KR101101573B1 - Sensor for measuring biomaterial used with measuring meter, and measuring device using this sensor - Google Patents

Abstract

The present invention relates to a sensor used in conjunction with a detector to measure a biomaterial and an apparatus using the same. In the present invention, the biomaterial measuring sensor includes a body part having one end inserted into the detector, a reaction part attached to the body part and causing a biochemical reaction with the biomaterial, and a signal transmitting part transmitting a signal generated by the reaction part to the detector. And a handle portion attached to the body portion at an opposite side of one end of the body portion inserted into the detector and accessible to a sample inlet for introducing a biomaterial into the reaction portion by bending up or down relative to the body portion. According to the present invention, it is possible to provide a sensor strip that is easy to handle, such as insertion into a detector, removal from a detector, and the like regardless of the size of a reaction part used for actual measurement. In addition, the handle strip is removed from the sample inlet after use and the sensor strip is removed, so there is little concern for the blood on the sensor strip.

Description

Sensor for measuring biomaterial used with detector and device using same {SENSOR FOR MEASURING BIOMATERIAL USED WITH MEASURING METER, AND MEASURING DEVICE USING THIS SENSOR}

The present invention relates to a sensor used in conjunction with a detector to measure a biomaterial and a device using the same, and relates to a biomaterial measuring sensor having a structure that can be easily attached and detached and minimizes contamination of the sensor, and a measuring device using the same.

Biosensor refers to a measuring device that investigates the properties of materials by using functions of living organisms. Since biomaterials are used as detection devices, they have excellent sensitivity and reaction specificity. Therefore, it is used in a wide range of fields such as clinical chemical analysis in the medical / medical field, process measurement in the bio industry, environmental measurement, and stability evaluation of chemicals. Especially in the field of medical diagnostics, biosensors are widely used to analyze biological samples including samples. Biosensors include enzyme analysis and immunoassay according to the type of detection device, and optical biosensors and electrochemical biosensors according to the method of quantitative analysis of a target substance in a biological sample.

Enzyme assay biosensors use specific reactions of enzymes and substrates, enzymes and enzyme inhibitors. Immunoassay biosensors use specific reactions of antigens and antibodies.

The optical biosensor is a method of measuring the concentration of a target substance by measuring light transmittance, absorbance or wavelength change, and is the most commonly used method. The reaction mechanisms of the various materials to be analyzed are already known and measured after the reaction has been performed for a sufficient time, so there is an advantage that the variation in measurement time is small. However, compared with electrochemical biosensors, the measurement time is long and a large amount of samples is required. In addition, there is a problem that the measurement result is affected by the turbidity of the sample and it is difficult to miniaturize the optical unit.

An electrochemical biosensor is a method of measuring the concentration of a target substance by measuring an electrical signal obtained from a biochemical reaction. Electrochemical biosensors have the advantages of being able to amplify signals with very small amounts of samples, being easy to miniaturize, reliably acquiring measurement signals, and being easily integrated with information and communication devices, but requiring electrode processes and high production costs. The disadvantage is that the measurement signal is very sensitive to the reaction time.

On the other hand, conventional biosensors are usually manufactured by stacking a reaction part that causes a biochemical reaction with an analyte and a signal transmission part that transmits a signal generated as a result of the biochemical reaction to a detector on a flat strip-shaped substrate. The substrate in the form of a planar strip generally has a small size depending on the size of the reaction section and the signal transmission section. Therefore, diabetics or elderly people are not easy to insert the strip-type biosensor into the narrow slit of the detector. In addition, when removing the biosensor from the detector after measuring blood sugar, the user grabs and pulls out the vicinity of the area where the blood is buried, and the user may feel uncomfortable because the blood may be on the hand. In addition, the conventional strip type biosensor has a problem in that it is susceptible to contamination when inserted into the detector by the user.

Therefore, an object of the present invention is to provide a biomaterial measuring sensor that is easy to handle regardless of the size of the reaction unit and the signal transmission unit.

Another object of the present invention is to provide a biomaterial measuring sensor that is less likely to get blood on the user's hand when removing the biosensor from the detector after measuring blood glucose.

It is another object of the present invention to provide a biomaterial measuring sensor which is less likely to be contaminated from the outside when the biosensor is inserted into the detector.

