WO2014125431A4 - Personal health data collection - Google Patents

Personal health data collection Download PDF

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Publication number
WO2014125431A4
WO2014125431A4 PCT/IB2014/058969 IB2014058969W WO2014125431A4 WO 2014125431 A4 WO2014125431 A4 WO 2014125431A4 IB 2014058969 W IB2014058969 W IB 2014058969W WO 2014125431 A4 WO2014125431 A4 WO 2014125431A4
Authority
WO
WIPO (PCT)
Prior art keywords
phhm
phhcd
photo
body part
blood
Prior art date
Application number
PCT/IB2014/058969
Other languages
French (fr)
Other versions
WO2014125431A1 (en
Inventor
Christopher Elliott
Mark-Eric Jones
Mikhail Nagoga
Shady Gawad
Gabriel KLEIN
Original Assignee
Léman Micro Devices Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1302548.1A external-priority patent/GB201302548D0/en
Priority claimed from GB201316914A external-priority patent/GB201316914D0/en
Priority claimed from GBGB1316915.6A external-priority patent/GB201316915D0/en
Priority to AU2014217528A priority Critical patent/AU2014217528B2/en
Priority to US14/767,444 priority patent/US20150374249A1/en
Priority to JP2015557549A priority patent/JP6722456B2/en
Priority to CN201480021065.2A priority patent/CN105120737A/en
Priority to CA2900904A priority patent/CA2900904C/en
Application filed by Léman Micro Devices Sa filed Critical Léman Micro Devices Sa
Priority to SG11201506365XA priority patent/SG11201506365XA/en
Priority to MX2015010353A priority patent/MX2015010353A/en
Priority to BR112015019259-9A priority patent/BR112015019259B1/en
Priority to RU2015138778A priority patent/RU2674087C2/en
Priority to KR1020157025173A priority patent/KR102329229B1/en
Priority to EP14708328.1A priority patent/EP2956048A1/en
Publication of WO2014125431A1 publication Critical patent/WO2014125431A1/en
Publication of WO2014125431A4 publication Critical patent/WO2014125431A4/en
Priority to HK16105390.7A priority patent/HK1217626A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/022—Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
    • A61B5/02233—Occluders specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14557—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted to extracorporeal circuits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4887—Locating particular structures in or on the body
    • A61B5/489—Blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6887—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient mounted on external non-worn devices, e.g. non-medical devices
    • A61B5/6897—Computer input devices, e.g. mice or keyboards
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6887—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient mounted on external non-worn devices, e.g. non-medical devices
    • A61B5/6898—Portable consumer electronic devices, e.g. music players, telephones, tablet computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient ; user input means
    • A61B5/7405—Details of notification to user or communication with user or patient ; user input means using sound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient ; user input means
    • A61B5/742—Details of notification to user or communication with user or patient ; user input means using visual displays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/04—Constructional details of apparatus
    • A61B2560/0406—Constructional details of apparatus specially shaped apparatus housings
    • A61B2560/0425—Ergonomically shaped housings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A61B2562/0238—Optical sensor arrangements for performing transmission measurements on body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • A61B5/02416—Detecting, measuring or recording pulse rate or heart rate using photoplethysmograph signals, e.g. generated by infrared radiation
    • A61B5/02427—Details of sensor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • A61B5/0245—Detecting, measuring or recording pulse rate or heart rate by using sensing means generating electric signals, i.e. ECG signals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Cardiology (AREA)
  • Physiology (AREA)
  • Vascular Medicine (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dentistry (AREA)
  • Pulmonology (AREA)
  • Multimedia (AREA)
  • General Engineering & Computer Science (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

This disclosure provides a personal hand-held monitor (PHHM) which comprises a signal acquisition device for acquiring signals which can be used to derive a measurement of a subject's blood pressure (BP), the signal acquisition device being integrated with a personal hand-held computing device (PHHCD).The signal acquisition device comprises a blood flow occlusion means adapted to be pressed against one side only of a body part or to have one side only of a body part pressed against it, a means for measuring the pressure applied by or to the body part, and a means for detecting the flow of blood through the body part in contact with the blood flow occlusion means. The blood flow occlusion means comprises at least part of an external surface of the PHHM and wherein the pressure is sensed by means of a flexible and essentially incompressible gel in which is immersed a pressure sensor. The pressure sensor is adapted to provide electrical signals to the processor of the PHHCD.

