensor according to the second preferred embodiment of the present invention, as shown in FIG. 5, an identification code is formed on at least one side of both side portions of the inlet 13, and the identification code is located inside the measuring device 1. Recognized through the recognition means 3 is formed and is transmitted to the measuring device (1).

The identification code is composed of recessed

grooves

32a and 32b recessed in at least one side portion of both side portions of the lead portion 13. That is, as shown in (a) of FIG. 5, a structure in which the recessed grooves 32a are formed in one side surface portion of both side portions, and as shown in (b), the recessed grooves 32b are formed in the other side surface portions of both side portions. As shown in (c), the concave convex groove 32a is formed in one side surface portion of both side portions, and the concave concave groove 32b is formed in the other side surface portion. The on / off signal is generated by the recognition means 3 according to the presence or absence of the recessed

grooves

32a and 32b formed in the side portions of the inlet portion 31, and the measuring device 12 is turned on as in the first embodiment described above. The binary code can be calculated through the on / off signal, and the calculated binary code is used as identification information of the biosensor 10. Through the on / off signal, (a) is code 1, (b) code 2 and (c) code 3 is classified.

Similarly, in the biosensor according to the third preferred embodiment of the present invention, as shown in FIG. 6, an identification code is formed at the front side of the handle part 11, and the identification part is handled to be recognized by the recognition means 2. It consists of

incision grooves

33a, 33b, 33c recessed in at least one front part of (11). At this time, the front portion of the handle portion 11 is configured to be introduced into the measuring device, the recognition means 3 inside the measuring device 1 is formed at a position capable of recognizing the identification code formed on the handle portion (11). . This identification code is recognized by the recognition means 3 formed inside the measuring device 1 and transmitted to the measuring device 1.

The identification code is composed of

incision grooves

33a, 33b, 33c recessed in at least one front portion of the handle portion 11. That is, as shown in (a) of FIG. 6, one cut groove 33a is formed in the front portion of the handle portion 11, and as shown in (b) two cut grooves 33a and 33b. ) Is formed in parallel with the structure, and as shown in (c) three cut grooves (33a, 33b, 33c) is formed. The on / off signal is generated by the recognition means 3 according to the presence or absence of the cutting

grooves

33a, 33b, 33c formed in the front portion of the handle portion 11, and the measuring device is turned on as in the first embodiment described above. The binary code can be calculated through the on / off signal, and the calculated binary code is used as identification information of the biosensor 10. Through the on / off signal, (a) is code 1, (b) code 2 and (c) code 3 is classified.

Likewise, in the biosensor according to the fourth preferred embodiment of the present invention, as shown in FIG. 7, an identification code is formed on at least one side of the upper and lower surfaces of the inlet 13, and the identification code is formed inside the measuring device 1. Recognized through the recognition means (3) formed in the transfer to the measuring device.

The identification code is composed of

irregularities

34a, 34b, 34c formed on at least one side of the upper and lower surfaces of the lead portion 13. That is, as shown in (a) of FIG. 7, one unevenness 34a is formed at each of both sides of the upper surface of the inlet 13, and as shown in (b) of the inlet 13. One concave and convex portion 34a is formed at one side of the upper surface both sides, and two concave and convex portions 34b are formed at the other side, and as shown in (c), one side of both sides of the upper surface of the inlet portion 13 is shown. It is composed of a structure in which three unevenness 34c is formed. The number of the

unevennesses

34a, 34b, and 34b formed on the upper surface of the inlet portion 31 may be changed according to a worker's request, and the recognition means (according to the presence or absence of the

unevennesses

34a, 34b, and 34c) 3) generates an on / off signal, and as in the first embodiment described above, the measuring device 12 can calculate a binary code through the on / off signal, and the calculated binary code of the biosensor 10 It is used as identification information. Through the on / off signal, (a) is code 1, (b) code 2 and (c) code 3 is classified.