The objects of the present invention are not limited to the above-mentioned objects, and other objects and advantages of the present invention which are not mentioned can be understood by the following description, and will be more clearly understood by the embodiments of the present invention. Also, it will be readily appreciated that the objects and advantages of the present invention may be realized by the means and combinations thereof indicated in the claims.

In order to achieve the above object, the present invention provides a sensor for measuring a biomaterial, which is used together with a detector, a body portion having one end inserted into the detector, a reaction attached to the body portion, and causing a biochemical reaction with the biomaterial. And a sample for transmitting the signal generated by the reaction unit to the detector, and a sample attached to the body and introducing the biomaterial into the reaction unit by bending up or down with respect to the body. It is characterized by having a handle portion for making the inlet accessible.

In another aspect, the present invention is a sensor for measuring a biological material used in conjunction with a detector, the body portion is inserted into the detector, the reaction is attached to the body portion to be connected to the sample inlet and causing a biochemical reaction with the biological material And a handle configured to transmit a signal generated by the reaction unit to the detector, and a handle formed on the side of the body so that the sample inlet is exposed to the outside and one end of the body can be inserted into the detector. It is another feature to provide a part.

In another aspect, the present invention provides a device for measuring a biological material having a detector and a measuring sensor, the measuring sensor is attached to the body end, the body is attached to the body portion causing the biochemical reaction with the biological material A reaction unit, a signal transmission unit for transmitting a signal generated by the reaction unit to the detector, and attached to the body portion and bent up or down relative to the body portion to enable the introduction of the biological material into the reaction unit. It is provided with a handle to make, the detector is characterized in that it further comprises an analysis unit for measuring the concentration of the analysis target material by analyzing the signal transmitted through the signal transmission unit.

In another aspect, the present invention is a device for measuring a biological material having a detector and a measuring sensor, the measuring sensor is attached to the body portion and the body portion to be connected to the sample inlet, the body portion is inserted into the detector and the biological material and A reaction unit for causing a biochemical reaction of the reaction unit, a signal transmission unit for transmitting a signal generated by the reaction unit to the detector, and the body so that the sample introduction port is exposed to the outside and one end of the body unit can be inserted into the detector. It is provided with a handle portion formed on the side of the part, the detector is characterized in that it further comprises an analysis unit for measuring the concentration of the analysis target material by analyzing the signal transmitted through the signal transmission unit.

According to the present invention, it is possible to provide a sensor strip that is easy to handle, such as insertion into a detector, removal from a detector, and the like regardless of the size of a reaction part used for actual measurement. In addition, the handle strip is removed from the sample inlet after use and the sensor strip is removed, so there is little concern for the blood on the sensor strip.

In addition, according to the present invention, since the sample inlet is accessible only after inserting the sensor strip into the detector and bending the handle, the contamination of the sensor strip in the process of inserting the sensor strip into the detector can be reduced. In addition, the handle portion may serve to guide the finger when the finger is introduced to the sensor strip against the sensor strip, thereby facilitating the introduction of blood into the sensor strip.

In addition, since the reaction part in mass production can be used in various models of detectors through the body part, it is advantageous in the process. In addition, since the size of the portion used for the actual measurement can be made very small, the manufacturing cost of the sensor strip can be reduced.

BRIEF DESCRIPTION OF THE DRAWINGS The above and other objects, features and advantages of the present invention will become more apparent from the following detailed description of the present invention when taken in conjunction with the accompanying drawings, It can be easily carried out. In the following description, well-known functions or constructions are not described in detail since they would obscure the invention in unnecessary detail. Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings.

1 is a view illustrating a structure of an exposed biosensor 100 according to an embodiment of the present invention, FIG. 2 is a side view of the biosensor 100, and FIG. 3 is a biosensor at the boundary 112. Shear view of 100). As shown, the biosensor 100 is provided with a body portion 102, the handle portion 104, the reaction portion 106, the signal transmission unit 108. The reaction part 106 and the signal transmission part 108 are exposed on the upper surface of the body part 102. In FIG. 3, the thickness of the reaction part 106 is exaggerated for convenience of understanding.