Claims

AMENDED CLAIMS received by the International Bureau on 15 September 2014 (15.09.2014) CLAIMS
1. A personal hand-held monitor (PHHM) which comprises a signal acquisition device for acquiring signals which can be used to derive a measurement of a subject's blood pressure (BP), the signal acquisition device being integrated with a personal hand-held computing device (PHHCD), wherein the signal acquisition device comprises a blood flow occlusion means adapted to be pressed against one side only of a body part or to have one side only of a body part pressed against it, a means for measuring the pressure applied by or to the body part, and a means for detecting the flow of blood through the body part in contact with the blood flow occlusion means, wherein the blood flow occlusion means comprises at least part of an external surface of the PHHM wherein the pressure is sensed by means of a flexible and essentially incompressible get in which is immersed a pressure sensor which is adapted to provide electrical signals to the processor of the PHHCD.
2. The PHHM of claim 1, wherein the essentially incompressible gel is a fluid covered by a flexible membrane forming some or all of the external surface.
3. The PHHM of claim 1 or claim 2, wherein the blood flow occlusion means is saddle-shaped.
4. The PHHM of any one of claims I to 3, which is arranged to act as a tonometer.
5. The PHHM of claim 4, which is adapted to calibrate the tonometer by use of occlusion measurements obtained from the pressure sensor when used to occlude an artery.
6. The PHHM of any one of claims 1 to 5, wherein the means for detecting the flow of blood through the body part comprises a blood photosensor having one or more photo-emitters for transmitting light to a body part of a user and one or more photo-detectors for detecting light transmitted through or scattered by the body part, wherein the or each photo-emitter and/or the or each photo-detector is/are provided with one or more lenses to narrow the field of view.
7. The PHHM of any one of claims 1 to 6, wherein the means for detecting the flow of blood through the body part comprises comprises a blood photosensor having one or more photo-emitters for transmitting light to a body part of a user and one or more photo- detectors for detecting light transmitted through or scattered by the body part, wherein there are either two photo-emitters or two photo-detectors arranged such that light emitted in two different directions can be detected, and the processing means of the processor of the PHHCD is adapted to process the signals received from each direction to locate a blood vessel in the user's body.
8. The PHHM of claim 6 or claim 7, which is adapted to provide a visible or audible signal to the user to move a body part to optimise the position of the photo-sensor with respect to the blood vessel.
9. The PHHM of claim 7 or claim 8 when dependent on claim 7, whioh is adapted to compensate the signals from the photo-detector(s) when the blood vessel is not optimally positioned with respect to the photo-sensor.
10. The PHHM of any one of claims 6 to 9, wherein the optical axes of the photo- emitter(s) and photo-detector(s) are aligned: to maximise the sensitivity of the signal produced by the photo-detectors to absorption of the emitted light by blood; and/or to minimise the sensitivity of the signal produced by the photo-detectors to the location of the blood vessel; and/or to optimise the performance of the personal hand-held monitor.
1 1. The PHHM of any one of claims 1 to 10, wherein the PHHM is used to provide a binary or continuously variable means for the subject to enter data to the PHHCD in order to control some function of the PHHCD other than the measurements that are made by the PHHM.
12. The PHHM of any one of claims 1 to 11, wherein processor of the PHHCD is adapted to correlate the signals received from the pressure sensor with the signals received from the means for detecting the flow of blood or the optical sensor so that the pressure exerted between the occlusion means and the body part is correlated with the luminal area of the artery and to fit the correlated values to a curve to provide measurements of the subject's SBP and/or DBP.
13. The PHHM of any one of claims 1 to 12, which includes a plurality of pressure-responsive or force-responsive devices.
14. The PHHM of any one of claims 1 to 13, wherein the processor of the PHHCD is adapted to provide audible or visual instructions, advantageously via a display means, if present, to the user to enable the user to use the device optimally.
15. The PHHM of claim 14, wherein the processor of the PHHCD is adapted so that the instructions are interactive and based on signals received from the sensor(s) which can be used to determine whether the device is in the best position or being used correctly,
16. A PHHM of any one of claims 1 to 15, wherein the PHHCD is a games controller, computer pointing device (usually referred to as a mouse) or a remote controller for a television or other electronic equipment.
17. The PHHM of claim 16, wherein, when the PHHCD is a computer pointing device, the PHHM communicates with the computer with which the pointing device is being used or another PHHCD by means of a cable or by means of a wireless connection.
18. The PHHM of any one of claims 1 to 17, which is adapted to estimate the height of the PHHM with respect to a fixed point on the subject's body.
19. The PHHM of claim 18, wherein the fixed point is the subject's eyes and the PHHM is adapted to analyse an image of the subject's face obtained from a camera in a PHHCD to detect the eyes and a measure of the tilt angle of the PHHCD obtained from tilt sensors incorporated within the PHHCD.
20. The PHHM of any of claims 1 to 19, which is adapted to use other sensors incorporated within the PHHCD to detect if the PHHCD has been agitated in the period before the measurement and hence to warn the user of possible errors in blood pressure measurement or to prevent such measurements until the PHHCD has been essentially at rest for sufficient time.
21. The PHHM of any one of claims 1 to 20, which is adapted to provide audible or visual instructions requesting the user to adopt two or more phases of operation, the first of which is used to measure the approximate values of SBP and DBP and/or to check that the user's body part is correctly located and/or at a suitable temperature, the second of which is used to make measurements of the said SBP and DBP and the subsequent phases (if any) are used to refine those measurements.
22. The PHHM of any one of claims 1 to 21, wherein the PHHM has a unique identifier that may be read by the associated processing means.
23. The PHHM of claim 22, wherein the sensors are calibrated on manufacture and the calibration data for each device associated with its unique identifier so that they may be downloaded to the device via the internet.
24. A module comprising a housing, an occlusion means, a pressure sensor, optionally an optical sensor, optionally at least one of the electrodes of an electrical sensor and connections for electrically connecting those components to the remainder of a PHHM according to any one of claims 1 to 23 to form a connected device.
25. A module comprising a housing, an occlusion means, a pressure sensor, optionally an optical sensor, optionally at least one of the electrodes of an electrical sensor and connections for mechanically and electrically connecting those components to the remainder of a PHHM according to any one of claims 1 to 23 to form an integrated device.
PCT/IB2014/058969 2013-02-13 2014-02-13 Personal health data collection WO2014125431A1 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
RU2015138778A RU2674087C2 (en) 2013-02-13 2014-02-13 Personal health data collection
KR1020157025173A KR102329229B1 (en) 2013-02-13 2014-02-13 Personal health data collection
EP14708328.1A EP2956048A1 (en) 2013-02-13 2014-02-13 Personal health data collection
MX2015010353A MX2015010353A (en) 2013-02-13 2014-02-13 Personal health data collection.
JP2015557549A JP6722456B2 (en) 2013-02-13 2014-02-13 Personal health data collection
CN201480021065.2A CN105120737A (en) 2013-02-13 2014-02-13 Personal health data collection
CA2900904A CA2900904C (en) 2013-02-13 2014-02-13 Personal health data collection
AU2014217528A AU2014217528B2 (en) 2013-02-13 2014-02-13 Personal health data collection
SG11201506365XA SG11201506365XA (en) 2013-02-13 2014-02-13 Personal health data collection
US14/767,444 US20150374249A1 (en) 2013-02-13 2014-02-13 Personal health data collection
BR112015019259-9A BR112015019259B1 (en) 2013-02-13 2014-02-13 Personal health data collection personal handheld monitor
HK16105390.7A HK1217626A1 (en) 2013-02-13 2016-05-11 Personal health data collection