In the above description, for convenience of description, three cases have been described as examples, but a larger number of codes may be formed based on a combination according to the number or location of grooves or irregularities constituting the identification code. May be used to identify the type of analyte and the other may be used to identify the calibration code. For example, as shown in FIG. 7, the unevenness of one side of the inlet part 13 indicates that the unevenness is a biosensor for measuring blood sugar if one unevenness is used. It may indicate that the purpose, and the other side irregularities may be used to distinguish the calibration code of the biosensor. In addition, according to need or convenience may be provided with identification codes of different shapes. For example, one side of the inlet 13 may be provided with the recessed grooves as shown in FIG. 5, and the other side may be provided with the irregularities as shown in FIG. 7.

Although a biosensor having such identification information has been described with respect to an electrochemical measuring method, it is apparent to those skilled in the art that the present invention can be applied to other measuring methods, such as an optical measuring method. That is, the biosensor is mounted on the measuring device, and the measuring device can be used in any measuring system for identifying the type or characteristic of the biosensor by the identification shape formed by the identifier. In an optical or immunodiagnostic biosensor, a reaction unit or a reaction zone may be provided instead of the reactor plate. In addition, a reaction indicator means for directly indicating the reaction result may be further included.

Such a biosensor according to the present invention provides a technology for providing a measuring device with identification information for identifying a biosensor through an identification code determined by an identifier. In addition, the biosensor having identification information according to the present invention can be manufactured in a small size, and the power consumption of the measuring device can be reduced.

The present invention is not limited to the above-described specific preferred embodiments, and various modifications can be made by any person having ordinary skill in the art without departing from the gist of the present invention claimed in the claims. Of course, such changes will fall within the scope of the claims.

Claims

In the biosensor 10 consisting of a reactor plate 20 for generating a reaction signal in response to the fluid sample introduced, and the main body 12 on which the reactor plate 20 is mounted,

The main body 12 is inserted into the measuring device 1 so that the identification information of the biosensor 10 can be recognized by the measuring device 1 at the same time as the measuring device 1 is inserted into the measuring device 1. Biosensor having identification information, characterized in that at least one identification code forming the irregularities in the portion.
The method of claim 1, wherein the reactor plate 20,

A working electrode 21 and a reference electrode 22 are provided, a reaction reagent is applied to the working electrode 21 and the reference electrode 22, and the working electrode 21 and the reference electrode 22 are measured by a measuring device ( 1) A biosensor having identification information, characterized in that each of the transfer electrodes (23, 24) extending so as to be connected to.
The method of claim 1, wherein the reactor plate 20

It is mounted to the mounting region 14 of the main body 12 to form a capillary portion 15 into which the fluid sample flows, and the main body 12 communicates with the middle region of the capillary portion 15 to the outside to discharge air. Biosensor having identification information, characterized in that the exhaust hole 16 is formed.
According to claim 1, wherein the side of the main body 12, the handle portion 11 is gripped by the user by the hand is formed, the front portion of the main body 12, the inlet portion 13 which is introduced into the measuring device Biosensor having identification information, characterized in that the provided.
The method according to claim 4, so that it can be recognized by the recognition means (3) formed inside the measuring device.

The identification code is a biosensor having identification information, characterized in that it consists of a cutout groove (31a, 31b) recessed in at least one side of both ends of the front portion of the inlet (13).
The method according to claim 4, so that it can be recognized by the recognition means (3) formed inside the measuring device.

The identification code is a biosensor having identification information, characterized in that it comprises a recessed groove (32a, 32b) recessed in at least one side portion of both side portions of the inlet portion (13).
The method according to claim 4, so that it can be recognized by the recognition means (3) formed inside the measuring device.

The identification code is a biosensor having identification information, characterized in that it is made of at least one cutting groove (33a, 33b, 33c) recessed in the front portion of the handle portion (11).
The method according to claim 4, so that it can be recognized by the recognition means (3) formed inside the measuring device.

The identification code is a biosensor having identification information, characterized in that it comprises an uneven groove (34a, 34b, 34c) formed on at least one side of the upper and lower surfaces of the lead portion (13).