Body portion 102 has one end inserted into a detector (not shown) such that one end of signal delivery portion 108 is electrically connected to the detector. The boundary 110 of the body portion 102 that surrounds the handle portion 104 in a 'c' shape is cut. The remaining boundary 112, which is not cut, may have a groove formed on one side or both sides thereof, and the groove may be easily bent in the upward or downward direction with respect to the body portion 102. The cross section of the groove may be triangular, semicircular, or the like. When the boundary 112 of the body portion 102 and the handle portion 104 is formed thin or narrow, the biosensor 100 may be easily bent against the body portion 102 even if there is no groove. It may not have a groove. Since the boundary 110 is a 'c' shape derived from the boundary 112, the reaction unit 106 or the sample introduction port 300 protrudes when the handle part 104 is bent.

The reaction part 106 is formed by being exposed to the body part 102 as shown in FIG. 3 and undergoes a biochemical reaction with the biological material to be analyzed. The signal transmitter 108 transfers the signal generated by the reaction unit 106 to a detector (not shown). The reaction unit 106 and the signal transmission unit 108 may be configured as a two-electrode type, a three-electrode type, or the like. The reaction unit 106 and the signal transmission unit 108 may be integrally formed with a strip electrode attached to the body portion 102. An analytical reagent (not shown) for causing a biochemical reaction with the analyte is fixed on the electrode constituting the reaction part 106.

The reaction unit 106 may be easily manufactured by conventional thin film deposition technology, plating technology, or printed electronic technology, and may be easily manufactured using a printed circuit board (PCB). . The reaction unit 106 has a plurality of reaction electrodes formed on the lower surface connected to the sample inlet 300 through the sample path 302 in the biomaterial, and the upper surface generated by the biochemical reaction. A plurality of transfer electrodes can be formed that deliver the signal to the detector. The reaction electrode and the transfer electrode may be electrically connected through a conductor passing through the reaction unit 106.

The handle portion 104 is formed at a portion different from the body portion 102 to be inserted into the detector, in particular on the opposite side. When the handle part 104 is bent up or down with respect to the body part 102, the sample inlet 300 for introducing a sample of the biological material into the reaction part 106 is accessible from the outside. The sample introduction port 300 is preferably formed at a portion different from the body portion 102 inserted into the detector, particularly on the opposite side, to facilitate the introduction of the sample into the reaction portion 106, and is made of a capillary tube.

4A is a view illustrating a state in which the handle 104 is folded in the biosensor 100 illustrated in FIG. 1, and FIG. 4B is a side view illustrating a state in which the handle 104 is folded in the biosensor 100. .

As shown, when the handle portion 104 is bent down or up with respect to the body portion 102 along the groove formed in the boundary 112, the reaction portion 104 or the sample introduction port (not shown) protrudes. Becomes

5A to 5D are diagrams illustrating a method of using the biosensor shown in FIG. 1. By inserting the biosensor 504 into the detector 502, a device for measuring biomaterials is provided. The detector 502 analyzes the signal transmitted through the signal transmitter of the biosensor 504 to measure the concentration of the analyte.

First, as shown in FIG. 5A, the handle 508 is held and the biosensor 504 is inserted into the slit of the detector 502. Next, as shown in FIG. 5B, when the biosensor 504 is folded in a 'b' shape by holding the handle 508, the reaction unit 506 protrudes. Next, as shown in FIG. 5C, a finger is applied to the protruding reaction part 506 (particularly, a sample introduction port) to introduce blood into the biosensor 504 and to analyze blood sugar contained in the blood. After the analysis is completed, as shown in FIG. 5D, the biosensor 504 is removed by holding the handle 508 and pulling the biosensor 504 out of the detector 502.

According to this embodiment, the size of the overall biosensor 504 can be increased regardless of the size of the reaction unit 506 used for the actual measurement, so that the biosensor 504 is inserted into the detector 502, and the detector ( Handling such as removing the biosensor 504 from the 502 becomes easy. In addition, since the handle strip 504 is removed from the sample introduction port where the blood is deposited after use, and the sensor strip 504 is removed, there is little fear that the blood on the sensor strip 504 may get on the hands.

In addition, according to the present embodiment, since the sample inlet is accessible from the outside only after the sensor strip 504 is inserted into the detector 502 and the handle 508 is bent, the sensor strip 504 is connected to the detector 502. Contamination of the sensor strip 504 can be reduced during insertion. The handle 508 can also facilitate the introduction of blood into the sensor strip 504 because it can serve to guide a finger when introducing a finger to the sensor strip 504 against the sensor strip 504. .