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB1302548.1 2013-02-13
GBGB1302548.1A GB201302548D0 (en) 2013-02-13 2013-02-13 Personal Health Data Collection
GBGB1316915.6A GB201316915D0 (en) 2013-09-23 2013-09-23 Device for the non-invasive measurement of blood pressure
GB1316914.9 2013-09-23
GB1316915.6 2013-09-23
GB201316914A GB201316914D0 (en) 2013-09-23 2013-09-23 Device for the non-invasive measurement of blood pressure

Publications (2)

Publication Number Publication Date
WO2014125431A1 WO2014125431A1 (en) 2014-08-21
WO2014125431A4 true WO2014125431A4 (en) 2014-12-18

Family

ID=50236226

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/IB2014/000139 WO2014125355A1 (en) 2013-02-13 2014-02-10 Non-invasive blood analysis
PCT/IB2014/058969 WO2014125431A1 (en) 2013-02-13 2014-02-13 Personal health data collection

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/IB2014/000139 WO2014125355A1 (en) 2013-02-13 2014-02-10 Non-invasive blood analysis

Country Status (13)

Country Link
US (2) US10265002B2 (en)
EP (2) EP2922468B1 (en)
JP (5) JP2016509868A (en)
KR (2) KR102256808B1 (en)
CN (3) CN105307568B (en)
AU (2) AU2014217645B2 (en)
BR (2) BR112015019505B1 (en)
CA (2) CA2900691C (en)
HK (2) HK1214112A1 (en)
MX (2) MX360972B (en)
RU (2) RU2655518C2 (en)
SG (2) SG11201506213VA (en)
WO (2) WO2014125355A1 (en)

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