In addition, when the reaction unit and the signal transmission unit are manufactured using, for example, a PCB, the size of the mass-produced PCB can be used in detectors of various models, which is advantageous in the process. In addition, since the size of the reaction part used for the actual measurement can be made very small, the manufacturing cost of the sensor strip can be reduced.

6 is a view illustrating a case where the embedded biosensor 60 according to another embodiment of the present invention is viewed from above, and FIG. 7 is a view illustrating the case where the biosensor 60 is seen below. 8 is a side view of the biosensor 60, and FIG. 9 is a front sectional view of the biosensor 60 at the boundary 66. Unlike the biosensor 100, the biosensor 60 has a reaction unit 72 embedded in the sample path 92 of the body 62. In this embodiment, the reaction unit 72 has all sides embedded in the body portion 62, but some side surfaces may not be embedded in the body portion 62.

As shown, the biosensor 60 is provided with a body portion 62, the handle portion 64, the reaction portion 72, the signal transmission portion 74. In FIG. 9, the thickness of the reaction unit 72 is exaggerated for convenience of understanding.

The body portion 62 has one end inserted into a detector (not shown) so that one end of the signal transfer portion 74 is electrically connected to the detector. The '68' shaped border 68 between the body 62 and the handle 64 is cut off. The remaining border 66, which is not cut, may have a groove formed on one side or both sides of the bottom or top, and the groove allows the handle 64 to be easily bent up or down with respect to the body portion 62. The cross section of the groove may be triangular, semicircular, or the like. When the boundary 66 between the body portion 62 and the handle portion 64 is formed thin or narrow, the biosensor 60 may be easily folded against the body portion 62 even if there is no groove. It may not have a groove. The boundary 68 is drawn out in a 'c' shape with respect to the boundary 66 so that the reaction unit 72 or the sample introduction port 90 protrudes when the handle 64 is bent.

The reaction part 72 is formed in the sample path 92 of the body part 62, and a biochemical reaction with the biological material to be analyzed is performed in the reaction part 72. The signal transmission unit 74 transfers the signal generated by the reaction unit 72 to a detector (not shown). The reaction unit 72 and the signal transmission unit 74 may be of a two-electrode type, a three-electrode type, or the like. The reaction unit 72 and the signal transmission unit 74 may be integrally formed with a strip electrode attached to the body portion 62. An analytical reagent (not shown) which causes a biochemical reaction with the analyte to be fixed is fixed on the electrode constituting the reaction unit 72.

The reaction unit 72 may be easily manufactured by conventional thin film deposition technology, plating technology, or printed electronic technology, and may be easily manufactured by using a printed circuit board (PCB). . In the reaction unit 72, a plurality of reaction electrodes are formed on the upper surface connected to the sample inlet 90 through the sample path 92, and a biochemical reaction to the biomaterial is formed. A plurality of transfer electrodes can be formed that deliver to the detector. The reaction electrode and the transfer electrode may be electrically connected through a conductor passing through the reaction unit 72.

The handle 64 is formed at a part different from the body 62 which is inserted into the detector, in particular on the opposite side. When the handle portion 64 is bent up or down with respect to the body portion 62, the sample introduction port 90 for introducing a sample of the biological material into the reaction portion 72 is accessible from the outside. The sample introduction port 90 is preferably formed at a portion different from the body portion 62 inserted into the detector, particularly on the opposite side, to facilitate the introduction of the sample into the reaction portion 72 and is made of a capillary tube. As used herein, "capillary" refers to a pathway that causes capillary action on a sample of biological material.

10 is a view illustrating a case where the handle 64 is folded in the biosensor 60, and FIG. 11 is a side view of the biosensor 60 of FIG. 10. As shown, when the handle 64 is bent downward with respect to the body 62 along the groove formed in the boundary 66, the reaction portion 72 or the sample introduction port 90 is exposed.

12 is a view for explaining the structure of a biosensor according to another embodiment of the present invention.

The biosensor 120 includes a body 121, a handle 122, a reaction unit 123, and a signal transmission unit 124. The reaction part 123 and the signal transmission part 124 are exposed on the upper surface of the body part 121.

One end of the body 121 is inserted into a detector (not shown) so that one end of the signal transmission unit 124 is electrically connected to the detector. The boundary 125 of the body portion 121 surrounding the handle portion 122 in a 'c' shape is cut. Since the groove 127 is formed at the side 127 at the remaining border 126 that is not cut, the border 126 is formed relatively narrower than the handle 122, and thus the handle 122 is the body 121. Easily bend it up or down relative to. Since the boundary 125 is a 'c' shape derived from the boundary 126, the reaction part 123 protrudes when the handle part 122 is bent.

The reaction part 123 is embedded or exposed to the body part 121, and a biochemical reaction of the biomaterial to be analyzed occurs in the reaction part 123. The signal transmitter 124 transfers the signal generated by the reaction unit 123 to a detector (not shown). The reaction unit 123 and the signal transmission unit 124 may be configured as a two-electrode type, a three-electrode type, or the like. An analytical reagent (not shown) for causing a biochemical reaction with the analyte is fixed on the electrode constituting the reaction part 123.

In this embodiment, the handle portion 122 is formed on the other portion, in particular the opposite side to the portion of the body portion 121 to be inserted into the detector. When the handle part 122 is bent up or down with respect to the body part 121, a sample inlet (not shown) for introducing a sample of the biological material into the reaction part 123 is accessible from the outside.

FIG. 13 is a diagram illustrating manufacturing a plurality of biosensors shown in FIG. 1 at one time. As shown in FIG. 13, a plurality of biosensors 602 may be manufactured at the same time, and the biosensors 602 may be cut and used in the cutting unit 604 one by one. In this case, since the biosensors do not have to be handled one by one during the manufacturing process, the manufacturing process can be made very simple, thereby reducing the manufacturing cost of the sensor strip.

14A and 14B are side views of a biosensor 700 according to another embodiment of the present invention. As shown, the biosensor 700 includes a body 702, a handle 714, a reaction unit 706, and a signal transmission unit 708. Compared with the biosensor 100 shown in FIG. 1, the biosensor 700 has a difference in that the film 712 is further attached to the lower surface.

Body portion 702 has one end inserted into a detector (not shown) such that one end of signal delivery portion 708 is electrically connected to the detector. At the boundary between the body portion 702 and the handle portion 714, a part is cut, and the other portion has a groove 710 formed on the lower surface as shown in the figure, so that the handle portion 714 with respect to the body portion 702. Can be easily bent up or down. The film 712 serves to prevent the handle 714 from being cut from the body 702 in the process of bending the handle 714 with respect to the body 702. The film 712 is preferably a flexible plastic film. In the case of the biosensor in which the handle portion 714 is bent downward with respect to the body portion 702, the film is attached to the bottom surface, and in the case of the biosensor bent in the upper surface, the film is attached to the upper surface.

15 is a view for explaining a biosensor according to another embodiment of the present invention. As shown, the biosensor 800 includes a body portion 802, a handle portion 804, a reaction portion 806, and a signal transmission portion 808.

First, the body portion 802 is inserted into the detector (not shown) in the direction of the arrow. The reaction unit 806 includes a sample introduction port 810 for introducing a sample of a biological material into the reaction unit 806. The sample introduction port 810 is made of a capillary tube to facilitate the introduction of the sample. The reaction part 806 is formed in the body part 802 and a biochemical reaction with the biological material occurs. The signal transmitter 808 transmits the signal generated by the reaction unit 806 to the detector, and the detector performs an analysis on the material to be analyzed using the transmitted signal. The handle portion 804 is attached to the side of the body portion 802 so that the sample inlet 810 is exposed to the outside and one end of the body portion 802 can be inserted into the detector.

The present invention described above is capable of various substitutions, modifications, and changes without departing from the technical spirit of the present invention for those skilled in the art to which the present invention pertains. It is not limited by the drawings.

1 is a view for explaining the structure of a biosensor according to an embodiment of the present invention.

FIG. 2 is a side view of the biosensor shown in FIG. 1.

3 is a front sectional view of the biosensor shown in FIG. 1.

4A is a perspective view illustrating a state where the handle part is bent in the biosensor illustrated in FIG. 1.

4B is a side view illustrating a state where the handle part is bent in the biosensor shown in FIG. 1.

5A to 5D are diagrams illustrating a method of using the biosensor shown in FIG. 1.

6 is a view illustrating a case where the biosensor according to another embodiment of the present invention is viewed from above.

FIG. 7 is a view illustrating the biosensor of FIG. 6 as seen below.

8 is a side view of the biosensor of FIG. 6.

9 is a front sectional view of the biosensor of FIG. 6.

FIG. 10 is a view illustrating a case where the handle part is bent in the biosensor of FIG. 6.

FIG. 11 is a side view of the biosensor of FIG. 10.

12 is a view for explaining the structure of a biosensor according to another embodiment of the present invention.

FIG. 13 is a diagram illustrating manufacturing a plurality of biosensors shown in FIG. 1 at one time.

14A and 14B are side views of a biosensor according to another embodiment of the present invention.

15 is a view for explaining a biosensor according to another embodiment of the present invention.

Claims (15)

A sensor used in conjunction with a detector to measure a biomaterial, A body portion having one end inserted into the detector; A reaction part attached to the body part and causing a biochemical reaction with the biological material, A signal transmission unit for transmitting the signal generated in the reaction unit to the detector; The handle portion is attached to the body portion and bent up or down relative to the body portion to allow access to the sample introduction port for introducing the biological material into the reaction portion Biological material measuring sensor comprising: The method of claim 1, The biological material measuring sensor, characterized in that the periphery of the sample inlet is cut out of the boundary between the body portion and the handle portion. The method of claim 1, The biomaterial measuring sensor, characterized in that a groove is formed at the boundary of the body portion and the handle portion. The method of claim 1, The boundary of the body portion and the handle portion is a biomaterial measurement sensor, characterized in that formed narrower than the handle portion. The method of claim 1, And a film adhered to the body portion and the handle portion. The method of claim 1, And the reaction part is attached to the body part such that the reaction part protrudes when the handle part is bent. The method of claim 1, And the handle portion is formed on the opposite side of one end of the body portion inserted into the detector. The method of claim 1, The reaction unit A plurality of reaction electrodes in which a biochemical reaction to the biological material occurs is formed on the side connected to the sample inlet, A plurality of transfer electrodes for transmitting a signal generated by the biochemical reaction to the detector is formed on the other side Biomaterial measuring sensor, characterized in that. The method of claim 8, And the reaction electrode and the transfer electrode are electrically connected to each other via a conductor passing through the reaction unit. A sensor used in conjunction with a detector to measure a biomaterial, A body portion having one end inserted into the detector; A reaction part attached to the body part so as to be connected to the sample inlet and causing a biochemical reaction with the biological material; A signal transmission unit for transmitting the signal generated in the reaction unit to the detector; The handle portion is formed on the side of the body portion so that the sample introduction port is exposed to the outside and one end of the body portion can be inserted into the detector Biological material measuring sensor comprising: In the apparatus for measuring a biological material having a detector and a measuring sensor, The measuring sensor A body portion having one end inserted into the detector; A reaction part attached to the body part and causing a biochemical reaction with the biological material, A signal transmission unit for transmitting the signal generated in the reaction unit to the detector; A handle part attached to the body part and configured to allow the introduction of the biomaterial into the reaction part by bending up or down with respect to the body part, The detector is An analysis unit configured to analyze a signal transmitted through the signal transmission unit and measure a concentration of an analysis target material Biomaterial measuring device, characterized in that. The method of claim 11, A biomaterial measuring apparatus, characterized in that a groove is formed at the boundary of the body portion and the handle portion. The method of claim 11, The boundary between the body portion and the handle portion is a biological material measuring device, characterized in that formed narrower than the handle portion. The method of claim 11, And the reaction part is attached to the body part such that the reaction part protrudes when the handle part is bent. In the apparatus for measuring a biological material having a detector and a measuring sensor, The measuring sensor A body portion having one end inserted into the detector; A reaction part attached to the body part so as to be connected to the sample inlet and causing a biochemical reaction with the biological material; A signal transmission unit for transmitting the signal generated in the reaction unit to the detector; It is provided with a handle portion formed on the side of the body portion so that the sample introduction port is exposed to the outside and one end of the body portion can be inserted into the detector, The detector is An analysis unit configured to analyze a signal transmitted through the signal transmission unit and measure a concentration of an analysis target material Biomaterial measuring device, characterized in that.

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